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association between pre-transplant natural kill and graft-versus-host disease after stem-cell transplantation.natural killer activity against herpes simplex virus type 1 infected fibroblasts nk(hsv-1) was studied prospectively in patients undergoing allogenic bone-marrow or fetal-tissue stem-cell transplantation. thirteen patients showed evidence of engraftment and survived long enough to develop graft-versus-host disease (gvhd). of this group, all of the seven having normal nk(hsv-1) activity before transplantation acquired gvhd and the six having low nk(hsv-1) had no evidence of gvhd. these results we ...197991840
mechanism of action of beta-d-xylosidase from bacillus pumilus prl b12: ph- and alpha-deuterium kinetic isotope effects [proceedings]. 197993945
site dependence for topical absorption of nitroglycerin in rats. 197899511
hemolytic streptococci in supramammary lymph nodes from healthy pigs from the peruvian jungle.hemolytic streptococci were isolated from 53 percent (18) supramammary lymph nodes from healthy adult pigs raised at the peruvian jungle. the isolates were identified as streptococcus zooepidemicus, streptococcus infrequens, streptococcus faecalis and groups p and s. the possible significance of the findings are discussed.1978101478
effects of nitroglycerin and dipyridamole on regional myocardial blood flow.the effects of intravenous administration of nitroglycerin or dipyridamole on distribution of myocardial blood flow in the heart after coronary underperfusion were investigated. in 18 open chest, anesthetized dogs, flow of the tubing supplying the left circumflex coronary artery (lca) was reduced and kept constant, and then the drug was given intravenously. before and after an administration of saline, nitroglycerin (0.04 mg/kg) and dipyridamole (0.2 mg/kg), myocardial blood flow was measured by ...1978103535
the composition and calcium transport activity of the sarcoplasmic reticulum from goats with and without heritable myotonia.studies were conducted on purified sarcoplasmic reticulum isolated from myotonic goats, an animal model of heritable myotonia. when compared to sarcoplasmic reticulum from normal goats, fragmented sarcoplasmic reticulum from the myotonic goat had (1) increased levels of calcium, (2) increased rates of calcium uptake and efflux, (3) an increased sialic acid content, and (4) an increased content of saturated fatty acids. these differences support the concept of a structural and functional defect a ...1979106184
interpretive criteria for cefamandole and cephalothin disk diffusion susceptibility tests.a multi-center study of 1,838 clinical isolates established the accuracy of diffusion susceptibility tests with 30-mug cephalothin disks and 30-mug cefamandole disks. the same interpretive zone standards can be applied to tests with either disk but the two drugs cannot be tested interchangeably.1979106770
chemosynthetic, photosynthetic, and cyanobacterial ribulose bisphosphate carboxylase. 1978106835
staphylococcal micrococcins. i. isolation of antibiotic-producing strains.seven strains belonging to the family micrococcaceae and possessing strong antagonistic properties against staph. aureus and several other gram-positive bacteria, have been isolated. the strains were characterized and identified, phage typed, tested for antibiotic-sensitivity and antagonistic activities. two patients of inhibition were noted.1975126688
modification of immunogenicity on kidney allografts treated with acid mucopolysaccharides. 1975129878
[comparative anatomy of the arteries of the forelimbs of domestic mammals. i. the arteria radiales system]. 1979161484
the effect of reserpine on hypothalamo-pituitary-adrenocortical function in the rat.1. the effect of reserpine on hypothalamo-pituitary-adrenocortical (hpa) function in the rat was investigated by the use of direct and indirect indices of pituitary adrenocorticotrophic activity. 2. administration of a single dose of the drug induced prolonged hypersecretion of corticotrophin (acth). 3. corticotrophin release in response to the drug no longer occurred after repeated daily injections, indicating that some form of 'adaptation' occurred. 4. the increase in hpa activity normally cau ...1975167893
alterations of acetylcholine enzymes in neuroblastoma cells persistently infected with lymphocytic choriomeningitis virus. 1977193868
herpesvirus-induced urolithiasis in specific-pathogen-free male cats. 1977201200
isolation of equine rhinovirus type 1. 1977201238
[putreanin in the tissue of human intracerebral tumors]. 1977203109
studies on the immune response of congenitally athymic (nude) mice.the central role of the thymus in immunity was assessed in nude mice. nudes failed to reject allografts and xenografts and to respond to foreign erythrocytes but responded normally to endotoxin and pneumococcal polysaccharide. thymus reconstitution was demonstrated in vivo and in vitro whereas reconstitution with thymic humoral factors or polyanions was not detected. coliform overgrowth and depressed iga levels in nudes appeared to contribute to wasting. these data emphasize the need for thymus ...1975238688
