| the actions of neuroleptic drugs and putative serotonin receptor antagonists on lsd and quipazine-induced reductions of brain 5-hiaa concentrations. | | 1977 | 22629 |
| hyperaccumulation of nickel by alyssum linnaeus (cruciferae). | herbarium specimens of all except one of the 168 recognized species of alyssum linnaeus have been analysed for their nickel content in order to identify hyperaccumulators (greater than 1000 microgram per g dry mass) of nickel. a further 31 hyperaccumulators (all in section odontarrhena) were discovered in addition to the 14 european species reported earlier. pot trials on the non-accumulator a. serpyllifolium desfontaines and the hyperaccumulator a. pintodasilvae dudley in ed. involving addition ... | 1979 | 34161 |
| the effects of dopamine, bromocriptine, lergotrile and metoclopramide on prolactin release from continuously perfused columns of isolated rat pituitary cells. | the control of secretion of prolactin was studied using continuous perfusion of a column of isolated rat pituitary cells supported by bio-gel polyacrylamide beads. prolactin secretion was inhibited repeatedly by dopamine and rapidly recovered in its absence. maximum inhibition was achieved at 5 x 10(-7) m dopamine. bromocriptine and lergotrile directly inhibited prolactin release from the pituitary cells. bromocriptine had a longterm action in inhibiting secretion. the dopamine receptor blocking ... | 1979 | 34491 |
| campylobacter jejuni post-transfusional septicaemia. | | 1979 | 91012 |
| detection of a low-molecular-weight antigen on melanoma cells by a human antiserum in leukocyte-dependent antibody assays. | biochemical characterization of serologically detected human melanoma antigens was undertaken for the development of immunodiagnostic assays in melanoma. an antiserum from a human melanoma patient, which detected melanoma antigens expressed on a large proportion of different melanoma cells, was used in leucocyte-dependent cytotoxic antibody (lda) 51cr-release assays to monitor the purification of melanoma antigens in urea/acetate extracts of lactoperoxidase 125i-labelled melanoma cell membranes. ... | 1979 | 91379 |
| dependence of macromolecular composition and morphology of streptomyces hygroscopicus on specific growth rate. | the dependence of macromolecular composition and morphology of streptomyces hygroscopicus on specific growth rate micron was investigated. the percentage of dna on dry weight (%dna) is constant, % protein is also nearly independent of micron whereas %rna rises considerably with increasing micron, regarding mycelia grown in glucose-limited and ammonium-limited continuous cultures as well as in discontinuous cultures with various carbon sources. it is probable that the overall synthesis of dna, rn ... | 1979 | 94484 |
| metabolism of histamine during anaphylactic shock in guinea-pigs [proceedings]. | | 1978 | 98974 |
| selectivity of clorgyline and pargyline as inhibitors of monoamine oxidases a and b in vivo in man. | during 4 weeks of treatment with clorgyline, a selective mao-a inhibitor, platelet monoamine oxidase (mao) activity was unchanged. during a similar 4-week crossover treatment period with pargyline, a selective mao-b inhibitor, platelet mao activity was essentially completely inhibited in the same individuals. the differential effects of the two drugs on platelet mao, which consists exclusively of the mao-b form, suggests that the in vitro selectivity of clorgyline, and possibly of pargyline, on ... | 1979 | 111275 |
| radiosensitization of mouse l cells by an electron affinic radiosensitizer, ro-07-0582 under an extremely hypoxic condition. | | 1979 | 522019 |
| polypeptides that inhibit human breast cancer cell division. | medium sized (10-15 amino acids) polypeptides isolated from normal human urine inhibit the growth of five established cell lines of human mammary cancer. cytostatic and cytotoxic effects are dose dependent and reversible at lower doses. evidence suggests a block to cell division in s phase. | 1979 | 552902 |
| altered epitope expression of human interstitial fluid apolipoprotein a-i reduces its ability to activate lecithin cholesterol acyl transferase. | in human peripheral interstitial fluid, esterification of cholesterol by lecithin cholesterol acyltransferase (lcat) was found to occur at a rate of only 10% of that in plasma (5.6 +/- 1.8 compared with 55.6 +/- 7.8 nmol/ml per h). measurement of cholesterol esterification in the presence of excess reconstituted apoa-i hdl (ra-i hdl) revealed an lcat activity in interstitial fluid of 24% of that in plasma, indicating that the low rate of esterification could not be caused by limiting mass of lca ... | 1992 | 1281832 |
| a rapid and sensitive high performance liquid chromatographic analysis of clofazimine in plasma. | the high performance liquid chromatographic (hplc) method of gidoh, et al. has been modified substantially to provide a simple, rapid, and relatively inexpensive procedure for measuring clofazimine in plasma. the modification involves the use of commonly available laboratory reagents instead of custom-made ones. it also employs a solid phase system for efficient extraction instead of the conventional, less efficient and more labor intensive, liquid-liquid extraction. the inclusion of an internal ... | 1992 | 1299710 |
