| factors affecting the proteolytic degradation of elastin. | | 1977 | 17270 |
| acupuncture: its neurophysiological basis: an anaesthetist's foreword. | | 1978 | 29773 |
| blockade by n-methylhydroxylamine of activation of guanylate cyclase and elevations of guanosine 3',5'-monophosphate levels in nervous tissues. | hydroxylamine and n-methylhydroxylamine prevented the activation of soluble guanylate cyclase by the endogenous activator as well as by nitroso compounds such as n-methyl-n'-nitro-n-nitrosoguanidine or nitroprusside, while other derivaties of hydroxylamine were ineffective. hydroxylamine and n-methylhydroxylamine did not alter the basal guanylate cyclase activity of purified enzyme preparations. kinetics analysis indicated that n-methylhydroxylamine competes with n-methyl-n'-nitro-n-nitrosoguani ... | 1978 | 31192 |
| a serial study of pregnancy proteins in primigravidae. | the plasma concentrations from four 'pregnancy proteins' and three steroid hormones have been measured throughout pregnancy in 15 primigravidae. two of the proteins, human placental lactogen (hpl) and pregnancy-specific beta1-glycoprotein (psbetag), are specific for pregnancy and correlate well with the stage of gestation. it is suggested that measurement of psbetag may be useful in assessing feto-placental wellbeing. neither of the pregnancy-associated proteins, steriod-binding beta-globulin (s ... | 1976 | 57799 |
| driving of slow oscillations in the human somatosensory system. | potentials evoked by brief electrical pulses applied to the median nerve, were recorded from the frontal, central and vertex regions of human subjects. averaging and spectral analysis showed that the responses contained time-locked components ranging in frequency from 0.75 to 4 c/sec and extending over periods as long as 3500 msec after the stimulus. there was no significant difference between evoked potentials induced by stimuli which were accompanied by a twitch in the muscles innervated by th ... | 1976 | 58778 |
| the use of trypan blue for counterstaining in the sepharose bead immunofluorescence test. the application of the test for the demonstration of primate retrovirus-specific antibodies and antigens. | the sepharose bead immunoflurorescence test was performed by counterstaining the beads with trypan blue. this results in a red staining of negative beads which allows an easy distinction from positive green-fluorescent beads. sepharose beads conjugated with viral proteins or antiviral antibodies were used to demonstrate mason-pfizer monkey virus (mpmw)- and simian sarcoma virus (ssv) - specific antigens or antibodies. the test shows a high sensitivity and specificity and needs a small amount of ... | 1978 | 86253 |
| immune response genes have a variable influence on the selection of antigenic foreign and self determinants of insulin. | we studied the proliferative response of mouse t lymphocytes to determinants on ungulate insulins. the immunopotency of defined determinants on the molecule was found to be regulated by three factors: the immune response genes of the immunized mouse, the mode of presentation of insulin on cells or in adjuvant, and the intramolecular cooperativity between different determinants on the insulin molecule. autosensitization against self determinants was observed under specific conditions. these findi ... | 1979 | 91175 |
| effect of sensitization on spontaneous and phosphatidylserine-induced histamine release and on cyclic amp and gmp levels in isolated rat mast cells. | sprague dawley rats were sensitized with 20 microgram or 100 mg egg albumin (using pertussis vaccine as adjuvant). mast cells isolated from the former group of animals showed a higher degree of histamine release upon challenge in vitro with egg albumin than those from the latter group. using the lower amount of antigen for immunization mast cells from hooded lister rats showed an even higher degree of histamine release induced by antigen. an increased antigen-induced histamine release was associ ... | 1979 | 91306 |
| a new fluorescence technique for staining of mononuclear phagocytes. | a recently developed fluorochrome, 4',6-diamidino-2-phenylindole (dapi), is used to stain mononuclear phagocytes of the mouse. after addition of heparin, these cells showed a bright yellow outer ring. | 1979 | 91397 |
| condensation--inhibition by 33258-hoechst of centromeric heterochromatin in prematurely condensed mouse chromosomes. | | 1979 | 91529 |