proceedings: recent advances in skeletal trans-imaging. 1976179403
activities of hepatic enzymes in spontaneous diabetes rats produced by selective breeding of normal wistar rats.acitivites of the hepatic enzymes were determined in spontaneous diabetes rats. the activities of the enzymes were compared with those in normal rats and in streptozotocin diabetic rats. in the spontaneous diabetes rats, glycogen phosphorylase and glycogen synthase were 14.6 +/- 0.6 and 1.73 +/- 0.15 u respectively. the activities of both the enzymes were significantly increased. in the spontaneous diabetes rats glucokinase was 3.82 +/- 0.5 u showing a significant increase. on the contrary, the ...1978151947
effects of tetrahydropapaveroline on dopamine and 5-hydroxytryptamine metabolism in rat brain in vivo.hva and 5-hiaa levels have been assayed in the rat brain at different time intervals after acute or chronic i.p. administration of tetrahydropapaveroline (thp), 8 and 60 mg/kg. in addition, the influence of thp pretreatment on the l-dopa-induced hva increase in the rat brain as well as the pcpa-induced 5-hiaa decrease have been studied. the results support the possibility that thp may displace brain monoamines in vivo. this property of thp may be related to certain side effects of l-dopa long-te ...1976134381
a proposed treatment for trimethylolpropane phosphite poisoning. 1977404408
serological evidence of human leptospirosis in northern greece.a) 1069 human blood samples were tested for the presence of c. f. antibodies to leptospirae. 98 of these sera were from patients suffering from weil's syndrome. 13 out of 98 patients were found to be suffering from leptospirosis; one of these died. 460 sera were from patients with febrile (acute) illness of unknown origin and 511 sera from patients with respiratory disease (especially "influenza like disease"). none of these patients was found to be suffering from leptospirosis. b) 191 human ser ...197994493
metabolism of n-acetylglucosamine and glucose in membranes from lactating bovine mammary tissue. 197994066
unusual features in a case diagnosed as subacute sclerosing panencephalitis (sspe).sspe is characterised by progressive mental deterioration, myoclonic and similar motor disorders and final severe comatose states, increase of immunoglobuline g in the csf, strongly elevated antibody titers to measles virus in serum and csf and typical periodic k-complexes in the eeg. the disease appears commonly in childhood and has a fatal course. cases with atypical signs have occasionally been reported. the case described in this paper shows a number of uncommon features: late onset, partial ...197992553
[ability of yeast from the genus candida to assimilate sugars and acetic acid from mineral medium and sulfite liquors]. 19751214648
antigenic marker on a functional subpopulation of b cells, controlled by the i-a subregion of the h-2 complex.cba/n mice have an x-linked recessive effect that results in the absence of a subpopulation of b cells carrying the lyb3 surface marker. it has been shown previously that this marker is present on a mature subset of b cells in all mouse strains. in this paper the lyb3+ b cell population in c57bl/6 mice was analyzed further. this subset of b cells selectively expresses a surface marker controlled by the i-a subregion of the h-2 complex. a cytotoxic antiserum recognizing this marker was raised by ...197991165
patulin biosynthesis: the metabolism of m-hydroxybenzyl alcohol and m-hydroxybenzaldehyde by particulate preparations from penicillium patulum.the ring hydroxylation of m-hydroxybenzyl alcohol to gentisyl alcohol by a particulate preparation from penicillium patulum has been characterised. the activity was shown to be closely associated with, but not necessarily identical to, m-cresol 2-hydroxylase activity of the 105 000 x g microsomal fraction. as with both the m-cresol hydroxylases of this system, m-hydroxybenzyl alcohol hydroxylase required oxygen and nadph for activity. a km value for m-hydroxybenzyl alcohol of 15 mum was measured ...1975241643
liquoid-induced arterial lesions and the generalized shartzman reaction. 1977202152
concentrations of endothelial-cell-stimulating angiogenesis factor, a major component of human uterine angiogenesis factor, in human and bovine embryonic tissues and decidua.embryonic development involves the establishment of new patterns of vascular growth in the fetus and within the lining of the womb. a factor, human uterine angiogenesis factor, has been purified from the decidua and stimulates the growth of blood vessels in collagen sponge implants and in the chick chorioallantoic membrane. evidence is presented that suggests that a major active component of human uterine angiogenesis factor is an activator of latent matrix metalloproteinases, of low m(r), calle ...19921317450
