| antimicrobial susceptibility of vibrio cholerae from zaire and rwanda. | | 1979 | 90940 |
| characterization of various horse thyroid forms of cyclic-nucleotide phosphodiesterase [proceedings]. | | 1979 | 92956 |
| a presumed intron of the mitochondrial mosaic gene controlling cytochrome b in saccharomyces cerevisiae contains a diuron-resistant genetic locus [proceedings]. | | 1979 | 93452 |
| the symptomatology with the most severe clinical course of spontaneous subarachnoid hemorrhage. | the symptomatology of 18 patients with the severest clinical course after subarachnoid hemorrhage (sah) is described and analyzed. seventeen patients died, five with an acute bulbar syndrome with cardiac arrest, and 12 with irreversible breakdown of brain function. one patient had an apallic syndrome with minimal signs of remission, who died 4 months after the first rebleeding. the cases are divided into five clinical groups on the basis of the acute brainstem symptomatology which set in instant ... | 1979 | 93630 |
| [the effects of bleomycin on chemically induced squamous cell carcinoma in oral membrane of rats (author's transl)]. | | 1978 | 95058 |
| production and chemical studies of protease from bacillus subtilis (sh-6) egyptian strain. | bacillus subtilis (sh-6) egyptian strain, isolated from hides, gave the highest protease activity. luxurious growth and protease production were obtained by the use of a medium containing 8% of potato starch, 0,1 m of ammonium phosphate as carbon and nitrogen sources. results indicate that borate buffer exerted a deleterious effect on the protease production. comparing citrate and phosphate buffers, it was found that citrate gave lower protease activity than phosphate. there is a positive respon ... | 1978 | 98932 |
| congeners of dom: effect of distribution of the evaluation of pharmacologic data. | | 1978 | 101880 |
| jacob h. vastine, ii, 1897--1976. | | 1979 | 106678 |
| linear arrays of intramembrane particles on microvilli in primate large intestine. | distinctive linear arrays of intramembrane particles were present in microvillar membranes of approximately 5% of surface columnar cells observed in freeze-fracture replicas of monkey colon and human rectum. on these cells, longitudinally-oriented rows of p face particles and corresponding e face grooves appeared on all exposed microvilli. the constituent particles varied from round (8-9 nm in diameter) to rod-shaped (18 nm long). microvilli of the great majority of columnar cells displayed rand ... | 1979 | 106744 |
| the subicular cortex of the cat: an anatomical and electrophysiological study. | | 1979 | 107038 |
| glycogen synthase kinase-2 from rabbit skeletal muscle is activated by the calcium-dependent regulator protein. | | 1979 | 107045 |
| influence of cholinergic drugs on the lateral geniculate phasic waves. | the lateral geniculate phasic wave (gl wave, glw) was studied at awaking, during the rem period of sleep (remp) and after administration of reserpine (rsp) and parachlorophenylalanine (pcpa). the glws were classified by the time relation to the eye movements (ems) into three groups of the gl-preceding glw (glws precede ems or concur with ems), the em-preceding glw (ems precede glws) and the em-discording glw (glws not associated with ems). changes in occurrence of thus classified glws and in the ... | 1976 | 134943 |
| 5-nitro-2'-deoxyuridine 5'-monophosphate is a potent irreversible inhibitor of lactobacillus caesi thymidylate synthetase. | | 1978 | 103545 |
| comparison of antigens of pneumonia-associated mycoplasma species by gel diffusion. | comparison of fluorocarbon-extracted antigens of six mycoplasma species by double immunodiffusion and counterimmunodiffusion techniques revealed a close reciprocal relationship among mycoplasma dispar, m. ovipneumoniae, and m. hyopneumoniae. a lesser degree of cross-reaction was also demonstrated between these three species and m. hyorhinis and m. bovoculi. the interrelationships were more clearly demonstrated by double immunodiffusion than by counterimmunodiffusion. | 1978 | 101469 |
| biological variation of immunoglobulin concentrations in normal human tears related to age and sex. | single radial immunodiffusion method was used to measure the concentration of igg, iga, igm and igd in tears of 220 healthy individuals aged from 2 to 86 years. relation of the values to age and sex has been evaluated statistically by regression analysis method. mean iga level was 30.7 mg/100 ml. igg could be detected in 200 samples and the level was less than 1 mg/100 ml. igm was detected in only 7 samples and the value was less than 1 mg/100 ml. igd could not be detected in any of the sample. ... | 1978 | 98956 |
| isoelectric focusing of oligopeptides: detection by specific stains. | by using ultrathin (350 micrometers) polyacrylamide gels, which at the end of the fractionation are pasted to filter paper and dried in an oven at 110 degrees c, and after isoelectric focusing it has been possible to detect oligopeptides in the di- to tetradecapeptide range, which could not be detected by protein staining techniques. this is achieved by developing a series of specific stains for the following amino acids: arg, tyr, his, trp, met and cys. except for met and cys, the detection lim ... | 1979 | 95344 |
| [effect of various plant preparations on influenza virus replication. ii. interferon induction]. | | 1979 | 95152 |
