| acupuncture: its neurophysiological basis: an anaesthetist's foreword. | | 1978 | 29773 |
| contraceptive properties of luteinising hormone releasing hormone. | the report of dr bergquist and colleagues (aug. 4, p. 215) on the contraceptive effect of an intranasally administered analogue of luteinising hormone releasing hormone (lhrh) holds out the promise of a new approach to contraception that is safer than oral contraception or intrauterine devices. we have studied the endocrine effects of the natural peptide when administered subcutaneously in a dose of 100 mg daily to four normally ovulation women. measurements on blood-samples taken daily during ... | 1979 | 90901 |
| interaction of human polymorphonuclear leukocyte elastase with human igm in vitro production of an fabmu-like fragment. | | 1979 | 91095 |
| selective vital staining of companion cells of potato tuber and parsnip root with neutral red. | when staining the internal phloem region of a potato tuber with the vital stain neutral red, it was observed that files of elongated cells of narrow diameter were heavily stained and were easily distinguishable from the more isodiametric parenchyma cells, many of which did not stain with neutral red. the elongated cells were identified as companion cells by locating the adjacent sieve-tube members through counterstaining with aniline blue and reviewing under violet light. of a number of other pl ... | 1979 | 91243 |
| transfusion of hydroxyethylated amylopectin-protected frozen blood in man. i. plasma clearance and renal excretion of the cryoprotectant. | in man following the autologous transfusion of blood previously frozen with 14% low molecular weight-hydroxyethylated amylopectin (cryo-hes), the clearance of this material from the intravascular space was compound, and appeared to consist of exponential components. the overall half-life -- however, was 10.6 +/- 3.0 (sd) h. approximately 17% of the total infused cryo-hes was excreted in the urine 1 h postinjection, and 40% by 72 h. the erythrocyte sedimentation rate (esr) was not affected by the ... | 1979 | 91262 |
| methods for the in situ characterization of the interstitial space. | | 1979 | 91364 |
| interactions of guinea pig eye tissue to fluorescein isothiocyanate labelled homologous serum and anti-polymer sera. | | 1978 | 91473 |
| hyperbaric hyperreflexia: tendon-jerk and hoffmann reflexes in man at 43 bars. | tendon jerk (tjr) and hoffmann (h) reflexes of the soleus muscle were studied in two men during a 26-day simulated oxygenhelium dive to a maximum pressure of 43 bars. the amplitude of the tjr response was observed to increase markedly after compression and also at the end of decompression. this biphasic pattern of enhanced reflectivity was reproduced by synchronised but much smaller variations in h reflex response. the positive facilitatory effects of applying jenkdrassik's manoeuvre were reduce ... | 1979 | 91497 |
| purification of the subunit clq from the first component of equine complement. | initial separation and concentration of clq from fresh, normal equine serum was accomplished by precipitation in 0.02 m acetate buffer, ph 5.5, at 4 degrees for 24 h. the re-dissolved precipitate was clarified by centrifugation at 80,000 g for 1 h and then dialysed against tris-hcl buffer (0.05 m, ph 8.0) containing 10-3 m edta. the clarified dialysate remained biologically active at 5 degrees for at least 4 weeks. biological activity of equine clq was determined by assay of its ability to agglu ... | 1979 | 91570 |
| antibodies specific for bovine abnormal (des-gamma-carboxy-)prothrombin. | | 1979 | 91611 |
| a comparative study of the immunohistochemical localization of basic protein to myelin and oligodendrocytes in rat and chicken brain. | antisera to highly purified basic protein (bp) from rat and chicken brain were prepared and their purity and specificity demonstrated by double immunodiffusion and cross-immunoadsorption. these antisera were used for immunohistochemical localization of bp in the brains of adult and developing rat and chick. myelin basic protein was exclusively localized to myelin or the myelin forming elements of the cns. it was present in high concentrations in white matter and absent in areas free of myelin. n ... | 1979 | 91628 |
| [use of ethidium for the cytochemical study of chromatin]. | a cytochemical method of chromatin study by means of nuclear staining with ethidium (bromide) is described. dependence of stain binding by chromatin on ethidium concentration, ionic composition and buffer ph value has been analyzed. it is suggested that cells be stained in 2.10(-5) m solution of ethidium in 0.1 m tris-hcl buffer at ph 8.0 during 30 min. the fluorescence of nuclei stained with ethidium under conditions described is shown to reflect changes in physico-chemical properties of chroma ... | 1979 | 92086 |
| murine lymphocyte surface antigens. | | 1979 | 92182 |
| inhibitory effect of tricyclic antidepressant drugs on spontaneous activity of noradrenergic neurons. relation with blood and brain concentrations [proceedings]. | | 1979 | 92235 |
