| effect of prostaglandin e1 analogue tfc 612 on diabetic neuropathy in streptozocin-induced diabetic rats. comparison with aldose reductase inhibitor ono 2235. | the effect of a newly developed oral agent, prostaglandin e1 (pge1) analogue tfc 612, on diabetic neuropathy was studied by giving it for 6 wk to streptozocin-induced diabetic rats that had been diabetic for 3 mo and was compared with the effects of aldose reductase inhibitor ono 2235. although both compounds improved decreased motor nerve conduction velocity, the effect of tfc 612 continued during the 6 wk of treatment, whereas that of ono 2235 became weaker from wk 4. the abnormality in sciati ... | 1989 | 2525492 |
| subtype-specific increase in g-protein alpha-subunit mrna by interleukin 1 beta. | the guanine nucleotide regulatory proteins (g-proteins) which are substrates for adp-ribosylation by pertussis toxin (alpha i-1, alpha i-2, alpha i-3 and alpha o) transduce a variety of hormonal signals. endothelial cells express mrna for three alpha i subtypes although the level of alpha i-1 mrna is very low. interleukin 1 beta (il 1 beta), a pleiotropic inflammatory mediator which stimulates a complex series of responses in human endothelial cells leading to increased coagulation and platelet ... | 1989 | 2525485 |