| activation of solubilized g-proteins by muscarinic acetylcholine receptors. | binding of gtp and its analogue, guanosine 5'-o-[gamma-thio]triphosphate (gtp[s]) to g-proteins, and release of gtp[s] from g-proteins are stimulated by muscarinic acetylcholine (mach) receptors in intact cardiac membranes. upon solubilization of receptors and g-proteins by membrane extraction with the detergent, 3-[(cholamidopropyl)dimethylammonio]-1-propanesulphonate, followed by sucrose density gradient centrifugation, agonist-liganded mach receptors stimulated binding of gtp[s] and hydrolysi ... | 1992 | 1489667 |
| design of site-specific protein drugs. | the ability to clone and express proteins at high levels of abundance and purity has led to their increasing consideration as therapeutic agents. the use of various protein engineering and recombinant dna techniques has enabled progression to where proteins can be tailored so that they have not only the ability to interact with a unique (extra)cellular component in order to produce a pharmacological effect, but their structure can be altered so as to achieve a selective biological disposition. t ... | 1991 | 1815386 |
| prognostic value of rhesus blood groups in oral squamous cell carcinomas. | in the current study of the prognosis of all patients (n equals 70) with squamous cell carcinomas (scc) of floor of mouth in norway during the period 1963 to 1972, the authors found that patients with rhesus (rh) (d)-negative blood group had significantly poorer prognosis (mean 5-year survival, 8%) than patients with rh (d)-positive blood group (5-year survival, 30%) (p equals 0.04). this extends the authors' previous observations in another group of oral cancer patients. the authors do not know ... | 1991 | 1913459 |
| antibodies to distal carboxyl terminal epitopes in the v-fms-coded glycoprotein do not cross-react with the c-fms gene product. | the product of the v-fms oncogene is an integral transmembrane glycoprotein that is closely related to the cell surface receptor for the macrophage colony stimulating factor, csf-1. a fragment of the v-fms gene encoding a major portion of the extracellular amino terminal domain, the membrane-spanning segment, and the entire carboxyl terminal tyrosine kinase domain of the glycoprotein was molecularly cloned into an inducible prokaryotic expression plasmid. polypeptide products consisting only of ... | 1986 | 2425481 |
| redifferentiation and subsequent dedifferentiation of the livers of roosters resulting from acute estrogen challenges. | 1. histologic and metabolic changes take place in livers of rooster receiving challenges consisting of acute doses of estrone. 2. during initial growth and redifferentiation livers rapidly increase in size by division of hepatocytes within most lobules, changing from cordlike to acinar configurations. 3. no new lobules appear and degeneration of some cells within lobules takes place even as cell divisions predominate. 4. cells within lobules assume secretory features. 5. vitellogenins, very low ... | 1987 | 2887384 |
| human milk-derived lactoferrin inhibits mitogen and alloantigen induced human lymphocyte proliferation. | purified lactoferrin (lf), isolated from human milk, was tested for its effect on human t-lymphocyte proliferative responses to phytohemagglutinin (pha) and to alloantigens in mixed lymphocyte culture. lf inhibited proliferation in both assays in a dose-dependent manner. the suppressive effect was not due to lf mediated cytotoxicity since washing cells that had been pre-incubated with lf restored their proliferative activity. lf was most effective in suppressing the pha response when added withi ... | 1987 | 2963123 |
| tumor necrosis factor is partly responsible for the differentiation of mouse myeloid leukemia cells. | when mouse myeloid leukemia m1 cells were incubated with 0.1% tns(serum containing tumor necrosis factor, tnf), they were induced to differentiate into macrophage-like cells within 14 h. the stability of the differentiation activity to heat treatment was very similar to that of the cytotoxicity of tnf for l929 cells. the differentiation activity could not be separated from the tnf activity by sequential chromatography procedures using deae-sephadex and sephacryl s-200 or by isoelectric focusing. ... | 1987 | 3440028 |
