| spin-labeling studies of beef-liver glutamate dehydrogenase. | | 1977 | 14634 |
| a simplified decerebration technique in cats and its applicability to neuro-cardiovascular drug studies. | | 1977 | 15088 |
| dna and enzyme behaviour during the early period of experimental hepatic regeneration proceedings. | | 1976 | 16335 |
| role of low-molecular weight factors isolated from methanobacillus kuzneceovii in the activating effect of visible light on methane formation and reduction of pyridine nucleotides. | four low molecular weight fluorescent factors are isolated from thermophylic methaneproducing facteria methanobacterium kuzneceovii. these factors are: the factor 340; the factor 420 (both reduced and oxidized); and a flavine derivative, comprising together with proteins a biochemical system, which reduces pyridine nucleotides in dark (at 55degrees c) and in the light (at 21degrees c). | 1977 | 16669 |
| cellular factors. immunologic tolerance: irradiation and bone marrow transplantation in induction of canine allogeneic unresponsiveness. | | 1977 | 17203 |
| some dental effects of xylitol under laboratory and in vivo conditions. | | 1977 | 18284 |
| effect of experimental diabetes on drug metabolism in the rat. | the effect of experimental diabetes on hepatic drug metabolism was studied in male holtzman rats. treatment of animals with streptozotocin and 6-aminonicotinamide, both agents which produce an insulin-deficient animal, caused prolongation of hexobarbital sleeping times and inhibition of the rate of metabolism of both hexobarbital and, to a lesser extent, aniline in vitro. treatment of animals with n-methylacetamide, a diabetogen which does not cause insulin deficiency in the animal but rather pr ... | 1977 | 19220 |
| cyclic adenosine 3',5'-monophosphate regulation of membrane energetics in escherichia coli. | mutants of escherichia coli k-12 lacking functional adenylate cyclase (cya) or the cyclic adenosine 3',5'-monophosphate (camp) receptor protein (crp) were compared with their wild type to evaluate the role played by the camp-camp receptor protein complex in regulating this organism's membrane-associated bioenergetic functions. both mutants were found to be equally defective in carrying out various electron transport activities. in particular, their capacity for synthesizing a functional oxygen-l ... | 1977 | 19422 |
| the direction of light-induced ph changes in purple membrane suspensions. influence of ph and temperature. | | 1977 | 21811 |
| bacteroides fragilis septicemia. | on the basis of eight cases of bacteroides fragilis septicaemia, the authors review recent data from the literature related to this topic. they first note the increasing prevalence, accounting for approximately 10 per cent of all septicaemias at the present time. they note that the most frequent portals of entry are sites of localised suppuration, related on the one hand to digestive or gynaecological surgery and, secondly, to the post-partum or post-abortum period. from a therapeutic standpoint ... | 1977 | 23026 |
| change in levels of rna & protein in epididymidis, ductus deferens & accessory glands of reproduction of the albino rat during postnatal development. | | 1977 | 23998 |
| stabilization of the relaxed state of aspartate transcarbamoylase by modification with a bifunctional reagent. | native aspartate transcarbamoylase from escherichia coli was modified with the bifunctional reagent tartaryl diazide in the presence of the substrate carbamoyl phosphate and the substrate analog succinate. the product had the same sedimentation coefficient as the native enzyme but showed a marked increase in affinity for the substrate aspartate with a hyperbolic saturation curve. the michaelis constant for aspartate (7.4 mm) is similar to that estimated for the relaxed state of the enzyme. the h ... | 1978 | 24638 |
| oxygen affinity and 2,3-diphosphoglycerate in blood of australian marsupials of differing body size. | oxygen carriage and 2,3-diphosphoglycerate (2,3-dpg) levels have been measured in the blood of seven species of australian marsupials ranging in size from 35 to 0.03 kg. they were red and grey kangaroos, wallaroo, tammar wallaby, brush-tailed possum, potoroo, and brown marsupial mouse. oxygen affinity decreased with decrease in adult body size, standard p50 (at 36 c) varying from 24.6 torr in the largest (red kangaroo) to 41.9 torr in the smallest (brown marsupial mouse). the relationship betwee ... | 1977 | 24866 |
| the successful treatment of a case of primary sterility resulting from fredrickson's type v hyperlipemia and panhypopituitarism. | successful treatment of primary sterility in a woman having the rare association of panhypopituitarism with fredrickson's type v hyperlipemia is described. replacement therapy with l-thyroxine, prednisone and a low fat diet cleared the patient's blood of the excessive chylomicrons and very low density lipoproteins. ovulation was induced with human gonadotrophins, and triplets (two normal girls and a boy) were born. | 1978 | 25805 |
