| clinical and microbiologic surveillance of neonatal staphylococcal disease. relationship to hexachlorophene whole-body bathing. | neonatal staphylococcal disease occurred in the nurseries of a university hospital three weeks after discontinuation of routine, daily, whole-body bathing of newborns with hexachlorophene. of 16 infants who had clinical manifestations within a two-week period, 11 cases were confirmed bacteriologically. shortly after onset of the outbreak, daily clinical and microbiologic surveillance and control measures on all infants and personnel were inaugurated. clinical surveillance after the outbreak did ... | 1975 | 123704 |
| [clinical conference: hl-a antigens in chronic myeloid leukemia]. | | 1975 | 126439 |
| studies of the histochemistry, ultrastructure, motor innervation, and regeneration of mammalian intrafusal muscle fibres. | | 1976 | 137430 |
| the storage lipids in tangier disease. a physical chemical study. | the physical states and phase behavior of the lipids of the spleen, liver, and splenic artery from a 38-yr-old man with tangier disease were studied. many intracellular lipid droplets in the smectic liquid crystalline state were identified by polarizing microscopy in macrophages in both the spleen and liver, but not in the splenic artery. the droplets within individual cells melted sharply over a narrow temperature range, indicating a uniform lipid composition of the droplets of each cell. howev ... | 1977 | 193870 |
| comparison of interferon action in interferon resistant and sensitive l1210 cells. | translation inhibition, leu-trna aminoacylation and double-stranded rna and atp dependent phosphorylation were examined in interferon-treated and control cell-free lysates of leukaemic mouse l 1210 r and l 1210 s cells. no differences were observed between the respective interferon-treated and control cell-free extracts, except for the presence of an enhanced 67k dalton phosphoprotein fraction in interferon-treated l 1210 s cell-free extracts. in non-responding cell-free lysates, the lack of sti ... | 1978 | 212514 |
| mucin-producing atypical bronchial carcinoid. | in a case of atypical mucin-producing bronchial carcinoid in a 40-year-old man covert metastases were present at the time of lobectomy and were revealed at necropsy--a feature highlighting the malignant potential of the atypical carcinoid. | 1978 | 219040 |
| inherited immunodeficiency in chickens: a model for common variable hypogammaglobulinemia in man? | | 1977 | 303448 |
| the diagnostic application of specific antiprocollagen sera. ii. analysis of liver biopsies. | frozen, unfixed sections of human liver biopsies from patients with acute, subchronic, and chronic hepatitis or fibrotic liver disease were studied in indirect immunofluorescence with specific antisera to type i and type iii procollagen. in early stages of both hepatitis and fibrotic liver disease, intralobular type iii collagen synthesis is increased. maximum values are reached years after the onset of disease. intralobular procollagen i content is not increased in the acute stage, but rises on ... | 1978 | 344227 |
| studies on selective induction of lysosomal enzyme activities in mouse peritoneal macrophages. | | 1979 | 522087 |
| a study of absorption of compounds from the rat biliary tree by retrograde intrabiliary injection (rii). | absorption of compounds from the biliary tree of rats was studied by a retrograde intrabiliary injection (rii) technique. after rii of a number of compounds in volumes that exceeded the maximum distended capacity of the biliary tree, only that volume of rii solution which corresponded to biliary tree capacity remained therein. furthermore, this latter portion of rii solution was absorbed by a first-order process when the duration of bile duct cannula occlusion was extended. thus, the present stu ... | 1975 | 1151745 |
| what's new in diagnosis and treatment of hpv-associated cervical lesions. | the human papilloma virus (hpv) has been subject to intense discussion during the last decade, as evidence has accumulated to strongly suggest that viruses play an essential part in the genesis of cervical neoplasms. the contamination rate of the female population is reported to range between 5 and 80%, depending on the modality of detection. many indications almost reliably suggest the oncogenicity of certain hpv-types. the highest progression rate was found in hpv 16 lesions, followed by hpv 1 ... | 1992 | 1317558 |
| the pathogenicity of drug-resistant variants of herpes simplex virus. | | 1992 | 1317602 |
| analysis of the glucose transporter content of islet cell lines: implications for glucose-stimulated insulin release. | glucose transport across the plasma membrane of mammalian cells is mediated by a family of homologous proteins. each glucose transporter isoform has a specific tissue distribution which relates to that tissue's demand for glucose. the beta-cells of pancreatic islets are known to express a distinct glucose transporter isoform, termed glut 2, which has a high km for glucose. in this study, we examined the glucose transporter content of normal rat islets and three beta cell lines, beta-tc, hit and ... | 1992 | 1489658 |
| presence of paf-acether in rheumatic diseases. | paf-acether (paf) is a naturally occurring phospholipid involved in inflammatory processes. the presence of paf, its precursor lyso paf, and lipo-paf has been determined in blood and synovial fluid from 13 patients with rheumatoid arthritis (ra), 11 with spondylarthropathies, eight with other inflammatory rheumatisms, 13 with chondrocalcinosis, 15 with osteoarthritis, and also in blood from nine healthy subjects. paf and lipo-paf were measured by rabbit platelet aggregation after isolation by hi ... | 1992 | 1540032 |