sequence analysis of the 5' noncoding region of hepatitis c virus.we have determined the nucleotide sequence of the 5' noncoding (nc) region of the hepatitis c virus (hcv) genome in 44 isolates from around the world. we have identified several hcv isolates with significantly greater sequence heterogeneity than reported previously within the 5' nc region. the most distantly related isolates were only 90.1% identical. nucleotide insertions were seen in three isolates. analysis of the nucleotide sequence from 44 hcv isolates in this study combined with that of 37 ...19921317578
positive and negative regulation by thyrotropin of thyroid cyclic amp response to thyrotropin in porcine thyroid cells. 1977201503
partial duplication 5q syndrome: phenotypic similarity in two sisters with identical karyotype (partial duplication 5q33 leads to 5qter and partial deficiency 8p23 leads to pter).two sisters with statomotor developmental retardation microcephaly, hydrocephalus internus and externus without signs of pressure, heart defect (ventricular septal defect), early pulmonary resistance and characteristic facial changes were found to have the same unbalanced karyotype with partial trisomy 5q3300 leads to 5qter and partial monosomy 8p2300 leads to 8pter, derived from a balanced reciprocal paternal translocation: 46,xy,t(5;8)(q3300;p2300). the older girl was tested for the erythrocyt ...1977305758
noradrenergic sensitivity of the cerebral cortex after chronic ethanol ingestion and withdrawal.the effects of both chronic ethanol treatment and 3 days of ethanol withdrawal on the cyclic adenosine 3':5'-monophosphate (camp) response of cerebral cortical slices to norepinephrine (ne) were studied. ed50 camp responses for each group were determined using graded doses of ne. chronic ethanol fed rats displayed subsensitivity to ne. there was a 4.3-fold shift of the dose-response curve to the right. rats chronically fed ethanol and then put on 3 days of ethanol withdrawal developed supersensi ...1975168350
the death penalty. 19921392916
effect of a mild exercise program on myocardial function and the development of hypertrophy.cardiac function and the development of myocardial hypertrophy were studied in rats conditioned by an exercise program consisting of 8 wk of running on a treadmill. at the end of the training period a group of exercised and sedentary rats was subjected to hemodynamic evaluation under general anesthesia. except for a slight elevation in the heart rates of the exercised animals there were no significant differences between the exercised and sedentary rats at rest. following an increase in afterloa ...1979154493
insulin counteraction of alpha-adrenergic effects on liver glycogen metabolism.insulin counteracted the effects of a pure alpha-adrenergic agonist, phenylephrine, on hepatocyte glycogen synthase and phosphorylase. these results argue against current concepts of insulin increasing cytoplasmic ca2+ concentration.1978103580
human lung tissue and anaphylaxis:cyclic nucleotide response and prostaglandin synthesis. 197991946
convulsive effects of 3-aminopyridine on cortical neurones.the authors examined the effects of 3-aminopyridine (3-ap) on pyramidal tract neurones in the motor cortex of anesthetised cats. 3-ap proved to be a strong convulsive agent. local application of 3-ap in concentrations of 15-20 mm resulted in typical paroxysmal alterations of neuronal activity: (a) enhancement of background firing, (b) augmentation of epsps, (c) depression of ipsps and (d) single and serial paroxysmal depolarization shifts (pdss). serial pdss were reflected by large synchronous w ...197991505
human hepatic microsomal metabolism of delta 1-tetrahydrocannabinol.hepatic microsomal metabolism of delta 1-tetrahydrocannabinol (thc) has been extensively studied in many rodent species, but there have been few reports describing such metabolism in humans. because several thc metabolites are known to be pharmacologically active, identifying the p-450 subfamilies responsible for their formation is of clinical importance. we have found that, in addition to catalyzing the formation of significant amounts of 7-hydroxy-thc, hepatic microsomes from nine human livers ...19921352216
metabolic fate of menthofuran in rats. novel oxidative pathways.metabolic fate of menthofuran (ii) in rats was investigated. menthofuran (ii) was administered orally (200 mg/kg of the body weight/day) to rats for 3 days. the following metabolites were isolated from the urine of these animals: p-cresol (vi), 5-methyl-2-cyclohexen-1-one (vii), 3-methylcyclohexanone (viii), 3-methylcyclohexanol (ix), 4-hydroxy-4-methyl-2-cyclohexen-1-one (v), geranic acid (xi), neronic acid (xii), benzoic acid (xiii), and 2-[2'-keto-4'-methylcyclohexyl]propionic acid (x). incub ...19921352224
complement activation decreases the ability of hiv transmembrane envelope protein to bind to specific antibody. 19921388901
[proceedings: biochemical studies of cardiac sarcoplasmic reticulum. report 2. relationship between cyclic amp and calcium binding]. 1975168419
effect of parathyroid hormone and adenosine 3',5'-monophosphate on renal carbonic anhydrase. 1975164869