| studies on the role of vasopressin in blood pressure control of spontaneously hypertensive rats with established hypertension (shr, stroke-prone strain). | we investigated the role of arginine-vasopressin (avp) in maintaining the blood pressure of spontaneously hypertensive (sh) rats (stroke-prone strain) with established hypertension (22--28 weeks of age). in comparison with normotensive wistar kyoto (wky) rats, plasma avp concentrations of sh rats with benign hypertension (bh) were elevated twofold and in rats with severe or malignant hypertension (s-mh), fourfold. the height of the blood pressure was quantitatively related to plasma avp in both ... | 1979 | 94626 |
| [correlation between axoplasmic transport and occurrence or recovery of optic nerve involvement. part 1. axoplasmic transport of protein and lipid in normal rabbit optic pathway (author's transl)]. | | 1979 | 93414 |
| immunotherapy in spring-time hay fever. a clinical and immunological study comparing two different treatment extract compositions. | in a study of the efficacy of two different treatment schedules for perennial immunotherapy, 47 adult patients with spring-time hay fever due to allergy against birch and other deciduous trees were randomly assigned to three treatment groups: one group received birch, alder and hazel allergen in allpyral, another group received the same allpyral mixture and in addition all relevant tree pollens in aqueous extract and a control group received no injections. for determination of antibody titres th ... | 1979 | 92897 |
| immunochemical evidence for multiple serotypes of bacteroides fragilis. | an immunochemical comparison of outer membrane antigens obtained from five select and biochemically defined strains indicated that there are several serotypes of bacteroides fragilis. each strain was serologically defined by individual or by combinations of determinant groups composed of carbohydrates in the form of polysaccharides or glycoproteins. the carbohydrate constituents were tentatively identified as glucose, galactose, fucose, rhamnose, glucosamine, galactosamine, and traces of mannose ... | 1979 | 91622 |
| study on lipid-digestion disorder as a contribution to the problem of pancreas involvement in acute hepatitis. | | 1977 | 21330 |
| a thymus cell marker in murine leukemia virus-induced lymphomas of rats. | a specific marker for an immature population of thymus cells in the rat was shown by the rosette formation between thymus cells and guinea pig erythrocytes. this method was used to classify murine leukemia virus-induced rat lymphomas. eight of nine gross virus-induced rat lymphoma lines, which originated in the thymus, formed rosettes; whereas friend, rauscher, or moloney virus-induced rat lymphoma lines, which originated in either the thymus, spleen, or mesenteric lymph nodes, did not form rose ... | 1979 | 225024 |
| stability and immunogenicity of empty particles of foot-and-mouth disease virus. | three strains of foot-and-mouth disease virus were shown to contain significant amounts of naturally occurring 75s, empty particles as well as the infectious, 140s full particles. one of these strains--a pando (1970)--was studied in detail. the empty particles from this virus strain were shown to have an observed sedimentation coefficient of 67s in 0.04 m phosphate buffer; they were labile in sds, non-infectious and probably rna-free and, on heating, they broke down to 12s subunits as did the 14 ... | 1979 | 218538 |
| interaction of vinblastine with the secretagogue action of db-camp in the rat exocrine pancreas,. | | 1979 | 215420 |
| role of ca++ in virus-induced membrane fusion. ca++ accumulation and ultrastructural changes induced by sendai virus in chicken erythrocytes. | some of the ultrastructural (freeze-etching technique), morphological, and biochemical effects of sendai virus interaction with chicken erythrocytes have been studied under fusogenic (in the presence of cacl2) and nonfusogenic (in the presence of ethyleneglycol-bis-n,n'-tetraacetic acid, [egta]) conditions. the following phenomena occur, irrespective of the presence of cacl2 or egta: (a) binding of iodinated virus particles to chicken erythrocytes at 4 degrees c and their partial release from th ... | 1978 | 211140 |
| the second signal system as conceived by pavlov and his disciples. | pavlov clearly formulated his ideas on the second signal system (specifically, language) in the 1930s. this occurred in conjunction with his interest in interspecies differences and in the study of human neuroses. pavlov proposed that conditional reflexes signal concrete reality while symbolic-language provides abstractions of reality. phylogenetically, language emerged in the humans because this form of communication had survival value to the species. pavlov's disciples l. a. orbeli and n. i. k ... | 1990 | 2075026 |
| [isolation and detection of avian adenoviruses on cell cultures]. | it is important, from the hygienic and epizootological view-point, to detect the presence of various microbiological agents in birds. the authors present the results of the virological examination of poultry, avian adenoviruses being the main object of investigation. ninety-eight virus strains were isolated from chickens of different age categories and were included in the group of avian adenoviruses according to the form of cytopathic changes on the cell cultures of hen kidneys, according to th ... | 1978 | 208217 |