| localization and quantification of nonapeptide binding sites in the kidney of xenopus laevis: evidence for the existence of two different nonapeptide receptors. | the distribution and properties of nonapeptide binding sites in the kidney of the anuran xenopus laevis were investigated using quantitative in vitro autoradiography. the binding studies were performed with [3h]arginine vasopressin (avp) as ligand because [125i]arginine vasotocin (avt) lacks biological activity. specific binding sites for [3h]avp are located in the glomeruli of the kidney. [3h]avp binding results in a steady state of association and dissociation between ligand and binding sites. ... | 1992 | 1563620 |
| measurement of the human immune response to meningococcal lipooligosaccharide antigens by using serum to inhibit monoclonal antibody binding to purified lipooligosaccharide. | we developed a human inhibition monoclonal enzyme-linked immunosorbent assay (himelisa) to investigate the human immune response to the lipooligosaccharides (los) of neisseria meningitidis. monoclonal antibodies (mab) were used to define seven epitopes on four los molecules of a meningococcal strain (126e) previously shown to express immunogenic los epitopes. the assay could distinguish epitope-specific antibody within whole sera. neither the specificity nor the amount of the antibody measured b ... | 1990 | 1694820 |
| time course of changes in heart rate and sympathetic tone after coronary artery ligation in rats. | the purpose of this study was to investigate the changes of heart rate (hr) and sympathetic tone occurring after myocardial infarction. male rats (200-250 g) were submitted to ligation of the anterior branches of the left coronary artery to produce infarction (inf, n = 26) or to sham surgery (so, n = 24). groups of animals (n = 6-8) were studied 1,3,7 and 15 days later. a group not submitted to surgical procedures was used as control (c,n = 6). blood pressure and hr were measured in conscious un ... | 1991 | 1797278 |
| growth arrest induced by transforming growth factor beta 1 is accompanied by protein phosphatase activation in human keratinocytes. | protein phosphorylation and dephosphorylation are involved in regulation of cell growth. we tested the hypothesis that the growth inhibitory effect of transforming growth factor beta 1 (tgf-beta 1) involves activation of protein phosphatases. exposure of human keratinocytes in culture to 400 pm tgf-beta 1 for 48 h led to 80% inhibition of dna synthesis as measured by nuclear labeling. incubation of cultured keratinocytes with 400 pm tgf-beta 1 rapidly activated (within 30 min) protein serine/thr ... | 1991 | 1847373 |
| purification and cdna sequencing of an oleate-selective acyl-acp:sn-glycerol-3-phosphate acyltransferase from pea chloroplasts. | the soluble acyl-acp:sn-glycerol-3-phosphate acyltransferase from chloroplasts of chilling-sensitive and -resistant plants differ in their fatty acid selectivity. enzymes from resistant plants discriminate against non-fluid palmitic acid and select oleic acid whereas the acyltransferase from sensitive plants accepts both fatty acids. to use this difference for improving plant chilling resistance by biotechnology the gene for an oleate-selective enzyme is required. therefore, the oleate-selective ... | 1991 | 1932680 |
| assessment of abdominal fat deposition in female cynomolgus monkeys. | computed tomography (ct) was used to assess abdominal fat distribution in adult, female cynomolgus macaques (macaca fascicularis). the technique used was similar to that applied in human beings and allowed intra-abdominal, subcutaneous and total abdominal fat to be quantitated in 1 cm thick sections. correlations between single scans and the average of scans at several levels ranged from r = 0.96 to r = 1.00, indicating that a single scan is representative of abdominal fat distribution. signific ... | 1991 | 2045214 |
| hypoglycemia risk during exercise after intramuscular injection of insulin in thigh in iddm. | the influence of bicycle exercise (60% of w170 [working capacity at a pulse rate of 170 beats/min]; 40 min) on the absorption of 125i-labeled fast-acting insulin (10 u; actrapid human insulin) after intramuscular compared with subcutaneous injection in the thigh was studied on 2 consecutive days in 10 insulin-dependent diabetes mellitus (iddm) patients. insulin absorption was measured as disappearance of radioactivity (1st-order elimination rate constants) by continuous external monitoring and a ... | 1990 | 2190773 |
| [denture stomatitis. its relation to candida albicans]. | one of the most usual complications of the patients that carry a prosthesis is one called stomatitis denture. its etiology is not clear enough. in this work we study ninety people, sixty of them wear prosthesis. we take samples of different places in the mouth to plate and class c. albicans. we look for the relationship of results with the clinical parameters of the patient. | 1990 | 2203365 |
| serological relationships between serotype-iii streptococcus sanguis and lancefield group-h streptococci. | certain strains of streptococcus sanguis and group-h streptococci have been shown to have similar physiological properties and serological specificities. serological studies revealed that serotype-iii s. sanguis shared a common antigen with the so-called "british" group-h streptococci, but not with the "american" group-h streptococci. serotype-iii antigen was extracted in cold 5% trichloroacetic acid from isolated cell walls of s. sanguis atcc 10558, and purified chromatographically. the purifie ... | 1987 | 2438413 |