| immunochemical study on basement membrane (type iv) collagens. | basement membrane (type iv) collagens were extracted from a mouse tumour with acetic acid and from human placenta after limited enzymatic digestion. antisera were produced against both collagens in rabbits and guinea-pigs and examined by various assays. these antisera were found to be specific for basement membrane collagen and showed little or no cross-reactions with the interstitial collagens, types i, ii and iii or with human placenta collagen consisting of alpha a and alpha b chains. varying ... | 1979 | 92454 |
| alpha-1-foeto protein (afp) and hepatitis b surface antigen (hbsag) in various hepatic disorders. | | 1979 | 92470 |
| autoradiographic identification of acetylcholine in the rabbit retina. | rabbit retinas were studied in vitro under conditions known to maintain their physiological function. retinas incubated in the presence of [3h]choline synthesized substantial amounts of both [3h]phosphorylcholine and [3h]acetylcholine. with time, [3h]phosphorylcholine proceeded into phospholipids, primarily phosphatidylcholine. retinas pulse-labeled by a 15-min exposure to 0.3 microm [3h]choline were incubated for a subsequent hour under chase conditions designed either to retain newly synthesiz ... | 1979 | 92476 |
| the unlabeled antibody method. contrasting color staining of paired pituitary hormones without antibody removal. | | 1979 | 92498 |
| acute experimental allergic encephalomyelitis. myelin basic protein-reactive t cells in the circulation and in meningeal infiltrates. | mbp-reactive early t cells were determined simultaneously in the circulation and in inflammatory cells from the meninges of guinea pigs with acute eae. in addition, early and late t cells as well as b cells were estimated in both compartments. within the circulation, early t cells were found to decrease at the onset of clinical signs, and mbp-reactive early t cells were significantly higher than in normals. different changes were found in inflammatory cells from the meninges. in this cell popula ... | 1979 | 92528 |
| significance in neonatal myasthenia gravis of inhibitory effect of amniotic fluid on binding of antibodies to acetylcholine receptor. | the effect of amniotic fluid on the binding of anti-acetylcholine receptor (anti-achr) antibodies from myasthenia gravis (mg) patients to achr preparations was examined by radioimmunoassay using 125i-labelled alpha-bungarotoxin. human amniotic fluid from healthy women in their second trimester inhibited the in-vitro interaction between antibody and antigen. this finding suggests that during pregnancy there is a similar inhibitory effect in mg on the in-vivo binding of maternal anti-achr antibodi ... | 1979 | 92675 |
| asymmetric transcription of the globin genes by escherichia coli rna polymerase in isolated mouse foetal liver chromatin or nuclei [proceedings]. | | 1979 | 92966 |
| studies on the mechanism of vaccinal immunity to marek's disease. | | 1978 | 93038 |
| immunoperoxidase labelling of alpha 1-fetoprotein (afp) in normal and regenerating livers of a low and a high afp producing mouse strain. | | 1979 | 93094 |
| induction of ecotropic endogenous murine leukemia virus in long-term bone marrow cultures from mouse strains of varying natural leukemia incidence. | | 1979 | 93145 |
| suppression by antithyroid drugs of experimental hepatic necrosis after ethanol treatment. effect on thyroid gland or on peripheral deiodination? | | 1979 | 93320 |
| quantitation of skin bacteria: lethality of the wash solution used to remove bacteria. | a widely used technique for the quantitative removal of bacteria from the skin uses a detergent, triton x-100 (p, t-octylphenoxynonaethoxyethanol), to remove and suspend the bacteria. we determined the half-life for the survival of five common skin bacteria suspended in the solution. the shortest-lived was streptococcus pyogenes with a half-life of 0.9 hours. all of the others (propionibacterium acnes, staphylococcus epidermidis, staphylococcus aureus, and klebsiella pneumoniae) had half-lives o ... | 1979 | 93373 |
| [effects of the phospholipid environment and its composition on n-acetyl-muramyl-l-alanine amidase activity (proceedings)]. | | 1979 | 93468 |
| the detection of ia-like and drw antigens on activated t cells. | | 1979 | 93803 |
| biochemical properties of paramyxovirus duck/mississippi/75 neuraminidase. | the neuraminidase activity of two strains of duck/mississippi/75 virus:dk/mississippi/320 and dk/mississippi/334 was studied. these neuraminidases hydrolyse the alpha 2 leads to 3 and alpha 2 leads to 8 ketosidic bonds of different substrates such as fetuin, n-acetyl neuramine lactose and colominic acid, but do not hydrolyse the alpha 2 leads to 6 bonds of mucin type i and type ii. the kinetic values of the neuraminidases, michaelis constant, maximal and initial velocities and the effect of ph, ... | 1979 | 94350 |
| [study on the pathogenecity of chrysosporium species (author's transl)]. | | 1979 | 94426 |
| site dependence for topical absorption of nitroglycerin in rats. | | 1978 | 99511 |
| [comprehensive characterization of pseudomonas aeruginosa strains with particular reference to the habs and homma serological typing methods]. | | 1978 | 99734 |
