| pressure relaxation studies of isomerisations of horse liver alcohol dehydrogenase linked to nad+ binding. | | 1977 | 22461 |
| high densities of benzodiazepine receptors in human cortical areas. | | 1977 | 22814 |
| change in the protein components of milk during the preparation of a sour milk product with an increased biological value and biolact. | | 1978 | 27029 |
| [a case of richner-hanhart syndrome (tyrosinosis with ocular, cutaneous and mental manifestations]. | a case of richner-hanhart syndrom with tyrosinemia is being reported. the diagnosis was suggested from clinical manifestations of this syndrom : superficial opacities of the cornea in an infant preceeding hyperkeratosis of the palms and soles and mild mental retardation. it has been confirmed by the high levels of blood tyrosine. the introduction of a diet low in tyrosine and alanine has lead to a rapid improvement and finally a complete cure of the ophthalmological and dermatological symptoms. ... | 1979 | 34642 |
| selective vital staining of companion cells of potato tuber and parsnip root with neutral red. | when staining the internal phloem region of a potato tuber with the vital stain neutral red, it was observed that files of elongated cells of narrow diameter were heavily stained and were easily distinguishable from the more isodiametric parenchyma cells, many of which did not stain with neutral red. the elongated cells were identified as companion cells by locating the adjacent sieve-tube members through counterstaining with aniline blue and reviewing under violet light. of a number of other pl ... | 1979 | 91243 |
| the pharmacodynamics of 4-(p-chlorophenylthio)butanol (w-2719) in humans. | 4-(p-chlorophenylthio)butanol (w-2719) is absorbed, metabolized and excreted when administered orally to human volunteers. the butyrate (w-2718) and the acetate (w-2683) metabolites were found in plasma with w-2683 being the major biotransformation product and detectable seven days after administration with an apparent half-life of 33.2 h. p-chlorothiophenol appeared to be the major biotransformation product in urine and was detectable through day 6. as in plasma, the other major biotransformati ... | 1979 | 94548 |
| [leg ulcer caused by a monkey's bite]. | 35 days following a monkey's bite, the ulcer observed showed total necrosis associated with spotted zones of necrosis due to the deep penetration of the animal's teeth. it was treated like a regular ulcer and healed within seven weeks without complications. one should keep in mind that such ulcers involve infectious episodes due to the transmission of a pathogenic human-type flora through a septic orodental milieu: pathogenic cocci; pasteurella, shigella, salmonella; polio viruses or microbial a ... | 1978 | 99755 |
| effects of protein deficiency and food restriction during gestation in rats on maternal and fetal plasma and pituitary thyrotropin levels. | the effects of protein deficiency and food restriction during pregnancy on maternal and fetal plasma and pituitary thyrotropin (tsh) levels were investigated on day 20 of gestation. the same parameters were also determined following administration of exogenous thyrotropin-releasing hormone (trh). maternal plasma and pituitary basal tsh concentrations were significantly elevated in protein deficiency. trh injection to protein-deficient dams caused a marked reduction in pituitary tsh concentration ... | 1979 | 106341 |
| the role of pretransplant blood transfusions. | | 1979 | 109960 |
| what temperature is lethal for cells? | | 1979 | 110858 |
| enhancement of self-stimulation behavior in rats and monkeys after chronic neuroleptic treatment: evidence for mesolimbic supersensitivity. | the effect of chronic neuroleptic drug treatment on self-stimulation of the mesolimbic dopamine system was tested. rats with electrodes implanted into the ventral tegmental nucleus (a10 cell body area) were treated with haloperidol for three weeks. afterwards, the rats showed a 35% increase in self-stimulation rate, as compared to pre-drug control rates. this increase persisted for three weeks after drug withdrawal before returning to baseline rates. rats treated for three weeks with the atypica ... | 1979 | 114275 |
| muscle spindles in the human anterior digastric muscle. | the occurrence of muscle spindles in the anterior digastric muscle in man was investigated and the fibre calibre spectrum of the corresponding nerve was determined. after removal at autopsy from five individuals of both sexes (aged 23--73), the muscles were stained with weigert's iron hematoxylin-van gieson stain and the nerves according to the alzheimer - mann - häggqvist method. altogether 12 spindles were found in five out of ten muscles. only muscles from one individual were devoid of spindl ... | 1979 | 162026 |
| [encephalitis (predilectiveness and "slow" infections)]. | chronic progressive forms of encephalitis (epidemic economo, tick-borne) are considered from the concept of "slow infections" where the virus following the acute phase of the disease, in the latent state during many years, is persistent in the human organism. the author attributes herpetic encephalitis to this group of disorders. unlike the slow, gradually developing forms of encephalitis and diseases with a protracted incubational period, herpetical encephalitis develops acutely and may be allo ... | 1976 | 186989 |
| soluble cyclic amp-dependent protein kinases: review of the enzyme isolated from bovine cardiac muscle. | | 1977 | 193671 |
| [histochemical characteristics of the myocardium in acute coronary insufficiency]. | | 1979 | 425460 |
