| two independent hla-b-locus specificities expressed on a single haplotype. | | 1979 | 93796 |
| has myelin basic protein received a fair trial in the treatment of multiple sclerosis? | autosensitization to some central nervous system antigen still remains one of the best hypotheses for the continuing pathogenesis of multiple sclerosis (ms). enough is now known about the cause, pathogenesis, and treatment of experimental allergic encephalomyelitis (eae) to test this hypothesis. reports of therapeutic failure of the encephalitogen myelin basic protein (bp) in the treatment of ms have their counterparts in similar therapeutic failures in eae. only highly inbred strain 13 guinea p ... | 1979 | 93873 |
| influence of atropine on spontaneous or catecholamine-induced arrhythmias after experimental infarction in the dog. | the effects of atropine on ventricular tachyarrhythmias induced by ligature of the anterior descending coronary artery were studied in conscious dogs. on the first day after surgery, animals received a mixture of quinidine and phenytoin orally in order to partially correct rhythm disturbances on the second day. the same animals were used on the third and fourth days after occlusion, when spontaneous regression of arrhythmias was occurring. atropine (0.2 mg/kg i.v.) or methscopolamine (0.2 mg/kg ... | 1979 | 94403 |
| the role of antigen-specific t cell factors in the immune response. | | 1979 | 94504 |
| production and chemical studies of protease from bacillus subtilis (sh-6) egyptian strain. | bacillus subtilis (sh-6) egyptian strain, isolated from hides, gave the highest protease activity. luxurious growth and protease production were obtained by the use of a medium containing 8% of potato starch, 0,1 m of ammonium phosphate as carbon and nitrogen sources. results indicate that borate buffer exerted a deleterious effect on the protease production. comparing citrate and phosphate buffers, it was found that citrate gave lower protease activity than phosphate. there is a positive respon ... | 1978 | 98932 |
| [study of the "continuous cell antigen" and the human gastric mucosa]. | the antigen common for continuous epithelial cell lines and gastric mucosa of humans described earlier was studied. this antigen was revealed in one more cell line, namely in that prepared from human mammary carcinoma mda-mb-231, noncontaminated with hela cells. the antigen described can be detected in the exophytely growing adenocarcinomas of the stomach and in the mucosa of the carcinoma affected stomach at a distance of 10--12 cm from the site of affection; no such antigen was revealed in the ... | 1978 | 103592 |
| regulatory proteins of lobster striated muscle. | the regulatory proteins of lobster muscles consist of tropomyosin and of troponin. troponin contains a 17,000 chain weight component, two closely related components of about 30,000 and a 52,000 chain weight component. in addition to troponin, tropomyosin is required for the inhibition of the magnesium activated actomyosin atpase activity in the absence of calcium and for the reversal of this inhibition by calcium. lobster tropomyosin interacts with rabbit actin and lobster troponin interacts wit ... | 1975 | 123757 |
| fluorescence of human liver alanine aminopeptidase. | fluorescence of human liver alanine aminopeptidase has been attributed to tryptophan fluorescence. the fluorescence maximum is at 330 nm, 20 nm lower than that for free tryptophan, suggesting that most of the enzyme tryptophans are in a nonpolar environment and are shielded from solvent. quenching of enzyme fluorescence by iodide, pyridine, and n-methyl nicotinamide also demonstrates that enzyme tryptophan residues are largely buried and inaccessible to solvent. those accessible are in negativel ... | 1977 | 143669 |
| sertoli cell capacity to metabolize c19 steroids: variation with age and the effect of follicle-stimulating hormone. | | 1978 | 217658 |
| cytology and cytogenetics in chronic myelogenous leukaemias. | | 1978 | 279492 |
| the status of the state-federal tuberculosis eradication program. | | 1979 | 298936 |
| [pathophysiologic mechanisms of the therapeutic effect of corticosteroids in shock and shock-like states (review of the foreign literature)]. | | 1978 | 355991 |
| mitochondrial protein-synthesizing machinery in saccharomyces cerevisiae grown in different metabolic conditions. variability of seryl-trna and alanyl-trna isoacceptor patterns. | 1. the isoacceptor patterns of mitochondrial seryl and alanyl-trnas from saccharomyces cerevisiae grown under different conditions and committed to fermentative or respiratory metabolism have been studied by reversed-phase chromatography. 2. an extensive variability of the chromatographic patterns of the four isoacceptors for serine and of the three isoacceptors for alanine has been observed as a function of carbon source and stage of growth, but the main differences were observed in the differe ... | 1979 | 381000 |
| viruses and lymphocytes in rheumatoid arthritis. ii. examination of lymphocytes and sera from patients with rheumatoid arthritis for evidence of retrovirus infection. | the possible involvement of retroviruses in the aetiology of rheumatoid arthritis (ra) was investigated. retrovirus antigens were not expressed on rheumatoid synovial and peripheral blood lymphocytes as judged by membrane immunofluorescence, radioimmunoassay, and complement-mediated cytotoxicity. the specific antiretroviral (anti-rd-144 and anti-ssav) sera used in this study were produced in rabbits immunised with viral antigens grown in a homologous system (rabbit cells and medium supplemented ... | 1979 | 395909 |