| temporal changes in ovarian ornithine decarboxylase and cyclic amp in immature rats stimulated by exogenous or endogenous gonadotrophins. | pregnant mare serum gonadotrophin given intravenously to immature rats caused a maximal (x 70) increase in ornithine decarboxylase activity (odc) at 3 h; enzyme activity declined to about ten times the control levels by 9 h and a second rise began after about 20 h. anti-pmsg given 30 min after pmsg reduced the peak response by 70%. actinomycin d, or cycloheximide, completely prevented an increase in odc when given with pmsg, but only cycloheximide lowered the enzyme activity when given 18 h late ... | 1977 | 194994 |
| [action of actidione on the multiplication of aujeszky's disease virus]. | studied was the effect of actidione on the propagation of the aujeszky's disease virus (strains 2,7,10--virulent,, and strain mk--avirulent virus mutant). it was found that at a concentration of 2 microng/cm3 actidione discontinues the reproduction of the most virulent strain 2 when the antibiotic was added immediately after the adsorption of the virus on the cells. the decrease in the virulence of the virus strain was associated with the decrease in the concentration of the antibiotic needed fo ... | 1976 | 193240 |
| specific modification of the gtp binding sites of rat 5'-adenylic acid aminohydrolase by periodate-oxidized gtp. | 1. rat skeletal muscle amp deaminase (amp aminohydrolase, ec3.5.4.6) can be inactivated by incubation with the periodate-oxidized analogue of the enzyme inhibitor gtp. 2. nucleoside triphosphates and kcl at high concentrations protect against inactivation, while adp has no effect. 3. the inactivation can be reversed by the addition of gtp and amino acids and made irreversible by reduction with nabh4. this indicates that, in the binding of the oxidized gtp to the enzyme, a schiff base is formed b ... | 1976 | 182275 |
| a circular dna-protein complex adenoviruses and its possible role in dna replication. | | 1975 | 169089 |
| electron microscopy of synaptonemal complexes in semithin sections. | the technique of osmium tetroxide fixation followed by a treatment with p-phenylenediamine was applied to mouse testes in order to analyze pachytene nuclei. observation of epon semithin sections (0.25--0.5 micrometer) in conventional electron microscopy revealed the presence of positively stained synaptonemal complexes surrounded by unstained chromatin. the present results show that by using this method a suitable contrast and resolution can be achieved for semithin sections, which facilitates t ... | 1979 | 156471 |
| [cardiac arrhythmia in dogs under the action of adrenaline and difluorodichloromethane (fc 12)]. | inhalation of gas mixtures containing different concentrations of fc 12 by anesthetized and normally oxygenated dogs produces blood levels of fc 12 which are stable and proportional to the rate of fc 12 in the mixture. from the arterial concentration of 40 microgram/ml fc 12 (5 % fc 12 mixture) and over, fc 12 alone causes effects proportional to doses: arterial pressure decrease with tachycardia. at high rates of fc 12 tachypnoea and slight morphological alterations of the electrocardiogram can ... | 1977 | 148958 |
| [the proteincomposition of human parotid saliva in acute and chronic parotitis. quantitativ densitometry of single protein-fractions in comparison to normal secretions]. | by means of acrylamidgelectrophoresis parotid secretions of patients with acute and chronic parotitis were examined. thereby significant changes in protein patterns of electrophoretic separation were found. especially two bands are described in detail. one in the cathodal near gel region, the isoamylases, and the otherone in the anodal part of the gel, identified as albumin. in rest and under stimulation these bands show signficant changes compared to normal secretions. furthermore information a ... | 1976 | 135180 |
| [microbiological quality of frozen vegetable foods. ii. indicator microorganisms]. | | 1979 | 122280 |
| comparison of the 10 000 and 43 000 dalton polypeptide populations isolated from the water soluble and insoluble fractions of human cataractous lenses. | | 1979 | 118040 |
| [ecological aspects of south american trypanosomiasis. xiii. domestic enzootic potential in an area of occurrence of panstrongylus megistus, under epidemiological surveillance]. | | 1978 | 111341 |
| [cloning effectivity of trypanosoma evansi obtained from different hosts]. | | 1979 | 293837 |
| [fourier model of the visual system and the mechanism of feature detection: progress in the last 15 years]. | | 1979 | 398413 |
| [transport and excretion of a fluorescent pigment by cells of a pseudomonas fluorescens culture]. | the transport and exretion of a yellow-green pigment were studied with the culture of pseudomonas fluorescens k-1. these processes were found to be accomplished by means of membranous formations having a lamellar structure. | 1977 | 409911 |
| metabolism of 1-beta-d-arabinofuranosyluracil in mouse l5178y cells. | | 1979 | 427752 |
| esculetin inhibits t cell activation without suppressing il-2 production or il-2 receptor expression. | esculetin (6,7-dihydroxycoumarin) was found to inhibit dose-dependently the proliferation of human t cells stimulated by pha or phorbolester plus ionomycin. proliferation in autologous and allogeneic mlr and generation of cytotoxic t cells under limiting dilution conditions were also suppressed, with more than 90% inhibition seen at 50 microm esculetin. the immunosuppressive effect of esculetin was not due to toxicity. esculetin did not inhibit interleukin-2 (il-2) production, nor did it interfe ... | 1989 | 2654016 |