| neoplastic transformation of rat mammary cells exposed to 7,12-dimethylbenz[alpha]anthracene or n-nitrosomethylurea in cell culture. | primary cultures of mammary cells from virgin lewis rats were seeded at 5 x 10(5) cells per cm2 in medium 199 supplemented with 10% fetal calf serum, insulin (5 microgram/ml), prolactin (5 microgram/ml), estradiol (5 ng/ml), progesterone (0.5 microgram/ml), and hydrocortisone (0.5 microgram/ml). on the second or third day of culture, cells were exposed to either 7,12-dimethylbenz[alpha]anthracene (0.1 microgram/ml for 24 hr) or n-nitrosomethylurea (80 microgram/ml for 2 hr). the cells were later ... | 1978 | 99742 |
| role of glucagon in the hyperglycemic response to catecholamines in fasted baboons. | the hyperglycemic activities of epinephrine (epi) and isoproterenol (iso) in baboons correlated with their ability to increase plasma glucagon (irg) levels relative to insulin (iri). epi inhibited iri release and produced greater increases in plasma glucose and irg than did iso. iso increased plasma iri levels more than irg. infusion of somatostatin blocked irg release and inhibited hyperglycemic responses to epi by approximately 50%. these findings indicate that, as in man, irg release contribu ... | 1978 | 99754 |
| adjuvant effect of a peptidoglycan attached covalently to a synthetic antigen provoking anti-phage antibodies. | the synthetic antigen denoted p2-a--l, comprising the fragment p2 of the coat protein of ms-2 coliphage attached to multichain poly-dl-alanine, served for the immunization of guinea-pigs. immunization was carried out either in phosphate buffered saline (pbs) or in freund's incomplete adjuvant (fia) in the presence or absence of a small molecular weight peptidoglycan prepared from bacillus megaterium, which was checked for its adjuvant effect. the various antisera were assessed by their capacity ... | 1978 | 101440 |
| identification of group a beta-hemolytic streptococci by the fluorescent antibody method. | | 1978 | 101905 |
| 5-nitro-2'-deoxyuridine 5'-monophosphate is a potent irreversible inhibitor of lactobacillus caesi thymidylate synthetase. | | 1978 | 103545 |
| computed tomography in a primate stroke model using selective balloon catheter arterial occlusion. | ten heparinized nonhuman primates (rhesus monkeys and papio maryumaya baboons) were subjected to temporary occlusion of an insular branch of the middle cerebral artery with a balloon catheter. an infarct was created. the lesions were monitored in vivo by computed tomography performed at intervals for 1 year. animals were sacrificed and the lesions examined histologically. the technique obviates the disadvantages of surgical reaction, intravascular thrombosis, and gross cerebral edema observed in ... | 1979 | 106076 |
| experimental dependence on barbiturates. ii. relationship between drug levels in serum and brain and the development of dependence in rats. | feeding rats on food containing phenobarbital (phb) (1 and 2 mg/g) for 13 consecutive days resulted in the inhibition of motor coordination (by rotarod test) for 7 days, followed by a gradual decrease in the inhibition. phb level in the serum reached a peak on the third day of feeding and then gradually decreased. phb level in the brain, unlike that in the serum, gradually increased up to the seventh day and then decreased until the thirteenth day of feeding. thus, alterations of the inhibited r ... | 1979 | 106421 |
| beta-galactosidase and selective neutrality. | three hypotheses to explain the amino acid composition of proteins are inconsistent (p congruent to 10(-9) with the experimental data for beta-galactosidase from escherichia coli. the exceptional length of this protein, 1021 residues, permits rigorous tests of these hypotheses without complication from statistical artifacts. either this protein is not at compositional equilibrium, which is unlikely from knowledge about other proteins, or the evolution of this protein and its coding gene have not ... | 1979 | 106468 |
| [age and season related dynamics of vitamin e levels in the serum of young cattle from birth to the age of 22 months]. | the dynamics of serum vitamin e levels in heifers was followed for 22 months. we found that calves were born with a very low, almost nil, content of this vitamin (on an average 0.029 mg%) as a result of the limited diaplacental transfer from the mother to the fetus. in the following period of extrauterine life and growing up of the young cattle conspicuous age dynamics was recorded which is, however, linked or affected by the seasons. colostral nutrition which is reflected in the increasing seru ... | 1979 | 106508 |
| purification by affinity chromatography and properties of a beta-lactamase isolated from neisseria gonorrhoeae. | beta-lactamase activity was detected in cell-free preparations obtained from ultrasonic treatment of neisseria gonorrhoeae after growth in liquid medium. crude preparations of beta-lactamase were subjected to affinity chromatography, using several beta-lactam antibiotics as ligands bound to agarose supports. affinity gels produced by coupling 7-aminocephalosporanic acid or 6-aminopenicillanic acid by their amino groups to carboxyl-terminal agarose via a five- to eight-carbon spacer arm proved to ... | 1979 | 106775 |