| the contribution of the 'second' visual system to directed visual attention in man. | the visual functions of a patient suffering from a brain lesion incorporating the left n. pulvinar was examined in order to assess the contribution of this structure to human vision. with the exception of the following abnormalities visual functions were normal. first, there was a decrease in the critical flicker frequency in the periphery (but not in the parafoveal region) of the right visual hemifield, that is, that contralateral to the pulvinar lesion. however, the second and most striking ch ... | 1979 | 509197 |
| isolation of corynebacterial enzymes from cultivation media by gel filtration and ion-exchange chromatography. | | 1979 | 524393 |
| [effect of feeding quinoxaline derivatives on the growth and metabolism of pigs]. | | 1978 | 556511 |
| levamisole as a microfilaricidal agent in the control of canine dirofilariasis. | the effectiveness of levamisole hydrochloride as a microfilaricidal agent when used 3 weeks after thiacetarsamide sodium therapy for canine dirofilariasis, was studied in 6 experimental dogs and 20 clinical cases. the drug, when administered orally in gelatine capsules daily, cleared microfilariae from the circulation in the experimental dogs in 7 to 11 days. a dose rate of 10mg/kg appeared as effective as 15mg/kg. in the clinical group 70% of dogs had zero microfilarial counts after 4 to 8 dose ... | 1975 | 1167138 |
| high-level expression using baculovirus, purification, and characterization of a monomeric form of type ii calmodulin-dependent protein kinase. | the type ii calmodulin-dependent protein kinase is an oligomer existing in multiple isozymic forms. to facilitate investigations of the regulatory mechanisms of this complex enzyme, we have constructed a truncated, calmodulin-dependent monomer of the alpha subunit. the n-terminal enzyme fragment (alpha 315) was expressed at high levels in a baculovirus/insect cell expression system. the recombinant protein was purified chromatographically using deae-cellulose, calmodulin-sepharose, and affigel b ... | 1992 | 1330134 |
| isolation and sequence of a cdna encoding the precursor of a bombesinlike peptide from brain and early embryos of xenopus laevis. | a cdna encoding the precursor of a bombesinlike peptide was isolated from brain of xenopus laevis. the predicted end product resembles neuromedin b, which was originally isolated from mammalian spinal cord. the mrna for this precursor was also present in gastrointestinal tract and in ovaries. moreover, it could be detected in early embryos (stage 2 and stage 10) of x. laevis. these findings suggest novel roles for peptides of the bombesin family in oocyte maturation and early amphibian developme ... | 1992 | 1409705 |
| effects of intrastriatal hormones on the dorsal immobility response in male rats. | previous research has shown that estradiol administered either peripherally or directly into the striatum potentiates the dorsal immobility response (dir) in ovariectomized female rats. male rats are even more responsive than females to intrastriatal estradiol, and furthermore respond to the effects of catecholestrogens while females do not. in order to determine whether the heightened effects of estrogens in males are due to conversion to catecholestrogens, castrated male rats were given bilate ... | 1990 | 2157227 |
| effects of intrastriatal hormones on the dorsal immobility response in male rats. | previous research has shown that estradiol administered either peripherally or directly into the striatum potentiates the dorsal immobility response (dir) in ovariectomized female rats. male rats are even more responsive than females to intrastriatal estradiol, and furthermore respond to the effects of catecholestrogens while females do not. in order to determine whether the heightened effects of estrogens in males are due to conversion to catecholestrogens, castrated male rats were given bilate ... | 1990 | 2157227 |
| tourette's disorder and associated complex behaviors: a case report. | a case of a man with tourette's disorder associated with obsessive-compulsive disorder, multiple sexual paraphilias, and aggressive behavior is described. treatment with haloperidol led to improvement in the characteristic tics of tourette's disorder as well as to improvement in these three complex-associated behaviors. after haloperidol was discontinued, an exacerbation of tics and the associated behaviors occurred. | 1990 | 2238716 |
| suicidal thoughts during early adolescence: prevalence, associated troubles and help-seeking behavior. | a total of 1600 adolescents between the ages of 13 and 16 living in a county bordering on paris were interviewed concerning their health, their use of drugs, both legal and illegal, their behavior, and their seeking of health care. fourteen percent of the boys and 23% of the girls had already thought about suicide and 5% and 10% (respectively) proclaimed having thought about it frequently. young adolescents who thought about suicide, the girls as well as the boys, had more health problems (fatig ... | 1990 | 2327280 |
| atypical presentation of chancroid in a patient infected with the human immunodeficiency virus. | | 1990 | 2368772 |