| interferon in experimental autoimmune encephalomyelitis (eae): effects of exogeneous interferon on the antigen-enhanced adoptive transfer of eae. | the transfer of experimental autoimmune encephalomyelitis (eae) can be enhanced by incubating lymph node cells (lnc) from eae rats with myelin basic protein (mbp). addition of rat fibroblast interferon (rfifn) to cultures of eae-lnc just before the addition of mbp, resulted in the inhibition of the adoptive transfer of eae. both development of clinical signs, such as weight loss and hind limb paralysis, and histopathological lesions, lymphocytic perivascular infiltrates of the central nervous sy ... | 1985 | 2579912 |
| factor xi gene (f11) is located on the distal end of the long arm of human chromosome 4. | chromosomal localization of the gene for human coagulation factor xi (f11) was determined by in situ hybridization using a genomic dna probe which contained exons viii, ix, and x of the gene. the results indicate that the gene is located at 4q35. | 1989 | 2612218 |
| the density of cones in the fovea centralis of the human dichromat. | we present estimates, based on psychophysical measurements, of the density of cones in the fovea centralis of human dichromats. the estimates for a group of three protanopes and three deuteranopes (this study) were compared to the estimates of the density of cones in a group of six color normal trichromats from previous studies (cicerone & nerger, 1985, 1989). the results support the conclusion that the density of cones in the fovea centralis of the dichromat is comparable to that of the color n ... | 1989 | 2635482 |
| cryptococcus neoformans var. neoformans and munia birds. | cr. neoformans var. neoformans has been persistently demonstrated in the saprobic environment of caged munia birds at a local zoological garden. the pathogen was also cultured from the beaks, feathers and legs of these birds. it is suggested that the role of munia birds should be further investigated to understand the ecology of this important human pathogen. | 1989 | 2668756 |
| effect of season and lactation on postpartum fertility of polypay, dorset, st. croix and targhee ewes. | the objective of this study was to compare rebreeding activities of spring- vs fall-lambing polypay, dorset, st. croix and targhee ewes that either suckled their lambs for 40 d or had lambs weaned at birth. seasonal effects of male fertility were reduced by utilizing an excess number of fertile rams in the spring. plasma concentrations of progesterone were monitored to assess days to the first normal ovulation, days to conception and estrous vs anestrous activity. breed, season and lactation aff ... | 1989 | 2737977 |
| prevention of rectal cancer induced by n-nitrosobis(2-oxopropyl)-amine by exogenous testosterone in mrc rats. | rectal carcinogenicity of n-nitrosobis(2-oxopropyl)amine (bop) in male mrc wistar rats was shown to be inhibited by exogenous testosterone (t) when the hormone was given during, but not after, administration of the carcinogen. this effect was independent of the dose and frequency of bop, which was given either weekly for 20 weeks orally or daily for 3 days subcutaneously. since, except for prostatic cancer, the incidence and the patterns of other bop-induced tumors were not altered by t, this ho ... | 1989 | 2805225 |
| prevention of rectal cancer induced by n-nitrosobis(2-oxopropyl)-amine by exogenous testosterone in mrc rats. | rectal carcinogenicity of n-nitrosobis(2-oxopropyl)amine (bop) in male mrc wistar rats was shown to be inhibited by exogenous testosterone (t) when the hormone was given during, but not after, administration of the carcinogen. this effect was independent of the dose and frequency of bop, which was given either weekly for 20 weeks orally or daily for 3 days subcutaneously. since, except for prostatic cancer, the incidence and the patterns of other bop-induced tumors were not altered by t, this ho ... | 1989 | 2805225 |
| specificity and cellular distribution of human polymorphonuclear leucocyte receptors for leukotriene c4. | human polymorphonuclear (pmn) leucocytes bind synthetic [3h]-labelled leukotriene c4 ([3h]ltc4) with rapid saturation and reversibility of approximately 90%, by a 700-fold higher concentration of non-radioactive ltc4. [3h]ltc4 is recognized specifically by 10,778 +/- 6260 (mean +/- sd) sites per pmn leucocyte that exhibit a kd of 34.3 +/- 1.7 nm. the specificity of the ltc4 receptors is supported by the competitive inhibition of binding of [3h]ltc4 by ltc4, ltc4-sulphone, ltd4, and lte4 with rel ... | 1987 | 2820869 |
| specificity and cellular distribution of human polymorphonuclear leucocyte receptors for leukotriene c4. | human polymorphonuclear (pmn) leucocytes bind synthetic [3h]-labelled leukotriene c4 ([3h]ltc4) with rapid saturation and reversibility of approximately 90%, by a 700-fold higher concentration of non-radioactive ltc4. [3h]ltc4 is recognized specifically by 10,778 +/- 6260 (mean +/- sd) sites per pmn leucocyte that exhibit a kd of 34.3 +/- 1.7 nm. the specificity of the ltc4 receptors is supported by the competitive inhibition of binding of [3h]ltc4 by ltc4, ltc4-sulphone, ltd4, and lte4 with rel ... | 1987 | 2820869 |