hepatitis b virus markers in 97 long-term hemodialysis patients.a study was undertaken to assess the state of hepatitis b virus (hbv) infection in hemodialysis patients. from 97 hemodialysis patients tested, 51 were found to have at least one hepatitis b virus specific marker. 18 were hbsag carriers, 12 of these carriers have to be regarded as infectious as judged from the presence of hbeag and/or hbv-specific dna polymerase activity in the serum. antinuclear antibodies (ana) were found in the sera of approximately 20% of the hemodialysis patients with a hig ...1979492411
effects of ca+ and k+ on oscillatory afterpotentials in dog ventricular muscle fibers. 1979522140
tissue distribution and elimination of digoxin and methyldigoxin after single and multiple doses in dogs.glycoside concentrations in plasma and various tissues of dogs were determined after a single and repeated intravenous administration of tritium-labeled digoxin and beta-methyldigoxin. twenty-four hours after single dosing, the highest concentrations were measured in the kidney. this was followed by the heart, adrenal gland, liver, pancreas, lung, spleen, diaphragm, and skeletal muscle. the glycoside concentration in the brain was low after a single administration of dogoxin. a higher concentrat ...197994391
leiomyosarcoma in a patient with trisomy 8 mosaicism. 19911796968
leiomyosarcoma in a patient with trisomy 8 mosaicism. 19911796968
effects of the glycine prodrug milacemide (2-n-pentylaminoacetamide) on catecholamine secretion from isolated adrenal medulla chromaffin cells.1. milacemide (2-n-pentylaminoacetamide) is a glycine prodrug which readily crosses the blood brain barrier and increases brain glycine and glycineamide. in vitro and in vivo studies, with numerous tissues, including adrenal chromaffin cells, have clearly shown that the formation of the latter metabolites is exclusively mediated by monoamine oxidase b for which milacemide is a substrate. 2. milacemide, glycineamide and glycine caused a time- and dose-dependent release of catecholamines from bovi ...19911797336
hypoxic-ischemic damage in the neonatal brain: excitatory amino acids.perinatal brain damage is a major clinical problem. recent studies suggest that excitatory amino acids (eaas) may be important for the development of hypoxic-ischemic brain injury in the newborn. experimental work demonstrates that the immature brain is hypersensitive to the toxic effects eaa ('excitotoxicity'), hypoxic-ischemia is accompanied by an extracellular overflow of eaas and hypoxic-ischemic brain damage is reduced by eaa receptor antagonists. clinical investigations demonstrate the pre ...19921306803
studies on the estrogenic activity of chlordecone (kepone) in the rat: effects on uterine estrogen receptor. 197991089
sexual activities and preferences in a united kingdom sample of 16 to 20-year-olds.data are reported on the sexual behavior of a random sample of 2171 youth, 16-20 years old, in two locations in the u.k. lower bound prevalence estimates for a range of specific sex acts are presented with discussion of the likely biases in the data. given concerns about the spread of hiv through the heterosexual population, emphasis is given to the nontrivial estimates of a number of potential transmission risk behaviors, in particular, heterosexual anal penetration. data are also presented sug ...19921610289
ocular and systemic antiviral activity of vidarabine. 1977195767
gynaecological infections and strategies for treatment.frequently, encountered gynaecologic infections and pathogens involved are presented. a review is given of bartholinitis, vulvovaginitis-bacterial vaginosis, candidiasis, trichomoniasis cervicitis and pelvic inflammatory disease: neisseria gonorrhoeae, chlamydia trachomatis and herpes simplex virus 2. of each infection a thorough description of clinical symptoms and diagnostic criteria is followed by up-to-date treatment advices. for vulvovaginitis, cervicitis and pelvic inflammatory disease ant ...19902075077
hemodynamic effects of gi 87084b, an ultra-short acting mu-opioid analgesic, in anesthetized dogs.hemodynamic effects of gi 87084b, a novel ultra-short acting mu-opioid agonist, were studied in anesthetized dogs. in these studies, gi 87084b (0.3-20 nmol/kg/min i.v.) produced dose-dependent decreases in heart rate, arterial blood pressure, +dp/dt and cardiac output. alfentanil produced similar effects but was less potent. after termination of the infusions (397 nmol/kg cumulative dose), the hemodynamic effects of gi 87084b dissipated over 30 to 40 min. the effects of alfentanil, however, pers ...19921403806
diet, ddt, and the toxicity of drugs and chemicals.the toxic and carcinogenic effects of many compounds depend on their activation to reactive molecules in the cytochrome p-450 system of the endoplasmic reticulum of cells. changes in dietary input alter p-450 levels in different tissues and so alter toxicity. in this way, low protein diets protect against carbon tetrachloride poisoning. fats, proteins, and nonnutrients such as flavones, antioxidants, and contaminants like ddt all affect p-450 levels. the activated molecules may be diverted from ...1977321252
effects of pargyline on hypothalamic biogenic amines and serum prolactin. lh and tsh in male rats. 1977143580