| assessment of the safety of chemicals administered intravenously in the neonatal rat. | a 3-day-old neonatal rat model for the safety assessment of various drugs, chemicals, and nutrients administered intravenously is described. this model was used to assess the safety of di(2-ethylhexyl) phthalate (dehp), cyclohexanone, and a 3:1 mixture of medium and long-chain triglyceride emulsions following subchronic administration using the intravenous route. the administration of dehp at dosage of 164.8 mg/kg for 18 consecutive days resulted in a small but statistically significant increase ... | 1987 | 3603403 |
| assessment of the safety of chemicals administered intravenously in the neonatal rat. | a 3-day-old neonatal rat model for the safety assessment of various drugs, chemicals, and nutrients administered intravenously is described. this model was used to assess the safety of di(2-ethylhexyl) phthalate (dehp), cyclohexanone, and a 3:1 mixture of medium and long-chain triglyceride emulsions following subchronic administration using the intravenous route. the administration of dehp at dosage of 164.8 mg/kg for 18 consecutive days resulted in a small but statistically significant increase ... | 1987 | 3603403 |
| case records of the massachusetts general hospital. weekly clinicopathological exercises. case 29-1986. an asplenic woman with evidence of sepsis and diffuse intravascular coagulation after a dog bite. | | 1986 | 3724816 |
| [cloning of human leukocyte interferon cdna and a strategy for its production in e. coli]. | | 1985 | 3906813 |
| [cloning of human leukocyte interferon cdna and a strategy for its production in e. coli]. | | 1985 | 3906813 |
| [use of tissue adhesives in experimental arterial trauma]. | | 1974 | 4478705 |
| mendelian inheritance of variations in beta-galactosidase activities in the house mouse. | | 1973 | 4771319 |
| [primary transport of acute patients. optimal use of rescue resources exemplified by the canton of graubünden]. | | 2011 | 3927607 |
| [surgical treatment of primary chronic pancreatitis]. | surgical methods of treatment of chronic alcoholic pancreatitis must be chosen with special reference to the state of the duct and parenchyma of the pancreas. treatment of alcoholic patients should be performed with the participation of psychiatrists. | 2012 | 3424549 |
| neurological examination in subjects over 65 years: an epidemiological survey. | the frequency of abnormal findings at neurological examination was analyzed in an unselected sample of elderly people aged 67-87 years. absent deep tendon reflexes and impairment of proprioceptive sensation rarely occurred in the elderly. limitation of upward gaze and convergence appear a common finding, especially in the very old. overall, the presence of cortical disinhibition signs (primitive reflexes and paratonia) did not discriminate well between subjects without cns disease and demented p ... | 2008 | 2330069 |
| [biochemical effects of continuous and discontinuous muscular work (interval work)]. | | 2016 | 4720306 |
| [current approaches to immunological diagnosis of autoimmune and immune complex diseases]. | | 2010 | 2974642 |
| the under-reporting of alcohol use: the role of organic mental syndromes. | the under-reporting of alcohol use has been viewed as the consequence of alcoholic denial. alcoholic denial has been conceptualized as an unconscious ego defense. in this paper the authors present data suggesting that the under-reporting of alcohol use may be, in certain cases, the result of the influence of the organic mental syndromes commonly associated with alcoholism. | 2013 | 4053972 |
| varied appearance of cardiac pseudoaneurysms on blood pool images. | three cases of cardiac pseudoaneurysms were presented, with findings at the time of gated blood pool imaging. in only one of three was there the finding of a small neck connecting the ventricular cavity with the pseudoaneurysm. in the other two patients, there was a considerably larger communication. the size of the pseudoaneurysm itself was also of little diagnostic assistance. in one case it was small, while in a second patient it was larger in size. the third case revealed a pseudoaneurysm of ... | 2013 | 3595025 |
| misunderstanding possible in scope of work. | | 2010 | 2922197 |