| role of the n-terminal arginine in the histamine-releasing activity of substance p, bradykinin and related peptides. | a series of substance p (sp)- and bradykinin (bk)-related peptides have been compared for their histamine-releasing activities on rat peritoneal mast cells. some of these peptides only differed in the n-acetylation of the n-terminal arginine residue or by the removal of charged residue at the n-terminal. the aim was to examine the role of the n-terminal positive charges in the histamine-releasing activity of compounds that are selective for the sp receptor (named nk-1) or for the b2 type bradyki ... | 1989 | 2479572 |
| bronchodilator activity of atrial natriuretic peptide in guinea pigs. | atrial natriuretic peptide (anp) produced concentration-dependent relaxation of isolated guinea pig tracheal chains contracted with histamine, serotonin, carbachol, and arachidonic acid. anp was a full agonist. anp was two- to three-fold less potent when compared with isoprenaline in relaxing histamine-, serotonin-, and arachidonic acid-contracted tracheal chains. however, anp was 20-fold less potent than isoprenaline in relaxing carbachol-contracted tracheal chains. the relaxant potencies of is ... | 1989 | 2532949 |
| development of an intravascular lung assist device. | intravascular lung assist devices (ilads) must provide sufficient gas transport without excessive pressure drop. in vitro studies of fiber-bundle devices determined the effect of geometric configuration on gas transfer efficiency, the amount of surface area needed to achieve sufficient gas transport, and the relationship between gas transport and blood-side pressure drop. ilads with cross-flow fibers transfer at least 10 times more o2 than parallel flow ilads of the same surface area, and six to ... | 1989 | 2597558 |
| comparison of the nucleotide sequences of a yeast gene family. i. distribution and spectrum of spontaneous base substitutions. | the nucleotide sequences of closely related members of a gene family can be used to investigate spontaneous mutations. here we analyse the sequences of different yeast invertase genes which are more than 93% identical in the coding region and share some very similar, but not identical sequences in the noncoding flanking regions. since all except one of the invertase genes are active, most of the base substitutions are silent. within the coding region the base substitutions are unevenly distribut ... | 1989 | 2682226 |
| comparison of the nucleotide sequences of a yeast gene family. i. distribution and spectrum of spontaneous base substitutions. | the nucleotide sequences of closely related members of a gene family can be used to investigate spontaneous mutations. here we analyse the sequences of different yeast invertase genes which are more than 93% identical in the coding region and share some very similar, but not identical sequences in the noncoding flanking regions. since all except one of the invertase genes are active, most of the base substitutions are silent. within the coding region the base substitutions are unevenly distribut ... | 1989 | 2682226 |
| [preparation of catalytic subunits of camp-dependent protein kinase from cattle myocardium]. | a method is suggested for obtaining a catalytic subunit of camp-dependent protein kinase from the cattle myocardium. the specific activity of protein kinase is 0.5 mumol 32p per 1 mg of the enzyme. the method is based on the difference of protein kinase in the subunit and choloenzyme charges, it embraces the stages of homogenization, ultracentrifugation and biospecific elution on anion exchanger of deae-sepharose-cl-6b using 10(-4) m camp in the stationary variant. | 1989 | 2588346 |
| lever pressing for food reward and changes in dopamine turnover and uric acid in rat caudate and nucleus accumbens studied chronically by in vivo voltammetry. | the neurotransmitter dopamine (da) is widely held to be involved in the maintenance of positively reinforced behaviour, on the basis of self-stimulation experiments and of the effects of drugs which alter da transmission on self-stimulation, and on behaviours controlled by natural reinforcers. we have used the technique of linear sweep voltammetry at chronically implanted carbon paste electrodes to demonstrate that 30-min sessions of responding on a variable interval schedule for food pellet rew ... | 1990 | 2259235 |
| chromosome plotbooks and diskettes available from the human gene mapping library. | | 1990 | 2248303 |
| interrelationships of dietary sodium, potassium and chloride on growth in young swine. | in a preliminary experiment, pigs fed a purified diet gained at the same rate as pigs fed a natural ingredient diet if the purified diet was formulated to provide 150% of the na, k and cl requirements. subsequent experiments were designed to determine the interrelationships of dietary na, k and cl. pigs were fed diets with na (.03% to .60%), k (.1% to 1.0%) and cl (.03% to .60%) levels arranged in a three-factor central composite design. over the range of na levels, predicted gain increased by . ... | 1990 | 2211403 |
| hcfa-ball. | | 1990 | 2196331 |
| macrosialin, a macrophage-restricted membrane sialoprotein differentially glycosylated in response to inflammatory stimuli. | rat monoclonal antibody fa/11 has been used to identify macrosialin, a sialoglycoprotein confined to murine mononuclear phagocytes and related cells. originally identified as a macrophage-associated glycoprotein predominantly localized in intracellular membranes (smith, m.j., and g.l.e. koch. 1987. j. cell sci. 87:113), the antigen is widely expressed on tissue macrophages, including those in lymphoid areas, and is expressed at low levels on isolated dendritic cells. immuno-adsorption experiment ... | 1991 | 1919437 |