| association of nerve fibres with myoid cells in the chick thymus. | the presence of nerve fibres in the medulla of the chick thymus has been investigated ultrastructurally. unmyelinated nerve fibres were found not only in the perivascular space but also among the myoid cells. the nerve fibres were situated in close proximity to the myoid cells. the unmyelinated axons, containing predominantly clear vesicles and some dense-core vesicles, were found in recesses of the plasmalemma of the schwann cell. contacts between nerve fibres and fibroblasts were also observed ... | 1992 | 1304590 |
| introduction and maintenance of prokaryotic dna in ustilago violacea. | a strain of the basidiomycete, ustilago violacea, was transformed with a prokaryotic plasmid, pmp4-1, which confers resistance to neomycin. u. violacea transformants were selected at a frequency of 5 per microgram pmp4-1 dna. such transformants were at least 8-fold more resistant to neomycin than was the untransformed recipient u. violacea. enzyme activity associated with the neomycin resistance gene was also found in the transformants. southern dna-dna hybridization detected pmp4-1-derived sequ ... | 1990 | 1366759 |
| synthesis and evaluation of a new series of mechanism-based aromatase inhibitors. | a series of new 4-(alkylthio)-substituted androstenedione analogues was designed as potential suicide inhibitors of aromatase on the basis of mechanistic considerations on the mode of action of the enzyme. their synthesis and biological evaluation are described. among the most interesting are the 4-[(difluoromethyl)thio]-, 4-[(fluoromethyl)thio]-, and 4-[(chloromethyl)thio]androstenediones 12, 13, and 14 with respective ic50's of 2.7, 0.8, and 0.94 microm. compound 12 was a reversible inhibitor ... | 1992 | 1578485 |
| functional and electrophysiological effects of oxidant stress on isolated ventricular muscle: a role for oscillatory calcium release from sarcoplasmic reticulum in arrhythmogenesis? | the aim was to investigate the cellular basis of oxidant stress induced arrhythmias by studying the influence of oxidant stress on the contractile and electrophysiological function of isolated cardiac muscle. | 1991 | 1913755 |
| functional mapping of the human visual cortex by magnetic resonance imaging. | knowledge of regional cerebral hemodynamics has widespread application for both physiological research and clinical assessment because of the well-established interrelation between physiological function, energy metabolism, and localized blood supply. a magnetic resonance technique was developed for quantitative imaging of cerebral hemodynamics, allowing for measurement of regional cerebral blood volume during resting and activated cognitive states. this technique was used to generate the first ... | 1991 | 1948051 |
| [effect of some nonintercalative antitumor drugs on the activity of calf thymus dna topoisomerase i]. | dna topoisomerase i has been isolated from the nuclei of calf thymus by peg fractionation and chromatography on p11 and on bio-rex 70. either a positive or negative supercoiled pbr322 dna can be relaxed by the enzyme. the activity of topo i is mg2+ and atp independent. some of nonintercalative antitumor drugs such as camptothecine, hydroxycamptothecine, cyclophosphamide, methotrexate and mitomycin c were found to inhibit the activity of topo i. the results suggest that dna topo i can be used to ... | 1990 | 1965481 |
| allergens and asthma. | in many medical textbooks allergens are still listed as one of the "trigger factors" for asthma, with the implication that irritability of the lungs is an underlying physiologic property of the lungs. over the last few years it has become clear that asthma is an inflammatory disease. in addition, it has been shown that changes in allergen exposure can lead to changes in bronchial reactivity. these results lead to the view that continued allergen exposure of the lungs of allergic individuals with ... | 1990 | 2292373 |
| reactivity of ige antibodies with crustacea and oyster allergens: evidence for common antigenic structures. | ige-antibody reactivity to oysters and crustacea of sera from six oyster-sensitive, seven oyster- and crustacea-sensitive, and 12 crustacea-sensitive subjects was investigated. all six subjects with a history of only oyster sensitivity had minimal rast reactivity (ratios 2 to 5) to extracts of raw or boiled oysters. three of the seven oyster- and crustacea-sensitive subjects and six of the 12 crustacea-sensitive, oyster-tolerant or unexposed subjects had elevated rast ratios to oyster (14 to 41) ... | 1987 | 2440933 |
| some physico-chemical properties of the rigid form of the sendai virus nucleocapsid. | the effect of some dissociation agents (sds, beta-mercaptoethanol, urea, edta) on the rigid form of the sendai virus nucleocapsid was studied. polyacrylamide gel electrophoresis in the presence of lytic mixture (1% sds, 2% beta-mercaptoethanol, 5 m urea, for 2 min at 100 degrees c) revealed two types of polypeptide subunits (mol. wts. 46,000 and 14,000), as well as the dissociation in the presence of 0.1% sds only. the edta treatment leads to a disorganization of the protein part (10(-2) m) or o ... | 1989 | 2556836 |