| final maturation and ovulation provoked by supply of homologous hypophysis in hoplias m. malabaricus (pisces, erythrinidae). | the final maturation and the ovulation were induced in recently collected specimenes of hoplias m. malabaricus that show oocytes with complete vitellogenesis, by using homologous hypophysis. the hormonal supply was a gradual and positive results were obtained with 9 to 10 hypophysis/kg injected according to 3 different methods. the time of oocytes' maturation from the first dose ranges between 32 and 60 hours a 18 degrees c. the stages of maturation of the oocyte were controlled by intraovaric c ... | 2009 | 2762598 |
| single unit response of suprachiasmatic neurons to arginine vasopressin (avp) is mediated by a v1-like receptor in the hamster. | a large population of local circuit neurons within the suprachiasmatic nucleus (scn) exhibit immunopositive staining for arginine-vasopressin (avp). avp has been reported to be released from scn neurons in a circadian pattern that peaks during the subjective day. using an in vitro hypothalamic slice preparation, the present study investigated how scn neurons respond to avp over the circadian cycle and whether the response to avp is mediated by v1- or v2-like avp receptors. exposure of the slice ... | 2009 | 2702494 |
| mineral density of bone in the forearm in premenopausal women with fractured wrists. | | 2011 | 3144371 |
| investigation and treatment of a multiple limb birth. | we report a baby born with three fully developed normally functioning legs. the third leg was attached to the baby's sacrum via an iliac bone at the site of a spina bifida. a primitive perineum was present. innervation of the limb was via a sacral hiatus with a myelomeningocele. a rudimentary peritoneal sac was found at operation containing a blind loop of bowel suspended by a mesentery. the additional leg was found to have no cortical representation using somatic evoked potentials although lumb ... | 2007 | 1892571 |
| quantitation of hormone replacement induced withdrawal bleeds. | | 2007 | 1847822 |
| [aplastic anemia treated by isogeneic or allogeneic bone marrow transplantation (author's transl)]. | | 2004 | 368376 |
| thyroid function in affective disorders and alcoholism. | the psychoneuroendocrinology of mood disorders and alcoholism is reviewed here. for reasons of both space and clarity, the article focuses on the clinical data and largely omits the basic science data. | 2011 | 3132602 |
| search for the optimal treatment of ovarian cancer: heavy metals, "belly baths," and ... yew trees. | | 2006 | 1569441 |
| surgical history. evolution of the stoma. | the evolution of the procedures for the formation of a surgical abdominal stoma are outlined; this was first, intestinal exteriorization for trauma, then stoma formation alone and finally stoma formation associated with bowel resection. accounts and recommendations occurred in the 16th and 17th centuries as by pillore and duret, but were few in number. development of the stoma on a sound basis did not occur until the late 19th century. dupuytren, bryant, maydl, mikulicz von radecki and miles wer ... | 2008 | 2643941 |
| worker attitudes about aids may be potential timebomb. | | 2011 | 3180692 |
| thanatophoric dwarfism: a parent's point of view. | | 2013 | 3996686 |
| divalent cation-dependent atpase activities in ciliary membranes and other surface structures in paramecium tetraurelia: comparative in vitro studies. | cilia membrane preparations from axenically grown paramecium contain atpase activities with distinct electrophoretic mobilities on triton-polyacrylamide gels [m.j. doughty and e.s. kaneshiro (1983) j. protozool. 30, 569-575]. such gel analyses also show additional atpase activity bands associated with ciliary axonemes (dyneins), cell pellicles, exocytotic trichocysts, and the external cell surface (ectoenzyme). in the present report, the in vitro properties of these activities in various cell fr ... | 2011 | 3157347 |
| participation of endothelial cells in murine schistosomiasis. | the endothelial cells participate in the morphological events occurring during murine schistosomiasis, taking part in the development of hepatic periovular granuloma. the cells also show an increase in the expression of factor viii-related antigen in the portal vessels and hepatic sinusoids during the infection. endothelial cells are suggested to play an important role in the pathogenesis of the disease and in the balance of the coagulant-anticoagulant mechanisms which favor the intravascular su ... | 2011 | 3150298 |
