| mitochondrial protein-synthesizing machinery in saccharomyces cerevisiae grown in different metabolic conditions. variability of seryl-trna and alanyl-trna isoacceptor patterns. | 1. the isoacceptor patterns of mitochondrial seryl and alanyl-trnas from saccharomyces cerevisiae grown under different conditions and committed to fermentative or respiratory metabolism have been studied by reversed-phase chromatography. 2. an extensive variability of the chromatographic patterns of the four isoacceptors for serine and of the three isoacceptors for alanine has been observed as a function of carbon source and stage of growth, but the main differences were observed in the differe ... | 1979 | 381000 |
| the contribution of the 'second' visual system to directed visual attention in man. | the visual functions of a patient suffering from a brain lesion incorporating the left n. pulvinar was examined in order to assess the contribution of this structure to human vision. with the exception of the following abnormalities visual functions were normal. first, there was a decrease in the critical flicker frequency in the periphery (but not in the parafoveal region) of the right visual hemifield, that is, that contralateral to the pulvinar lesion. however, the second and most striking ch ... | 1979 | 509197 |
| an informative microsatellite repeat polymorphism in the human neurofilament light polypeptide (nefl) gene. | | 1992 | 1302625 |
| regulation of hepatic lipid metabolism by cytokines that induce the acute phase response. | | 1992 | 1303901 |
| levels of airborne man-made mineral fibres in dwellings in the uk: results of a preliminary survey. | levels of airborne man-made mineral fibres (mmmf) were measured during the insulation of lofts and after the disturbance of the insulation wools. transmission electron microscopy was used for the analysis. generally, the personal samples showed fibre levels of up to 0.7 f/ml, whereas static samples showed fibre levels of 0.05 f/ml in the lofts. little contamination of living space occurred during these operations. | 1989 | 2744831 |
| differential regulation of amyloid-beta-protein mrna expression within hippocampal neuronal subpopulations in alzheimer disease. | we have mapped the neuroanatomical distribution of amyloid-beta-protein mrna within neuronal subpopulations of the hippocampal formation in the cynomolgus monkey (macaca fascicularis), normal aged human, and patients with alzheimer disease. amyloid-beta-protein mrna appears to be expressed in all hippocampal neurons, but at different levels of abundance. in the central nervous system of monkey and normal aged human, image analysis shows that neurons of the dentate gyrus and cornu ammonis fields ... | 1988 | 3277189 |
| the possible transplacental action of vegetable oil on organ cultures of mouse embryonic lung tissue. | | 1974 | 4441712 |
| on riccati equations describing impedance relations for forward and backward excitation in the one-dimensional cochlea model. | recent experimental observations of otoacoustic emissions suggest the existence of spontaneous emitters of sound on the basilar membrane. these tend to send off waves not only in the normal direction of propagation. it is therefore significant to study the environmental conditions such an emitter finds inside the cochlea. the impedance relations seen by these emitters are described by the riccati equation for an inhomogeneous transmission line. the results reported in this paper differ considera ... | 2012 | 3558956 |
| evaluation of gastrointestinal function with isotopic tracers. | nuclear medicine is the application of tracer methodology mainly to clinical diagnosis. we use chemical compounds labelled with radioisotopes as tracers. the examinations provide us with the information on regional function of tissues and organs. in this review we describe the nuclear medicine procedures for the diagnosis of gastrointestinal diseases based on our experiences. the emphasis is put on the evaluation of the functional aspect of the gastrointestinal tract. the procedures to be descri ... | 2013 | 3566168 |
| hepatic glycogen concentration and hexobarbital-sleeping time in mice. | | 2015 | 4379918 |
| a circular dna-protein complex adenoviruses and its possible role in dna replication. | | 1975 | 169089 |
| has myelin basic protein received a fair trial in the treatment of multiple sclerosis? | autosensitization to some central nervous system antigen still remains one of the best hypotheses for the continuing pathogenesis of multiple sclerosis (ms). enough is now known about the cause, pathogenesis, and treatment of experimental allergic encephalomyelitis (eae) to test this hypothesis. reports of therapeutic failure of the encephalitogen myelin basic protein (bp) in the treatment of ms have their counterparts in similar therapeutic failures in eae. only highly inbred strain 13 guinea p ... | 1979 | 93873 |