susceptibility of mastomys natalensis to brugia malayi following pretreatment with antifilarials.mastomys natalensis pretreated with diethylcarbamazine (dec), levamisole or centperazine were exposed to the standard inoculum of infective larvae of brugia malayi. percentage 'take' of infection, duration of prepatent period, course of microfilaraemia and number of adult worms recovered were compared with those of untreated infected mastomys (control). dec and centperazine did not alter the 'take' (dec/centperazine: 100%; control: 88.24%) and the average prepatent period (dec: 105.44 days; cent ...19902227711
susceptibility of mastomys natalensis to brugia malayi following pretreatment with antifilarials.mastomys natalensis pretreated with diethylcarbamazine (dec), levamisole or centperazine were exposed to the standard inoculum of infective larvae of brugia malayi. percentage 'take' of infection, duration of prepatent period, course of microfilaraemia and number of adult worms recovered were compared with those of untreated infected mastomys (control). dec and centperazine did not alter the 'take' (dec/centperazine: 100%; control: 88.24%) and the average prepatent period (dec: 105.44 days; cent ...19902227711
a note on the occurrence of leuconostoc oenos as a spoilage organism in canned mango juice.a strain of leuconostoc oenos was isolated from a blown can of mango juice. various tests to identify and characterize the bacterium suggested that it could be a strain of l. oenos. this is the first report of l. oenos as a spoilage organism in fruit products other than wine.19852414264
the radiographic diagnosis of heart disease in the dog. 1975123974
characterization and nucleotide sequence determination of a repeat element isolated from a 2,4,5-t degrading strain of pseudomonas cepacia.pseudomonas cepacia strain ac1100, capable of growth on 2,4,5-trichlorophenoxyacetic acid (2,4,5-t), was mutated to the 2,4,5-t- strain pt88 by a cole1::tn5 chromosomal insertion. using cloned dna from the region flanking the insertion, a 1477-bp sequence (designated rs1100) was identified which was repeated several times on the wild-type chromosome and was also present on ac1100 plasmid dna. various chromosomal fragments containing this sequence were cloned and their nucleotide sequence was det ...19892546860
[identification of a virus similar to hepatitis b virus in non-a non-b hepatitis].hepatitis b virus-like particles (including dane particles) with dna polymerase activity but negative for hbs ag have been identified in non-a, non-b hepatitis sera positive for hc ag. although specifically associated with the particles, hc ag is not a surface antigen of the hepatitis c virus identified here for the first time. the relationship of this agent with hbv seems obvious, and deserves further study.1979120782
effects of physostigmine on novelty-related location preferences.novelty-related location preferences and activity in an exploration box were recorded for male and female wistar albino rats following intraperitoneal injections of 0.04 or 0.08 mg/kg of either physostigmine or neostigmine. although rearing was reduced by the highest dose of both drugs and ambulation was reduced by the same dose of neostigmine, neither agent affected the significant preferences for novelty that typified all subjects. in a second experiment designed to assess the effects of 0.08 ...19921409795
vaccination against ovine cysticercosis using a defined recombinant antigen.cysticercosis caused by larval tapeworms is a major public health problem and a cause of substantial economic losses in the farm-animal industries. taenia ovis in sheep is a particularly important example. immunity to reinfection with the larvae has a central role in regulating natural transmission of the parasites, and vaccination with antigens from the early larval oncosphere stage can induce complete protection against infection. as it is impractical to obtain enough oncospheres for a commerc ...19892648160
[nematoda of blackbird (turdus merula l.) and mavis (turdus philomelos br.) from the wroclaw region. i. faunistic studies]. 1979524890
effects of magnesium on cocaine-reinforced responding in mice, rats and squirrel monkeys. 19921435977
cd45 isoform expression on human neonatal t cells: expression and turnover of cd45 isoforms on neonatal versus adult t cells after activation.neonatal t cells are phenotypically similar to "naive" t cells from adult donors in the cd45 isoform expression. despite the phenotypic similarity, large differences were found between neonatal and adult t cells when t cells were activated. after activation with pha, adult cd45ra+ t cells began to express cd45ro and no loss of cd45ra expression had yet occurred at day 3 post-stimulation. three days after activation, cd45ra+ neonatal t cells also coexpressed cd45ro; however, in contrast to adult ...19921534035
on the mechanism of action of picrotoxin on gaba receptor channels in dissociated sympathetic neurones of the rat.1. the mechanism of action of picrotoxin on gaba receptor channels in rat sympathetic neurones has been investigated with whole-cell clamp. in addition, the action of picrotoxin on single gaba channels has been examined in outside-out membrane patches from these cells. 2. picrotoxin, at concentrations which dramatically reduced the amplitude of whole-cell gaba currents, did not alter the spectral time constants or single-channel conductance estimated by analysis of gaba-activated current noise. ...19921317428