| sugar absorption by foetal and neonatal rat intestine in vitro. | 1. sugar absorption by foetal and neonatal rat intestine has been examined using an in vitro accumulation technique. 2. the capacity for active sugar absorption is present in the rat intestine by the 17th day of gestation. considerable variation in uptake occurs during the first month post partum; the greatest uptake place during the first week. 3. the absorption of sugars by the developing gut resembles in several respects that by the mature intestine. however, the adult pattern of functional l ... | 1975 | 1151786 |
| assignment of three human gene loci to regions of chromsome 2. | | 1975 | 1192813 |
| [histochemical tracing of the iron in the body of piglets injected with an iron-dextran preparation]. | a comparative study was carried out with thirteen pigs, aged 1 to 3 days, to follow up the resorption and distribution of the bulgarian iron-dextran preparations ferdex-100, dextrofer-75, a-100, and miofer-100 in the body. histochemically, an activation of the reticulo-endothelial system was established. most macrophages that had phagocytised iron were established in the regional lymph nodes, followed by the liver, kidneys, marrow, while in the spleen their count was negligible. using the histoc ... | 1975 | 1198919 |
| the field adaptation of the human rod visual system. | 1. incremental thresholds were measured in a retinal region 12 deg temporal from the fovea with a target of 200 ms in duration and 6 deg in diameter superimposed on background fields of various intensities and wavelengths. measurements were made under rod-isolation conditions in five normal observers and in a typical, complete achromat observer who had no cone function. 2. the rise in threshold with background intensity changes with background wavelength in the normal trichromat observers. on 45 ... | 1992 | 1501137 |
| nucleotide binding and gtp hydrolysis by elongation factor tu from thermus thermophilus as monitored by proton nmr. | proton nmr experiments of the gtp/gdp-binding protein ef-tu from the extremely thermophilic bacterium thermus thermophilus hb8 in h2o have been performed paying special attention to the resonances in the downfield region (below 10 ppm). most of these downfield signals are due to hydrogen bonds formed between the protein and the bound nucleotide. however, three downfield resonances appear even in the nucleotide-free ef-tu. the middle and c-terminal domain (domain ii/iii) of ef-tu lacking the gtp/ ... | 1992 | 1550822 |
| [the mechanism of the pineal gland in inhibiting sexual receptivity of female rats: (ii) does it concern progesterone?]. | the present study was designed to find the role of progesterone in modulating the effect of pineal gland upon reproductive behavior in the female rat. monosodium l-glutamate (msg) was used as a neurotoxin to induce hypogonadal function. in the first part of the experiment, rats were divided into four groups: (1) normal, (2) pinealectomized (px), (3) msg-treated (msg), and (4) pinealectomized msg-treated (px-msg), as immature rats became mature, the iec (incidence of estrous cycle) in each group ... | 1992 | 1578519 |
| [international control of the quality of microscopic-numerical analysis of the levels of man-made mineral fibers (mmmf) in the air of the work area]. | in the years 1986-1990 the institute of occupational medicine in lodz (department of aerosols) participated in seven exchanges of preparations within the who/euro mmmf reference scheme programme. the number of persons analysing the preparations increased from three, during the first exchange, to seven in the sixth. markings in the 1st and 3rd exchange constituted two thirds of the reference markings. in the 2nd, 5th and 7th exchange the markings were similar, and in the 6th exchange they were lo ... | 1992 | 1635445 |
| epidermal growth factor exerts neuronotrophic effects on dopaminergic and gabaergic cns neurons: comparison with basic fibroblast growth factor. | basic fibroblast growth factor (bfgf) and epidermal growth factor (egf) have been described to exert neuronotrophic effects on central nervous system neurons in culture. to study the selectivity of trophic actions of these growth factors, neurotransmitter-identified populations of embryonic rat mesencephalon were used. at 20 days in vitro, egf (3 ng/ml) promoted survival and neurite outgrowth from these neurons. the neuritogenic effect of bfgf (3 ng/ml) was, however, more robust. quantitative an ... | 1991 | 1800771 |
| hydrogen peroxide as a mediator of dopac-induced effects on melanoma cells. | dopac increases tyrosinase activity and exerts cytotoxic effects in cultures of human melanoma cells. the possible role of hydrogen peroxide in these actions was examined. catalase (100 micrograms/ml) completely reversed the cytotoxic action of 0.3 mm dopac and reduced its tyrosinase-stimulating effect by approximately one half. the results show that extracellular hydrogen peroxide is a mediator of both the tyrosinase-stimulating and cytotoxic actions of dopac. analysis of the degradation produc ... | 1991 | 1899444 |
| effects of ethanol and hepatic vitamin a on the proliferation of lipocytes in regenerating rat liver. | the effects of ethanol and hepatic vitamin a on lipocyte proliferation were studied in regenerating rat livers. positive identification of proliferating lipocytes was achieved by a double immunostaining sequence for cytoplasmic desmin and bromodeoxyuridine-labelled nuclei. ethanol administration caused a 76 and 36% reduction in labelling indices of lipocytes 2 and 3 days after hepatectomy, respectively, thereby delaying the onset of the proliferative peak of lipocytes by 1 day compared to the co ... | 1991 | 1940265 |