| characterization of equine herpesvirus type 1 immediate early proteins. | ehv-1 immediate early (ie) gene expression in lytic infection results in the production of four high mol wt immediate early polypeptides (ieps), designated ie1, ie2, ie2, and ie4; however, ie transcription is limited to the synthesis of a single 6-kb mrna. together, these findings raised questions as to whether the four ieps were related products of the same gene. in the present study the ieps were characterized with respect to their structural similarities, antigenic relatedness, and postsynthe ... | 1988 | 2833023 |
| the potassium channel opening action of pinacidil; studies using biochemical, ion flux and microelectrode techniques. | in rat aorta and rat portal vein, (-)- and (+)-pinacidil each produced a concentration-dependent inhibition of tension development. although the (-) isomer was the more potent, concentration effect curves for each isomer were steep with similar slopes. in rat portal vein, tetraethylammonium and procaine antagonised the relaxant effect of (+/-)-pinacidil, whereas 3,4-diamino-pyridine was without effect. intracellular microelectrode recording in rat portal vein showed that low concentrations of (+ ... | 1988 | 2848206 |
| [participation of the catecholaminergic system in estrogen formation in sexually immature rats]. | | 1988 | 2851940 |
| interactions between vecuronium and suxamethonium in the dog. | the non-depolarising muscle relaxant vecuronium (0.2 mg kg-1) was administered to four dogs. at 50 per cent return of neuromuscular activity, as measured by the train-of-four technique, the depolarising muscle relaxant suxamethonium (0.3 mg kg-1) was injected intravenously. at 50 per cent return of neuromuscular activity reversal of the block was achieved with atropine and neostigmine. the duration of action of suxamethonium was reduced by the prior administration of vecuronium. in the second se ... | 1986 | 2876469 |
| the burden of proof. donated blood runs a costly gauntlet of tests. | | 1989 | 2928768 |
| effect of mononuclear cell factors on calcium transport in sarcoplasmic reticulum vesicles. | the effect of supernatants from cultures of mitogen-stimulated human mononuclear cells on calcium transport by sarcoplasmic reticulum was examined. calcium transport was assayed by measuring the time course of calcium accumulation by sarcoplasmic reticulum incubated with supernatants from stimulated mononuclear cells was 20% less than that by vesicles exposed to control supernatants (p less than 0.001). in contrast, no difference in calcium-dependent atpase activity was noted between vesicles in ... | 1986 | 2946307 |
| [changes in the properties of brain opiate receptors during the development of morphine tolerance in rats]. | the effects of prolonged administration of morphine on the properties of opiate receptors of rat brain were studied. for this purpose the isotherms of binding of labeled mu-, delta-, and chi-ligands--morphine, d-ala2, d-leu5-enkephalin and ethylketocyclazocine--with brain membrane preparations of morphine-tolerant rats as well as those of control animals were analyzed. for quantitative determination of dissociation constants of the ligand-receptor complexes (k) and receptor concentrations ([q]), ... | 1986 | 3021240 |
| [changes in the properties of brain opiate receptors during the development of morphine tolerance in rats]. | the effects of prolonged administration of morphine on the properties of opiate receptors of rat brain were studied. for this purpose the isotherms of binding of labeled mu-, delta-, and chi-ligands--morphine, d-ala2, d-leu5-enkephalin and ethylketocyclazocine--with brain membrane preparations of morphine-tolerant rats as well as those of control animals were analyzed. for quantitative determination of dissociation constants of the ligand-receptor complexes (k) and receptor concentrations ([q]), ... | 1986 | 3021240 |
| aldosterone production after short-term culture of rat adrenal capsule: responsiveness to angiotensin ii, potassium and acth. | in vitro studies of aldosterone production have traditionally used freshly isolated adrenal glomerulosa tissue. in the present study we examined the effects of short-term culture of rat adrenal capsule on its secretory capacity by measuring both basal and stimulated aldosterone production. capsules were maintained in culture for 24 h, and then responses to administered angiotensin ii (1 x 10(-7) m), potassium (an increase of 2mm) and acth (1 x 10(-8) m) were determined during perifusion. results ... | 1987 | 3035282 |
| estradiol-binding proteins from mycelial and yeast-form cultures of paracoccidioides brasiliensis. | paracoccidioides brasiliensis, the etiologic agent of paracoccidioidomycosis, causes disease much more frequently in men than it does in women, suggesting that the hormonal milieu of the host might influence p. brasiliensis pathogenicity. we recently demonstrated that cytosol from yeast cultures of p. brasiliensis contains a high-affinity, low-capacity, tritiated 17 beta-estradiol [( 3h]estradiol)-binding protein. estradiol and, to a lesser degree, diethylstilbestrol (des), inhibited the transfo ... | 1986 | 3079729 |
| anemia-inducing substance (ais) in advanced cancer: inhibitory effect of ais on the function of erythrocytes and immunocompetent cells. | the effects of anemia-inducing substance (ais), found in the plasma of tumor-bearing subjects, on red blood cells (rbc) and cellular immunity were examined. the results obtained may be summarized as follows: 1) the osmotic resistance and the deformability of rbc were decreased in patients with terminal cancer. 2) normal human rbc were made less deformable and their membrane was made fragile by treatment with cachectic plasma from those patients, and these changes in physical properties were irre ... | 1987 | 3112075 |