| macrosialin, a macrophage-restricted membrane sialoprotein differentially glycosylated in response to inflammatory stimuli. | rat monoclonal antibody fa/11 has been used to identify macrosialin, a sialoglycoprotein confined to murine mononuclear phagocytes and related cells. originally identified as a macrophage-associated glycoprotein predominantly localized in intracellular membranes (smith, m.j., and g.l.e. koch. 1987. j. cell sci. 87:113), the antigen is widely expressed on tissue macrophages, including those in lymphoid areas, and is expressed at low levels on isolated dendritic cells. immuno-adsorption experiment ... | 1991 | 1919437 |
| [a histological study of the meniscal insertion of the external pterygoid muscle]. | the paper reports a study of the relationship between the upper head of the pterygoid muscle and the temporomandibular joint disc. using optical microscopy, tmj serial sections of 10 human embryos and fetuses aged from 6 to 22 weeks were examined. from the observation of serial sections, it appears that from the start of histogenesis the lateral pterygoid muscle is in contact with the condylar blastema and later with the disc and the condyle. a fibrous attachment was detected between the muscle ... | 1991 | 1895999 |
| novel human fgf receptors with distinct expression patterns. | | 1991 | 1664691 |
| determination of concentrations by time domain fitting of proton nmr echo signals using prior knowledge. | a fast and flexible time domain iterative fitting procedure that can be used to fit free induction decays as well as echo-like signals is described. damping constants of the first and second part of the echo do not have to be identical. prior knowledge can be used to diminish the number of parameters to be fitted, which results in an improved accuracy. it is shown how prior knowledge is mathematically incorporated in the gauss-newton method. from proton nmr measurements of model solutions actual ... | 1992 | 1435212 |
| purification of cross-reacting protein antigen shared by yersinia enterocolitica and other gram-negative bacteria with monoclonal antibody. | a monoclonal antibody against the yersinia enterocolitica 60-kilodalton (kda) antigen, designated cross-reacting protein antigen (crpa), was obtained by cell fusion. the crpa common to gram-negative bacteria was purified from y. enterocolitica by the affinity chromatography with the monoclonal antibody (igg1) thus obtained. the purified crpa showed a single band of 60 kda in sds-polyacrylamide gel electrophoresis (sds-page), and reacted with rabbit antisera against y. enterocolitica, vibrio chol ... | 1989 | 2779474 |
| purification of cross-reacting protein antigen shared by yersinia enterocolitica and other gram-negative bacteria with monoclonal antibody. | a monoclonal antibody against the yersinia enterocolitica 60-kilodalton (kda) antigen, designated cross-reacting protein antigen (crpa), was obtained by cell fusion. the crpa common to gram-negative bacteria was purified from y. enterocolitica by the affinity chromatography with the monoclonal antibody (igg1) thus obtained. the purified crpa showed a single band of 60 kda in sds-polyacrylamide gel electrophoresis (sds-page), and reacted with rabbit antisera against y. enterocolitica, vibrio chol ... | 1989 | 2779474 |
| characterization of the structure and properties of the his 62-->ala and arg 38-->ala mutants of yeast phosphoglycerate kinase: an investigation of the catalytic and activatory sites by site-directed mutagenesis and nmr. | the role of two "basic patch" residues, arg-38 and his-62, in the catalytic function and anion-dependent activation of yeast 3-phosphoglycerate kinase (pgk) was investigated by site-directed mutagenesis. steady-state kinetics and nmr experiments were conducted to characterize the functional properties and structural integrity of the r38a and h62a mutants. the results of these studies, in combination with earlier mutagenesis experiments, suggest that arg-38 is the only catalytically essential res ... | 1992 | 1304916 |
| assessing the needs and quality of life of patients with hiv infection: development of the hiv overview of problems-evaluation system (hopes). | to develop and evaluate the psychometric properties (reliability, validity etc.) of a comprehensive quality of life (qol) tool, for patients infected with the human immunodeficiency virus (hiv), that was adapted from a previously validated cancer tool. | 1992 | 1299472 |
| functional reconstitution of proton-pumping cytochrome-c oxidase in phospholipid vesicles. | | 1986 | 2856142 |
| developmental changes in membrane transport and permeability in the early mouse embryo. | | 1977 | 557425 |
| [effect of eledoisin on the process of corneal repair in rabbits]. | eledoisin cured corneal lesions produced in the rabbit by cocaine but failed to heal those produced by sodium hydroxide. the effect was probably due to accelerated epithelial proliferation. | 1979 | 553618 |
| polypeptides that inhibit human breast cancer cell division. | medium sized (10-15 amino acids) polypeptides isolated from normal human urine inhibit the growth of five established cell lines of human mammary cancer. cytostatic and cytotoxic effects are dose dependent and reversible at lower doses. evidence suggests a block to cell division in s phase. | 1979 | 552902 |