| effect of a fluoride solution on dentinal hypersensitivity. | this two-phase experiment assessed the effects over time of a solution containing 1.09% sodium fluoride, .40% stannous fluoride, and .14% hydrogen fluoride (.717% fluoride solution, dentinbloc) on pain associated with dentinal hypersensitivity. during phase i, 30 subjects demonstrating dentinal hypersensitivity to a blast of cool air were divided into three double blind experimental groups. after baseline data were collected for all subjects, one group was instructed to apply the .717% fluoride ... | 2004 | 1304175 |
| tic disorders in childhood (and beyond). | tic disorders are classified into three main categories: transient (duration more than 1 month but less than 1 year), chronic (duration more than 1 year), and tourette's syndrome (multiple motor and vocal tics lasting more than 1 year to life). typically, symptoms increase with emotional stress, diminish with distraction or concentration, and disappear during sleep. because of the risks involved and the lack of any truly curative value, drug therapy should be used only when tics are seriously di ... | 2008 | 2662159 |
| [a study of the prevalence of alcohol consumption in the baix ebre region (tarragona)]. | a cross-sectional study was carried out in the baix ebre region about the prevalence of alcohol use, within a wider study of hypertension and other risk factors. the following characteristics were considered for the elaboration of the present study: non drinker, moderate drinker and heavy drinker, as well as the amount of alcohol intake related with demographic, socioeconomical and cultural variables such as: age, sex, urban or rural medium, marital status, place of origin, working status, socia ... | 2008 | 2518951 |
| utilization of medically-trained birth attendants in rural bangladesh. | using case-control methodology, this study compared the characteristics of women who requested medically-trained birth attendants at home with those who did not, in order to identify constraints to service delivery and suggest program changes to increase service utilization in a rural area of bangladesh. by several different measures, prior contact with medical professionals were much more common among cases than controls, with the greatest differences observed in the frequency of antenatal visi ... | 2004 | 1304774 |
| [mode of action of cardiovascular drugs. echocardiographic studies (author's transl)]. | echocardiography--combined with additional non-invasive methods--has proved a sensitive tool for measuring hemodynamic and left ventricular function parameters. this study was undertaken to measure by these methods the effect of digoxin, isoproterenol, of the beta-receptorblocker sotalol, sodium nitroprusside and isosorbide dinitrate on the hemodynamics and left ventricular contractility in various patients and normal volunteers. besides the good reproducibility of results of recent invasive inv ... | 1965 | 305521 |
| military dependent medical care during world war ii. | dependent medical care at army expense or at army facilities during world war ii was offered only on an emergency basis and at the discretion of the facility commanding officer. this had been the practice since 1884 when such care was specifically authorized by congressional appropriation. mobilization in 1898 and 1917 had brought a large number of state militiamen or inductees into the army--men who could leave their families behind. when mobilization began again in 1940, it was thought that a ... | 1965 | 2106646 |
| a model program to teach parenting skills to schizophrenic mothers. | | 2013 | 3666702 |
| acellular pertussis vaccines and fatal infections. | | 2010 | 2895385 |
| [veno-occlusive disease of the liver (a review of the literature)]. | | 2009 | 2678753 |
| the correlation between family planning program inputs and contraceptive use in indonesia. | using 1980 census and 1986 service statistics program inputs, this paper evaluates the net correlation of socioeconomic, region, and program variables with 1987 contraceptive prevalence and method-specific use rates for indonesian regencies and municipalities. the region variables--primarily, though not exclusively, reflecting program design and maturity--correlate most strongly with the contraceptive prevalence rates. field-worker activities, field-worker supervisor activities, and community-ba ... | 2009 | 2711417 |
| maximum likelihood analysis of free-response receiver operating characteristic (froc) data. | receiver operating characteristic (roc) methodology is widely used in evaluating medical imaging modalities. while appropriate in some cases, it has several drawbacks when the detection task, e.g., nodule detection, involves localizing the abnormality. free-response receiver operating characteristic (froc) methodology offers a more natural framework to describe observer performance in such studies and has other advantages. due to the lack of a statistical analysis procedure comparable to the max ... | 2009 | 2770630 |