gaba-receptors in the vertebrate nervous system. 1977202995
differences in the transport systems between cementocytes and osteocytes in rats using microperoxidase as a tracer.microperoxidase (mp) tracer was injected intravenously into rats to investigate any differences in transport pathways of tissue fluids in the lacunae and canaliculi of cementum and bone. light microscopically, in deep cementum lacunae, pericellular spaces contained a large amount of mp, while close to the cementum surface, the spaces contained scarcely any. in bone, mp was detected throughout all pericellular spaces. mp was detected intracellularly as granular reaction products in most cementocy ...19921610305
purification and properties of a malolactic enzyme from leuconostoc oenos atcc 23278.the malolactic enzyme of leuconostoc oenos atcc 23278 was purified 136fold. the molecular weight was estimated at 132,000 when determined by gel filtration. the enzyme contained two identical subunits (mw = 66,000 using sodium dodecyl sulfate gel electrophoresis). the malolactic enzyme catalyzes the nad(+)- and mn(+)-dependent reaction l-malate----l-lactate + co2. the apparent km values for malic acid, nad+, and mn2+ were 17 mm, 0.044 mm, and 0.017 mm, respectively. the optimal ph and the optima ...19902097345
electrogenic malate uptake and improved growth energetics of the malolactic bacterium leuconostoc oenos grown on glucose-malate mixtures.growth of the malolactic bacterium leuconostoc oenos was improved with respect to both the specific growth rate and the biomass yield during the fermentation of glucose-malate mixtures as compared with those in media lacking malate. such a finding indicates that the malolactic reaction contributed to the energy budget of the bacterium, suggesting that growth is energy limited in the absence of malate. an energetic yield (yatp) of 9.5 g of biomass.mol atp-1 was found during growth on glucose with ...19921644757
conduction velocity distribution of afferent fibers innervating the rat urinary bladder.the conduction velocities of individual afferent fibers innervating the rat urinary bladder were determined by the antidromic stimulation of dorsal roots while recording from bladder postganglionic nerves. conduction velocities ranged from 0.5 to 21.0 m/s; 70% of the velocities were less than 2.5 m/s. the distribution within the dorsal roots was ipsilateral with 84% in l6 and 16% in s1. neuroanatomical tracing with horseradish peroxidase applied to individual bladder postganglionic nerves result ...19901698508
the relationship between prostaglandin e1 applied area and flap survival rate.using a silicone gel sheet continuous drug delivery system containing prostaglandin e1 (pge1), the relationship between flap survival rate and the site of drug application was studied. skin flaps measuring 2 x 9 cm were raised on the dorsum of rats, and divided into 3 areas. area 1 was within 3 cm of the flap tip, area 2 was between 3-6 cm from the flap tip including the critical zone, and area 3 was the portion within 4 cm of the flap base. further, area 4 was a strip of skin around the flap, 1 ...19921393251
lysogeny in leuconostoc oenos.thirty strains of leuconostoc oenos were exposed to mitomycin c to induce lysogenic bacteriophages. lysis curves typical for lysogenic strains were obtained with 19 strains. indicator strans were found for 17 of these phages. five were characterized by electron microscopy, lytic spectrum, molecular masses of the proteins, sequencing of five n-terminal amino acids of the two major proteins and dna analysis (restriction patterns, cross hybridization). the results revealed a very close relationship ...19911748868
[toxic pulmonary and neuronal reactions to nitrofurantoin]. 19902223723
opioids and behavior: genetic aspects.three animal models, based on genetic differences in endogenous opioid peptides and opioid receptors, are described. obese mice and rats, whose pituitary opioid content is elevated, may be used to investigate eating disorders. recombinant inbred strains of mice, which differ in brain opioid receptors and analgesic responsiveness, can be used for study of opioid- and nonopioid-mediated mechanisms of pain inhibition. individual reactivity to opioids can be examined in c57bl/6 and dba/2 inbred stra ...19882837410
[toxic pulmonary and neuronal reactions to nitrofurantoin]. 19902223723
influence of immunomodulatory agents on bovine humoral and cellular immune responses to parenteral inoculation with bovine rotavirus vaccines.sodium diethyldithiocarbamate (dtc), mycobacterium cell wall extract (mcwe, regressin), killed corynebacterium parvum (c. parvum, immunoregulin) and muramyldipeptide (mdp) were each combined with purified, live bovine rotavirus and inoculated into 3 month-old holstein-friesian calves in order to examine their ability to potentiate specific humoral and cellular immune responses. the vaccinated calves were boosted twice at 3 and 6 weeks after initial vaccine inoculation. the rotavirus was administ ...19882847397