| hypothalamic sensitivity to leukocytic pyrogen of adult and new-born guinea-pigs. | 1. experiments were conducted to localize the hypothalamic site of action of microinjected leucocytic pyrogen and to compare the pyrogenic sensitivity of this locus in adult and new-born guinea-pigs.2. to identify the site reactive to leucocytic pyrogen, bilateral (0.8-1.0 mm from the mid line) injections of 1 microliter were made into conscious adult guinea-pigs via cannulas stereotaxically palced at 0.5 mm intervals and varying depths from the olfactory tegmentum to the mammillary bodies. inje ... | 1979 | 529081 |
| the biological activity of glyphosate to plants and animals: a literature review. | glyphosate is a widely-used broad-spectrum herbicide with little to no hazard to man or the environment. glyphosate is highly effective against 90 kinds of emerged grasses, brush and broad-leaf weeds. there is no residual soil activity, it does not leach into non-target areas, and it is non-volatile. it is practically nontoxic to mammals, birds and fish, showing no bioaccumulation in the food chain; it is biodegraded into natural products. when used correctly, glyphosate poses no threat to the e ... | 1992 | 1287975 |
| [differential diagnosis of ascites and abscess forming hepatitis in aids patients with reference to the first patient with microsporidia infection in austria]. | we report on a 30 years-old female aids patient suffering from generalized pneumocystosis and intestinal microsporidiosis. the chest x-ray showed a right-sided pleural effusion; the lungs showed no areas of consolidation and the heart and the vessels were normal in size. sonography revealed multiple cystic lesions of the liver measuring 1-3 cm in diameter, as well as ascites. pneumocystis carinii was detected on cytological examination of the bronchoalveolar lavage fluid, the pleural effusion an ... | 1992 | 1288019 |
| residues of polychlorinated biphenyls (pcbs) in fish, water and sediment from shing mun river. | the level and pattern of contamination by polychlorinated biphenyls (pcbs) were investigated in tilapia, oreochromis mossambicus (peters), sediment, and water from the shing mun river. the range of total pcbs was 12.9 ng/g to 181.6 ng/g wet weight in tilapia, 12.7 ng/g to 46.0 ng/g freeze-dried weight in sediment, and 3.8 ng/l to 13.6 ng/l in water. the effect of biomagnification was also observed, pcb concentrations increased from water to sediment to tilapia. pcb congeners occurred in such a w ... | 1991 | 1781935 |
| the relationship of kcl- and prostaglandin f2 alpha-mediated increases in tension of the porcine coronary artery with changes in intracellular ca2+ measured with fura-2. | 1. changes in intracellular free ca2+ concentration ([ca2+]i) were measured simultaneously with changes in muscle tension by use of the fluorescent ca2+ indicator, fura-2, in coronary arterial rings of the pig. 2. changes in [ca2+]i were measured by monitoring the ratio of fluorescence due to excitation at 340 nm (f340) to that at 380 nm (f380). 3. increases in tension of the porcine coronary artery induced by prostaglandin f2 alpha (pgf2 alpha) (2-30 microm) and kcl (25-70 mm) were accompanied ... | 1991 | 1797304 |
| the relationship of kcl- and prostaglandin f2 alpha-mediated increases in tension of the porcine coronary artery with changes in intracellular ca2+ measured with fura-2. | 1. changes in intracellular free ca2+ concentration ([ca2+]i) were measured simultaneously with changes in muscle tension by use of the fluorescent ca2+ indicator, fura-2, in coronary arterial rings of the pig. 2. changes in [ca2+]i were measured by monitoring the ratio of fluorescence due to excitation at 340 nm (f340) to that at 380 nm (f380). 3. increases in tension of the porcine coronary artery induced by prostaglandin f2 alpha (pgf2 alpha) (2-30 microm) and kcl (25-70 mm) were accompanied ... | 1991 | 1797304 |
| nafarelin controlled release injectable: theoretical clinical plasma profiles from multiple dosing and from mixtures of microspheres containing 2 per cent, 4 per cent and 7 per cent nafarelin. | nafarelin controlled release injectable (cri) releases a decapeptide drug for target one month therapy. nafarelin, a luteinizing hormone releasing hormone agonistic analogue, is microencapsulated in biodegradable poly(lactide-co-glycolide) microspheres and given by intramuscular injection. clinical data from a human single dose phase i clinical study are modelled to develop theoretical multiple dose profiles and theoretical single dose profiles from mixtures of two or three formulations. single ... | 1990 | 2143531 |
| indirect immunofluorescence test performance and questionnaire results from the centers for disease control model performance evaluation program for human immunodeficiency virus type 1 testing. | results from laboratories performing indirect immunofluorescence (iif) testing for human immunodeficiency virus type 1 antibody and participating in the centers for disease control model performance evaluation program in 1988 are presented. approximately 90% of all laboratories receiving specimen panels or questionnaires furnished results to the centers for disease control. in september 1988, 111 reports were received from iif laboratories from 34 states and nine countries; most of these laborat ... | 1990 | 2168439 |