| the effects of l-vesamicol on transmitter release from rat motor nerve terminals at high frequencies of nerve stimulation. | | 1989 | 2575420 |
| adrenergic input from medullary ventrolateral c1 cells to the nucleus raphe pallidus of the cat, as demonstrated by a double immunostaining technique. | by means of a double immunostaining technique using unconjugated cholera-toxin b subunit (ctb) as a retrograde tracer combined with phenylethanolamine-n-methyltransferase (pnmt) immunohistochemistry, we demonstrated that the nucleus raphe pallidus of the cat receives a major projection from the ventrolateral part of the rostral medulla corresponding to the nucleus paragigantocellularis lateralis and the ventrolateral medullary reticular formation just caudal to it. we further showed that nearly ... | 1989 | 2586829 |
| whole blood aggregation, thromboxane release and the lyso derivative of platelet activating factor in myocardial infarction and unstable angina. | to investigate the pathophysiology of intracoronary thrombus formation we measured whole blood aggregation in response to adp, platelet activating factor (paf) and collagen, along with thromboxane b2 (txb2) production during collagen induced aggregation, plasma txb2 and plasma levels of lyso-paf, in 38 subjects with and without ischaemic heart disease (12 with acute myocardial infarction, 9 with prolonged ischaemic chest pain without infarction and 17 normals). lyso-paf was measured, after in vi ... | 1989 | 2590911 |
| [the autodehelminthizing capacity of the soil]. | a description of the methodology used for the study of soil deshelminthizing processes is presented, as well as some of the results already obtained. this method has already been tested on the soil of different countries, including mexico, and it is still in an experimental stage; notwithstanding, the results obtained are encouraging. further research is needed for its successful application as a tool on the control of human soilborne diseases. | 1989 | 2626721 |
| hypertonic saline resuscitation is prevented by intracerebroventricular saralasin but not by captopril. | hypertonic saline resuscitation (hr, 7.5% nacl, 4 ml/kg) effectively reverts severe hemorrhage, but a central neural component is probably involved in the survival response. this experiment examines the role of central angiotensinergic pathways in hemorrhage-hypertonic resuscitation interaction. severely bled (43 +/- 2 ml/kg) pentobarbital-anesthetized dogs with chronically implanted cerebral ventricular cannulae were resuscitated with 4 ml/kg 7.5% nacl, iv 10 min after intracerebroventricular i ... | 1989 | 2676039 |
| a light microscopic and autoradiographic study of non-irradiated and irradiated ocular wounds. | focal gamma irradiation was used to limit the intraocular extension of scar tissue which typically occurs after posterior perforating injury to the eye. standard posterior perforating injuries were created in the right eye of forty-eight rabbits, half of which had the site of perforation focally irradiated using a cobalt 60 ophthalmic plaque. non-irradiated wounds healed with profuse formation of highly cellular and vascularised granulation tissue which invaded the vitreous to form contractile v ... | 1989 | 2721224 |
| [infection caused by paracoccidioides brasiliensis in people living in cocle and veraguas, republic of panamá]. | intradermal application of yeast phase paracoccidioidin antigen obtained by sonication and lysis from the fungus to 111 residents of veraguas province (68 men and 43 women) and 130 cocle province residents (57 men and 73 women) elicited a positive reaction in 9.01% (1/111) and 26.15% (34/30) of the veraguas and cocle residents respectively. positive reactions ranged between papules of 5 and 27 mm in diameter, the majority being between 11 and 20 mm. infection was more frequent in men (1:1.47 for ... | 1989 | 2762594 |
| atp formation from deoxyadenosine in human erythrocytes: evidence for a hitherto unidentified route involving adenine and s-adenosylhomocysteine hydrolase. | a novel route of atp formation has been identified using erythrocytes from patients deficient in four different enzymes associated with atp formation. it entails prior adenine production from deoxyadenosine (or adenosine) in a reaction involving s-adenosylhomocysteine hydrolase. the postulated route has been demonstrated in human erythrocytes which, unlike other human cells, cannot form atp from imp. it is based on studies by others using purified s-adenosylhomocysteine hydrolase preparations in ... | 1989 | 2785825 |