| a saved little heart--transposition of great arteries. | | 2005 | 1305656 |
| a structure-function relationship for the calcium affinities of regulatory proteins containing 'ef-hand' pairs. | using a series of homologous calcium-binding proteins, a quantitative structure-activity relationship (qsar), log(1/kd) = -18.986 - 1.6278(x1) + 0.7981(x2) + 0.2312(x3), has been established, which relates the calcium-binding affinities (1/kd) of the regulatory proteins with (i) the net ligand charge (x1) of the two calcium binding loops, (ii) the hydrophobicity (x2) of the beta-sheet segment of the loops and (iii) the hydrophobicity (x3) of the four 'ef-hand' helices. it is found that the bindi ... | 2011 | 3244696 |
| the transgenic window on lymphoid malignancy. | transgenic mice bearing an oncogene targetted for expression in a specific tissue can reveal how that oncogene influences differentiation and help to delineate the pathways to malignancy. to explore lymphoid neoplasia, we have made strains of transgenic mice bearing different oncogenes driven by the immunoglobulin heavy chain enhancer (e mu), which promotes expression within lymphocytes and certain myeloid cells. the prototype e mu-myc mice succumb to pre-b and b cell lymphomas, following a pren ... | 2007 | 2518688 |
| the pathology of tumors. part 1: precancerous and pseudomalignant lesions. | | 1998 | 106933 |
| why the problem of reductionism in biological science will not go away. | | 2013 | 3623192 |
| early clinical and morphologic alterations in the pathogenesis of furazolidone-induced toxicosis in ducklings. | clinical and pathologic alterations during the development of furazolidone-induced toxicosis were investigated in a group of 35 newly hatched male pekin ducklings fed a ration containing 700 mg of furazolidone/kg of feed for 27 days. a control group (n = 25) was fed the same ration without added furazolidone. every 3 days, ducklings were weighted and palpated for ascites and 3 were chosen at random for euthanasia to determine the severity of lesions and to obtain hearts for gross measurements an ... | 2005 | 1952346 |
| althesin: a group trial as an intravenous anaesthetic. | | 2015 | 4439547 |
| reverse genetics approaches for cloning ril-1, a major locus involved in susceptibility to leukemia. | | 2012 | 3416638 |
| an immunohistochemical evaluation of c-erbb-2 expression in human breast carcinoma. | the c-erbb-2 gene codes for a putative transmembrane protein, similar in structure to the epidermal growth factor (egf) receptor. amplification of the gene has been described in a variety of human adenocarcinomas and is particularly well documented in breast carcinoma. it has been suggested that amplification is indicative of poor prognosis and, as such, is comparable with lymph node status as a predictor of clinical outcome. this study examines the suggestion indirectly by an immunohistochemica ... | 1988 | 2849974 |
| inhalation teratology study on hexachloro-1,3-butadiene in rats. | pregnant rats were exposed to 0, 2, 5, 10 or 15 ppm hexachloro-1,3-butadiene (hcbd) 6 h/d during days 6-20 of gestation. maternal reproduction and fetal parameters were evaluated on gestational day 21. a significant reduction in maternal weight gain and in fetal body weight occurred at 15 ppm. the incidences of external, visceral and skeletal alterations were not significantly increased in any of the hcbd-exposed groups. it is concluded that exposure of pregnant rats to hcbd by inhalation of con ... | 1989 | 2749768 |
| [mechanism of depressing effect of diazepam on the blood pressure and on ventricular extrasystoles induced by hypothalamic stimulation in the rabbit]. | experiments were carried out on 62 rabbits anesthetized with urethane and chloralose and immobilized with gallamine triethiodide under artificial ventilation. ventricular extrasystoles were induced by electrical stimulation of the hypothalamic defence area (hve). following intravenous administration of diazepam (0.5 mg/kg), the pressor response and hve induced by electrical stimulation of the hypothalamus were attenuated, as blood pressure (bp) dropped. bilateral microinjection of flurazepam (20 ... | 1989 | 2474857 |
| the effect of age on motor neurone death following axotomy in the mouse. | the ability of mouse motor neurones to survive axotomy during the first month of life was studied. the motor neurones that lie in the dorsolateral columns of spinal segments c7 and c8 and supply the flexor muscles of the forepaw were axotomized by cutting and removing part of the median and ulnar nerves above the elbow. the number and position of cell bodies with axons in these nerves were confirmed by retrograde labelling of the cut axons with horseradish peroxidase. the ability of these neuron ... | 1991 | 1769343 |