| applications of the isolated perfused rat liver in transplantation research. | | 1988 | 3154076 |
| biosynthesis of anthracyclinones: isolation of a new early cyclization product aklaviketone. | five metabolites were isolated from fermentations of a mutant strain s 383 of streptomyces galilaeus. components s 383-o and s 383-a were identified as known derivatives of anthraquinone and naphthacenequinone, respectively, previously isolated from cultures of other blocked mutants of s. galilaeus strains. component s 383-x was identical with 7-deoxyaklavinone. compound s 383-y (aklaviketone) was found to be a new metabolite. its chemical structure has been determined by physico-chemical method ... | 1988 | 3165374 |
| delta reinfection in human liver transplantation: report of two cases. | | 1987 | 3306705 |
| anti-candida drugs--the biochemical basis for their activity. | the past years have seen a continuous effort toward the synthesis of new antifungal agents. most of them belong to the n-substituted imidazoles and triazoles. another interesting series of antifungals are the allylamines. biochemically, both the azole derivatives and the allylamines belong to the class of ergosterol biosynthesis inhibitors and thus differ from the polyene macrolide antibiotics. indeed, it is now believed that the antifungal action of the polyenes, nystatin and amphotericin b, is ... | 1987 | 3319421 |
| microvasculature of the epididymis and ductus deferens of domestic fowls. | | 1988 | 3386094 |
| satellite cells in the regenerated and regrafted skeletal muscles of rats. | soleus (sol) muscles were grafted into extensor digitorum longus (edl) muscle beds (edl-first-graft). sixty days later, some mature edl-first-grafts were regrafted into their own beds (edl-second-grafts). fully regenerated muscle fibers and satellite cells were observed in both types of mature grafts. the ratios of satellite cell nuclei per total nuclei (myonuclei and satellite cell nuclei) were 4.81 +/- 0.47% for edl-2nd graft, 4.26 +/- 0.51% for edl-1st-graft, 4.30 +/- 0.33% for control sol, a ... | 1988 | 3396655 |
| tumor imaging by antineuroblastoma monoclonal antibody and its application to treatment. | antineuroblastoma monoclonal antibody (moab) was labeled with iodine-131 (131i) and injected into transplantable human neuroblastoma-bearing nude mice in vivo. imaging of the tumor by gamma camera was then attempted. at the fourth day after injection of the antibody, relatively heavy labeling was observed in the tumor. principal organs were removed and their 131i uptake was determined. a high radioactivity count was detected in the tumor, indicating efficacy of this antibody in tumor imaging of ... | 1988 | 3416269 |
| tumor necrosis factor is partly responsible for the differentiation of mouse myeloid leukemia cells. | when mouse myeloid leukemia m1 cells were incubated with 0.1% tns(serum containing tumor necrosis factor, tnf), they were induced to differentiate into macrophage-like cells within 14 h. the stability of the differentiation activity to heat treatment was very similar to that of the cytotoxicity of tnf for l929 cells. the differentiation activity could not be separated from the tnf activity by sequential chromatography procedures using deae-sephadex and sephacryl s-200 or by isoelectric focusing. ... | 1987 | 3440028 |
| immobilization of pig muscle enolase. studies on the activity of subunits. | the native dimeric form of enolase from pig muscle was immobilized on sepharose 4b activated with cyanogen bromide. the amount of matrix-bound enolase, its specific activity and kinetic properties depend on the extent of gel activation with cnbr. only on the sepharose activated with small quantities of cnbr the amount of protein which remained after treatment with gdn.hcl was about 50% of the initially bound enolase, indicating that the enzyme was bound covalently to the matrix through a single ... | 1987 | 3450104 |
| inhibition of endothelial regeneration by type-beta transforming growth factor from platelets. | damage to the vessel wall is a signal for endothelial migration and replication and for platelet release at the site of injury. addition of transforming growth factor-beta (tgf-beta) purified from platelets to growing aortic endothelial cells inhibited [3h]thymidine incorporation in a concentration-dependent manner. a transient inhibition of dna synthesis was also observed in response to wounding; cell migration and replication are inhibited during the first 24 hours after wounding. by 48 hours ... | 1986 | 3461562 |
| purification and kinetic characterization of a phenol-sulfating form of phenol sulfotransferase from human brain. | the identification of three forms of phenol sulfotransferase (pst) in human brain and the subsequent purification and kinetic characterization of a phenol-sulfating form of the enzyme are described. two forms of pst which were capable of conjugating phenol and a third form which sulfated dopamine were resolved from one another using deae-cellulose chromatography. one of the phenol-sulfating forms (p1-pst) was subsequently purified on affi-gel blue and sephacryl s-200, giving a final purification ... | 1986 | 3463246 |