| major salivary gland lymphoepithelial lesions and the acquired immunodeficiency syndrome. | presently, there is no consensus regarding the most appropriate diagnostic and therapeutic approach to patients with human immunodeficiency virus (hiv)-associated lymphoepithelial lesions of the major salivary glands. a retrospective review of 60 consecutive patients with lymphoepithelial lesions is presented. thirty-eight cases were associated with hiv infection. lesions associated with hiv infection were usually bilateral, multiple, cystic, and associated with lymphadenopathy. in contrast, in ... | 1991 | 1951883 |
| effect of 21-aminosteroid u-74006f on lipid peroxidation in subarachnoid clot. | the present study was undertaken to investigate the effect of u-74006f on malondialdehyde (a by-product of lipid peroxidation) in subarachnoid clot. eighteen cynomolgus monkeys were divided into three groups of six each. there were two u-74006f-treated groups, receiving doses of 0.3 or 1.0 mg/kg, and a placebo-treated group. each monkey underwent baseline cerebral angiography followed by right-sided craniectomy and placement of subarachnoid clot around the middle cerebral artery (mca). treatment ... | 1991 | 1993911 |
| serum copper, zinc, calcium and phosphorus concentrations of calves stressed by bovine respiratory disease and infectious bovine rhinotracheitis. | the relationship between serum minerals and stress and(or) disease has not been fully evaluated in beef cattle. two trials were conducted to determine the changes in serum cu and zn during market-transit stress and(or) disease. two additional trials were conducted to determine the changes in serum cu and zn after inoculation with infectious bovine rhinotracheitis virus (ibrv), with one of the trials determining the changes in serum ca and p. trials 1 (n = 80) and 2 (n = 100) utilized calves that ... | 1990 | 2211419 |
| [mechanisms of thrombin-induced plasminogen activator release]. | the protein kinase c inhibitor h7 (10(-5) mol/l) is able to inhibit the thrombin-induced t-pa release in the isolated perfused pig ear. the thrombin-induced t-pa release can be blocked by increasing the intracellular c-amp via either the activation of adenylate cyclase by means of forskolin, or the inhibition of the phosphodiesterase by means of motapizone or milrinone. protein kinase c is assumed to be involved in the process of thrombin-induced t-pa release. | 1989 | 2483708 |
| two distinct quisqualate receptors regulate ca2+ homeostasis in hippocampal neurons in vitro. | addition of quisqualate to mouse hippocampal neurons in vitro elicited two types of changes in [ca2+]i as assessed by fura-2-based microfluorimetry. the first was a transient spike or group of oscillations and the second was a long lasting "plateau" response. the long-lasting response was abolished on removal of either ca2+ or na+ from the external medium or by blocking voltage-sensitive ca2+ channels. furthermore, the novel glutamate antagonist 6-nitro-7-cyano-quinoxaline-2,3-dione was a compet ... | 1989 | 2566904 |
| identification of phenolyl cobamide from the homoacetogenic bacterium sporomusa ovata. | phenolyl cobamide was isolated from cyanide extractions of the anaerobic eubacterium sporomusa ovata. the proposed corrinoid structure [co alpha,co beta-(monocyano,monoaquo)-phenolyl cobamide] has been deduced from 1h nmr, fast-atom-bombardment mass spectroscopy and ultraviolet/visible spectroscopy data. the complete corrinoid resembled p-cresolyl cobamide [co alpha,co beta-(monocyano,monoaquo)-p-cresolyl cobamide], which recently has been obtained from cyanide extractions of the same bacterium. ... | 1989 | 2606109 |
| effect of ok-432 on the lymphnode metastasis of mca-sarcoma cell lines: a new therapeutic approach. | the two unique highly metastatic mca-sarcoma cell lines have been established by the present authors. the inoculation of 1153ln, one of the cell lines, either into footpad or subcutaneously on the back of syngeneic mice resulted in the development of metastasis exclusively in almost all lymphnodes of the body. we evaluated the therapeutic effect of a streptococcal preparation, ok-432, on the lymphnode metastasis. two ke per mouse of ok-432 were injected intratumorally (it) at 4, 7 or 10 days aft ... | 1989 | 2637250 |
| effects of trypanocidal drugs on protein biosynthesis in vitro and in vivo by trypanosoma cruzi. | nifurtimox (nf) and benznidazole (bz), drugs used in the treatment of chagas' disease, did not inhibit protein biosynthesis in in vitro homologous cell-free systems isolated from trypanosoma cruzi and crithidia fasciculata; nevertheless, their addition to growing cultures caused polyribosomal depolymerization. on the other hand, berenil, antrycide and suramin, used against african trypanosomiasis, inhibited protein biosynthesis in vitro but did not affect ribosomal distribution, probably due to ... | 1989 | 2673249 |
| inhibition of endopeptidase 24.15 slows the in vivo degradation of luteinizing hormone-releasing hormone. | endopeptidase (ep) 24.15 cleaves the tyr5-gly6 bond of luteinizing hormone-releasing hormone (lhrh) (pglu-his-trp-ser-tyr-gly-leu-arg-pro-gly-nh2), and is the primary lhrh degrading enzyme in pituitary and hypothalamic membrane preparations. potent and specific inhibitors were used to identify the enzymes involved in the in vivo degradation of lhrh. after i.c.v. administration of lhrh, only about 1% of the peptide was recovered from brain after 1 hr. concurrent administration of lhrh and n-[1-(r ... | 1989 | 2681686 |