| in vitro activity of lomefloxacin (sc-47111) against enterobacteriaceae, enterococci and staphylococci. | the activity of lomefloxacin, a new difluorinated quinolone, was tested against 190 enterobacteriaceae strains (belonging to 23 different species), 70 enterococci and 70 staphylococci. as regards enterobacteriaceae, the activity of lomefloxacin was the same as that of norfloxacin in 9 out of the 23 species tested, and only slightly lower in further 8 species. minimum inhibitory concentrations (mic) values for 90% of strains were 0.5 microgram/ml in 2 species, 0.25 microgram/ml in 6, 0.125 microg ... | 1989 | 2786558 |
| effect of enoxacin on theophylline neurotoxicity. | concomitant use of the bronchodilator theophylline and the antibacterial agent enoxacin has been associated with significant neurologic and other adverse effects. enoxacin and certain other quinolones are known to inhibit the biotransformation of theophylline, thereby increasing the plasma concentrations of the bronchodilator. it was considered possible that this may not be the only interaction because theophylline as well as enoxacin are known to have neurotoxic potential. to explore the possib ... | 1989 | 2786601 |
| [aids epidemiology and hiv prevalence among beneficiaries of the regional hospital of mexican oils, salamanca, gto]. | we studied the hiv prevalence among oil workers and their families in a middle size population. results were analyzed and compared with previous reports from usa, brazil, and other cities in méxico. there were no differences in prevalence between workers and their families (3.4 vs. 3.7 per 1,000). the only way of transmission in adults was sexual, while in two children with aids, the mechanism was perinatal. seven of the 16 patients hiv positive detected were found screening contacts. we detecte ... | 1989 | 2814210 |
| detection of hemolytic listeria monocytogenes by using dna colony hybridization. | a fragment of about 500 base pairs of the beta-hemolysin gene from listeria monocytogenes was used to screen different bacterial strains by dna colony hybridization. the cells in the colonies were lysed by microwaves in the presence of sodium hydroxide. of 52 different strains of listeria species screened, only the dna from beta-hemolytic (camp-positive) strains of l. monocytogenes hybridized with this probe. | 1987 | 2823710 |
| ferric uptake regulation protein acts as a repressor, employing iron (ii) as a cofactor to bind the operator of an iron transport operon in escherichia coli. | the fur (ferric uptake regulation) protein is a negative regulator of the aerobactin operon and of several other siderophore-mediated, high-affinity iron transport systems in escherichia coli. the purified fur protein and a plasmid containing a lacz fusion to the aerobactin operon were used in conjunction with an in vitro coupled transcription/translation system to demonstrate that the fur protein requires fe(ii) or certain other divalent metals as a cofactor to negatively regulate expression of ... | 1987 | 2823881 |
| [changes in camp levels in bacterial cells during the cell cycle]. | the changes in the camp level during the cell cycle in the synchronous cultures of e. coli were demonstrated. two maxima in the camp level were revealed during each generation period. in the cell cycle of 40-45 min duration the first increase was observed approximately in the middle of the cycle, i. e., it was coincident with the initiation of dna synthesis. under these conditions the camp level increased 8-10 times (from 0.5 to 5.0 pmole per ml of cell suspension). the second, less pronounced i ... | 1987 | 2823913 |
| degradation of aflatoxin by aspergillus flavus. | aflatoxin degradative activity was demonstrated in 6- to 12-d-old intact mycelium and cell-free extracts of aspergillus flavus. the addition of cycloheximide, skf 525-a or metyrapone to cultures of a. flavus prevented subsequent degradation of the aflatoxins, while in cell-free extracts degradation was inhibited by skf 525-a, metyrapone and cytochrome c but not by kcn. in cell-free extracts, aflatoxin degradation was enhanced by nadph and naio4. the results suggest the involvement of cytochrome ... | 1987 | 2832516 |
| distribution and molecular forms of peptides containing somatostatin immunodeterminants in extracts from the entire gastrointestinal tract of man and pig. | specimens from human porcine mucosal and muscular tissue from the entire gastrointestinal tract were extracted in acid ethanol, subjected to chromatography and analysed for somatostatin-like immunoreactivity by region-specific radioimmunoassays. the concentration of somatostatin-like immunoreactivity from man and pig ranged from 1.13 +/- 0.37 to 101.15 +/- 33.93 pmol/g wet weight, and from 7.64 to 159.48 +/- 23.79 pmol/g wet weight, respectively. in both species the highest concentrations were f ... | 1985 | 2857096 |
| tracazolate metabolites in rat tissue. | tracazolate (4-n-butylamino-1-ethyl-6-methyl-1h-pyrazolo[3,4-b] pyridine-5-carboxylic acid ethyl ester) undergoes extensive biotransformation to lipophilic metabolites following oral dosage to male rats. twenty-one metabolites were identified in a plasma hexane extract by mass spectrometry. coadministration of unlabeled tracazolate with its stable carbon-13 isotope expedited the isolation and identification of 11 biotransformation products. the various metabolites resulted from either hydrolysis ... | 1985 | 2859159 |