| comparative biodistributions and rates of catabolism of radiolabelled anti-cea monoclonal antibody and control immunoglobulin in nude mice with human tumour xenografts showing specific antibody localization. | the rate of catabolism of a radiolabelled monoclonal anti-cea antibody has been compared with that of control igg1 in control nude mice and in mice with cea producing xenografts and antigen negative xenografts. the rate of catabolism of antibody, but not of igg, was increased 3-4 fold in mice with xenografts localizing the antibody, but not in mice with antigen negative tumours. there was no evidence of immune complex formation and/or clearance of antibody from the serum of xenografted mice and ... | 1987 | 3478194 |
| the effect of t cells from patients with infectious mononucleosis on cfu-cgm proliferation: a preliminary report. | the neutropenia occurring during infection is a poorly understood phenomenon. immunologically-stimulated t lymphocytes, acting upon normal bone marrow stem cells, have been etiologically implicated in several disorders. fifteen patients, ages 17 to 25 years, and diagnosed with infectious mononucleosis by positive heterophile titers, were studied. peripheral blood t lymphocytes were separated using sheep red blood cell rosetting. they were then cocultured with normal bone marrow cells, in a conce ... | 1986 | 3485024 |
| the effect of citric acid on growth of proteolytic strains of clostridium botulinum. | in strictly anaerobic conditions in a culture medium adjusted to ph 5.2 with hcl and incubated at 30 degrees c, inocula containing less than 10 vegetative bacteria of clostridium botulinum zk3 (type a) multiplied to give greater than 10(8) bacteria per ml in 3 d. growth from an inoculum of between 10 and 100 spores occurred after a delay of 10-20 weeks. citric acid concentrations of 10-50 mmol/l at ph 5.2 inhibited growth from both vegetative bacteria and spore inocula, a concentration of 50 mmo ... | 1986 | 3531139 |
| the effect of citric acid on growth of proteolytic strains of clostridium botulinum. | in strictly anaerobic conditions in a culture medium adjusted to ph 5.2 with hcl and incubated at 30 degrees c, inocula containing less than 10 vegetative bacteria of clostridium botulinum zk3 (type a) multiplied to give greater than 10(8) bacteria per ml in 3 d. growth from an inoculum of between 10 and 100 spores occurred after a delay of 10-20 weeks. citric acid concentrations of 10-50 mmol/l at ph 5.2 inhibited growth from both vegetative bacteria and spore inocula, a concentration of 50 mmo ... | 1986 | 3531139 |
| [effect of prodigiozan, levamisole and methyluracil on the course of an experimental infection and primary immune response]. | the effect of prodigiosan, levamisol and methyluracil on the process of experimental sepsis caused by proteus was studied comparatively on mice, and the primary immune response was studied on intact animals treated with prednisolone, cyclophosphan or azathioprin. it was shown that prodigiosan was a more active stimulator of antiinfectious resistance of the intact animals than levamisol or methyluracil. its effect was evident with administration before the infection, while the effect of levamisol ... | 1986 | 3532939 |
| mitotic inhibitors arrest the growth of plasmodium falciparum. | we report that the mitotic inhibitor, vinblastine (vlb), is highly toxic to the malarial parasite, plasmodium falciparum. in cultures in vitro growth is inhibited by 50% at a vlb level of about 28 nm, and totally abolished at a level of 100 nm. by tests on synchronized cultures we have found that the effect of vlb takes place at the trophozoite stage. colcemid also inhibits schizogony with somewhat different kinetics. by mutagenesis with nitrosoguanidine followed by vlb selection we have isolate ... | 1986 | 3542560 |
| determination of ivermectin in human plasma and milk by high-performance liquid chromatography with fluorescence detection. | | 1987 | 3597637 |
| assessment of the safety of chemicals administered intravenously in the neonatal rat. | a 3-day-old neonatal rat model for the safety assessment of various drugs, chemicals, and nutrients administered intravenously is described. this model was used to assess the safety of di(2-ethylhexyl) phthalate (dehp), cyclohexanone, and a 3:1 mixture of medium and long-chain triglyceride emulsions following subchronic administration using the intravenous route. the administration of dehp at dosage of 164.8 mg/kg for 18 consecutive days resulted in a small but statistically significant increase ... | 1987 | 3603403 |
| assessment of the safety of chemicals administered intravenously in the neonatal rat. | a 3-day-old neonatal rat model for the safety assessment of various drugs, chemicals, and nutrients administered intravenously is described. this model was used to assess the safety of di(2-ethylhexyl) phthalate (dehp), cyclohexanone, and a 3:1 mixture of medium and long-chain triglyceride emulsions following subchronic administration using the intravenous route. the administration of dehp at dosage of 164.8 mg/kg for 18 consecutive days resulted in a small but statistically significant increase ... | 1987 | 3603403 |
| [immunology of human seminal plasma in normal and pathologic ejaculates]. | | 1987 | 3664589 |
| disposition and metabolism of [14c]-haloperidol in rats. | absorption, distribution, excretion and metabolism of [14c]-haloperidol in rats were studied after administration of 5 mg/kg. after oral and intramuscular administration, plasma levels of [14c]-haloperidol radioactivity reached the maximum at 1 h and decreased biphasically. the biphasic elimination was also observed after intravenous administration. the area under plasma level-time curve (auc) from 0 to 24 h after intramuscular and oral administration was 110 and 87% of auc after intravenous rou ... | 1986 | 3707663 |