| differential inhibition by ergonovine of norepinephrine release in the coronary artery and saphenous vein of the dog. | experiments were performed to determine the effect of ergonovine on adrenergic neurotransmission in the blood vessel wall. strips of canine left circumflex coronary arteries and saphenous veins were incubated with [3h]norepinephrine and suspended for superfusion. ergonovine (10(-6) m) decreased the overflow of [3h] norepinephrine to a modest degree in the coronary artery, whereas a profound inhibition of overflow was observed in the saphenous vein. methiothepin, but not rauwolscine, reversed the ... | 1989 | 2709336 |
| 18-cycloalkyl analogues of enisoprost. | by use of standard cuprate methodology, a series of 18-cycloalkyl analogues of enisoprost was prepared in an effort to impede omega chain metabolism and prolong duration of gastric antisecretory activity. an initial product of omega chain oxidation, the c-20 hydroxy analogue, was also synthesized for pharmacological comparison. the cyclopropyl, cyclobutyl, and cyclopentyl analogues were approximately one-fourth as potent as enisoprost in inhibiting gastric acid secretion, while the cyclohexyl an ... | 1989 | 2709370 |
| in-vitro biotransformation of 3-nitropropanol (miserotoxin aglycone) by horse liver alcohol dehydrogenase. | the oxidation of 3-nitropropanol (npoh) by equine alcohol dehydrogenase (adh) was examined by hplc. the intermediate product, 3-nitropropanal (npal), was synthesized and it was also trapped in the reaction mixture as the semicarbazone. at neutral ph, npal spontaneously decomposed to nitrite and acrolein but in the presence of adh, npal was partially oxidized to 3-nitropropionic acid (npa). hplc conditions are described which simultaneously resolve the components of the reaction mixtures. however ... | 1989 | 2741179 |
| toxicity and therapeutic efficacy of high-dose interleukin 2. in vivo infusion of antibody to nk-1.1 attenuates toxicity without compromising efficacy against murine leukemia. | in the current study we used the therapy of established murine leukemia to identify the lymphocyte subsets responsible for toxicity and for therapeutic efficacy of high-dose il-2. initial results confirmed that high-dose il-2 induces marked proliferation of a variety of host cells, including nk cells, lyt-2+ t cells, l3t4+ t cells, and b cells. infusion of antibody to nk-1.1 depleted nk-1.1+ cells in vivo and greatly reduced the toxicity of il-2, but did not decrease therapeutic efficacy. by mar ... | 1989 | 2783332 |
| structural and functional studies of the early t lymphocyte activation 1 (eta-1) gene. definition of a novel t cell-dependent response associated with genetic resistance to bacterial infection. | we describe a murine cdna, designated early t lymphocyte activation 1 (eta-1) which is abundantly expressed after activation of t cells. eta-1 encodes a highly acidic secreted product having structural features of proteins that bind to cellular adhesion receptors. the eta-1 gene maps to a locus on murine chromosome 5 termed ric that confers resistance to infection by rickettsia tsutsugamushi (rt), an obligate intracellular bacterium that is the etiological agent for human scrub typhus. with one ... | 1989 | 2787378 |
| [yearly dynamics of arylsulfatase activity in the myocardium in intact rabbits]. | | 1989 | 2804317 |
| [yearly dynamics of arylsulfatase activity in the myocardium in intact rabbits]. | | 1989 | 2804317 |
| [studies on tissue distribution of unusual estrogen-binding protein in rats with the help of immunoblotting]. | tissue distribution in male and female rats of unusual immunoreactive material specific for the hepatic estrogen-binding protein (uebp) was studied by means of immunoblotting analysis. from 28 organs and tissues studied only the liver of animals of both sexes was found to contain polypeptide with mr, close to mr of purified uebp (approximately 31,000), which reacts with anti-uebp specific antiserum. detection of the immunoreactive material in female liver, which does not contain any hormone-bind ... | 1989 | 2804329 |
| unusual presentation of cat scratch disease in a patient positive for antibody to the human immunodeficiency virus. | | 1989 | 2814165 |
| unusual presentation of cat scratch disease in a patient positive for antibody to the human immunodeficiency virus. | | 1989 | 2814165 |
| effects of pertussis toxin on growth factor-stimulated inositol phosphate formation and dna synthesis in swiss 3t3 cells. | we have compared the effects of pretreatment of swiss 3t3 cell with pertussis toxin on the stimulation of dna synthesis and phosphoinositide hydrolysis in response to a wide variety of mitogens. the toxin substantially inhibited the stimulation of dna synthesis in response to a phorbol ester or various peptide and polypeptide growth factors irrespective of their ability to activate phosphoinositidase c. production of inositol phosphates in response to platelet-derived growth factor, fibroblast g ... | 1988 | 2833233 |
| conversion of cua to a type ii copper in cytochrome c oxidase. | when cytochrome c oxidase is incubated at 43 degrees c for approximately 75 min in a solution containing the zwitterionic detergent sulfobetaine 12, the cua site is converted into a type ii copper as judged by changes in the 830-nm absorption band and the epr spectrum of the enzyme. sds-page and sucrose gradient ultracentrifugation indicate concomitant loss of subunit iii and monomerization of the enzyme during the heat treatment. comparison of the optical and resonance raman spectra of the heat ... | 1988 | 2852958 |