| tracazolate metabolites in rat tissue. | tracazolate (4-n-butylamino-1-ethyl-6-methyl-1h-pyrazolo[3,4-b] pyridine-5-carboxylic acid ethyl ester) undergoes extensive biotransformation to lipophilic metabolites following oral dosage to male rats. twenty-one metabolites were identified in a plasma hexane extract by mass spectrometry. coadministration of unlabeled tracazolate with its stable carbon-13 isotope expedited the isolation and identification of 11 biotransformation products. the various metabolites resulted from either hydrolysis ... | 1985 | 2859159 |
| protective activity of vi capsular polysaccharide vaccine against typhoid fever. | the protective efficacy against typhoid fever of a single intramuscular injection of 25 micrograms of the vi capsular polysaccharide (cps) was assessed in a randomised double-blind controlled trial. vaccination of 11,384 children was followed by 21 months' surveillance. 47 blood-culture-proven cases of typhoid occurred in children who received meningococcal a + c cps vaccine and 19 cases in those vaccinated with vi cps. protective efficacy was 60% calculated from the day of vaccination and 64% f ... | 1987 | 2890805 |
| cortical amino acid neurotransmitter release is altered by cck perfused in frontal region of unrestrained aged rats. | the purpose of this study was to investigate in the aged animal the functional interaction between cholecystokinin (cck) and amino acid neurotransmitter activity in the frontal cortex, a structure of importance in age-related disabilities. guide cannula for repeated push-pull perfusion were implanted bilaterally in the superficial frontal cortex of male sprague-dawley rats. two groups of animals were selected on the basis of their age at the time of stereotaxic surgery: 90 days and two years. fo ... | 1988 | 2901740 |
| balloon-dilatable arterial banding prosthesis: experimental study. | two arterial banding prostheses were developed that could be dilated by an intraluminal balloon dilator. one prosthesis consisted of radiopaque umbilical tape with a pleat secured by four 8-0 silk sutures thinly coated with silicone type a medical adhesive. this design was used to band the main pulmonary artery in five dogs, the subclavian artery in five, and the aorta in one. the second prosthesis, a stainless steel fatigued helix encased in a siliconized shield, was used to band the main pulmo ... | 1987 | 2954182 |
| human milk-derived lactoferrin inhibits mitogen and alloantigen induced human lymphocyte proliferation. | purified lactoferrin (lf), isolated from human milk, was tested for its effect on human t-lymphocyte proliferative responses to phytohemagglutinin (pha) and to alloantigens in mixed lymphocyte culture. lf inhibited proliferation in both assays in a dose-dependent manner. the suppressive effect was not due to lf mediated cytotoxicity since washing cells that had been pre-incubated with lf restored their proliferative activity. lf was most effective in suppressing the pha response when added withi ... | 1987 | 2963123 |
| the release mechanism for atrial natriuretic factor during blood volume expansion and tachycardia in dogs. | atrial natriuretic factor (anf) is released during blood volume expansion and tachycardia, but only blood volume expansion causes atrial distension, which presumably promotes anf release. our study was undertaken to search for a common release mechanism. in five anaesthetized, closed-chest dogs, plasma immunoreactive (ir) anf was measured at three levels of blood volume, which were obtained by infusing a ringer's solution. at each level of blood volume, plasma ir-anf was measured at three pacing ... | 1988 | 2976238 |
| testosterone is not required for the enhancement of sexual motivation by yohimbine. | yohimbine hcl (2 mg/kg, 20 min prior to testing) administration was followed by significant decreases in the latencies to initial mount, intromission and ejaculation in castrated male rats bearing 2 mm testosterone-containing silastic capsules 51 days after castration. further, yohimbine stimulated copulatory activity in castrated, nonhormone-treated male rats up to 91 days after castration. finally, yohimbine induced mounting in intact, nonreceptive female rats. these observations indicate that ... | 1985 | 2999845 |
| diabetic embryopathy and fuel-mediated organ teratogenesis: lessons from animal models. | the growing recognition that faulty maternal metabolism during early organogenesis may be implicated in the increased incidence of birth defects in pregnancies complicated by diabetes has prompted worldwide efforts to institute improved preconceptional metabolic regulation. however, the failure to identify the periods of greatest risk for diabetic embryopathy, the mediating teratogen(s), and the underlying mechanisms have complicated attempts to establish precise therapeutic guidelines and targe ... | 1988 | 3053387 |