| effect of various histological fixatives on fluorescent antibody detection of legionnaires disease bacteria. | human lung tissue containing the legionnaires disease bacterium was fixed in seven different histological fixatives, processed, and embedded in paraffin. deparaffined sections from each were stained by fluorescent antibody and by dieterle silver impregnation. with the fluorescent antibody stain, the legionnaires disease bacterium could be detected in tissues prepared with any of the fixatures, but the dieterle silver impregnation was not satisfactory on zenker-fixed tissues. | 1979 | 91621 |
| immunochemical evidence for multiple serotypes of bacteroides fragilis. | an immunochemical comparison of outer membrane antigens obtained from five select and biochemically defined strains indicated that there are several serotypes of bacteroides fragilis. each strain was serologically defined by individual or by combinations of determinant groups composed of carbohydrates in the form of polysaccharides or glycoproteins. the carbohydrate constituents were tentatively identified as glucose, galactose, fucose, rhamnose, glucosamine, galactosamine, and traces of mannose ... | 1979 | 91622 |
| membrane orientation and location of multiple and distinct allotypic determinants of mouse lymphocyte igd. | | 1979 | 91644 |
| b-cell activation in angioimmunoblastic lymphadenopathy after immunisation with multivalent pneumococcal polysaccharide vaccine. | | 1979 | 91879 |
| [chemical composition of the cell wall of streptomyces chrysomallus which produces the antibiotic aurantin]. | the cell wall chemical composition of streptomyces chrysomallus producing the antibiotic aurantin was studied. the cell wall represents 11--13% of the dry cell weight and contains three major polymers, namely, peptidoglycan, ribitol teichoic acid and a polysaccharide. each muramic acid of peptidoglycan has a peptide subunit which consists of two alanine residues, glutamic acid and diaminopimelic acid residues. peptide chains are connected with bridges consisting of one glycine residue. the poly( ... | 1979 | 91941 |
| vitamin k deficiency in male rats fed diets containing butylated hydroxytoluene (bht). | | 1979 | 92074 |
| the o antigenic relationships of kloeckera africana, salmonella aberdeen and escherichia coli o75. | the immune sera for salmonella aberdeen (o11) and escherichia coli (o75) agglutinated kloeckera africana strain. the immune serum for k. africana agglutinated s. aberdeen (o11) and e. coli (o75) strains. absorption and agglutination cross-tests demonstrated common antigenic factor(s) in the tested yeast and salmonella o11 and e. coli o75 antigens. | 1979 | 92211 |
| [modification of anaphylactic bronchospasm in guinea pigs by two nonsteroidal anti-inflammatory agents: l.8027 and indomethacin (proceedings)]. | | 1979 | 92242 |
| amino-acid sequence analysis of the amino-terminal tryptic peptides of different actins from the same mammal [proceedings]. | | 1979 | 92280 |
| amino acid sequence analysis of group e allotype-related peptides derived from lagomorph igg. | a tryptic peptide (t 19) was isolated from a cnbr fragment of igg from several representatives of present-day lagomorphs including domestic rabbit, hare, cottontail rabbit and pika. the amino acid sequence of this peptide revealed differences which can be correlated with serological polymorphism associated with group e igg allotypes. the results confirm previous studies establishing the importance of ala309 for the expression of e 15, particularly the i subspecificity. arg315 correlates with the ... | 1979 | 92412 |
| generation of virus-specific cytotoxic t cells in vitro. i. induction conditions of primary and secondary sendai virus-specific cytotoxic t cells. | h-2-restricted cytotoxic t cells specific for sendai virus were generated in vitro in a primary response from normal mouse lymphocytes cultured in the presence of infective as well as inactivated sendai virus. antigen-presenting cells of different origin, including t cells, were found to be effective stimulators. antibodies to sendai virus were shown to inhibit the activation of specific precursor killer cells when added to cultures before, but not after, the addition of viral antigen. data obta ... | 1979 | 92413 |
| n-acetylprocainamide and ischemia-induced ventricular fibrillation in the dog. | open-chest dogs anesthetized with pentobarbital were treated with saline or n-acetylprocainamide (20 mg/kg, i.v.) 10 min prior to simultaneous ligation of the left anterior descending and septal coronary arteries. ventricular fibrillation occurred in 20 of 26 control dogs but in only 6 of 15 dogs treated with n-acetylprocainamide (p less than 0.05). since n-acetylprocainamide significantly reduced spontaneous heart rate this may have contributed to its antifibrillatory effect. | 1979 | 92414 |