| effect of diffusional barriers on drug and metabolite kinetics. | previous experimental and simulation studies have alluded to the presence of a diffusional barrier for enalaprilat, the polar, dicarboxylic acid metabolite of enalapril, entering hepatocytes. the present study examined the roles of diffusional clearances of drug and metabolite on the distribution and elimination characteristics in liver. the hepatic intrinsic clearances for enalapril (26.1 ml/min) and enalaprilat (0.7 ml/min), found in a previous study, were used for simulation because, along wi ... | 1987 | 2881759 |
| antibodies to strongyloides stercoralis in healthy jamaican carriers of htlv-1. | | 1989 | 2911314 |
| idiopathic benign lichenoid keratosis on the pinna of the ear in four dogs. | histologically, multiple wart-like papules or hyperkeratotic plaques on the ear pinnae from 4 dogs were characterized as idiopathic benign lichenoid keratosis. common histologic features included a discrete lesion of irregular and papillated epidermal hyperplasia with a moderate diffuse lichenoid interface inflammatory infiltrate consisting of lymphocytes and plasma cells. there was also focal hydropic degeneration of the epidermal basal cell layer, pigmentary incontinence, and mixed orthokerato ... | 1989 | 2924581 |
| [interferon production in vitro]. | interferon production in vitro was induced by poly i: c and pha in leukocytes obtained from patients with cancer, benign diseases and control subjects. the interferon response per lymphocyte was relatively constant in all groups. however, interferon production was slightly inhibited in patients receiving cancer chemotherapy. the peak response of interferon occurred at 48 hours after the initiation of the combined culture in each specimen. from our observations, it was suggested that interferon p ... | 1987 | 2952067 |
| purification and properties of the phosphoglycerate mutase isozymes from the mouse. | the two homodimeric isozymes of phosphoglycerate mutase have been purified from murine kidney and muscle. no differences were observed in the michaelis-menten constant for the substrate 2-phospho-d-glycerate, in molecular weight, temperature and ph optima, when the purified isozymes were compared. the isozymes differ in their inhibition constants for phosphoenolpyruvate, in their michaelis constants for 3-phospho-d-glycerate and 2,3-bisphospho-d-glycerate, their thermal and ph lability and in th ... | 1985 | 2994951 |
| [cytomegaloviruses in sperm and the risk of sexual transmission]. | | 1985 | 2996789 |
| asynchronous regulation of mouse h-2d and beta-2 microglobulin rna transcripts. | the major transplantation (or h-2) antigens in the mouse are cell-surface glycoproteins composed of a heavy chain and a light chain, the beta-2 microglobulin (beta 2m). the expression of these proteins is regulated during development. embryonic cells at early stages of development do not express these proteins. on the other hand, these molecules are present on the surface of all adult somatic cells. we investigated whether the expression of both chains was coordinately regulated. using specific ... | 1985 | 2998982 |
| asynchronous regulation of mouse h-2d and beta-2 microglobulin rna transcripts. | the major transplantation (or h-2) antigens in the mouse are cell-surface glycoproteins composed of a heavy chain and a light chain, the beta-2 microglobulin (beta 2m). the expression of these proteins is regulated during development. embryonic cells at early stages of development do not express these proteins. on the other hand, these molecules are present on the surface of all adult somatic cells. we investigated whether the expression of both chains was coordinately regulated. using specific ... | 1985 | 2998982 |
| development of auditory-evoked potentials in the cat. ii. wave latencies. | brain stem and forebrain auditory-evoked potentials were studied parametrically during the first 90 postnatal days in unanesthetized kittens using tonal and click stimuli. this paper describes changes that occur in transmission time through the auditory pathway during development by analyses of the maturational time courses of latencies associated with waves of both auditory brain stem responses (abr's) and late-occurring auditory-evoked potentials (aer's), recorded subdermally from the vertex. ... | 1986 | 3007595 |
| [infantile case of herpes simplex encephalitis with spontaneous recovery]. | | 1986 | 3015169 |
| [infantile case of herpes simplex encephalitis with spontaneous recovery]. | | 1986 | 3015169 |
| depolymerization of solubilized gastric (h+ + k+)-atpase by n-octylglucoside or cholate. | we have previously shown that an active (h+ + k+)-atpase can be extracted from gastric apical membranes using n-octylglucoside (soumarmon, a., grelac, f. and lewin, m.j.m. (1983) biochim. biophys. acta 732, 579-585). this extract contained an holomeric enzyme of 390-420 kda and contained 68% of the k+-stimulated atpase specific activity originally present. we demonstrate here that inactivation, induced during a more classically designed protocol, is associated with the appearance of smaller, pol ... | 1986 | 3015211 |