| induction of drug metabolizing enzymes in polybrominated biphenyl-fed lactating rats and their pups. | polybrominated biphenyls (pbbs) cause a mixed-type (phenobarbital- plus 3-methylcholanthrene-like) induction of liver microsomal drug metabolizing enzymes in rats. however, 2,2',4,4',5,5'-hexabromobiphenyl and 2,2',3,4,4',5,5'-heptabromobiphenyl, which together comprise less than 80% of pbbs (firemaster), were shown to be strictly phenobarbital-type inducers. other components (unidentified) must therefore cause the 3-methylcholanthrene-like effects. the potential for pbbs to exert effects on neo ... | 1978 | 209970 |
| [the proteincomposition of human parotid saliva in acute and chronic parotitis. quantitativ densitometry of single protein-fractions in comparison to normal secretions]. | by means of acrylamidgelectrophoresis parotid secretions of patients with acute and chronic parotitis were examined. thereby significant changes in protein patterns of electrophoretic separation were found. especially two bands are described in detail. one in the cathodal near gel region, the isoamylases, and the otherone in the anodal part of the gel, identified as albumin. in rest and under stimulation these bands show signficant changes compared to normal secretions. furthermore information a ... | 1976 | 135180 |
| nickel dermatitis hazards from prostheses. in vivo and in vitro solubilization studies. | this report reviews data relating to the nickel hazard from implanted prostheses. it is shown that nickel is released from stainless steel prostheses by the action of sweat, blood and physiological saline solution. in laboratory animals, solubilized nickel isn the tissue near the implant. | 1975 | 125098 |
| studies of the rate of regression of the glomerular lesions in diabetic rats treated with pancreatic islet transplantation. | diabetes was induced in lewis rats with streptozotocin. six to eight months later glomeruli showed mesangial thickening: igg, igm and c3 were seen in large quantities in the mesangium by immunofluorescent microscopy. ten animals then had successful pancreatic transplantation resulting in normal glucose and insulin levels within one to three weeks. biopsies obtained within the first two weeks following transplantation demonstrated a significant reduction in mesangial thickening and in mesangial s ... | 1975 | 123209 |
| [inhibitory effect of n-ethylmaleimide on caries development in rats inoculated with streptococcus mutans 6715]. | | 1986 | 3467274 |
| comparison of a slide coagglutination technique with the minitek system for confirmation of neisseria gonorrhoeae. | the phadebact gonococcus test was performed on 314 bacterial isolates to compare the coagglutination technique with the minitek system for the confirmation of neisseria gonorrhoeae. direct testing, using colonies of n. gonorrhoeae mixed with the phadebact gonococcus test reagents, produced noninterpretable results in many cases. however, an alternative method, described by the manufacturer, of heating several colonies in distilled water for 20 min before testing alleviated most interpretation d ... | 1979 | 114531 |
| evidence for peptidoglycan-associated protein(s) in neisseria gonorrhoeae. | | 1978 | 27176 |
| inhibition of experimental immediate hypersensitivity reactions by a novel xanthone, ru 31156. | ru 31156, the tris-(hydroxymethyl)-aminomethane salt of 7-(s-methylsulphonimidoyl)-5-(n-hexyl)-xanthen-9-one-2-carboxylic acid has been found to be a potent inhibitor of experimental immediate hypersensitivity reactions in vivo. in the ige-mediated rat pca test, ru 31156 had an ed50 of 0.0046 (00037--0.0057) mg/kg which compared to a figure of 1.21 (1.04--1.42) mg/kg for disocium cromoglycate (dscg), both compounds being administered intravenously. ru 31156 was also active when administered oral ... | 1978 | 25634 |
| coding nucleotide sequence of rat malic enzyme mrna and tissue specific regulation by thyroid hormone. | a nearly full length me cdna has been obtained and sequenced. the identity has been established by comparison of the translated nucleotide sequence with the amino acid sequence of 7 tryptic peptides from purified me. northern analysis with this cdna shows that me mrna consists of two different messages of about 27s and 21s. the size difference between two me mrnas (approximately equal to 27s and 21s) is attributed to the differences in the 3' noncoding regions. the relative ratios of the two me ... | 1989 | 2699453 |
| prospects for cancer control and prevention through genetics. | at the cellular level, cancer is a genetic disease and, in populations, most cancers have genetic, congenital or familial determinants. virtually all malignant neoplasms likely have cytogenetic abnormalities and some constitutional cytogenetic syndromes are complicated by cancer. of 4344 known or suspected mendelian traits in human beings, 338 (8%) have neoplasia as a feature or a complication; 25% of preneoplastic genes have been mapped to specific chromosomes. certain syndromes of familial agg ... | 1989 | 2689001 |
| the fat content of suckled breast milk: a new approach to its assessment. | using a modification of the "interrupted feed" technique (woolridge et al., 1982, early hum. dev., 6, 265-272), the authors devised an equation relating milk fat content at any point during a feed from a breast to the volume consumed since the start of the feed. hence, an equation was obtained to estimate the mean fat content (mf) of milk consumed during a feed from the fat content of small samples of fore-milk (fb) and hind-milk (fe): mf = 0.57fb + 0.43fe the authors argue that their approach y ... | 1989 | 2606054 |