| myocardial effects of lithium in vitro. | the myocardial effects of increasing concentrations of ionic lithium were investigated in isolated, spontaneously beating rabbit hearts, which were retrogradely perfused with a modified krebs-henseleit solution containing lithium in concentration of 1, 5 or 10 mm. the following functional parameters were continuously recorded: heart rate, amplitude and rate of contraction, coronary flow, myocardial oxygen consumption and ecg. the lowest concentration of 1 mm lithium did not cause any measurable ... | 1978 | 26164 |
| selective suppression of primary igm responses by induction of low dose paralysis to type iii pneumococcal polysaccharide. | | 1978 | 26471 |
| bacterial etiology of otitis media during the first six weeks of life. | tympanocentesis was performed on 70 infants who had otitis media during the first six weeks of life. the bacteria isolated from their middle-ear effusions were streptococcus pneumoniae (13 patients), neisseria catarrhalis (11 patients), hemophilus influenzae (ten patients), enterobacteriaceae (four patients), staphylococcus aureus (four patients), streptococci (groups a and b) (three patients), and pseudomonas aeruginosa (two patients). thirty patients (42.9%) had middle-ear effusions which did ... | 1978 | 26735 |
| origin of adifferentiated variants of streptomyces roseoflavus in submerged culture. | adifferentiated nocardia-like variants (nv) of streptomyces roseoflavus var. roseofungini, similar in their cultural characteristics with the variant 1-68 described elsewhere (nikitina, 1968; kalakoutskii a. nikitina, 1976), can be obtained not only in the course of growth of the parent culture on a solid medium containing fructose in the form of secondary colonies, but also during submerged cultivation with stirring. interruptions in aeration do not affect accumulation of the cells of such vari ... | 1978 | 26856 |
| the relationship between cholinesterase inhibition in the chick biventer cervicis muscle and its sensitivity to exogenous acetylcholine. | the effect of physostigmine has been studied on cholinesterase in homogenates of chick biventer cervicis muscles and on the contractile responses of the intact muscles to acetylcholine and carbachol. the concentration of physostigmine required to produce the maximum increase in sensitivity to acetylcholine almost completely inhibited the cholinesterase in muscle homogenates. this concentration of physostigmine had no effect on muscle contractures elicited by carbachol. by taking account of the c ... | 1978 | 27608 |
| blockade by n-methylhydroxylamine of activation of guanylate cyclase and elevations of guanosine 3',5'-monophosphate levels in nervous tissues. | hydroxylamine and n-methylhydroxylamine prevented the activation of soluble guanylate cyclase by the endogenous activator as well as by nitroso compounds such as n-methyl-n'-nitro-n-nitrosoguanidine or nitroprusside, while other derivaties of hydroxylamine were ineffective. hydroxylamine and n-methylhydroxylamine did not alter the basal guanylate cyclase activity of purified enzyme preparations. kinetics analysis indicated that n-methylhydroxylamine competes with n-methyl-n'-nitro-n-nitrosoguani ... | 1978 | 31192 |
| [study of the dynamics of acid formation in the stomachs of dogs under the influence of thyroidin by the method of intragastric ph-graphy]. | intragastral ph-graphy was applied to the study of the dynamics of acid production in the stomach of dogs with fistulae of the fundal portion of the stomach out of and during digestion, and also before and after the thyroidin prescription. biphasic character of the changes in acid production in the stomach under the effect of the hormonal preparation was revealed. | 1978 | 31210 |
| purification and properties of an inducible beta-galactosidase isolated from the yeast kluyveromyces lactis. | beta-galactosidase (ec 3.2.1.32) was purified 80-fold from the yeast kluyveromyces lactis induced for this enzyme by growth on lactose. when the purified enzyme was subjected to electrophoresis on an acrylamide gel in the presence of sodium dodecyl sulfate, one protein with an apparent molecular weight of 135,000 was observed. the enzyme has a sedimentation coefficient of 9.6s. this beta-galactosidase and the one from escherichia coli are not antigenically related. maximal enzyme activity requir ... | 1979 | 33153 |
| adrenoceptor-mediated activation of liver glycogen phosphorylase: effects of thyroid state. | | 1979 | 33312 |
| vasomotor rhinitis--pathophysiological aspects. | vasomotor rhinitis is commonly defined as an unspecific hyperractivity of the nasal mucosa. the symptoms might be due to increased parasympathetic activity to the nose with the release of vaso-secretory active substances. experimental data from the cat suggest that the postganglionic parasympathetic mediator of nasal secretion is cholinergic, whereas the vascular responses appears to be due to a different mechanism. apart from a rich sympathetic and parasympathetic innervation of the nasal mucos ... | 1979 | 34866 |