| [calmodulin and neuron: immunohistochemical studies]. | calmodulin is present in higher concentrations in brain tissues. the content rapidly increased during the 2nd postnatal week in rat brain. although the protein is ubiquitous in all eukaryotic cells, immunohistochemical studies have revealed that calmodulin is mainly localized in the neurons, exhibiting a similar distribution to that of gamma-type neuron-specific enolase. in the mouse retina, both calmodulin and gamma-enolase were found to be localized in optic nerves, ganglion cells, and inner a ... | 1988 | 3074601 |
| ontogenetic development of pancreatic thyrotropin-releasing hormone in human foetuses and in infants. | the ontogeny of thyrotropin-releasing hormone (trh) in pancreata of human foetuses from 15-36 weeks of gestation and of infants has been studied. trh was detectable in the pancreas of a 15 week old foetus; a progressive increase of pancreatic trh content was observed until the 34th week of gestation, whereas a progressive decrease was found in the late period of pregnancy and in 1 year old infants. in contrast, the pancreatic insulin content showed a progressive increase during the entire pregna ... | 1986 | 3092527 |
| medullasin stimulates the maturation of natural killer cells from human large granular lymphocytes. | medullasin, a serine protease in bone marrow cells, has been shown to enhance human natural killer cell activity by acting directly on large granular lymphocytes. in the present report the mechanism of activation of natural killer cells by medullasin was studied by employing a single cell assay method in agar. medullasin enhanced the target-binding capacity of lymphocytes, but the percentage of target-binding cells with dead target remained essentially unchanged. the maximum recycling capacity o ... | 1987 | 3102441 |
| arachidonic acid, prostaglandin e2 and f2 alpha inhibit leucine degradation in chick skeletal muscle. | arachidonic acid (5 microm), prostaglandin e2 (0.28 microm) and f2 alpha (14 microm) inhibited (p less than 0.01) the rates of net leucine transamination, leucine oxidative decarboxylation and total co2 production from leucine in extensor digitorum communis muscles from fed ten-day-old chicks. indomethacin (50 microm) markedly inhibited (p less than 0.01) the rate of pge2 production in the presence of 5 microm arachidonic acid and prevented the inhibition of leucine degradation by arachidonic ac ... | 1988 | 3130060 |
| haemolytic uraemic syndrome associated with faecal cytotoxin and verotoxin neutralizing antibodies. | forty-nine patients with a diagnosis of idiopathic haemolytic uraemic syndrome (hus) were investigated to determine evidence of infection by verotoxin-producing escherichia coli (vtec). free faecal cytotoxin active on vero cells (vt) was detected in 15 out of 49 patients (31%). seroconversion or high titres of vt-neutralizing antibodies were detected in 11 out of 18 patients (61%). the results of the present study suggest an association between hus and infection by vtec. | 1988 | 3153027 |
| excision of cutaneous tumors in the horse using histologic guidance. | a highly successful surgical technique for removing cutaneous tumors in humans was used in seven horses with cutaneous squamous cell carcinoma (n = 3) or sarcoid (n = 4). in humans, the complete underside of the tumor is evaluated histologically by processing horizontal sections from the tumor base, and orientation between the wound surface and the undersurface of the excised tumor is maintained by mapping both surfaces. the technique ensures that small foci of residual tumor can be located accu ... | 1988 | 3227634 |
| growth of pure cultures of retinal pigment epithelial cells using chorioretinal biopsies from the pig. | | 1988 | 3289957 |
| a simple method to eliminate the antigenicity of surface class i mhc molecules from the membrane of viable cells by acid treatment at ph 3. | we describe here a simple, reproducible method which specifically eliminates the antigenicity of surface class i major histocompatibility complex (mhc) molecules by acid treatment at ph 3 from the membrane of viable cells. when fresh mononuclear cells (mnc) or established cultured cell lines were treated at 4 degrees c for 2 min with citric acid buffer at ph 3 containing 1% bovine serum albumin, the antigenicity of class i mhc molecules, but not those of class ii mhc and the other non-mhc antige ... | 1987 | 3298442 |
| amikacin alone and in combination with trimethoprim-sulfamethoxazole in the treatment of actinomycotic mycetoma. | we report the excellent therapeutic response obtained with amikacin alone and in combination with trimethoprim-sulfamethoxazole in the treatment of 15 patients with actinomycotic mycetoma who had a poor response to the traditional pharmacologic agents and/or in whom important organs such as lungs, spinal cord, and bone were involved. we evaluated the results by clinical, radiologic, and laboratory tests. no important side effects were detected during or after the therapy. | 1987 | 3308980 |
| transcriptional activation of the rat liver s14 gene during postnatal development. | the mrna coding for the rat liver s14 protein (mr 17,000, pi 4.9) shows profound increases during postnatal development. in an effort to define the molecular basis for the postnatal rise in mrnas14 we examined the chromatin organization of the s14 gene, its dna methylation state, the hepatic expression of mrnas14, and the in vitro s14 "run-on" activity prior to and after weaning at 21 days postpartum. in animals less than or equal to 15 days of age, the hepatic s14 gene is transcriptionally inac ... | 1988 | 3366778 |
