| intravenous captopril treatment in patients with severe cardiac failure. | the effect of intravenous captopril was studied in 26 patients with severe chronic heart failure. fourteen patients received a 25 mg intravenous bolus dose and 12 patients were given a series of incremental intravenous doses over the range 0.3125-45 mg. after the 25 mg bolus dose there was a rapid reduction in systemic vascular resistance and systemic blood pressure. the effect was greatest five minutes after the dose when cardiac output was increased by 20%. mean right atrial pressure and pulmo ... | 2012 | 3510643 |