| comparative study of chemical modifiers for the determination of molybdenum in milk by electrothermal atomisation atomic absorption spectrometry. | a comparative study of various chemical modifiers for the determination of molybdenum in milk by electrothermal atomisation atomic absorption spectrometry was carried out. methods with nitric acid or barium difluoride as the chemical modifier and in the absence of a chemical modifier were studied by introducing the milk samples directly into the graphite furnace with octyl alcohol. the graphite furnace programme, amount of modifier and the calibration and additions graphs were studied in all ins ... | 1990 | 2168685 |
| the purification and characterization of recombinant human renin expressed in the human kidney cell line 293. | the cdna encoding human preprorenin has been introduced into the adenovirus-transformed human kidney cell line 293. the recombinant 293 cells expressed and secreted prorenin; trypsin was used to activate the secreted prorenin to renin in vitro. the recombinant protein was purified to homogeneity by a single affinity chromatographic step. using synthetic tetradecapeptide, the km was 57.1 +/- 9.3 microm and the kcat was (7.48 +/- 1.57) x 10(3)/hr. activation with trypsin resulted in a secondary cl ... | 1990 | 2203348 |
| interrelationships of dietary sodium, potassium and chloride on growth in young swine. | in a preliminary experiment, pigs fed a purified diet gained at the same rate as pigs fed a natural ingredient diet if the purified diet was formulated to provide 150% of the na, k and cl requirements. subsequent experiments were designed to determine the interrelationships of dietary na, k and cl. pigs were fed diets with na (.03% to .60%), k (.1% to 1.0%) and cl (.03% to .60%) levels arranged in a three-factor central composite design. over the range of na levels, predicted gain increased by . ... | 1990 | 2211403 |
| gradients of neurogenesis in possum neocortex. | gradients of neurogenesis in neocortex of the brushtailed possum were determined with [3h]thymidine autoradiography, using data taken from 16 possums injected with [3h]thymidine between postnatal (p) days 5-68, and allowed to survive until brain cytoarchitecture was mature. gradients of neurogenesis shown in neocortex were: (a) an inside-out radial gradient within cortical areas with neurogenesis beginning around p5 in layer 6 and concluding between 1 and 2 months later in layer 2, and (b) a sin ... | 1990 | 2253327 |
| the downfield resonances in the 1h nmr spectra of azotobacter vinelandii and pseudomonas putida seven-iron ferredoxins. | pseudomonas putida and azotobacter vinelandii ferredoxins each contain one [4fe-4s] cluster and one [3fe-4s] cluster. their polypeptide chains are nearly identical, differing by only 15 residues out of a total of 106. t1 measurements and temperature dependence studies of the 1h nmr spectrum of each ferredoxin demonstrate that all six resolved downfield resonances are near an iron-sulfur center. the five most downfield resonances are shown to arise from protons on cysteinyl beta-carbons by incorp ... | 1990 | 2373698 |
| a new technique for differential and simultaneous staining of nerve cells and fibers. | a new and simple method for the simultaneous staining of nerve cells and fibers is described. the use of formol-thionin under controlled conditions of concentration and ph provides a highly reliable method for the staining of nerve cells in blue and fiber tracts in red, making any posterior differentiation redundant. this technique provides constant and reproducible results allowing simultaneous staining of many sections. | 1985 | 2409409 |
| [persistence of antibodies of the igg class against cytomegaloviruses in blood donors]. | high titre plasmas gained from blood donors are the initial material used for producing human immunoglobulin containing cytomegalovirus antibodies (cmv-hig). for this purpose the sera gained from 467 permanent donors at the district institute for blood and transfusion service in berlin were investigated on their cmv antibody content of igg class by means of an indirect immunofluorescence test (ift). the infection rate of blood donors amounted to 62% (291/467). cmv-igg titre greater than or equal ... | 1987 | 2446998 |
| genetic and other effects on antibody and cell mediated immune response in swine leucocyte antigen (sla)-defined miniature pigs. | miniature pigs of eight swine leucocyte antigens (sla) haplotypes were immunized with sheep erythrocytes (srbc), hen egg white lysozyme (hewl) and the synthetic peptide (t, g)-a--l to induce antibody. bacillus calmette geurin (bcg) and dinitrochlorobenzene (dncb) were used to induce cell mediated immune response (cmi). analysis of variance by least squares was used to assess the effects of sla haplotype, sire, dam, litter and sex of pig on the magnitude of the primary and secondary antibody resp ... | 1989 | 2527014 |
| receptor-independent metabolism of platelet-activating factor by myelogenous cells. | human neutrophils incorporate and metabolize platelet-activating factor (paf). we dissociated these events from paf binding to its receptors. cells were pretreated with either pronase, a paf antagonist (l652731), or excess paf. this reduced paf receptor numbers by 70 to almost 100% but had no comparable effect upon the neutrophil's ability to metabolize paf. furthermore, hl-60 cells efficiently metabolized, but did not specifically bind, paf. thus, paf receptor availability did not correlate wit ... | 1989 | 2546802 |
| the epidemiology of the acquired immunodeficiency syndrome. | | 1986 | 3008169 |