| [acid-base equilibrium in mother and fetus during labor and the resistance of newborn calves]. | investigated were a total of 59 cows presenting normal processes, of giving birth as well as dystocia, the time of delivery lasting 2, 10, 24, and 36 hours. seventeen cows with dystocia were treated intravenously with 500 cm3 of a 4 per cent solution of sodium bicarbonate and 40 g glucose. it was found that the changes in the ph values, alkali reserves, glycogen, and the peroxydase activity of the neutrophiles in the mothers and fetuses were dependent on the duration of parturition. cases of dif ... | 1978 | 34922 |
| cache valley virus: isolations from mosquitoes in saskatchewan, 1972-1974. | eighteen isolations of cache valley virus (bunyaviridae) were obtained from a total of 113,694 mosquitoes collected in saskatchewan during the summers of 1972 to 1974. most of the isolations were from mosquitoes collected during august. culiseta inornata, the most abundant mosquito (38% of total collected), had the highest minimum vector-infection rate (0.83 isolations per 1000 mosquitoes). the virus was also isolated from culex tarsalis and aedes vexans. it is indicated in the isolations that t ... | 1979 | 38897 |
| alpha-adrenoceptor attenuation of the coronary vascular response to severe exercise in the conscious dog. | | 1979 | 39683 |
| the charge stoichiometry of cytochrome c oxidase in the reconstituted system. | purified cytochrome c oxidase was reconstituted into phospholipid vesicles having high internal ph buffering capacity. in the presence of valinomycin, 2 k+ ions were taken up by the vesicles per electron transferred from cytochrome c to oxygen. the charge stoichiometry of 2 was obtained from simultaneous measurement of changes of k+, h+, and oxygen in the medium after addition of the reductant ascorbate/tmpd (n,n,n',n'-tetramethyl-p-phenylenediamine). the changes in oxygen concentration were mea ... | 1979 | 40970 |
| application of fine-needle aspiration biopsy for the diagnosis of dysplastic and neoplastic liver cell changes induced by n-nitrosomorpholine in rats. | male rats were treated with the hepatocarcinogen, n-nitrosomorpholine (nnm, 10 mg ad 100 ml drinking water) for 19 weeks. repeated fine-needle aspiration biopsies of the liver were performed percutaneously. cytomorphologic and cytochemical criteria were used for the characterization of dysplastic and carcinoma cells. the alterations seen in the smears were correlated with histopathologic findings in the punctured liver lobes. cells showing type i dysplasia were recognized in smears obtained from ... | 1979 | 42375 |
| [effect of cyclic somatostatin on ethanol-induced hypoglycemia]. | the authors examined the activity of the cyclic somatostatin on ethanol hypoglycemia. while the peptide is capable of increasing the plasma glucose levels of hypoglicemia starved rats, it does not increase the levels of plasma glucose in normal rats under the action of ethanol perfusion. | 1979 | 45000 |
| [the effects of electrical and pharmacological stimulation with the combination of atropine, phentolamine and propranolol on the types of proteins secreted by rat parotid and submandibular glands]. | | 1978 | 45019 |
| in vivo and in vitro binding of dihydrostreptomycin to escherichia coli ribosomes. | | 1975 | 45914 |
| alteration of mycobacterium phlei membrane structure by freezing and thawing: reversal by heating. | | 1975 | 49172 |
| stains for a, b, and d cells in fetal rat islets. | ten techniques often used for identification of a, b, and d cells in adult islets of langerhans were applied to fetal rat pancreas. modifications were tried with many of these techniques. two indole methods (xanthydrol and postocoupled benxylidene reactions) and a cryostat technique using o-phthaladehyde failed to stain fetal islets. phosphotungstic acid hematoxylin and lead hematoxylin lightly stained fetal a cell granules in helly's fixed tissue. the grimelius silver nitrate technique stains a ... | 1975 | 49951 |
| the specificity and applications of antibodies to helical nucleic acids. | | 1975 | 50162 |
| specificity of the antibody response in inbred mice to bovine type i and type ii collagen. | mouse antibodies to soluble bovine skin (type i) collagen react with determinants which are located in the rigid triple-helical portion of the antigen and become destroyed upon unfolding the molecule. helical antigenic determinants are dependent on the genuine chain assembly, e.g. alpha[1(i)]2alpha2. artefactual triplehelical structures of the composition [alpha1(i)]3 or [alpha2]3 or a genetically distinct type ii collagen from cartilage showed no or only weak cross-reactivity. pepsin treatment ... | 1975 | 52615 |
| identification of the vasopressin producing and of the oxytocin producing neurons in the hypothalamic magnocellular neurosecretroy system of the rat. | immuno-enzyme histochemical investigations showed that, in the magnocellular hypothalamo-hypophysial neurosecretory system of the rat, vasopressin and oxytocin are synthetized in separate neurons. both the vasopressin neurons and the oxytocin neurons are present in both the supraoptic and the paraventricular nuclei in about the same number. preferential location of the two kinds of rat neurosecretory neurons is not as obvious as in the bovine hypothalamus. their perikarya do not show distinct mo ... | 1975 | 53102 |