| lingual epithelium of spontaneously hypertensive rats has decreased short-circuit current in response to nacl. | alterations in ion transport associated with hypertension have been found in a variety of organs. we used a modified ussing chamber to compare the nacl dependence of the short-circuit current across the dorsal lingual epithelium in vitro from spontaneously hypertensive rats (shr) with that from wistar-kyoto rats (wky). the short-circuit current in response to mucosal nacl was less in shr than in wky at hyperosmotic concentrations (above 0.15 m and up to 2.0 m). since ion transport in the lingual ... | 1988 | 3384467 |
| evidence for nh4+ switch-off regulation of nitrogenase activity by bacteria in salt marsh sediments and roots of the grass spartina alterniflora. | the regulatory effect of nh4+ on nitrogen fixation in a spartina alterniflora salt marsh was examined. acetylene reduction activity (ara) measured in situ was only partially inhibited by nh4+ in both the light and dark after 2 h. in vitro analysis of bulk sediment divided into sediment particles, live and dead roots, and rhizomes showed that microbes associated with sediment and dead roots have a great potential for anaerobic c2h2 reduction, but only if amended with a carbon source such as manno ... | 1986 | 3456738 |
| the effects of an anti-i-ab antibody on murine host resistance to listeria monocytogenes. | infection with listeria monocytogenes stimulates t cell proliferation and t cell-derived lymphokine production. the release of lymphokines, in turn, "activates" macrophages, enhancing their bactericidal capacity. because prior studies suggest that i-a+ accessory cells play a critical role in this pathway, we assessed the effects of an anti-i-a antibody on the murine host resistance to listerial infection. to this end, we infused listeria into control c57bl/6 mice (i-ab haplotype) and mice of the ... | 1987 | 3494082 |
| in vitro effect of molybdenum on fluoride uptake and remineralization in artificial subsurface lesions of bovine enamel. | | 1986 | 3504970 |
| gonadotropin-releasing hormone neurosecretion in the human hypothalamus: in vitro regulation by dopamine. | an in vitro perifusion system was used to investigate gnrh release from adult human hypothalami in response to dopamine (da) and the da receptor antagonist haloperidol (hal). administration of a 1-microm pulse of da consistently elicited a mean +/- se 218 +/- 59% increase (p less than 0.05; n = 5) in gnrh release, whereas 1 microm hal had no effect. administration of 1 microm da during three perifusions in which 1 microm hal was added to the medium failed to alter basal gnrh release. in contrast ... | 1986 | 3511082 |
| [hyperbaric oxygenation in the intensive treatment of otorhinolaryngological patients]. | | 1986 | 3518184 |
| adult respiratory distress syndrome. a live e coli septic primate model. | | 1987 | 3548404 |
| determination of ivermectin in human plasma and milk by high-performance liquid chromatography with fluorescence detection. | | 1987 | 3597637 |
| maternal suprachiasmatic nuclei are necessary for maternal coordination of the developing circadian system. | during late fetal and early neonatal life, the maternal circadian system coordinates the timing of a circadian clock in the hypothalamic suprachiasmatic nuclei (scn) to the prevailing light-dark cycle. the role of the maternal scn in the process of maternal coordination was investigated in rats. complete lesions of the maternal scn on day 7 of gestation disrupted rhythms of scn glucose utilization in fetuses and pineal n-acetyltransferase activity in 10-d-old pups. this disruption was probably d ... | 1986 | 3746430 |
| relationship between metabolic recovery and the eeg prolonged ischemia of cat brain. | in normothermic cats, cerebral blood flow was arrested for 1 hour followed by blood recirculation for 5-6 hours. functional recovery was evaluated by qualitative and quantitative eeg analysis, and metabolic recovery by measuring metabolite and electrolyte levels in tissue samples taken from the cerebral cortex. in 5 out of 12 animals eeg activity did not recover after ischemia (group i); in 3 animals, intermittent eeg activity (group ii) and in 4 animals continuous eeg activity returned during t ... | 1986 | 3810716 |
| effect of proteus vulgaris lipopolysaccharide on resistance of mice inoculated with tumor cells sensitized to ehrlich carcinoma transplantation. | | 1973 | 4124878 |
| [comparative histological, histochemical and electron microscopic studies of the lacrimal glands. v. cattle]. | | 1968 | 4301808 |
| histocompatibility antigens on mouse spermatozoa. | | 1969 | 4390514 |
| leucocyte values in 1-6-day-old calves of bos indicus crossbred and bos taurus in a tropical environment. | | 1974 | 4414474 |
| effect of swimming and treadmill exercise on plasma enzyme levels in rats. | | 1974 | 4438321 |