| biopharmaceutical evaluation of sustained-release ethylcellulose microcapsules containing amoxicillin using beagle dogs. | a beta-lactam antibiotic, amoxicillin, was microencapsulated with ethylcellulose using a solvent evaporation process in liquid paraffin containing sorbitan tristearate as a dispersing agent, and the microcapsules obtained showed first-order drug release. usage of the previous log-log relationship of cefadroxil between in vitro dissolution half-lives (t50) and the experimental release rate constants (k'r) of the drug in vivo, and the nomogram for the design of satisfactory sustained-release prepa ... | 1989 | 2632091 |
| biopharmaceutical evaluation of sustained-release ethylcellulose microcapsules containing amoxicillin using beagle dogs. | a beta-lactam antibiotic, amoxicillin, was microencapsulated with ethylcellulose using a solvent evaporation process in liquid paraffin containing sorbitan tristearate as a dispersing agent, and the microcapsules obtained showed first-order drug release. usage of the previous log-log relationship of cefadroxil between in vitro dissolution half-lives (t50) and the experimental release rate constants (k'r) of the drug in vivo, and the nomogram for the design of satisfactory sustained-release prepa ... | 1989 | 2632091 |
| comparison of 3 methods of exposing rats to cigarette smoke. | | 1989 | 2637153 |
| pancreas-graft immunogenicity and pretreatment with anti-class ii monoclonal antibodies. | pretreatment of organ allografts to reduce graft immunogenicity is an attractive and potentially clinically applicable concept. we have studied the effect of perfusing rat pancreases with anti-class ii monoclonal antibody (moab), to remove class ii- positive accessory cells from the intact organ, on prolongation of allograft survival after transplantation. the capacity of pancreatic islets obtained from these perfused organs to stimulate proliferation of allogeneic t-lymphocytes was studied in a ... | 1989 | 2642828 |
| bromodeoxyuridine uptake in the assessment of hyperthermic therapy for intraocular tumor. | assessment of uveal melanoma response after many nonenucleation therapies is difficult with current modalities, since tumor regression is usually delayed. the goal of most treatments, including ionizing radiation or radiation and adjunct hyperthermia, is to destroy the reproductive capacity of the tumor. cell cycling analysis with bromodeoxyuridine, a thymidine analogue only incorporated during dna synthesis, was a useful indication of tumor control after hyperthermia was used to treat a greene ... | 1989 | 2719590 |
| [antidiuretic mechanism in rhodnius prolixus (stal, 1859) (hemiptera, reduviidae)]. | an antidiuretic mechanism is proposed for rhodnius prolixus, whose activity is manifested when the diuretic phase has terminated and is maintained until the insect has fed again. presumably this mechanism acts at the level of the proximal rectal sphincter and is inhibited by ingestion, mechanical distension of the gut and central disinhibition by decapitation. it is suggested that the antidiuretic activity is maintained by the nervous system and is modified when there is distention of the gut or ... | 1986 | 3302595 |
| reduced human peritoneal plasminogen activating activity: possible mechanism of adhesion formation. | a unifying pathophysiological hypothesis states that the plasminogen activating activity (paa) of the peritoneal mesothelium determines whether the fibrin which forms after peritoneal injury is either lysed or organized into permanent fibrous adhesions. the paa of human peritoneal biopsies was measured using a fibrin plate lysis technique to assess the changes that occur in inflammation and ischaemia, conditions which both produce fibrous adhesions. activity was found in all biopsies from normal ... | 1989 | 2720348 |
| influence of low-temperature storage and glucose starvation on growth recovery in escherichia coli rela and rela+ strains. | to study the influence of microgravity on bacterial growth behavior during a space mission, the special experimental conditions and the hardware environment necessitate storage of cells at low temperature, and permit a relatively short experimental period. before this experimental period, cells have to recover their condition of steady-state growth, because it is only in this condition that the growth behavior of the flight and ground populations can be adequately compared. to meet these require ... | 1991 | 1367237 |
| fate of microinjected genes in preimplantation mouse embryos. | the state of genes microinjected into mouse embryos was followed from the one-cell to the blastocyst stage using the polymerase chain reaction (pcr). microinjected dna was detected in all one-, two-, and four-cell injected embryos and in 44% of morula and 26% of blastocysts. head-to-tail ligation of microinjected genes, a common feature of stably integrated transgene arrays, was detected in all embryos after injection of microinjected genes and occurred irrespective of the structure at the ends ... | 1992 | 1472374 |
| microvascular architecture of the mucosa of the gastric corpus in man. | vascular casts of human gastric mucosa of the corpus area were studied by scanning electron microscopy and compared with vertical and horizontal series of semithin sections of perfusion-fixed corpus mucosa. the submucosal arteries give off short and long arterioles. the short arterioles branch into a basal capillary network reaching from the basis to the isthmus of the gastric glands. the long arterioles pass through the lamina propria without ramifications and supply a second, apical capillary ... | 1987 | 3504083 |