| [electrophysiological study on mexiletine in man with reference to dose-response relation]. | the electrophysiological properties of mexiletine were investigated by endocavitary his bundle recording and programmed electrical stimulation of the heart in 30 patients. differing dosage (2, 2.7 and 3.4 mg/kg) were given intravenously in 3 groups of 10 patients. the effects on the length of the sinus cycle, conduction intervals and cardiac refractory periods were observed and the following results obtained : 1. sinus rhythm increased at all dosages but this effect was much more pronounced with ... | 1978 | 106799 |
| local antivirals in a herpes simplex stromal keratitis model. | a herpes simplex stromal keratitis rabbit model, which was produced by intrastromal injection of live virus, was used to evaluate the effects of local antivirals on the natural course of the disease. topical trifluridine (trifluorothymidine) and vidarabine monophosphate (adenine arabinoside monophosphate), when given early and frequently, suppressed the disease, indicating that viral replication was important in initiating the disease. however, seven days after the stromal disease had begun to d ... | 1979 | 106813 |
| a dental service for children suffering from cardiac disease. | | 1975 | 123751 |
| amino acid sequence studies on plasmin-derived fragments of human fibrinogen: amino-terminal sequences of intermediate and terminal fragments. | the progressive changes in amino-terminal sequence brought about by the digestion of human fibrinogen by plasmin have been studied. in addition, the limit products (fragments d and e) have been isolated and characterized in the same way. these studies have confirmed the generally accepted scheme of fibrinogen being changed into a large molecular weight fragment x, which in turn is converted into an intermediate fragment y and a limit fragment d, followed by the breakdown of fragment y into an ad ... | 1975 | 123758 |
| physiological and genetic modifications of the expression of the yeast mitochondrial adenosine triphosphatase inhibitor. | 1. the oligomycin-sensitive atpase activity of submitochondrial particles of the glycerol-grown "petite-negative" yeast: schizosaccharomyces pombe is markedly stimulated by incubation at 40 degrees c and by trypsin activations are treatment. both increased in triton-x 100 extracts of the submitochondrial particles. 2. a trypsin-sensitive inhibitory factor of mitochondrial atpase with properties similar to that of beef heart has been extracted and purified from glycerol-grown and glucose-grown s. ... | 1975 | 123768 |
| relationship of lymphotoxin secretion and dna synthesis in the human mixed lymphocytes reaction in vitro. | | 1975 | 123828 |
| control of the synthesis of a single enzyme by multiple regulatory circuits in neurospora crassa. | neurospora crassa synthesizes and secretes an extracellular protease into its growth medium when an exogenous protein serves as its principal source of sulfur, nitrogen, or carbon. the enzymes produced under these three growth conditions have been compared by a number of criteria. the results indicate that the same extracellular protease with a molecular weight of 31,000 is synthesized during the three different metabolic conditions. a regulatory mutant, which lacks a positive signal required fo ... | 1975 | 124058 |
| development of the atheromatous lesion. overview. | | 1975 | 124530 |
| [clinical conference: hl-a antigens in chronic myeloid leukemia]. | | 1975 | 126439 |
| specific inhibition of hl-a alloantisera by various carbohydrate-containing macromolecules. | | 1975 | 126539 |
| adjuvant activity of bacterial peptidoglycans. | purified peptidoglycans isolated from various gram negative and gram positive bacteria can substitute for mycobacteria in freund's adjuvant. monomeric subunits possess the same adjuvant activity. this activity seems to be related to the peptidic fraction. | 1975 | 126567 |
| elementary particles in isolated rat liver and spleen nuclear membranes. | elementary spherical particles similar to those described in the mitochondria are found in isolated rat liver and spleen nuclear membranes. the particles are characterized by electron microscopy of sections and preparations negatively stained with phosphotungstic acid or with the atpase histochemical reaction product. the particles exhibit adenosine triphosphatase activity and have a mushroom-like shape with a sphere about 85-90 angstrom in diameter attached to inner face of the inner nuclear me ... | 1975 | 126876 |
| carbon-13 nuclear magnetic resonance study of chondroitin 4-sulfate in the proteoglycan of bovine nasal cartilage. | the fourier transform 13c nuclear magnetic resonance spectra of bovine nasal cartilage proteoglycan subunit and complex and whole bovine nasal cartilage were obtained and compared with that of chondroitin 4-sulfate. the spectrum of chondroitin 4-sulfate in solution revealed multiple resolvable resonances with linewidths that are consistent with considerable segmental motion in the polysaccharide chain. the spectra of proteoglycan subunit and complex in solution and that of whole cartilage were v ... | 1975 | 127176 |
| [novocaine block in bronchopneumonia in calves]. | | 1975 | 129909 |