| antigenic determinants of bovine myelin encephalitogenic protein recognized by rabbit antibody to myelin encephalitogenic protein. | the antigenic determinants of bovine myelin encephalitogenic protein were investigated by quantitative complement fixation and hapten inhibition using rabbit anti-monkey protein and anti-bovine protein and purified and characterized fragments of bovine protein. the two regions of bovine encephalitogenic protein containing determinants were sequences 1 to 43 and 90 to 170. one rabbit antiserum recognized a determinant(s) probably in residues 15 to 40 while for another rabbit antiserum the determi ... | 1975 | 53232 |
| [synthesis of atp by reversal of cation transport atpase (author's transl)]. | | 1975 | 53861 |
| [cells of rat lymphosarcoma in chambers for intravital microscopy]. | in a chamber for intra vital microscopy, implanted subcutaneously in a rat, stained rat lymphosarcoma cells were applied into a preliminary formed connective tissue layer. the process of intracellular transformation of a dye and its elimination from the cytoplasm was observed. following elimination of the dye a duplication of lymphosarcoma cells would proceed. this is a very intensive process, and after 5-7 days the connective tissue is completely substituted by tumor cells. | 1975 | 53940 |
| an improved fluorescence probe cytotoxicity assay. | the phenanthridine dye, ethidium bromide, which is actively excluded by viable cells, undergoes a significant fluorescence enhancement at 5900 a upon binding intracellular double-stranded polyribonucleotides. a rapid and sensitive assay of antibody mediated cytotoxicity to cells grown in vitro has been developed using this phenomenon. in this communication, we describe this fluorescence probe cytotoxicity assay and a sensitive electro-optical system designed to measure the fluorescence enhanceme ... | 1975 | 54391 |
| a serial study of pregnancy proteins in primigravidae. | the plasma concentrations from four 'pregnancy proteins' and three steroid hormones have been measured throughout pregnancy in 15 primigravidae. two of the proteins, human placental lactogen (hpl) and pregnancy-specific beta1-glycoprotein (psbetag), are specific for pregnancy and correlate well with the stage of gestation. it is suggested that measurement of psbetag may be useful in assessing feto-placental wellbeing. neither of the pregnancy-associated proteins, steriod-binding beta-globulin (s ... | 1976 | 57799 |
| high density lipoprotein (hdl) polymorphisms in rabbit. iii. quantitative determination of hdl and the inherited hl 1 and r 67 antigens. | immunological quantification of hdl and the inherited antigens hl 1 and r 67 was performed on serum samples from two rabbit populations (dutch and albino) comprising a total of 106 animals. the female animals were found to have a higher concentration of both antigens and of hdl than the male animals. the amounts of antigens and of hdl were not obviously normally distributed, but appeared to be more bimodally distributed. the relationship between the amount of antigens and amount of hdl were test ... | 1976 | 58950 |
| [a further case of tn-polyagglutination]. | another case of tn-polyagglutination is described where for 6 years those responses have been observed which are typical of the acquired erythrocyte changes, viz. mixed-field polyagglutination by normal adult sera of all blood groups, no response with anti-tah, agglutination of a certain part of erythrocytes by anti-tnss, anti-adb, anti-ahp, agglomeration of the other part by protamin sulfate and a-like specificity. papain treatment eliminates polyagglutination by human sera of adults. sera of n ... | 1979 | 89994 |
| antimicrobial susceptibility of vibrio cholerae from zaire and rwanda. | | 1979 | 90940 |
| reverse transcriptase pauses at n2-methylguanine during in vitro transcription of escherichia coli 16s ribosomal rna. | a restriction fragment strand complementary to a sequence near the 3' end of escherichia coli 16s rrna has been used to prime reverse transcriptase (avian myeloblastosis virus rna-directed dna nucleotidyltransferase; deoxynucleosidetriphosphate:dna deoxynucleotidyltransferase, ec 2.7.7.7). in addition to transcripts that were extended to the 5' end of the rna, two major transcription intermediates were observed. these discrete-sized cdna intermediates are the result of a kinetic barrier imposed ... | 1979 | 91169 |
| inhibitory effects of 9-beta-d-arabinofuranosylguanine 5'-triphosphate and 9-beta-d-arabinofuranosyladenine 5'-triphosphate on dna polymerases from murine cells and oncornavirus. | the effects of the newly synthesized compound 9-beta-d-arabinofuranosylguanine 5'-triphosphate (ara-gtp) on the activity of dna polymerases from mouse cells and oncornavirus were compared with those of 9-beta-d-arabinofuranosyladenine 5'-triphosphate. ara-gtp did not replace deoxyguanosine 5'- triphosphate as substrate for these dna polymerases but inhibited the activities of dna polymerase alpha, beta, and gamma and viral dna polymerase. dna polymerase alpha was more sensitive than dna polymera ... | 1979 | 91427 |