| depolymerization of solubilized gastric (h+ + k+)-atpase by n-octylglucoside or cholate. | we have previously shown that an active (h+ + k+)-atpase can be extracted from gastric apical membranes using n-octylglucoside (soumarmon, a., grelac, f. and lewin, m.j.m. (1983) biochim. biophys. acta 732, 579-585). this extract contained an holomeric enzyme of 390-420 kda and contained 68% of the k+-stimulated atpase specific activity originally present. we demonstrate here that inactivation, induced during a more classically designed protocol, is associated with the appearance of smaller, pol ... | 1986 | 3015211 |
| b-lymphoma induction by reticuloendotheliosis virus: characterization of a mutated chicken syncytial virus provirus involved in c-myc activation. | nondefective reticuloendotheliosis virus induces chicken bursal lymphoma in a manner similar to that of avian leukosis virus. the provirus integrates in the c-myc locus and uses a promoter insertion mechanism to activate c-myc expression. we cloned a provirus involved in c-myc activation from a b lymphoma. detailed structural characterization of this clone, including sequence determination, revealed proviral insertion at 512 base pairs preceding the second c-myc exon. the provirus has a deletion ... | 1987 | 3035210 |
| diabetic embryopathy and fuel-mediated organ teratogenesis: lessons from animal models. | the growing recognition that faulty maternal metabolism during early organogenesis may be implicated in the increased incidence of birth defects in pregnancies complicated by diabetes has prompted worldwide efforts to institute improved preconceptional metabolic regulation. however, the failure to identify the periods of greatest risk for diabetic embryopathy, the mediating teratogen(s), and the underlying mechanisms have complicated attempts to establish precise therapeutic guidelines and targe ... | 1988 | 3053387 |
| cloning and sequencing the hinfi restriction and modification genes. | the hinfi restriction and modification genes were cloned on a 3.9-kb psti fragment inserted into the psti site of plasmid pbr322. both genes are confined to an internal 2.3-kb bcli-avai subfragment. this subfragment was sequenced. two large open reading frames (orf's) are present. orf1 codes for the methylase [predicted 359 amino acids (aa)] and orf2 codes for the endonuclease (predicted 262 or 272 aa). | 1988 | 3063606 |
| cloning and sequencing the hinfi restriction and modification genes. | the hinfi restriction and modification genes were cloned on a 3.9-kb psti fragment inserted into the psti site of plasmid pbr322. both genes are confined to an internal 2.3-kb bcli-avai subfragment. this subfragment was sequenced. two large open reading frames (orf's) are present. orf1 codes for the methylase [predicted 359 amino acids (aa)] and orf2 codes for the endonuclease (predicted 262 or 272 aa). | 1988 | 3063606 |
| [ultrastructure of the surface sculpture of the nematodes thelazia gulosa and thelazia rhodesi]. | an electron-microscope study of the cuticle of two thelazia species revealed very interesting architectonics of the sculpture of the body surface of these nematodes. the surface layer of the cuticle is crosswise and lengthwise ridged. while certain uniformity of the shape and distribution of the surface structures can be seen in thelazia gulosa, the case is contrary in thelazia rhodesi. the ridges and projections of the cuticle have different structure and incidence in particular thirds of the n ... | 1987 | 3103309 |
| [subrenal capsule (src) assay of human tumor xenografts in normal mice]. | | 1987 | 3127022 |
| [dynamic changes of structures of human tongue squamous cell carcinoma cells (tca 8113) after hyperthermia]. | | 1988 | 3150335 |
| [early diagnosis of liver fluke infection in sheep]. | the sera and livers of slaughtered lambs were studied in october 1987 in order to achieve a suitable interpretation of the indirect haemagglutination assay (iha) in the diagnosis of fascioliasis in flocks. in view of these studies, it is concluded that the iha is useful in the early diagnosis of liver fluke infection in lambs. it is recommended to take samples from at least five lambs in each flock. an interpretation model is provided. | 1988 | 3175996 |
| [the role of the ventral medulla oblongata in the vasopressor reaction induced by habenular nucleus stimulation]. | | 1988 | 3187560 |
| hypophysectomy and adrenalectomy decrease ca2+-induced swelling of rat liver mitochondria. | hypophysectomized rats showed significant modifications in ca2+-induced swelling and mgatp-induced contraction of liver mitochondria. two-three months after operation, maximal swelling (ms), rate of swelling (vs), maximal contraction (mc) and rate of contraction (vc) were decreased by 77 (ms), 83 (vs), 79 (mc) and 62 (vc) % (in all cases p less than 0.05 as compared with normal rat mitochondria). treatment of hypophysectomized rats with bovine pituitary extract, for two weeks, counteracted the e ... | 1988 | 3190710 |
| encapsulated thymic epithelial cells as a potential treatment for immunodeficiencies. | the epithelial cells of the thymus produce hormones that have been implicated in the maturation of t lymphocytes. thymic epithelial cells can be encapsulated in a permselective polymer membrane that allows the passage of thymic hormones, but prevents the entry of antibodies, complement, cells, and viruses. a pure culture of thymic epithelial cells, identified as such by transmission electron microscopy and keratin staining, was obtained by low temperature organ culture of fetal mouse thymus. the ... | 1988 | 3196584 |