| action of atp-dependent dnase from hemophilus influenzae on cross-linked dna molecules. | the atp-dependent dnase from hemophilus influenzae digests double-stranded linear dna molecules exonucleolytically while hydrolyzing large amounts of atp to adp. various cross-linked linear duplex dna molecules are partially resistant to the exonuclease action. vaccinia dna, containing natural terminal cross-links (probably in the form of terminal single-stranded loops), is much more slowly degraded than comparable "open-ended" dna molecules, and atp is consumed at a proportionately lower rate. ... | 1976 | 134999 |
| treatment of gonorrhea -- is penicillin passé. | | 1977 | 139566 |
| [the protective effect of magnesium-aspartate-procaine cardioplegia on the hypertrophied left ventricle of the mini-pig (author's transl)]. | after induction of left ventricular hypertrophy by supravalvar constriction of the ascending aorta in mini pigs (atp and lactate) were measured under different cardioplegic conditions. in normothermia and plain anoxic arrest atp decrease and lactate increase were significantly slower in hypertrophied myocardium compared to normal myocardium. injection cardioplegia using magnesium-aspartate-procaine at 37 degrees c did not influence the atp decrease and lactate increase in the hypertrophied ventr ... | 1978 | 150067 |
| immunoglobulin and complement deposits in the lungs of new zealand black/white mice. | forty-four new zealand black/white (nzb/w) f1 hybrid mice were studied for evidence of immune complex deposition in the lungs and kidneys. positive immunofluorescence was seen in the lungs of 27 mice. the pattern of lung fluorescence was granular in association with capillary walls in 16 mice and intracellular in 12. the incidence of granular fluorescence was increased with age and was seen in 80% of the lungs of mice over 13 months old. there was a correlation between capillary wall fluorescenc ... | 1978 | 150120 |
| [use of intraspecific differentiation of sh. sonnei for the purpose of studying patterns in the epidemic process of dysentery]. | the use of complex typing of sh. sonnei by the colicinogenic and enzymatic properties in epidemiological analysis of dysentery caused by sh. sonnei, apart from establishment of epidemiological connections in the foci, offered a possibility of introducing significant corrections in the determination of the sizes and duration of existence of the epidemic foci, as well as in detection of the sources and factors of transmission of the infection established in epidemiological examination. typing of s ... | 1978 | 154276 |
| differences in the histochemical properties of skeletal muscles of different breeds of horses and dogs. | histochemical profiles of individual muscle fibres were established using myosin adenosine triphosphatase (myosin atpase), succinate dehydrogenase (sdhase), and glycogen phosphorylase (gpase) reactions in three muscles (semitendinosus, diaphragm, and pectoralis transversus) of the horse and dog. the major histochemical difference between fibres lies in their myosin atpase activity; fibres can be subdivided into those with a high and those with a low activity. in horse muscle, all fibres have a h ... | 1978 | 154495 |
| scanning electron microscopy of interaction of peripheral blood lymphocytes from colonic cancer patients with human colonic cancer-derived cells; p-4788. | peripheral blood lymphocytes and the various lymphocyte fractions from patients with cancer of the colon were cultivated with target cells (p-4788) derived from the colon cancer. changes in the surface ultrastructure during tumor cell destruction were studied by scanning electron microscopy (sem). p-4788 cells adhering to the coverslip showed various surface activity. the surfaces of some cells were relatively flat; others were smooth or had fine granules. still other cells were villous, round o ... | 1979 | 161468 |
| [serratia marcescens (author's transl)]. | | 1979 | 161519 |
| blocks in elongation and initiation of protein synthesis induced by interferon treatment in mouse l cells. | synthesis of polypeptide chains coded by exogenous messenger rnas is inhibited in cell-free extracts from interferon-treated mouse l cells, due to a "deficiency" in some specific trna species. a detailed analysis shows that polypeptide chain elongation is blocked and incomplete chains are formed. after a few minutes, however, initiation of new polypeptide chains is also blocked. messenger rna still binds to ribosomes but initiator met-trna(fmet) binding is inhibited. the block in initiation appe ... | 1975 | 168074 |
| cervical carcinogenesis with herpes simplex virus, type 2. | in the past few years there have been a number of reports correlating a high frequency of herpes simplex virus type 2(hsv-2) infection with lesions of the uterine cervix. these studies have used a clinical history of herpetic infection or the demonstration of herpetic antibodies in the cancer patients. the present study was performed to evaluate any possible carcinogenic activity of the formalin-inoculated herpes simplex virus type 2 in the reproductive tract of the female mouse. this approach t ... | 1975 | 168521 |