vitamin d analogs with low affinity for the vitamin d binding protein: enhanced in vitro and decreased in vivo activity.the affinity of 1 alpha,25-dihydroxyvitamin d3 [1 alpha,25-(oh)2d3] and analogs with side-chain modifications [mc 903 or calcipotriol, mc 1147 or 24,24-dihomo-1 alpha,25-(oh)2d3 and 1,25-(oh)2-16ene-23yne-d3] for the vitamin d receptor and the serum vitamin d binding protein (dbp) were compared. the affinity of mc 903 for the receptor from chick and rat duodenum or from human peripheral blood mononuclear cells or hl-60 cells varied between 60 and 100% relative to the affinity of 1,25-(oh)2d3. th ...19911796753
studies on cytochrome c oxidase, xi. the amino-acid sequence of bovine heart polypeptide vic.the complete primary structure of the cytoplasmically synthesized polypeptide vic from beef heart cytochrome c oxidase was determined via isolation and sequencing of overlapping methionine and glutamic acid fragments. the protein consists of 73 amino acids (mr 8 480). through the protein contains, from residues 21 to 40, a hydrophobic sequence interrupted by one lysine it may not penetrate the membrane. a sequence of 33 amino acids highly homologous to the c-terminal part of vic has been transla ...19852988583
intravenous hypertonic saline induces fos immunoreactivity in neurons throughout the lamina terminalis.expression of fos, the protein product of c-fos, was studied immunohistochemically in the forebrain of rats infused intravenously with hypertonic solutions. intravenous 1.5 or 0.75 mol/l nacl or 1.2 mol/l sucrose in 0.15 mol/l nacl, but not isotonic 0.15 mol/l nacl, caused increased fos expression in the hypothalamic paraventricular and supraoptic nuclei and throughout the lamina terminalis (organum vasculosum laminae terminalis, median preoptic nucleus and subfornical organ). these results show ...19911797341
intravenous hypertonic saline induces fos immunoreactivity in neurons throughout the lamina terminalis.expression of fos, the protein product of c-fos, was studied immunohistochemically in the forebrain of rats infused intravenously with hypertonic solutions. intravenous 1.5 or 0.75 mol/l nacl or 1.2 mol/l sucrose in 0.15 mol/l nacl, but not isotonic 0.15 mol/l nacl, caused increased fos expression in the hypothalamic paraventricular and supraoptic nuclei and throughout the lamina terminalis (organum vasculosum laminae terminalis, median preoptic nucleus and subfornical organ). these results show ...19911797341
nitric oxide alters renal function and guanosine 3',5'-cyclic monophosphate.endothelium-derived relaxing factor (edrf) activates soluble guanylate cyclase, resulting in an increase in vascular smooth muscle guanosine 3',5'-cyclic monophosphate (cgmp) levels, which correlates with its relaxing effect. using a microdialysis technique, we investigated changes in right and left renal interstitial fluid cgmp levels in response to right intrarenal administration of an edrf inhibitor, ng-monomethyl-l-arginine (l-nmma). studies were conducted in anesthetized dogs (n = 5) in met ...19921317356
relationship between calcium current and cytosolic calcium in canine gastric smooth muscle cells.we measured free intracellular ca2+ concentration ([ca2+]i) and ca2+ current (ica) simultaneously in voltage-clamped, indo-1-loaded smooth muscle cells isolated from the circular layer of the canine antrum. resting [ca2+]i averaged 144 +/- 20 nm in cells held at -70 mv. depolarization positive to -50 mv elicited ica and increased [ca2+]i. peak [ca2+]i occurred between 0 and +10 mv and averaged 372 +/- 48 nm. on repolarization, [ca2+]i decreased slowly (time constant 2-3 s) and the rate depended ...19911852104
regulation of enzymes by ligand induced change in polymerization. 19863020906
tetrahydroaminoacridine and other allosteric antagonists of hippocampal m1 muscarine receptors.tetrahydroaminoacridine (tha) and a variety of other nonclassical antagonists of muscarine receptors were studied for their ability to bind to primary and allosteric sites on muscarine receptors in rabbit hippocampal membranes. competition curves between 13 antagonists and 1 nm [3h]pirenzepine (kd = 3 nm) were simple mass action curves, but tha produced steeper curves, indicating positive cooperativity. nonetheless, tha inhibited the binding of low concentrations of [3h]pirenzepine, [3h]n-methyl ...19892725474
comparison of interferon action in interferon resistant and sensitive l1210 cells.translation inhibition, leu-trna aminoacylation and double-stranded rna and atp dependent phosphorylation were examined in interferon-treated and control cell-free lysates of leukaemic mouse l 1210 r and l 1210 s cells. no differences were observed between the respective interferon-treated and control cell-free extracts, except for the presence of an enhanced 67k dalton phosphoprotein fraction in interferon-treated l 1210 s cell-free extracts. in non-responding cell-free lysates, the lack of sti ...1978212514