| the murine kupffer cell. i. characterization of the cell serving accessory function in antigen-specific t cell proliferation. | murine kupffer cells, the tissue macrophages of the liver, were isolated by collagenase digestion, differential sedimentation over metrizamide, and glass adherence. the resultant cell population was more than 86% phagocytic, and 95% of cells stained positively for alpha-naphthyl butyrate esterase activity. the cells also had cell surface receptors for complement (c) and the fc portion of igg. in addition, a large proportion of kupffer cells was shown to bear ia antigens: about half of the cells ... | 1979 | 91637 |
| more than one antigen contributes to the immunogenicity of neisseria gonorrhoeae in the guinea pig chamber model. | gonococci adapted to growth in guinea pig chambers [strain bs4 (agar)] were predominantly smooth organisms and produced a type-specific antigen. a vaccine prepared by treating these gonococci with formalin, protected guinea pig chambers against homologous challenge in contrast to a similarly treated laboratory strain (bsdh) which had been selected in vitro from the same parent strain and which did not produce the type-specific antigen. surface washes of bs4 (agar) contained the type-specific ant ... | 1979 | 91661 |
| [method of indicating staphylococci in the bile]. | | 1979 | 91710 |
| development of new antiallergic drugs (cromolyn sodium, lodoxamide tromethamine). what is the role of cholinergic stimulation in the biphasic dose response? | the antiallergy drugs, cromolyn sodium and lodoxamide tromethamine (u-42,585e) show in vitro dose responses which are bell-shaped or biphasic in mast cells. the nature of the biphasic dose response is poorly understood; however, through the use of specific antagonists, it has been possible to show that at the high concentrations of these drugs leading to enhanced histamine release or multiple high-dose tachyphylaxis, a cholinergic receptor is stimulated in the cell. this receptor is muscarinic i ... | 1979 | 91955 |
| inhibition of chemical mediator release from human leukocytes by a new antiasthma drug, hc 20-511 (ketotifen). | | 1979 | 91958 |
| conscious primate model for evaluating antiallergic drugs. | | 1979 | 91960 |
| [orthosympathetic stimulation after hypercapnia in the rat]. | inhalation of a gas mixture : co2, 25% -- o2, 37.5% -- n2, 37.5%, provokes regularly in the light anaesthetized rat, an increase of catecholaminemia of central origin, associated with systemic arterial hypertension. | 1979 | 92225 |
| amino-acid sequence analysis of the amino-terminal tryptic peptides of different actins from the same mammal [proceedings]. | | 1979 | 92280 |
| silver staining of nucleolar organizer regions in the domestic cat, felis catus. | | 1979 | 92390 |
| babesia rodhaini, babesia bovis, and babesia bigemina: analysis and sorting of red cells from infected mouse or calf blood by flow fluorimetry using 33258 hoechst. | | 1979 | 92419 |
| biosynthesis of butirosins. ii. biosynthetic pathway of butirosins elucidated from cosynthesis and feeding experiments. | | 1979 | 92468 |
| hapten-specific t-cell responses to 4-hydroxy-3-nitrophenyl acetyl. ii. demonstration of idiotypic determinants on suppressor t cells. | the ability of np-coupled syngeneic spleen cells to induce antigen-specific t-suppressor cells capable of binding to np-bsa-coated petri dishes and mediating transfer of specific suppressive activity to np was demonstrated. furthermore, in strains of mice bearing the ig-1b allotype, including sjl, and in (non-ig-1b x ig-1b)f1 hybrids, the np-specific suppressor cells also interferes with expression of immunity after priming with nip-bgg. anti-npb anti-idiotype antiserum plus complement treatment ... | 1979 | 92517 |
| the accessibility of antigenic determinants of ribosomal protein s4 in situ. | antibodies to escherichia coli ribosomal protein s4 react with s4 in subribosomal particles, eg, the complex of 16s rna with s4, s7, s8, s15, s16, s17, and s19 and the ri reconstitution intermediate, but they do not react with intact 30s subunits. antibodies were isolated by three different methods from antisera obtained during the immunization of eight rabbits. some of these antibody preparations, which contained contaminant antibodies directed against other ribosomal proteins, reacted with sub ... | 1979 | 92615 |
| aberrant form of hymenolepis nana: possible opportunistic infection in immunosuppressed patients. | | 1979 | 92715 |
| [effect of sympathetic nerve stimulation on the microvascular permeability for proteins and lipoproteins]. | | 1979 | 92794 |