| basal and dibutyryl cyclic amp-stimulated release of newly synthesized and stored growth hormone from perifused rat pituitaries. | the basal rate of pre-labeled stored 14c-labeled rat growth hormone ([14c]rgh) release from perifused rat pituitary explants is a constant fraction of pituitary gh content, suggesting random release from the storage pool. basal release of newly synthesized [3h]rgh occurs in two phases: 1) immediate and associated with [3h]rgh synthesis, and 2) late (delayed by 60 min) and independent of concurrent [3h]rgh synthesis. dibutyryl cyclic amp (10(-2)m)-stimulated release of stored [14c]rgh is characte ... | 1976 | 177264 |
| murine leukaemia virus group-specific antigen in tumor-resistant tetraparental akr reversible cba/h-t6 chimaeras. | various facts are now known about the relative lymphoma resistance of a group of tetraparental akr reversible cba/h-t6 chimaeras derived by early embryo aggregation. firstly, their tumour resistance is not due to the lack of the lymphomaprone akr cells. secondly, results showing titres of mulv-gs antigen comparable with, and occasionally in excess of, those in the akr suggest that the tumour resistance of the chimaeras is unlikely to be due to a lack of oncogenic leukaemia virus. however, in mar ... | 1976 | 182191 |
| determination of human apolipoprotein e by electroimmunoassay. | 1. apolipoprotein e ("arginine-rich" polypeptide) was isolated from delipidized human very low density lipoproteins by agarose column chromatography in the presence of 6 m guanidine-hydrochloride. 2. an electroimmunoassay ("rocket" electrophoresis) is described for quantitative determination of human serum apolipoprotein e. purified apolipoprotein e was used for the preparation of monospecific antisera and standardization of assay. this sensitive, specific, rapid (time required for the completio ... | 1976 | 182242 |
| [effect of early thymectomy on the growth of transplanted mammary gland tumors developing in mouse line c3hf]. | mammary tumours which developed in factorless c3hf mice when transplanted to mtv-s+ and mtv-s- recipients were found to grow at the same rate' early thymectomy failed to influence their growth. the observed accelerated growth of mammary tumour transplants from c3h/he mice to mtv-s+ recipients, as compared to the mtv-s- ones, and inhibition of the tumour growth after early thymectomy seemed to be connected with the peculiarities of the immunological reaction to the virus-induced antigens. | 1976 | 182306 |
| subunit structure and multifunctional properties of yeast phosphoglyceromutase. | 1. a new and efficient method for preparation of pure phosphoglyceromutase from baker's yeast (saccharomyces cerevisiae) is described. proteolytic alterations of the enzyme during extraction can be minimized by grinding the dried yeast with aluminium oxide at low temperature. 2. yeast phosphoglyceromutase contains four highly similar, probably idential subunits of molecular weight 28000, a conclusion based on the following observations. polyacrylamide gel electrophoresis containing dodecylsulpha ... | 1976 | 182494 |
| effect of a cholinergic stimulant on interaction of isoprenaline with beta-adrenoceptors. | the maximum contraction induced in taenia from the guninea pig caecum by a cholinergic stimulant, butyltrimethylammonium (butma) was relaxed by papaverine (10(-4) m) but not by l-isoprenaline (5 x 10(-7) m). the concentrations used relaxed the taenia completely in the absence of butma. butma (10(-4) m) decreased the increase of cyclic amp caused by isoprenaline but not that due to papaverine. futhermore, photoinactivation of the beta-adrenoceptors by l-isoprenaline was not observed on the taenia ... | 1976 | 182504 |
| antagonism of prostaglandin-induced cyclic amp accumulation in the rat anterior pituitary in vitro by somatostatin analogues. | the pge2-induced cyclic amp accumulation in the rat anterior pituitary in vitro is inhibited by [desamino1]-[desamino1] [descarboxy14]- and [d-lys4]-somatostatin similarly to somatostatin, while the [descarboxy14]-somatostatin exhibits reduced activity; [d-lys9]-somatostatin is ineffective at a higher concentration. | 1976 | 182523 |
| two levels of resting potential in canine cardiac purkinje fibers exposed to sodium-free solutions. | canine cardiac purkinje fibers exposed to sodium-free solutions containing 16 mm cacl2, 20 mm tetraethylammonium chloride, 108 mm tetramethylammonium chloride, and 2.7 mm kcl may be quiescent at a resting potential of either -50 mv or -90 mv. the membrane potential of these fibers can be switched from -50 mv to -90 mv by a hyperpolarizing current pulse and from -90 mv to -50 mv by a depolarizing current pulse. the transition from -50 mv to -90 mv depends on a voltage-dependent increase in potass ... | 1976 | 183909 |
| kinetic properties of a cyclic amp-dependent protein kinase from pig parotid gland. | | 1976 | 184768 |
| regulation of norepinephrine release from cardiac sympathetic fibers in the dog by presynaptic alpha- and beta-receptors. | the effect of phenoxybenzamine (pba), desmethylimipramine (dmi), clonidine (clnd), sotalol (stl), and isoproterenol (ispr) on the release of endogenous norepinephrine (ne) from the heart on right cardioaccelerator nerve stimulation was studied in anesthetized dogs. under control conditions, the catecholamine levels in coronary sinus blood increased linearly with increasing frequencies of stimulation up to 10 hz and did not increase further at 30 hz. the release of ne was markedly enhanced after ... | 1977 | 193655 |