| the action of some anticonvulsant drugs on cobalt-induced epilepsy and on the bemegride threshold in alert cats. | | 1972 | 4626570 |
| calcification processes in atherosclerosis. | | 1974 | 4836421 |
| physiological studies on clostridium botulinum, type f. progress report, december 1, 1966--november 30, 1967. oro-3347-4. | | 1967 | 4890186 |
| physiological studies on clostridium botulinum, type f. progress report, december 1, 1966--november 30, 1967. oro-3347-4. | | 1967 | 4890186 |
| the oxidation of acetoin to co 2 in intact animals and in liver mince preparation. | | 1972 | 5029485 |
| [primary transport of acute patients. optimal use of rescue resources exemplified by the canton of graubünden]. | | 2011 | 3927607 |
| bites and stings. part 2. bees and vespids. | | 2008 | 2519523 |
| longitudinal and cross-sectional assessments of age changes in physical strength as related to sex, social class, and mental ability. | | 2011 | 4833758 |
| serum-bile-acids in the stagnant-loop syndrome. | | 2014 | 4178587 |
| [biochemical effects of continuous and discontinuous muscular work (interval work)]. | | 2016 | 4720306 |
| [biochemical effects of continuous and discontinuous muscular work (interval work)]. | | 2016 | 4720306 |
| [adjuvant and palliative treatments for colo-rectal cancer]. | | 2000 | 94441 |
| substance p-like immunoreactivity, choline acetyltransferase activity and cholinergic muscarinic receptors in alzheimer's disease and multi-infarct dementia. | substance p-like immunoreactivity, choline acetyltransferase (chat) activity and muscarinic cholinergic receptors were measured in brains from 9 individuals with senile dementia of the alzheimer type (ad), 4 individuals with multi-infarct dementia (mid), 6 individuals with mixed type of dementia (ad/mid) and 9 controls. the chat activity was markedly reduced (50-60%) in the hippocampus of all demented brains. the number of muscarinic cholinergic receptors was reduced only in the mid and ad/mid b ... | 2006 | 1698512 |
| ovarian stimulation for disordered ovulatory cycles. | | 2010 | 3109361 |
| origin of immune diversity: genetic variation and selection. | | 2014 | 3927822 |
| [experimental study of radioimmunoassay of total serum thyroxine. (1)]. | | 2015 | 4475877 |
| proceedings: the effects of indomethacin and theophylline on the response of frog skin to prostaglandin e1. | | 2015 | 4544801 |
| rapid and sensitive high-performance liquid chromatographic assay for metformin in plasma and urine using ion-pair extraction techniques. | | 2013 | 3734008 |
| [osseointegrated implants. core-vent and screw-vent]. | 51 variously edentolous patients have been treated by placing 143 core-vent and screw-vent osteointegrated implants. the follow-up ranges from 8 to 20 months. just one implant was removed. the authors explain their surgical method and their considerations about the two different kinds of implants. some clinical cases are reported. | 2009 | 2700964 |
| single unit response of suprachiasmatic neurons to arginine vasopressin (avp) is mediated by a v1-like receptor in the hamster. | a large population of local circuit neurons within the suprachiasmatic nucleus (scn) exhibit immunopositive staining for arginine-vasopressin (avp). avp has been reported to be released from scn neurons in a circadian pattern that peaks during the subjective day. using an in vitro hypothalamic slice preparation, the present study investigated how scn neurons respond to avp over the circadian cycle and whether the response to avp is mediated by v1- or v2-like avp receptors. exposure of the slice ... | 2009 | 2702494 |
| nephrotoxic drugs. | the nephrotoxic effects of cyclosporine, aminoglycoside antibiotics, cisplatin, amphotericin b, beta-lactam antibiotics and indomethacin are reviewed. these drugs were chosen because they are among the most frequent causes of renal injury in children. in addition, their nephrotoxicity is caused by different mechanisms. several generalizations can be made, however. first, agents which cause tubular damage tend to be synergistic in their toxic effects. this synergism is seen when several nephrotox ... | 2011 | 3153061 |
| variables in the laboratory diagnosis of fabry's disease by measurement of methylumbelliferyl-alpha-galactosidase activity. | | 2013 | 4205035 |
| [importance of studying the sputum of pneumonia and bronchitis patients]. | | 2014 | 4002152 |
| [electrocardiographic control over the state of hypothyroid patients in the process of lyothyronine-2-hydrochloride treatment]. | | 2015 | 4453560 |
| guidelines for clinical intracardiac electrophysiologic studies. a report of the american college of cardiology/american heart association task force on assessment of diagnostic and therapeutic cardiovascular procedures. | | 2009 | 2688977 |
| chondrodysplasia punctata: case report with dental findings. | | 2010 | 2942843 |
| atypical presentation of multiple pulmonary emboli in a young air traveller. | | 2014 | 4078801 |
| [nutrition in the etiology of breast cancer. results of a survey in austria]. | | 2010 | 2934651 |
| humanism and technology. | | 2011 | 3191746 |