| isolation of tetraploid clones with high efficiency from diploid 3y1 rat fibroblasts treated with sodium butyrate. | sodium butyrate causes proliferation arrest with a g2 (4c) dna content and induces formation of tetraploid cells upon removal of the inhibitor, in rat 3y1 diploid fibroblasts. we isolated tetraploid clones from the butyrate-treated 3y1 cells with high efficiency; among 21 clones randomly isolated, 5 were pure diploid, 7 were mainly tetraploid with a small contaminating diploid population, and 7 were pure tetraploid. among the pure tetraploid clones, two showed doubled chromosome numbers with sli ... | 1985 | 4030625 |
| novel core, backbone and peripheral region sequences of the oligosaccharides of foetal gastrointestinal mucins present in human meconium. | structural and conformational studies have been carried out of the oligosaccharide chains of foetal gastrointestinal mucins purified from human meconium. combined gc, ms and 1h nmr analysis has been used to characterise the twenty-six major mono- to hexasaccharides. these show seven different core regions (including unsubstituted galnac-ol). extended glycosylation occurs on both branches at c6 and c3 of galnac-ol and both repeating type 1, gal beta 1-3glcnac, and alternating type 1/type 2, gal b ... | 1989 | 2701474 |
| [studies on fine structure of choroid plexus and ependyma in monkeys (with remarks to function)]. | | 1972 | 4208002 |
| specific inhibition of viral ribonucleic acid replication by gliotoxin. | gliotoxin inhibits intracellular replication of poliovirus in hela cells at a stage subsequent to adsorption and penetration of virus. the sensitive step is synthesis of viral rna: synthesis of viral protein is unaffected except as a consequence of blockade of rna synthesis. concentrations of gliotoxin sufficient to block viral rna synthesis completely do not affect cellular rna synthesis. | 1968 | 4294481 |
| specific inhibition of viral ribonucleic acid replication by gliotoxin. | gliotoxin inhibits intracellular replication of poliovirus in hela cells at a stage subsequent to adsorption and penetration of virus. the sensitive step is synthesis of viral rna: synthesis of viral protein is unaffected except as a consequence of blockade of rna synthesis. concentrations of gliotoxin sufficient to block viral rna synthesis completely do not affect cellular rna synthesis. | 1968 | 4294481 |
| levels of airborne man-made mineral fibres in dwellings in the uk: results of a preliminary survey. | levels of airborne man-made mineral fibres (mmmf) were measured during the insulation of lofts and after the disturbance of the insulation wools. transmission electron microscopy was used for the analysis. generally, the personal samples showed fibre levels of up to 0.7 f/ml, whereas static samples showed fibre levels of 0.05 f/ml in the lofts. little contamination of living space occurred during these operations. | 1989 | 2744831 |
| crystalline l-leucine dehydrogenase. | | 1971 | 4331041 |
| influenza immunization: field trial on a university campus. | | 1972 | 4559743 |
| [synoptic review: pathogenesis of intestinal viral infections in animals]. | | 1973 | 4582080 |
| infection of the central nervous system by rhinocladiella atrovirens in a patient with acquired immunodeficiency syndrome. | a case of central nervous system invasion by rhinocladiella atrovirens is described. the patient was an intravenous drug abuser suffering from acquired immunodeficiency syndrome. | 1989 | 2746436 |
| [acute renal insufficiency in the idiopathic nephrotic syndrome. observation of 4 cases]. | | 2003 | 262267 |
| insensitivity, limited joint mobility, and plantar ulcers in patients with diabetes mellitus. | the purpose of this study was to determine whether differences in sensation, ankle dorsiflexion (df), and subtalar joint (stj) motion exist between 1) diabetic patients with a history of plantar ulcer (dmw group), 2) diabetic patients without a history of plantar ulcer (dmwo group), and 3) a nondiabetic control group (ndc group). there were 23, 23, and 24 subjects in the respective groups. the mean age for each group was 58, 63, and 60 years, respectively. the mean df for each group was 2, 5, an ... | 2009 | 2727069 |
| adverse events temporally associated with immunizing agents: 1987 report. | | 2007 | 2804852 |
| [ige determination (rist, prist and others)]. | | 2004 | 490927 |
| [epidemiology of collagen diseases. (1). screening of collagen diseases]. | | 2005 | 1169518 |
| biochemical characteristics of mammalian myocardia. | selected biochemical parameters of the ventricular myocardium were compared among several orders of adult mammals with established differences in resting heart rate (cattle, 51 beats/min; swine, 68; canine, 107; rabbit, 256; guinea-pig, 273; rat, 355; mouse, 475). it was hypothesized that the biochemical character of mammalian myocardia is associated with the chronic functional demand on the muscle. therefore, differences observed in the myocardial biochemical potential among the species could r ... | 1989 | 2746658 |
| accurate and efficient rna polymerase iii transcription in a cell-free extract prepared from ascaris suum embryos. | high-speed supernatant (s100) extracts derived from homogenized ascaris suum embryos efficiently transcribe added rna polymerase iii templates including cloned 5s rrna genes of the filarial parasite brugia malayi. several criteria, including two-dimensional rnase t1 oligonucleotide fingerprint analysis, indicate that in vitro transcription is accurately initiated and terminated. | 1989 | 2747746 |