| isolation, characterization, and molecular cloning of cryptic plasmids isolated from edwardsiella ictaluri. | fifty-five isolates of edwardsiella ictaluri were examined for the presence of plasmid dna by a rapid alkaline extraction procedure. all 49 isolates from channel catfish and a single isolate from bengal danio carried 2 plasmids with molecular masses of approximately 3.2 and 3.7 megadaltons (mdal). five e ictaluri isolates from other fish contained 1 to 3 plasmids, which had molecular masses ranging from 2.5 to 45 mdal. the 2 plasmids (3.2 and 3.7 mdal) from the type strain of e ictaluri (atcc 33 ... | 1988 | 3247906 |
| [effect of uterotonic agents on the pathophysiology of endotoxin-induced shock]. | different uterus contracting compounds (methylergonovine, oxytocin and prostaglandin f2 alpha) were evaluated with respect to their effect on the pathophysiology of endotoxin-induced shock. we used the model developed by beller and theiss of a continuous endotoxin-infusion in female sprague-dawley rats. in each group fibrinogen, plasma hemoglobin, hematocrit and thrombocytes were measured. the body weight of the rats was determined before and after the infusions. after the end of the experiment ... | 1987 | 3300064 |
| an automatic autotransfusion system with a centrifugal pump: a hematologic evaluation in dogs. | the requirements that have to be met by an on-line autotransfusion system (ats) in case of massive blood loss are a sufficient capacity for reinfusing the shed blood, an optimal hemocompatibility, ability to prevent reinfusion of aspirated air, and ease of operation. in a previous study we tested a diaphragm pump in our pneumatically driven ats that met these requirements. in this study a centrifugal pump was used as an outflow pump in otherwise the same system. a centrifugal pump has important ... | 1988 | 3336870 |
| a cluster of three cases of aplastic anaemia in children. | during a 2-week period three unrelated children presented with severe aplastic anaemia at a general hospital serving a population of 25,000 children aged 0-15 years. the probability of this occurring by chance alone was 0.00009 (exact probability cluster analysis). serology for common viral infections including hepatitis a & b and infectious mononucleosis was negative. it was not possible to demonstrate igm antibodies to human parvovirus (hpv) by radioimmunoprecipitation or hpv virions by dna hy ... | 1988 | 3365932 |
| role of lipophorin in lipid transport to the insect egg. | lipid accounts for 40% of the dry weight of a mature manduca sexta egg. less than 1% of the total egg lipid is derived from de novo synthesis by the follicles. the remaining egg lipid originates in the fat body and is transported to the ovary by lipoproteins. vitellogenin, the major egg yolk lipoprotein, accounts for 5% of the total egg lipid. the remaining 95% lipid is attributable to the hemolymph lipophorins, adult high density lipophorin (hdlp-a) and low density lipophorin (ldlp). when hdlp- ... | 1988 | 3379043 |
| the transfer of serum igg1 antibody into the gastrointestinal tract in newborn calves. | transfer of functional blood igg1 to the gastrointestinal tract was measured in neonatal calves. radiolabelled immunoglobulin g1 (igg1) anti-dnp antibody was administered to 2 day old calves by intravenous injection. the serum clearance rate was measured and was compared to the rate of protein-bound 125i excretion in the feces over a 10 day period to determine the importance of transfer to the gastrointestinal tract as a mechanism of serum igg1 clearance. the amount of protein-bound and dnp-bind ... | 1987 | 3433671 |
| dysregulation of the immune system in obese strain chickens with hashimoto-like thyroiditis: intrinsic and extrinsic mechanisms. | | 1987 | 3497505 |
| [infestation with stomach parasites in horses in north germany]. | | 1986 | 3536405 |
| synthesis and hypotensive activity of benzopyran derivatives. | | 1987 | 3594675 |
| atrial standstill in a dog. | | 1986 | 3700208 |
| [study of local shiftings of the brain stem in increased intracranial pressure by a supratentorial balloon]. | the study of the mechanism of pressure transmission is important for the treatment of rapid deterioration of a patient's condition with increased intracranial pressure (icp) from a space taking lesion in neurosurgical practice. the aim of this experiment is to clarify the mechanism of pressure transmission during supratentorial balloon inflation, by continuously monitoring local shiftings of the brain using strain gauge sensors. mongrel dogs and macaca fuscatas were fixed in stereotaxic head fra ... | 1986 | 3718782 |
| aortic baroreceptor characteristics in dogs with chronic high output failure. | it has been shown that the arterial baroreflex is depressed in heart failure. the role of alterations in afferent discharge as a possible mechanism for this depression has not been investigated previously. single unit aortic baroreceptor activity was recorded from six normal dogs and from nine dogs, each with a chronic aorto-caval fistula (avf). at the time of the acute experiment, mean arterial blood pressure (mabp) was not significantly different in the two groups of dogs; however, pulse press ... | 1986 | 3741352 |
| anthelmintic activity of triclabendazole. | triclabendazole was tested in vitro and in vivo against a range of helminths. although in vitro activity was found against hymenolepis diminuta (0.5 microgram/ml), fasciola hepatica (2.5 micrograms/ml), taenia crassiceps and schistosoma mansoni (50 micrograms/ml), in vivo activity was only found against f. hepatica, a single oral dose of 40 mg/kg killing 99% of adult flukes in the rat. this spectrum of activity suggests a mechanism of action unlike that of other benzimidazole anthelmintics. | 1986 | 3745874 |