| human prolactin gene expression. the use of an alternative noncoding exon in decidua and the im-9-p3 lymphoblast cell line. | the prolactin (prl) gene is normally expressed in the anterior pituitary lactotrope and the decidualized stromal cell of the human endometrium. we have recently described the ectopic expression of the human prl gene in a b-lymphoblastoid cell line, im-9-p. the im-9-p and decidual prl mrnas are approximately 150 nucleotides longer than the pituitary transcript. the protein coding sequence of the im-9-p and decidual prl cdnas is identical to the pituitary prl message, and the 3'-untranslated regio ... | 1990 | 1697858 |
| isolation of corynebacterial enzymes from cultivation media by gel filtration and ion-exchange chromatography. | | 1979 | 524393 |
| computer-specific spectacle lens design preference of presbyopic operators. | twenty-nine presbyopic subjects who spent at least 20 hours a week at a video display terminal compared a progressive addition lens designed for this function, with another commonly prescribed task-specific lens. each of the paired lens types was worn for 4 weeks and then compared directly for 1 week. a statistically significant (p < .05) portion of the subjects (76%) preferred the task-specific lenses overall. it also was preferred more frequently for each feature compared, although the differe ... | 2006 | 1403191 |
| functional brain spect: the emergence of a powerful clinical method. | | 2006 | 1403163 |
| major histocompatibility complex class i-restricted activation of cloned t cells by a soluble protein in the absence of accessory cells. | a t-cell clone, 10bk.1, was established from the draining lymph nodes of (b10 x b10.br)f1 mice immunized with ovalbumin (ova) according to standard protocols. upon coculture with the antigen, 10bk.1 cells reacted by production of lymphokines and by proliferation despite the absence of additional antigen-presenting cells. these t cells do not express major histocompatibility complex (mhc) class ii molecules on the cell surface as assessed on the basis of several criteria: by cytofluorometric anal ... | 2009 | 2784568 |
| [mesotheliomas among mechanics of the railways in italy: a current problem]. | asbestos has been used on rolling stock of the italian railways since the 1940's. from the 1950's to the 1970's it was used on a massive scale for the insulation of passenger carriages (up to more than 800 kg per carriage). about 10 years ago, a programme was began to remove asbestos from rolling stock and replace it with glass fibre. we must consider as exposed to the carcinogenic effects of asbestos all mechanics who, during the past years, worked at the major repair workshops (mrw), at the lo ... | 2009 | 2770615 |
| diagnosis and treatment of attention deficit disorder in two general hospital clinics. | in two clinics in military general hospitals, the charts of all children with a presumptive diagnosis of attention deficit disorder who were prescribed psychostimulants (n = 68) were audited to assess the quality of the primary physicians' evaluation and treatment. the audit instrument, constructed by a multidisciplinary team, indicated high interrater reliabilities, high face and concurrent validity, and moderate internal consistency. the audit found that only 51.5 percent of the children being ... | 2009 | 2777226 |
| recombinant erythropoietic growth factors as an alternative to erythrocyte transfusion for patients with "anemia of prematurity". | | 2009 | 2717299 |
| retinal arteriovenous shunts in takayasu disease. | the authors followed up on a series of 24 eyes in 12 patients with takayasu disease in its moderate to advanced stage over the past 10 years. they paid particular attention to arteriovenous shunt formation in the retina. the authors could identify two types of arteriovenous shunts based on rapid sequence fluorescein angiography. in six eyes, arteriovenous shunts had formed at arteriovenous crossings through direct communication of arterial and venous lumen in the midperipheral retina. in 22 eyes ... | 2010 | 2891097 |
| maintenance of na,k-homeostasis by na,k-pumps in striated muscle. | | 2010 | 2851799 |
| [the weakness of freedom or the power of responsibility--exemplified by gene research in humans]. | | 2012 | 3514530 |
| auditory brainstem response findings in rett syndrome. | the abr findings for 11 subjects with rett syndrome were compared with two normal control groups, one female and the other male. measurements were made for ipsilateral and contralateral recorded responses. significant findings were noted for the latency of wave v and for the iii-v interval between the rett subjects and the normal female controls on ipsilateral recording and between the rett group and both control groups for the difference obtained between ipsilateral and contralateral recorded i ... | 2012 | 3434729 |