| studies of non-disjunction of the major autosomes in drosophila melanogaster. ii. effects of dose-fractionation, low radiation doses, ems, and ageing. | | 1998 | 108593 |
| comparison between ketotifen and dscg in bronchial challenge. | a double-blind cross-over study showed that orally taken ketotifen and inhaled dscg have a comparable protective effect on allergen-induced bronchoconstriction. both drugs significantly inhibit the immediate bronchial reaction after a 3 day treatment with either 1 mg ketotifen or 20 mg dscg four times daily. late reactions, which occurred in three out of the ten patients, were inhibited in two of the three patients by ketotifen as by dscg. | 1999 | 97033 |
| [the application of fractal technics for the enhancement of radiographic images]. | this paper deals with digital radiological image processing, with a special emphasis on quantitative measurement extraction aimed at discriminating different lung pathologies. texture analysis of these images, not easily performed by the human eye, can be carried out by means of fractal techniques, which allow different textures to be characterized by a single parameter--i.e. the fractal dimension. to extract the fractal dimension of an image, the so-called "blanket" method is employed, which al ... | 1989 | 2748966 |
| cephaloridine nephrotoxicity in streptozotocin induced diabetic fischer 344 (f344) rats. | the purpose of this study was to determine if cephaloridine nephrotoxicity is attenuated in streptozotocin (stz)-induced diabetic rats. fischer 344 (f344) rats (205-250 g) were given a single injection (i.p.) of stz (27-35 mg/kg) or citrate buffer. the nephrotoxicity of (750 mg/kg) cephaloridine (i.p.) was then compared with normoglycemic and 14-day diabetic rats. increased blood urea nitrogen (bun) levels as well as diminished renal cortical slice accumulation of tetraethylammonium (tea) and la ... | 1989 | 2749746 |
| tissue calcium in uraemia. | the content of calcium in the thoracic aorta, the heart and the kidney was determined in rats with moderate renal failure treated with 1.25-dihydroxycholecalciferol (1.25-dhcc) 100 ng/kg/day and verapamil 20 mg/kg/day. in the aorta the content of calcium was significantly increased in uraemic rats and this increase was significantly augmented after administration of 1.25-dhcc. in the kidney no increase in calcium was seen in rats with uraemia, but treatment with 1.25-dhcc increased the calcium c ... | 1989 | 2756360 |
| renal acidification defects in patients with their first renal stone episode. | to rule out renal acidification defects, 40 consecutive patients with their first renal stone episode were evaluated by measurement of fasting morning urine ph levels followed by a short ammonium chloride loading test in cases with high levels. two patients (5%) exhibited incomplete distal renal tubular acidosis, the rest had normal urinary acidification. in view of the short duration of stone disease in the patients studied, the acidification defects were considered to be primary, and the stone ... | 2011 | 3187423 |
| pvp: in gastroenterology. | | 1998 | 106142 |
| increased myometrial responsiveness to oxytocin during term and preterm labor. | the contractile effects of oxytocin on the longitudinal and circular muscle of rat uteri from animals undergoing term and preterm labor were studied in vitro to define the action of the hormone. the maximal tension and slopes of oxytocin dose contractile-response curves, but not the pd2 values (-log ed50), were higher in both muscle layers at term delivery and also during preterm delivery induced with antiprogesterones compared with responses from tissues of nondelivering animals. these data ind ... | 1989 | 2764062 |
| [feasibility of applying pattern recognition techniques in psychopharmacology]. | the necessity to consider the effect of psychotropic agents on the human organism as on the integral system interrelated with the environment is grounded. the need of applying the pattern recognition theory techniques which allow to analyze the integral state of the organism is substantiated. an illustration of the analysis of a psychotropic agent cathinone by using these techniques is presented. | 1989 | 2792347 |
| [feasibility of applying pattern recognition techniques in psychopharmacology]. | the necessity to consider the effect of psychotropic agents on the human organism as on the integral system interrelated with the environment is grounded. the need of applying the pattern recognition theory techniques which allow to analyze the integral state of the organism is substantiated. an illustration of the analysis of a psychotropic agent cathinone by using these techniques is presented. | 1989 | 2792347 |
| [importance of studying the sputum of pneumonia and bronchitis patients]. | | 2014 | 4002152 |
| an erythrocyte membrane-protein anomaly in march haemoglobinuria. | in three patients with march haemoglobinuria a well-defined protein abnormality has been revealed by high-resolution sodium-dodecyl-sulphate/polyacrylamide-gel electrophoresis. | 2000 | 91785 |
| imaging the child with multiple trauma. | | 2007 | 3246382 |