| in vivo studies on halogen compound interactions. iii. effect of carbon tetrachloride plus 1,2-dichloroethane on liver necrosis and fatty accumulation. | the effect of a single dose of carbon tetrachloride (ct), 1,2-dichloroethane (dce) and the mixture on liver toxicity was investigated. the co-presence of both toxins exerts a more than additive effect on liver necrosis and on tba-reactive substances produced by liver homogenates incubated at 37 degrees c. both these effects are prevented in animals treated with vitamin e. the liver gsh is not involved in the synergistic action. the liver triglyceride levels of rats treated with the mixture are l ... | 1992 | 1636056 |
| auditory and visual neurons in the cat's superior colliculus selective for the direction of apparent motion stimuli. | in the cat, cells of the superior colliculus (sc) and the tectofugal pathways of the visual system are highly selective for the direction of a moving visual stimulus. deep layer units of sc in addition respond to auditory and somatosensory stimuli, but the proportion of such non-visual cells is usually found to be much lower than that of visual cells. we recorded the responses of 174 cells in the sc to sequentially presented, localized visual and/or auditory stimuli that produced the sensation o ... | 1989 | 2758330 |
| biochemical and functional characterization of the rat liver glucose-transport system. comparisons with the adipocyte glucose-transport system. | the properties of the glucose-transport systems in rat adipocytes and hepatocytes were compared in cells prepared from the same animals. hormones and other agents which cause a large stimulation of 3-o-methylglucose transport in adipocytes were without acute effect in hepatocytes. hepatocytes displayed a lower affinity for 3-o-methylglucose (20 mm) and alternative substrates than adipocytes (6 mm), whereas inhibitor affinities were similar in both cell types. the concentration and distribution o ... | 1986 | 3548706 |
| induction of experimental autoimmune thyroiditis in b cell-depleted mice. | the effect of b cell depletion on the induction and severity of murine experimental autoimmune thyroiditis was investigated. thirteen cba mice were given repeated intraperitoneal doses of 700 micrograms purified rabbit anti-mouse ig antibody from 24 hours to 8 weeks after birth. controls were given normal rabbit igg (14 mice) or were left uninjected (10 mice). at six weeks all mice received two doses of 70 micrograms murine thyroid extract in complete freund's adjuvant. only 2/13 of the anti-ig ... | 1989 | 2785490 |
| growth and morphogenesis of mouse prostate epithelial cells in collagen gel matrix culture. | epithelial cells were isolated from the ventral prostate gland of the mouse after prolonged incubation in a mixture of collagenase, dispase and hyaluronidase followed by extensive pipetting. the isolated epithelial cells were then embedded in collagen gels. after cultivation in dulbecco's modified eagle's medium supplemented with fetal bovine serum, epidermal growth factor, 5 alpha-dihydrotestosterone and cortisol, stimulation of growth and branching morphogenesis of the epithelial cells were ob ... | 1989 | 2788523 |
| pyrimidinone (bropirimine) mediated alteration of t lymphocyte subsets during murine cytomegalovirus infection. | murine cytomegalovirus (mcmv) infection of mice resulted in suppression of mitogen induced proliferation and interleukin 2 (il-2) responses of splenic cells. this suppression was also evident as a reduction in the number of cells expressing thy-1 or l3t4 and a reduction in the ratio of t helper/t suppressor cells. the pyrimidinone compound, bropirimine, when administered to mcmv infected mice was able to restore mitogen-induced proliferative and il-2 responses of splenic cells, to increase the n ... | 1987 | 2820635 |
| inhibitory action of pertussis toxin on parathyroid hormone and prostaglandin e2-stimulated bone resorption in cultured neonatal mouse calvaria. | | 1987 | 2823535 |
| effect of blood and ultrafiltrate flow rates on drug sieving during continuous hemofiltration. | | 1987 | 3675958 |
| inhibitory action of pertussis toxin on parathyroid hormone and prostaglandin e2-stimulated bone resorption in cultured neonatal mouse calvaria. | | 1987 | 2823535 |
| degradation of aflatoxin by aspergillus flavus. | aflatoxin degradative activity was demonstrated in 6- to 12-d-old intact mycelium and cell-free extracts of aspergillus flavus. the addition of cycloheximide, skf 525-a or metyrapone to cultures of a. flavus prevented subsequent degradation of the aflatoxins, while in cell-free extracts degradation was inhibited by skf 525-a, metyrapone and cytochrome c but not by kcn. in cell-free extracts, aflatoxin degradation was enhanced by nadph and naio4. the results suggest the involvement of cytochrome ... | 1987 | 2832516 |
| tracazolate metabolites in rat tissue. | tracazolate (4-n-butylamino-1-ethyl-6-methyl-1h-pyrazolo[3,4-b] pyridine-5-carboxylic acid ethyl ester) undergoes extensive biotransformation to lipophilic metabolites following oral dosage to male rats. twenty-one metabolites were identified in a plasma hexane extract by mass spectrometry. coadministration of unlabeled tracazolate with its stable carbon-13 isotope expedited the isolation and identification of 11 biotransformation products. the various metabolites resulted from either hydrolysis ... | 1985 | 2859159 |