| pressure-pain threshold in human temporal region. evaluation of a new pressure algometer. | a hand-held pressure algometer with a pressure sensitive strain gauge at the tip was used to measure the pressure-pain threshold (ppt) in the temporal region of healthy volunteers. various sizes of circular tips and various application rates were tested before selecting an area of 0.5 cm2 and a constant application rate of 0.68 n x sec-1 for future use. a highly significant correlation was found between ppt values obtained from the two sides (of the head) (p less than 0.001) and between ppt valu ... | 1986 | 3748589 |
| membrane properties of glossopharyngeal sensory neurons in the petrosal ganglion of the cat. | the active and passive properties of petrosal ganglion sensory neurons with axons in the glossopharyngeal nerve were examined with intracellular microelectrodes in an in vitro preparation. glossopharyngeal neurons could be classified into two groups: h-cells showing an inflexion or hump on the falling phase of the spike and f-cells, generating a short action potential without a hump. most of the neurons found (85%) were h-cells. the axonal conduction velocity of both types of cells fell into the ... | 1987 | 3815100 |
| growth response of mouse lymphoma cells to low concentrations of mercuric chloride. | three growth rate experiments involving several sampling points were performed to investigate the previous finding that very low concentrations of hgcl2 inhibit the growth of murine lymphoblasts in vitro. however, results presented here do not confirm this, there being no significant differences between the three independent growth rate experiments. | 1985 | 3832669 |
| [excitability cycle of the soleus motor nucleus during synergistic conditioning in man]. | electrical stimulation of medial or lateral gastrocnemius nerve modulates the h reflex of the soleus muscle in a well defined sequence of inhibitory and facilitatory phases the amplitude of which depends on the strength of the conditioning stimulus. this method of investigation of the soleus monosynaptic reflex pathway avoids the disadvantages of homonymous conditioning. discussion of our results points to the roles of ib and renshaw cells inhibitions in the early phases of the recovery cycle, a ... | 1985 | 3834855 |
| effect of scalding on tryptophan catabolism in rats. | | 1985 | 3937685 |
| objective evaluation of fibrosis in human testicular biopsies by analysis based on optical diffractometry. | bilateral testicular biopsies were obtained from 27 patients and submitted to two different treatments for each of them: firstly, a classical fixation and colouring, permitting the histopathological diagnosis and subjective appreciation of the degree of fibrosis; secondly, a new objective technique based on optical diffractometry: this method is based on the analysis of light intensity distribution in the diffraction pattern of an original image. using two different methods of discriminant analy ... | 1986 | 3953256 |
| salmonella osteomyelitis in a rhesus monkey. | an adult male rhesus monkey (macaca mulatta) developed clinical signs of severe osteomyelitis of the left femur 42 days after onset of enteritis. salmonella sp. were cultured from feces, blood, and femoral lesions. response to antibiotic therapy was poor, and the animal was euthanized. the left femur, with pathologic fracture and involucrum, and the right femur, tibia and fibula were most severely affected. additionally hepatic microgranulomas, mild tubulointerstitial nephritis, medullary histio ... | 1986 | 3962085 |
| development and characteristics of airstepping in chronic spinal cats. | airstepping, walking-like movements of the hindlimbs, is a commonly observed behavior in chronic spinal animals when they are held vertically. the purpose of this study was to: describe the development of airstepping after spinalization and compare it to the onset of segmental reflexes, characterize the emg pattern of muscle activity during spontaneous airstepping, and examine the effects of sensory perturbation on the characteristic pattern. airstepping was analyzed during three conditions of t ... | 1985 | 3998821 |
| the influence of isolation conditions on the molecular weight of bovine alpha-crystallin. | the molecular weight of bovine alpha-crystallin, isolated at 37 degrees c, was studied and found to be about 800,000. this contrasts with the results of thomson and augusteyn (thomson, j. a., and augusteyn, r. c. (1983) exp. eye res. 37, 367-377) who isolated a species of about half this molecular weight. we show here that this form of alpha-crystallin can only be isolated under unphysiological conditions with regard to buffer ph and ionic strength. | 1985 | 4055770 |
| [a technic for the isolation of rat peritoneal mast cells. semi-quantitative cytological evaluation of their in vitro reactivity]. | | 1972 | 4114251 |
| the amino acid sequence of human myoglobin and its minor fractions. | | 1974 | 4153103 |
| [morphogenetic and biochemical criteria for the differentiation of the genera nocardia and mycobacterium]. | | 1965 | 4183822 |
| [seasonal and age-related changes of protein composition of blood serum in albino rats]. | | 1967 | 4183861 |
| [serological study on scarlet fever]. | | 1973 | 4208600 |
| [immunological reactiviy of the population and prevalence of rheumatism]. | | 1971 | 4256347 |
| characterization of adenosine triphosphatase in erythrocyte membranes of the cow. | | 1972 | 4260712 |
| [cytochrome oxidase and succinic dehydrogenase activity during the process of human fetal development]. | | 1965 | 4287102 |