| normal immunosuppressive protein: in vitro inhibition of dna synthesis in t and b lymphocytes and lymphoid cell lines. | the biologic activity of normal immunosuppressive protein (nip) isolated from human plasma was studied. nip was found to inhibit the proliferation of both t and b lympohcytes in vitro. it suppressed the dna synthesis of normal mouse lymphocytes responding to the mitogens phytohemagglutinin and lipopolysaccharide, as well as the [3h]thymidine and [3h]leucine uptake by t and b lymphoid cell lines of human and murine origin. the lymphoid specificity of nip was demonstrated by showing that dna and p ... | 1979 | 93092 |
| [effect of test conditions on the results of the radial immunodiffusion reaction with viral antigens]. | | 1979 | 93161 |
| calcium-dependent increase in adenosine 3',5'-monophosphate and induction of the acrosome reaction in guinea pig spermatozoa. | experiments were designed to determine the interrelationship between cyclic amp and ca(2+) during the processes of sperm capacitation and the acrosome reaction. in minimal culture media containing pyruvate and lactate as substrates, guinea pig spermatozoa required a minimum of 1.0-1.5 hr to capacitate in the presence of 1.7 mm ca(2+) and a minimum of 0.5-1.0 hr to capacitate in the absence of added ca(2+). sperm cyclic amp concentrations were increased by as much as 30-fold within 0.5 min after ... | 1979 | 93280 |
| visualization of subsurface structures in cells and tissues by backscattered electron imaging. | a fraction of the beam electrons which interact with a specimen scatter back. the number of backscattered electrons (be's) increases with the atomic number of the elements encountered. cell and tissue structures lacking a heavy metal content yield few be's compared to structures affixed with heavy metals, either vitally or by means of staining methods applied after fixation. the be imaging mode of a scanning electron microscope (sem) provides an intensity map of the be yield from the specimen. b ... | 1979 | 93305 |
| current trends in therapy of ocular herpes simplex: experimental and clinical studies. | | 1979 | 93409 |
| the interaction of lanthanides with isolated sarcoplasmic reticulum vesicles from rabbit skeletal muscle. | the interaction of lanthanides with isolated sarcoplasmic reticulum (sr) vesicles from rabbit skeletal muscle and the effects of lanthanides on 45ca2+ uptake by the vesicles were studied. 153gd3+ was taken up by the vesicles in the absence of atp and oxalate in a time-dependent manner, reaching a maximum total accumulation of 380 nmol 153gd3+/mg protein after 20 min with 200 microm 153gd3+. this 153gd3+ accumulation was not washed out by 1 mm egta. the addition of atp induced the release of 87% ... | 1979 | 93439 |
| spectral responses of cytochrome b to inhibitors of the mitochondrial cytochrome bc1 segment in drug-resistant strains of saccharomyces cerevisiae [proceedings]. | | 1979 | 93451 |
| reverse transcriptase-associated rnase h. part iv. pyrophosphate does not inhibit rnase h activity of amv dna polymerase. | | 1979 | 93479 |
| [effects of tween stabilization on the sensitivity and specificity of mycobacterial purified protein derivatives]. | | 1979 | 93498 |
| regulation of ca2+ efflux from kidney and liver mitochondria by unsaturated fatty acids and na+ ions. | the effects of fatty acids and monovalent cations on the ca2+ efflux from isolated liver and kidney mitochondria were investigated by means of electrode techniques. it was shown that unsaturated fatty acids and saturated fatty acids of medium chain length (c12 and c14) induced a ca2+ efflux from mitochondria which was not inhibited by ruthenium red, but was specifically inhibited by na+ and li+. the ca2+-releasing activity of unsaturated fatty acids did not correlate with their uncoupling activi ... | 1979 | 93538 |
| effect of modification of reactive lysine on antitryptic and antichymotryptic activity of proteinase inhibitor from cow colostrum. | 40% of the primary structure of the cow colostrum proteinase inhibitor (cti) is homologous with the structure of the trypsin kallikrein inhibitor (tki) from bovine organs; the positions of the reactive lysine residues are also the same in both inhibitors. both cti and tki were modified by carbamoylation and the fully labeled derivatives were isolated by ion-exchange chromatography. the effect of the modification on the antitryptic and antichymotryptic activity of both inhibitors was investigated ... | 1979 | 93562 |
| chemical modification of timothy grass pollen antigen b--i. loss of antibody binding properties. | | 1979 | 93573 |
| the symptomatology with the most severe clinical course of spontaneous subarachnoid hemorrhage. | the symptomatology of 18 patients with the severest clinical course after subarachnoid hemorrhage (sah) is described and analyzed. seventeen patients died, five with an acute bulbar syndrome with cardiac arrest, and 12 with irreversible breakdown of brain function. one patient had an apallic syndrome with minimal signs of remission, who died 4 months after the first rebleeding. the cases are divided into five clinical groups on the basis of the acute brainstem symptomatology which set in instant ... | 1979 | 93630 |