| the storage lipids in tangier disease. a physical chemical study. | the physical states and phase behavior of the lipids of the spleen, liver, and splenic artery from a 38-yr-old man with tangier disease were studied. many intracellular lipid droplets in the smectic liquid crystalline state were identified by polarizing microscopy in macrophages in both the spleen and liver, but not in the splenic artery. the droplets within individual cells melted sharply over a narrow temperature range, indicating a uniform lipid composition of the droplets of each cell. howev ... | 1977 | 193870 |
| the viral etiology of cancer: a realistic approach. | the etiology of cancer resembles that of many other diseases in that multiple factors may be required. because of this, the role or viruses in the etiology of human cancers is especially difficult to assess. when animal tumor systems were used as models, the roles of various predisposing characteristics in virus oncogenesis were elucidated. extrapolation of these findings to the human diseases suggests the importance of genetics, age, hormones, immune competence, and stress in determining suscep ... | 1977 | 195710 |
| stimulation by follicle stimulating hormone and dibutyryl cyclic amp of incorporation of 3h-thymidine into nuclear dna of cultured sertoli cell-enriched preparations from immature rats. | | 1975 | 195775 |
| characteristics of herpes simplex virus resistance to disodium phosphonoacetate. | herpes simplex virus (hsv), which was partially resistant to the inhibitory effect of disodium phosphonoacetate (paa), could be recovered following four virus passages in the presence of 100 microgram/ml paa. resistant strains were isolated from both hsv type 1 and hsv type 2. virus resistance to paa was not complete, and in most isolations a significant proportion of the virus stock remained susceptible to the drug. resistance was shown to be heritable and persisted through virus passage and cl ... | 1978 | 201588 |
| physicochemical characterization and pathogenicity studies of two turkey adenovirus isolants. | two turkey adenoviruses were isolated from poults with respiratory disease, and their physicochemical properties were studied. the virus particles were unenveloped. contained dna genome, replicated within the nuclei of infected cells, and were icosahedral in shape. pathogenicity studies in poults indicated that north carolina kennedy isolant was a pathogen of relatively low virulence whereas the north carolina jackson isolant was nonpathogenic in commercial turkey poults. | 1977 | 204278 |
| mechanism of action of c. parvum on a solid, subcutaneous mouse tumour. | the effects of i.v. c. parvum on the growth of a.s.c. inoculum of the lewis lung carcinoma were studied in normal c57 b1 mice, and in those in which separate components of the immune response were impaired. c. parvum given either at the same time as tumour inoculation or when the carcinoma was 1 cm in diameter, and fully vascularised, reduced tumour growth. macrophages were impaired by silica (si), cortisone acetate (ca) or trypan blue (tb), and t cells by thymectomy and sublethal irradiation (t ... | 1977 | 204533 |
| peripheral nerves in early experimental diabetes: expansion of the endoneurial space as a cause of increased water content. | the aim of the present study was to examine whether the nerve water content and the schwann cell cytoplasm are increased in early experimental diabetics, as suggested in the sorbitol theory. the sciatic nerves of streptozotocin diabetic rats were found to have an increased wet weight. the amount of schwann cell cytoplasm was reduced by 30%. the increased wet weight was paralleled by enlargement of the cross sectional area of the nerve which was explained by an expansion of the endoneurial space. ... | 1978 | 204534 |
| topical epinephrine causes a decrease in density of beta-adrenergic receptors and cathecholamine-stimulated chloride transport in the rabbit cornea. | a single administration, or twice daily administration for 4.5 days, of topical 2% epinephrine to the rabbit eye in vivo causes a 30-40% decrease in the density of beta-adrenergic receptors on membranes prepared from the cornea. such treatment also causes complete loss of the ability of excised corneas to respond to epinephrine in vitro with enhanced active chloride transport. these findings indicate that stimulation with a high concentration of catecholamine depresses the entire pathway from re ... | 1978 | 213130 |
| cross-reactivity between bacillus calmette-guérin and rous virus-induced sarcoma detected in rats by tube leukocyte adherence inhibition assay. | specific immunity to rous virus-induced sarcoma (rsl) was investigated by the tube leukocyte adherence inhibition (lai) assay in rats immunized with bacillus calmette-guérin (bcg). peritoneal cells from lewis rats immunized s.c. with bcg gave positive reactions in the tube lai assay with the antigen prepared from rsl in lewis rats. lymph node cells from lewis rats immunized with bcg had no cytotoxic effect on rsl cells in vitro, whereas peritoneal cells from the same rats were strongly cytotoxic ... | 1979 | 216490 |