| the effect of repeated small doses of radiation on recovery from sub-lethal damage by chinese hamster cells irradiated in the plateau phase of growth. | unfed plateau-phase cells have been irradiated with either single doses or up to ten fractions of x-rays 6 hours apart. the single-dose survival curve had an extrapolation number of 11-4, and the oxygen-enhancement ratio (o.e.r.) was 3-1. cells were exposed to multiple fractions of 200 rad or 150 rad in air and 600 rad or 450 rad in hypoxia. the resulting survival curves did not fit a multi-target, single-hit model of cell survival, being much steeper than that would predict. the curves were exp ... | 2001 | 1083845 |
| a new approach to teaching differential diagnosis of oral soft tissue pathosis. | | 2001 | 94926 |
| projection arteriography and venography: initial clinical results with mr. | motion currently limits the applications of magnetic resonance (mr) angiography in certain regions of the body. to overcome this problem, a series of breath-hold, two-dimensional, flow-compensated gradient-echo images were acquired. these images were then processed by means of the maximum intensity projection algorithm to produce projection angiograms. the method was evaluated in 10 healthy subjects and in 12 patients and validated by comparing conventional angiograms, contrast material-enhanced ... | 2004 | 2748814 |
| projection arteriography and venography: initial clinical results with mr. | motion currently limits the applications of magnetic resonance (mr) angiography in certain regions of the body. to overcome this problem, a series of breath-hold, two-dimensional, flow-compensated gradient-echo images were acquired. these images were then processed by means of the maximum intensity projection algorithm to produce projection angiograms. the method was evaluated in 10 healthy subjects and in 12 patients and validated by comparing conventional angiograms, contrast material-enhanced ... | 2004 | 2748814 |
| job sharing: a viable option. | | 2004 | 1304937 |
| in vitro attachment, salivary agglutination, and surface fibril density of fresh actinomyces isolates from two distinct oral surfaces. | whereas attachment specificity among bacterial species is well recognized, the question of specificity among strains of the same species isolated from distinct oral surfaces has not been studied. twenty strains of actinomyces, freshly isolated as they re-populated the cleaned teeth and tongues of a male twin pair, were compared for: (1) their ability to attach to saliva-coated hydroxyapatite (sha), (2) the density of their surface fibrils, (3) their agglutination in saliva, and (4) their ability ... | 1985 | 2860145 |
| rapid detoxification of infused ammonium by the anesthetized rat. | anaesthetized rats were given an i.v. overload of 200 mmoles of ammonium acetate. plasma ammonium levels were not altered for up to 20 minutes after the end of the infusion. the load of ammonium, however, increased the overall non-protein nitrogen content of circulating plasma, as for the increase in urea and amino acids (alanine, phenylalanine, aspartate + asparagine and glutamate + glutamine). the activities of glutamine synthetase was found increased in liver, muscle and kidney; and glutamate ... | 1988 | 2901836 |
| phosphatidylserine and calmodulin effects on ca2+-stimulated atpase activity of dog brain synaptosomal plasma membranes. | phosphatidylserine (ptdser)-liposomes when incubated with synaptosomal plasma membranes (spm) of dog brain, evoked a significant increase (approx 80%) of the ca2+-stimulated atpase activity with maximal effect achieved at around 0.7 mumol ptdser/mg spm protein. higher concentrations of ptdser led to inhibition of the enzyme activity with respect to the maximal percentage of stimulation. treatment of spm with egta, to minimize the presence of bound cytoplasmic activator calmodulin, resulted in a ... | 1985 | 2933282 |
| properties and localization of chitin synthase in ascaris suum eggs. | investigations were carried out into the properties and localization of chitin synthase (ec 2.4.1.16) in connection with the formation of ascaris suum egg-shells. the chitin synthase of eggs exhibited properties very similar to those found in other chitin-synthesizing organisms. it was stimulated by the presence of atp, glcnac and mg2+ with maximal activity at ph 7.0. in the phase of active chitin synthesis, during formation of the primary shell layers, chitin synthase was bound to the structure ... | 1986 | 2938060 |
| evaluation of gastrointestinal function with isotopic tracers. | nuclear medicine is the application of tracer methodology mainly to clinical diagnosis. we use chemical compounds labelled with radioisotopes as tracers. the examinations provide us with the information on regional function of tissues and organs. in this review we describe the nuclear medicine procedures for the diagnosis of gastrointestinal diseases based on our experiences. the emphasis is put on the evaluation of the functional aspect of the gastrointestinal tract. the procedures to be descri ... | 2013 | 3566168 |
| identification of membrane-bound calcium, calmodulin-dependent protein kinase ii in canine heart. | phospholamban, the putative regulatory proteolipid of the ca2+/mg2+ atpase in cardiac sarcoplasmic reticulum, was selectively phosphorylated by a ca2+/calmodulin (cam)-dependent protein kinase associated with a cardiac membrane preparation. this kinase also catalyzed the phosphorylation of two exogenous proteins known to be phosphorylated by the multifunctional ca2+/cam-dependent protein kinase ii (ca2+/cam-kinase ii), i.e., smooth muscle myosin light chains and glycogen synthase a. the latter p ... | 1987 | 2954508 |