| pathologic review of consecutive radical prostatectomy specimens. nerve sparing versus nonnerve sparing. | retrospective pathologic analysis was conducted of specimens from 88 radical retropubic prostatectomy operations performed between 1982 and 1987 inclusive. the median age of patients was sixty years (range, 46 to 73 years). of the 88 radical prostatectomies performed, 51 were nerve-sparing (40 bilateral) and 37 were nonnerve-sparing (11 unilateral) procedures. preoperative clinical staging was similar in both groups. thirty-five of 37 patients (95%) in nonnerve-staging group and 51 of 51 patient ... | 2007 | 1887533 |
| [abdominal ultrasonography]. | | 2004 | 321305 |
| igm-containing immune complexes and antiphospholipid antibodies in patients with sneddon's syndrome. | we report three patients with a sneddon syndrome in whom predominantly small (500-900 kd) igm-containing serum immune complexes were detectable. furthermore, antiphospholipid antibodies and increased von willebrand factor antigen were found in the sera of two cases. especially the data demonstrating small circulating immune complex as suggest that sneddon's syndrome, a rare vasculitis disorder, might immunologically be characterized by circulating igm-containing immune complexes which, in additi ... | 2009 | 2772486 |
| intermittent positive pressure ventilation by nasal mask: technique and applications. | intermittent positive pressure ventilation delivered non-invasively through a well-fitting nasal mask has been used to control nocturnal hypoventilation in three patients with severe, combined cardiorespiratory and skeletal disease. the advantages of this approach to domiciliary ventilation are described and the requirements of the ventilator are defined. | 2011 | 3283191 |
| [biomechanico-clinical study of gunshot wounds (general problems--ii)]. | whenever the surgeon finds himself face to face with a wound (probably this is the only opportunity for a meeting between physician and pathology which seems to be able to leave the "illness" on one side, almost forgotten, as it were), even when immersed in routine, he can hardly help making a number of considerations of a general nature, to which the sentence above in brackets is not entirely extraneous. in practice, we cannot help asking ourselves an apparently simple, almost banal, question: ... | 2011 | 3048729 |
| whose loss? | | 2014 | 4175335 |
| [the role of the v. m. bekhterev school in the formation of pathopsychology]. | | 2015 | 4592883 |
| mechanisms and management of respiratory failure. | management of respiratory failure is a complex endeavor that requires consideration of diverse etiologies and pathophysiology. future investigation may lead to specific pharmacologic interventions of greater efficacy. in the meantime, careful attention to basic tenets of pathophysiology, supportive care, and reversal of underlying pulmonary insults is the foundation of successful therapy. | 2011 | 3089676 |
| mechanisms and management of respiratory failure. | management of respiratory failure is a complex endeavor that requires consideration of diverse etiologies and pathophysiology. future investigation may lead to specific pharmacologic interventions of greater efficacy. in the meantime, careful attention to basic tenets of pathophysiology, supportive care, and reversal of underlying pulmonary insults is the foundation of successful therapy. | 2011 | 3089676 |
| no more noses to the glass. | | 2011 | 3342813 |
| [the early treatment of children with cheilognathopalatoschisis--the orthodontic aspects]. | maxillary alveolar arch morphology and growth was studied in 15 children with complete unilateral cleft lip and palate treated with passive orthopaedic plates. nine patients were treated to the "zurich concept" and compared to six children who had lip surgery and primary bone-grafting at about six months of age and complete palate closure at 18 months. maxillary alveolar arch morphology was described at birth, at six months, at 18 months and at 4.5 years. after early orthopaedic treatment the al ... | 2008 | 2227738 |