| phosphoribosylpyrophosphate (prpp) synthetase mutant in salmonella typhimurium. | | 1979 | 232626 |
| heterogeneity in the physical state of the exterior and interior regions of mycoplasma membrane lipids. | | 1975 | 238513 |
| two enzymes in streptomyces griseus forb the synthesis of dtdp-l-dihydrostreptose from dtdp-6-deoxy-d-xylo-4-hexosulose. | | 1975 | 238519 |
| purification and properties of a fructose-1,6-diphosphate activated l-lactate dehydrogenase from staphylococcus epidermidis. | l-(+)-lactate dehydrogenase (ldh) from staphylococcus epidermidis atcc 14990 was purified by affinity chromatography. the purified enzyme was specifically activated by fructose-1,6-diphosphate (fdp). the concentration of fdp required for 50% maximal activity was about 0.15 mm. the enzyme activity was inhibited by adenosine diphosphate (adp) and oxamate. the inhibition by adp appeared to be competitive with respect to reduced nicotinamide adenine dinucleotide (nadh). the catalytic activity of the ... | 1975 | 242300 |
| split thickness flap, apically replaced, with protected linear periosteal fenestration: a clinical and histological study in dogs. | | 1978 | 276601 |
| inherited immunodeficiency in chickens: a model for common variable hypogammaglobulinemia in man? | | 1977 | 303448 |
| screening of blood donors for the detection of antitetanus antibodies suitable for the production of human antitetanus immunoglobulin. | during a 12-month period, 40 146 blood donors were tested for the presence of high titre antitetanus antibodies. an attempt has been made to define the most suitable donors, those with antitetanus antibody titres of 4 iu/ml or above, by virtue of titre, sex, location, and length of time since most recent immunisation. particular note is made of those donors from university sessions. towards the end of the series, donors who had an initially acceptable level of antitetanus antibody were being t ... | 1977 | 321480 |
| [isolation of the bacterial strain of treponema pallidum with altered penicillin sensitivity]. | | 1977 | 331404 |
| characteristics of individual polymorphonuclear leucocyte motility obtained with a new opto-electronic method. | an opto-electronic device has been used for a quantitative assessment of the motility of individual polymorphonuclear leucocytes (pmnl) adhering to a glass cover slip. one of the oculars in a phase contrast microscope is provided with a mini-array of 32 x 32 light-sensitive elements. these are connected to an electronic unit, capable of recording the number of light-intensity changes on each element and of visualizing the path of a cell on an oscilloscope screen, as a pattern of dots. the result ... | 1979 | 379979 |
| catabolite inactivation of phosphoenolpyruvate carboxykinase in spheroplasts from saccharomyces cerevisiae. | catabolite inactivation of phosphoenolpyruvate carboxykinase was studied in yeast spheroplasts using 0.9 m mannitol or 0.6 m potassium chloride as the osmotic support. in the presence of potassium chloride the rate of catabolite inactivation was nearly the same as that occurring in intact yeast cells under different conditions of incubation. however, in the presence of mannitol, catabolite inactivation in spheroplasts was prevented. the mannitol inhibition of catabolite inactivation was released ... | 1979 | 383159 |
| adjuvant therapy in colorectal cancer. (a randomized trial comparing radio-chemotherapy and radio-chemotherapy combined with the methanol extraction residue of bcg, mer). | fifty-three patients with colorectal cancer dukes' b2 and c were randomized after surgery. one group was treated by radio-and/or chemotherapy and the second by radio-and/or chemotherapy and mer. after 24 and 36 months a significant longer disease free interval, lower recurrence rate and better survival was found in the group treated by radio-chemo- and immunotherapy. treatment was well tolerated and there were few local side effects from the mer injections. the long time efficacy of this adjuvan ... | 1979 | 383171 |
| assessment of several bcg vaccines in different animal test systems (additional studies to an iabs collaborative assay). | | 1979 | 387797 |
| serum opsonic activity in rodent malaria: functional and immunochemical characteristics in vitro. | the functional and immunochemical characteristics of serum opsonic activity in rodent malaria were examined in the present study. schizont- and late trophozoite-enriched populations of plasmodium berghei-infected red blood cells (irbc) were isolated on a ficoll density-gradient and used in an in vitro phagocytosis system composed of serum and monolayer cultures of rat peritoneal macrophages. hyperimmune serum augmented the phagocytosis of irbc to a greater degree than did nonimmune serum. when e ... | 1979 | 387873 |
| [cross-resistance of tubercle bacilli. (a review ii) (author's transl)]. | | 1977 | 404456 |
| repair of dna in replicated and unreplicated portions of the human genome. | | 1979 | 423247 |