| tracazolate metabolites in rat tissue. | tracazolate (4-n-butylamino-1-ethyl-6-methyl-1h-pyrazolo[3,4-b] pyridine-5-carboxylic acid ethyl ester) undergoes extensive biotransformation to lipophilic metabolites following oral dosage to male rats. twenty-one metabolites were identified in a plasma hexane extract by mass spectrometry. coadministration of unlabeled tracazolate with its stable carbon-13 isotope expedited the isolation and identification of 11 biotransformation products. the various metabolites resulted from either hydrolysis ... | 1985 | 2859159 |
| [the disseminated endocrine system of man. a contribution of pathology]. | the disseminated (or diffuse) endocrine system is composed of many single cells and small groups of cells disseminated in the whole organism, capable of producing biogenic amines and polypeptide hormones. they are also called apud cells and were first detected in the mucosa of the intestinal tract, where they occur in highest concentration. carcinoids are tumors of disseminated endocrine cells which sometime retain their hormone-producing capacity. these hormones are key factors in the control o ... | 1987 | 2891187 |
| properties of the deoxycholate-solubilized hela cell plasma membrane receptor for binding group b coxsackieviruses. | physical and chemical properties of deoxycholate-solubilized hela cell plasma membrane receptors for binding group b coxsackieviruses were determined. receptors eluted from sepharose 4b with an apparent molecular weight of 275,000 and sedimented with an s value of between 14.7 and 4.9 and a buoyant density of 1.06 to 1.10 g/cm3. virus-binding activity was destroyed after treatment with proteases, glycosidases, and periodate but was unaffected by lipases or reducing or alkylating agents. addition ... | 1985 | 2983096 |
| [blood-brain barrier opening microcirculation in human brain tumor]. | the changes of the human tumor microcirculation after blood-brain barrier (bbb) opening was studied. bbb opening was performed by retrograde injection of hyperosmotic solution, such as mannitol or glycerol, from superficial temporal artery in the operation procedure. serial fluorescein micro angiography of human tumor surface was taken by motor-driven camera equipped to surgical microscope. two glioblastomas, two astrocytomas and one metastatic tumor were studied. in glioblastoma multiforme, aft ... | 1985 | 2988587 |
| inhibition and activation of bovine heart nad-specific isocitrate dehydrogenase by atp. | in the absence of added calcium, inhibition of nad-specific isocitrate dehydrogenase by atp occurred without adp (i0.5 = 1.8 mm) and with 0.2 mm adp3- (i0.5 = 1.0 mm) at subsaturating substrate concentrations at ph 7.4. inhibition by atp was competitive with nad+ in the presence and absence of adp and was not reversed by magnesium citrate. no reversal of atp inhibition by free ca2+ was observed in the presence of adp (0.2 mm). however, when adp was absent, increasing ca2+ first caused progressiv ... | 1985 | 2990340 |
| electrophoretic types of transaldolase, transketolase, and other enzymes in bifidobacteria. | | 1974 | 4136709 |
| comparative study of teaching methods in human gross anatomy. | | 1967 | 4167329 |
| [masugi hetero-immune nephritis in rats. 3. histological and ultrastructural study. (attempt of comparison with protein data)]. | | 1969 | 4187677 |
| serologic diagnosis of mycoplasma infections by passive hemagglutination using sheep red blood cells sensitized by glutaraldehyde. | | 1974 | 4213376 |
| [effect of deuterium oxide on the heat resistance of staphylophage]. | | 1969 | 4249017 |
| [studies on the dermotoxins of the 6 clostridium welchii types in rabbits]. | | 1965 | 4287430 |
| [pseudomonas aeruginosa: immunotypes and drug resistance]. | serotyping of pseudomonas aeruginosa by fisher's schema has been used to study the prevalence of particular immunotypes among strains of p. aeruginosa obtained from clinical specimens. about 78% of the isolates were serotypable and about 22% were not. immunotypes 2 and 6 turned out to be the most prevalent, whereas immunotypes 5 and 7 were the least frequent. immunotypes 2, 5, 6 and 7 did not vary significantly as far as frequency in the various sources is concerned, with the exception of immuno ... | 1986 | 3119410 |
| spectroscopic evidence for beta structure in rat adipocyte plasma membrane protein. | | 1971 | 4331045 |
| synthesis and biological effects of 13-dehydro derivatives of natural prostaglandin f 2 and e 2 and their l5-epi enantiomers. | | 1973 | 4351914 |
| synthesis and biological effects of 13-dehydro derivatives of natural prostaglandin f 2 and e 2 and their l5-epi enantiomers. | | 1973 | 4351914 |
| characterization of a-i-containing lipoproteins in subjects with a-i milano variant. | the a-i milano variant of apolipoprotein a-i (a-im), by virtue of its arg-173----cys substitution, is capable of forming a disulfide bond with the 77-amino-acid apolipoprotein a-ii polypeptide (a-iis) as well as with itself to produce dimers, a-im/a-iis and a-im/a-im, respectively. a-i-containing lipoproteins (lp): particles with a-ii (lp(a-i with a-11)) and particles without a-ii (lp(a-i without a-ii)) in the plasma of two nonhyperlipidemic a-im carriers were investigated to determine the effec ... | 1988 | 3129016 |
| letter: crystalline perinuclear inclusions in myoblasts from human dystrophic muscle. | | 1974 | 4361764 |
| histocompatibility antigens on mouse spermatozoa. | | 1969 | 4390514 |