macular lesions in malignant arterial hypertension.we produced experimental renovascular malignant arterial hypertension by a modified goldblatt's procedure in 60 rhesus monkeys (25 one-kidney model and 35 two-kidney model), and studied various macular lesions by detailed serial ophthalmoscopy, and stereoscopic color fundus photography and fluorescein fundus angiography on a long-term follow-up. the various lesions which developed in the macular region included retinal edema, cystic retinal changes, serous retinal detachment, retinal pigment epi ...19892748100
coxsackie b myocarditis. 19873040137
microvessel diameter estimation: error bias correction of serial measurements.the assessment of vessel patency can be substantially improved by serial microvessel diameter measurements taken successively along an extensive length of the vessel. it is possible to avoid making the a priori assumptions about the existence or location of local constriction sites implicit in single diameter measurements. the problem then becomes one of making sense of tens or hundreds of measurements for each vessel. equivalent diameter is defined here as as the diameter of a uniform circular ...19911932720
2-bromo- and 16-bromo-estrogens and related compounds: potential inhibitors for both estradiol 2- and 16 alpha-hydroxylases in rat liver microsomes.kinetic studies of inhibition of estradiol 2- and 16 alpha-hydroxylase activities in male rat liver microsomes with 2-bromoestrogens, 4-bromo-estrone (4-bre1), 16 alpha- and 16 beta-bromoestrones and 16 beta-acetylthioestrone (16-acse1) were carried out. 2-bromoestrogens and 4-bre1 nonspecifically blocked the two enzyme activities in a competitive manner, and 2-bromo-estradiol (2-bre2) was the most potent inhibitor for the two hydroxylases among the 2- and 4-bromo steroids. kinetic data, the app ...19892761259
interleukins and iga synthesis. human and murine interleukin 6 induce high rate iga secretion in iga-committed b cells.freshly isolated murine pp b cells were cultured with 10 different cytokines, including il-1 alpha, il-2, il-4, il-5, il-6, il-7, ifn-gamma, tnf-alpha, and tgf-beta, to investigate a possible role for these cytokines in induction of ig synthesis. of interest was the finding that only il-5 and both mouse recombinant (mr) and human recombinant (hr) il-6 enhanced iga synthesis. the effect was greater with either mril-6 or hril-6 than with mril-5. il-6 induced cycling miga+ pp b cells to secrete hig ...19892786548
chemiosmotic energy from malolactic fermentation.by using the luciferase-luciferin atp assay and whole cells of leuconostoc oenos, we have demonstrated that malolactic fermentation does yield atp. this energy-yielding mechanism did not occur in a cell extract and was inhibited in the presence of dicyclohexylcarbodiimide or an ionophore such as monensin. a lactate:proton efflux mechanism for this proposed pathway is presented.19892793835
transposition of is50l activates downstream genes.a transposition system constructed to detect the transposition of tn5 to a site upstream of the lacz gene has revealed that transposition of is50l can activate downstream genes. expression is apparently mediated by the nptii promoter. transposase produced either by is50r or by the suppressed is50l catalyzed transposition of is50l.19882832393
epidemiology of autoallergic human thyroiditis. 19873316997
immune response of chickens inoculated with a recombinant avian leukosis virus.specific-pathogen-free embryos (18-day incubation) and hatched chicks were inoculated with a recombinant avian leukosis virus (alv) produced by recombinant dna techniques. enzyme-linked immunosorbent assays were used to measure the production of viral-protein-specific antibody and the viral protein, p27, in the serum at 2, 5, 8, 14, and 20 weeks of age. of the inoculated chickens surviving to 20 weeks, 64% produced viral-protein-specific antibodies and 42% transiently produced the viral protein, ...19882838018
purification of carp growth hormone and cloning of the complementary dna.the growth hormone (gh) was isolated and purified from common carp (cyprinus carpio) pituitary glands by salt precipitation and hplc on reverse-phase c18 columns. the carp gh cdna was synthesized and cloned in escherichia coli using ecori linkers and pbr322 as vector. the positive clones were selected and sequenced. the full-length carp gh cdna contains 1187 nucleotide basepairs with an open reading frame coding for the precursor form carp gh of 210 amino-acid residues. the partial amino-acid se ...19892920175
the acute cerebral effects of changes in plasma osmolality and oncotic pressure.although it is generally accepted that a decrease in plasma oncotic pressure may result in the formation of peripheral edema, the effect of a hypo-oncotic state on brain water content is less well known. therefore, utilizing the technique of hollow-fiber plasma-pheresis to manipulate plasma composition, the authors examined the effects of acute changes in either plasma osmolality or colloid oncotic pressure on the eeg, regional cerebral blood flow, intracranial pressure, and brain tissue specifi ...19872446535
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