| [immunotherapy of neoplasms, with special reference to the destruction of neoplastic cells]. | | 1979 | 93653 |
| the location and expression of idiotypic determinants in the immunoglobulin variable region--iii. expression of the protein 315 and 460 idiotypic determinants in mouse anti-dnp antibodies. | | 1979 | 93694 |
| substance p as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation. | | 1979 | 93706 |
| preferential replication of murine xenotropic type-c virus in human lymphosarcoma-derived cell lines. | murine xenotropic virus, designated 698/x, was recovered by implantation of human lymphosarcoma-derived cells u-698m into nude mice of giovanella's colony. the budded and extracellular particles revealed typical type-c morphology, the latter possessing reverse transcriptase (rt) activity and exhibiting a buoyant density 1.17 g/ml in sucrose gradient. in competitive radioimmunoassay using iodinated p30 of rauscher mulv, the 698x viral concentrate and cell extracts of both implanted lymphosarcoma ... | 1979 | 93707 |
| effect of transection on choline acetyltransferase, thyrotropin releasing hormone and substance p in the cat cervical cord. | the effects of a transection on the choline acetyltransferase activity, the thyrotropin releasing hormone and substance p contents in the cat cervical spinal cord have been investigated. seven days after the hemitransection at the c1 level, the grey matter of the c6-7 levels of the spinal cord were dissected for the biochemical measurements. the choline acetyltransferase activity and the thyrotropin releasing hormone content remained unchanged in any regions in the grey matter following the high ... | 1979 | 93714 |
| a horseradish peroxidase study of primary afferent projections to the medullary cuneate nucleus in the rat. | hrp was used to label first order afferent cells of the dorsal root ganglia which synapse at the cuneate nucleus. the results show that it is a population of predominantly large cells that project monosynaptically to the medullary cuneate nucleus and thus support anatomical and physiological studies showing that directly projecting axons to the dorsal column nuclei are larger, faster and conduct information from a select class of sensitive cutaneous mechanoreceptors. the finding, that approximat ... | 1979 | 93721 |
| distribution of carotid sinus nerve afferent fibers to solitary tract nuclei of the cat using transganglionic transport of horseradish peroxidase. | the distribution of carotid sinus nerve (csn) afferent fibers to the solitary tract and its various nuclei has been determined using transganglionic transport of horseradish peroxidase (hrp). the ipsilateral solitary tract was labeled and, in addition, the heaviest labeling was seen dorsomedial within the medial solitary nucleus, as well as just lateral to the tractus solitarius in the lateral solitary nucleus. bilateral labeling was present caudal to the obex in both the medial and commissural ... | 1979 | 93722 |
| has myelin basic protein received a fair trial in the treatment of multiple sclerosis? | autosensitization to some central nervous system antigen still remains one of the best hypotheses for the continuing pathogenesis of multiple sclerosis (ms). enough is now known about the cause, pathogenesis, and treatment of experimental allergic encephalomyelitis (eae) to test this hypothesis. reports of therapeutic failure of the encephalitogen myelin basic protein (bp) in the treatment of ms have their counterparts in similar therapeutic failures in eae. only highly inbred strain 13 guinea p ... | 1979 | 93873 |
| the csf [hco-3] adaptation after its experimental increase [proceedings]. | | 1979 | 93892 |
| isolation of an enriched mitochondrial fraction from bovine thyroid by zonal centrifugation in sucrose gradients [proceedings]. | | 1979 | 93921 |
| influence of antibody on activation of human complement (alternative pathway) by rabbit red cells: kinetic study [proceedings]. | | 1979 | 93922 |
| purification of cytochrome p-450 by double chromatography on substituted sepharose. effect of type i and type ii ligands [proceedings]. | | 1979 | 93930 |
| [effect of temperature on lysosomal membranes]. | | 1979 | 93936 |
| characterization of a bacteriocin produced by erwinia uredovora [proceedings]. | | 1979 | 93940 |
| differentiation of antibodies against brucella abortus and yersinia enterocolitica by enzyme-linked immunosorbent assay. | the enzyme-linked immunosorbent assay (elisa) was found to be from ten to hundred-fold more sensitive than commonly used tube agglutination text. the elisa using both direct and indirect inhibition assays revealed antigenic differences between brucella abortus and yersinia enterocolitica o-group v (serotype 9), which are undetected by commonly used serological routine tests. the results point to the possibility that the elisa assay can be used as a serological method for differentiation between ... | 1979 | 94003 |