| kinetics of the fab fragments of digoxin antibodies and of bound digoxin in patients with severe digoxin intoxication. | 17 patients with severe digoxin intoxication were successfully treated with 320 to 480 mg fab fragments of digoxin-specific igg from sheep. the infusion period ranged between 0.5 and 7 h. serum and urine concentrations of digoxin bound to fab fragments, and in 11 cases unbound fab fragments in serum, were determined during and after the infusion. the renal clearance of bound digoxin and therefore of the antibody was 13.6 ml/min. the median extrarenal clearance of the fab fragments was 10.9 ml/mi ... | 1986 | 3758140 |
| ethanol-induced genotoxicity. | unrelated, nondenatured, ethanol preparations, derived synthetically or by fermentation, were found to induce qualitatively similar concentration-dependent toxic and genotoxic effects as measured by rk mutatest. in this system ethanol was found genotoxic above a threshold concentration of 18-19% (v/v) when rk+ selector cells were transiently exposed for 10 min before selection for rk- survivors at 42 degrees c. | 1985 | 3889601 |
| effect of chronic cigarette smoke exposure on pulmonary vasomotion in beagle dogs. | to study the effect of chronic cigarette smoke exposure on the resistive properties of the pulmonary vasculature, left lower lobes from 12 control beagles and 6 beagles who had smoked cigarettes (50 cigarettes/wk for 40 wk) were perfused in situ to measure the vascular pressure-flow relationship and the resistance of the three vascular segments with the arterial and venous occlusion technique. in control subjects the vascular resistance in the arterial, middle, and venous segments was 23, 36, an ... | 1985 | 3908439 |
| [toxicological characteristics of halomethanes--dichlorobromomethane and dibromochloromethane formed during water chlorination]. | | 1985 | 4007549 |
| [nutrient medium for the isolation and cultivation of pneumococcus]. | a culture medium for the isolation and cultivation of pneumococci, produced in a solid or liquid form and based on raw material unsuitable for use as foodstuff (human placenta), has been developed. the amino acid composition of the medium has been studied. the medium has been found to contain 19 amino acids, to be free from ballast serum proteins and blood, and to ensure the good growth of pneumococci isolated from pathological material, the formation of the normal capsule, as well as active bio ... | 1985 | 4060949 |
| neutral c19-steroids and steroid sulfates in human pregnancy. 3. dehydroepiandrosterone sulfate, 16-alpha-hydroxydehydroepiandrosterone, and 16-alpha-hydrosydehydroepiandrosterone sulfate in cord blood and blood of pregnant women with and without treatment with corticoids. | | 1966 | 4227249 |
| [the effect of various gamma aminobutyric acid doses on the total and individual phospholipid levels in whole blood entering and leaving the brain]. | | 1968 | 4300822 |
| the action of some anticonvulsant drugs on cobalt-induced epilepsy and on the bemegride threshold in alert cats. | | 1972 | 4626570 |
| surface antigen(s) common to human astrocytoma cells. | | 1974 | 4859513 |
| a volumetric assessment of pollen levels in the air of ann arbor, michigan. | | 2005 | 1196148 |
| [primary transport of acute patients. optimal use of rescue resources exemplified by the canton of graubünden]. | | 2011 | 3927607 |
| inducibility of metallothionein biosynthesis in cultured normal and menkes kinky hair disease fibroblasts: effects of copper and cadmium. | metallothionein biosynthesis is not induced by extracellular copper in menkes kinky hair disease (mkhd) or in normal cultured fibroblasts under the conditions of these experiments. in the presence of copper, mkhd fibroblasts also incorporated less cysteine than did normal fibroblasts. extracellular cadmium greatly enhanced the uptake of cysteine in both normal and mkhd cultures. by the technique of polyacrylamide gel electrophoresis, it was demonstrated that metallothionein is induced by cadmium ... | 2004 | 471576 |
| carbohydrate specificity of the receptor sites of mistletoe toxic lectin-i. | the carbohydrate specificity of mistletoe toxic lectin-i (ml-i) was studied by haemagglutination-inhibition assay. the results indicated that ml-i has a broad range of affinity for gal alpha,beta linked sequences. the galabiose (e, gal alpha 1----4gal) sequence, a receptor of the uropathogenic e. coli ligand, was one of the best disaccharide inhibitors tested. the lectin also exhibits affinity for lac(gal beta 1----4glc), t(gal beta 1----3galnac), i/ii(gal beta 1----3/4glcnac) and b(gal alpha 1- ... | 2006 | 1525184 |
| sex ratio of the mutation frequencies in haemophilia a: estimation and meta-analysis. | a hereditary disease with excess mortality such as haemophilia is maintained in the population by the occurrence of new cases, i.e. mutations. in haemophilia, mutations may arise in female or male ancestors of a 'new' patient. the ratio of the mutation frequencies in males over females determines the prior risk of carriership of the mother of an isolated patient. an estimate of this prior risk is required for the application of bayes' theorem to probability calculations in carriership testing. w ... | 2007 | 2148300 |