| studies on renin activation in normal human plasma. | the phenomenon of plasma renin activattion by acid dialysis and preincubation with trypsin was studied in normal human plasma. activation of plasma renin by exposure to ph 3.3 was shown to require at least one dialysis step and could be inhibited by the presence of trasylol, indicating the involvement of a protease in acid activation. amniotic fluid exposed to ph 1.5 to destroy renin and renin substrate was also found to contain an enzyme capable of activating plasma renin. the michaelis-menten ... | 1979 | 94312 |
| comparative biochemical and serological analysis of five isolates of a single serotype of foot-and-mouth disease virus. | a comparison has been made of some of the biochemical and serological characteristics of five isolates of foot-and-mouth disease virus (fmdv), serotype a. three of the viruses have been assigned to the same subtype, a22; the other two belong to different subtypes, a5 and a24. rna competition hybridization and two-dimensional electrophoresis of the oligonucleotides produced by ribonuclease t1 showed that the three a22 viruses formed a group which could be distinguished from the a5 and a24 viruses ... | 1979 | 94348 |
| characterization of the coronary vasodilator and hemodynamic actions of monensin, a carboxylic ionophore. | the effects of monensin on coronary blood flow (cbf) and other hemodynamic parameters were studied in anesthetized dogs. a dose-response relationship was established, and it was found that the lowest doses of monensin (5-25 micrograms/kg) produced a dose-dependent increase (3-5x) in cbf with a concomitant decrease in total peripheral resistance (tpr). pretreatment with diphenhydramine, atropine, indomethacin, or propranolol resulted in no reduction in peak increase in cbf or in the duration of r ... | 1979 | 94374 |
| reversal of serotonin vasodilatation in the dog external carotid bed by sympathetic denervation. | in view of the conflicting reports of both constrictor and dilator effects of serotonin on the external carotid vascular bed of dogs, the influence of intraarterial infusions of the amine on blood flow through this territory was assessed by electromagnetic flowmeter techniques. in anesthetized intact dogs, serotonin produced dose-related increases in flow. these vasodilator responses were markedly diminished after ipsilateral vagotomy and were followed by delayed vasoconstriction, which then bec ... | 1979 | 94376 |
| influence of atropine on spontaneous or catecholamine-induced arrhythmias after experimental infarction in the dog. | the effects of atropine on ventricular tachyarrhythmias induced by ligature of the anterior descending coronary artery were studied in conscious dogs. on the first day after surgery, animals received a mixture of quinidine and phenytoin orally in order to partially correct rhythm disturbances on the second day. the same animals were used on the third and fourth days after occlusion, when spontaneous regression of arrhythmias was occurring. atropine (0.2 mg/kg i.v.) or methscopolamine (0.2 mg/kg ... | 1979 | 94403 |
| hereditary alpha 2-macroglobulin deficiency. | on screening of a normal material 1 man was found (age 37) who on repeated determinations had a low alpha 2m, namely 25 % with electroimmuno assay according to laurell. investigation of the family revealed that the mother (age 69) and one daughter (age 5) had low values too. all other coagulation and fibrinolytic components were normal. they had no signs of increased fibrinolysis and normal levels of alpha 2-antiplasmin, alpha 1-antitrypsin and antithrombin iii. liver function tests were normal. ... | 1979 | 94459 |
| dependence of macromolecular composition and morphology of streptomyces hygroscopicus on specific growth rate. | the dependence of macromolecular composition and morphology of streptomyces hygroscopicus on specific growth rate micron was investigated. the percentage of dna on dry weight (%dna) is constant, % protein is also nearly independent of micron whereas %rna rises considerably with increasing micron, regarding mycelia grown in glucose-limited and ammonium-limited continuous cultures as well as in discontinuous cultures with various carbon sources. it is probable that the overall synthesis of dna, rn ... | 1979 | 94484 |
| the role of antigen-specific t cell factors in the immune response. | | 1979 | 94504 |
| [studies on protein kinase in rat parotid glands]. | | 1978 | 94606 |
| regulation of expression of type c virion dna polymerase (reverse transcriptase) in human x mouse and human x rat hybrid cells. | human cells from 13 different individuals were fused to mouse and rat cells producing abundant type c viral particles. the results demonstrate that incorporation of active dna polymerase (reverse transcriptase) into mature type c particles is suppressed in many of the hybrid clones but not in the parental mouse cell clones. this low particle-associated dna polymerase phenotype was a heritable trait for over 100 cell generations but reversion to a high particle-associated dna polymerase phenotype ... | 1979 | 94700 |