| [single photon emission computed tomography by using n-isopropyl-p-[123i]-iodoamphetamine and 99mtc-hexamethyl propyleneamine oxime in a patient with herpes simplex encephalitis]. | single photon emission computed tomographies (spects) by using n-isopropyl-p-[123i-imp]-iodo-amphetamine (123i-imp) and 99mtc-hexamethyl propyleneamine oxime (99mtc-hm-pao) were serially performed in a 70 yrs. old male with herpes simplex encephalitis (hse), and the chronological changes of accumulations were studied. accumulations of both 123i-imp and 99mtc-hm-pao increased initially, and then decreased with the stage of hse being advanced. the sequential appearance of the lesion in hse with 12 ... | 2009 | 2786584 |
| reversible treatment-related leukoencephalopathy. | we present two children with acute lymphocytic leukemia who developed leukoencephalopathy following administration of a combination of intravenous ara = c and methotrexate during the consolidation phase of chemotherapy. cranial magnetic resonance imaging showed widespread, abnormally high signal intensity in the deep white matter in both patients, though one patient had normal cranial computed tomographic scan. treatment was modified, symptoms resolved in 1 to 2 weeks, and the white-matter chang ... | 2009 | 2768785 |
| treating erythema chronicum migrans of lyme disease. | the efficacy of antibiotic treatment of 117 patients with erythema chronicum migrans of lyme disease was evaluated in terms of the necessity for retreatment and the prevention of the late manifestations of lyme disease. fifty-six patients with a minor form of the illness did not require retreatment and did not develop late manifestations following antibiotic treatment. three pregnant patients were included in this group. fourteen of sixty-one patients with a major form of the illness required re ... | 2011 | 3093544 |
| [a case of venous air embolism during neurosurgery in the sitting position--the effect of superimposed hfjv on the postoperative pulmonary edema]. | | 2013 | 3682177 |
| [clinico-morphological signs of different forms of destructive pancreatitis]. | clinicomorphological comparisons in 434 cases of destructive pancreatitis showed that macroscopic signs of destruction develop in the first 12 hours from the onset of the attack. the elaborated criteria make it possible to evaluate the main morphological components of destructive pancreatitis--pancreonecrosis proper, parapancreatitis, peritonitis, and "polyvisceritis" and to use therapeutic measures on an individual basis. | 2006 | 1779556 |
| [a case of recurrent circinate erythematous psoriasis (lapière)]. | the authors report a case of infantile recurrent circinate erythematous psoriasis, as described by lapière, in a nine year old child. particular features of the case are the relative rarity of the disease that shows a benign chronic recurrent course. | 2008 | 2289816 |
| [percutaneous transluminal angioplasty for subclavian-steal syndrome]. | | 2010 | 2962914 |
| plasma camp and renin in diabetics during insulin induced hypoglycemia. | | 2002 | 187538 |
| [microscopic aspects of dental dysplasias. histological study]. | | 2003 | 151304 |
| failure of chronic glutathione elevation to reduce cytotoxicity produced by exposure to cis-diamminedichloroplatinum(ii), ionizing radiation, or hyperthermia. | chinese hamster ovary (cho) cells cultured in vitro were continuously exposed to increasing concentrations of diethylmaleate (dem). chronic exposure of these cells (designated cho/dem) to 80 microm diethylmaleate resulted in an increase in cystine transport, a decrease in glutathione inhibition of the enzyme gamma-glutamylcysteine synthetase, elevation of intracellular glutathione levels to 4.3 times control, and elevation of glutathione-s-transferase activity by 6.6 times. yet, cho/dem and cont ... | 2007 | 1974822 |
| imaging of the temporomandibular joint in juvenile rheumatoid arthritis. | | 2007 | 1932822 |
| 31p-nmr study on intracellular energy transport in muscle. | | 2009 | 2798486 |
| 31p-nmr study on intracellular energy transport in muscle. | | 2009 | 2798486 |
| hla in allergic twins. | interest in the study and determination of the influence of a genetic factor in the etiology of bronchial asthma was initiated by cook. this is a study of 13 pairs of twins that were seen in our department presenting some kind of allergic illness. each pair of twins underwent a complete clinical history and physical examination, routine laboratory analysis and radiography. in addition, they were also tested for the following: skin test, serum immunoglobulins, total ige, histamine release test, h ... | 2014 | 3890501 |
| nuclear-powered pacemakers. | | 2001 | 95305 |
| sex education for adolescents in israel. | | 2002 | 134979 |
| [anthropological studies on the cossacks in bulgaria]. | | 2002 | 126579 |
| [intensive monitoring of the fetus during labor. results of experience over a 4-year period (1974-77) at the l. mangiagalli clinic]. | | 2003 | 262120 |
| [repair of huge hernia in scar]. | | 2004 | 535813 |
| [considerations on surgical treatment of giant-cell tumors of bones]. | | 2005 | 1251627 |
| whole-body gallium 67 scans. role in diagnosis of sarcoidosis. | early studies of 67gallium (67ga) scanning in sarcoidosis focused on the lungs as a measure of disease activity, likelihood of progression, and the advisability of corticosteroid therapy. the predictive value of pulmonary uptake proved to be limited, but there has been renewed interest in 67ga scanning as a diagnostic aid with special attention to characteristic extrapulmonary uptake patterns. review of whole-body 67ga scans in 172 patients with sarcoidosis, 21 with lymphoma, and 51 with other d ... | 2005 | 1952451 |