| non-mutagenicity for salmonella of the chlorinated hydrocarbons aroclor 1254, 1,2,4-trichlorobenzene, mirex and kepone. | a polychlorinated biphenyl mixture, aroclor 1254, two commercial grade insecticides, mirex and kepone, and a pesticide breakdown product, 1,2,4-trichlorobenzene were evaluated for mutagenicity and hepatic enzyme induction potential in the salmonella/microsomal assay. none was found to revert strains ta1535, ta1537, ta98 or ta100 when tested with or without metabolic activation. liver microsomal extracts (s9) from rats induced with 1,2,4-trichlorobenzene were shown to differ from s9 of either con ... | 1979 | 92763 |
| [counterimmunoelectrophoresis on cellulose acetate membrane with a commercial lyophilized antigen in diagnosis of human hydatidosis]. | a very simplified method of crossed over electrophoresis (ciep) was employed with a lyophilized commercially produced antigen (previously submitted to several freezing and thawing) and cellulose acetate membrane, for the diagnosis of human hydatidosis. results are as follows: active hydatidosis (surgically confirmed): number of sera tested 35; positive 32 (91%). sera of patients with parasitic and non parasitic illnesses (especially malignancies of liver and lung) did not show any precipitin lin ... | 1979 | 92994 |
| the immunoglobulin-like t-cell receptor. ii. codistribution of fab determinants and antigen on the surface of antigen-binding lymphocytes of mouse thymus. | | 1979 | 93132 |
| [effects of the phospholipid environment and its composition on n-acetyl-muramyl-l-alanine amidase activity (proceedings)]. | | 1979 | 93468 |
| 5-hydroxytryptamine and myoclonus induced by 1,2-di-hydroxybenzene (catechol) in the guinea-pig. | myoclonus induced by catechol in the guinea-pig is not altered by manipulation of cerebral 5-hydroxytryptamine (5-ht). the administration of catechol does not alter brain levels of 5-ht or its metabolite 5-hydroxyindole acetic acid. this form of myoclonus therefore is not of relevance to the 5-ht-sensitive post-anoxic action myoclonus occurring in man. | 1979 | 93500 |
| lack of dr antigens on human b-lymphocyte-mouse fibroblast hybrids that express hla-a,b antigens. | | 1979 | 93795 |
| some histochemical aspects of keratinization of oral, esophageal and gastric membrane of the albino rat. | using histochemical methods a comparative study was carried out, to identify important substances at the keratinization metabolism. with the results obtained, we may conclude that: a) in the four layers of all regions studied, it was possible to detect the presence of the characteristic active radicals of the amino acids cysteine, cystine and arginine, mainly in the corneus layer; b) the presence of -sh radicals of cysteine in the keratohyalin granules was evident in all regions studied. | 1979 | 94029 |
| changes in ovarian activity during hepatocarcinogenesis by n-2-fluorenylacetamide: role of alpha-fetoprotein. | during chemical hepatocarcinogenesis by n-2-fluorenylacetamide, the hormonal status of female sprague dawley rats is largely modified. ovaries present a reduced activity which is evidenced by a decreased number of follicles and corpora lutea. the level of progesterone in n-2-fluorenylacetamide treated rats is low and agrees with the lack of corpora lutea. conversely, estradiol level remains normal. this fact may be explained by the presence of alpha-fetoprotein, a carcino-embryonic protein which ... | 1979 | 94191 |
| priming increases the amount of interferon mrna in poly(ri).poly(rc)-treated l cells. | priming by mouse interferon pre-treatment resulted in an accumulation of interferon mrna in poly(ri).poly(rc)-treated l cells, starting early in the period of interferon synthesis. on electrophoresis, the priming activity of an interferon preparation co-migrated with the antiviral activity, which suggests identity of the functional principle(s) for these activities. | 1979 | 94345 |
| the effect of glutaurine on the development of amphibian larvae with inhibited rna and protein synthesis. | 1. glutaurine (gamma-l-glutamyl-taurine) isolated from bovine parathyroid and later synthetized retards the metamorphosis of rana arvalis. 2. from day 13 of treatment glutaurine moderates the metamorphosis inhibiting effect of antibiotics acting at the transcription and translation level. | 1979 | 94855 |
| major and modified nucleosides in trna hydrolysates by high-performance liquid chromatography. | we describe a high-performance liquid chromatographic analytical method that can be readily placed in operation, and which is particularly well suited to scientists investigating trna structure, biosynthesis, and function, and for the determination of major and modified nucleosides of trna. the method is characterized by the following features: (1) sensitivity at the nanogram level; (2) high chromatographic resolution and selectivity; (3) direct measurement of nucleosides with accuracy and preci ... | 1979 | 94916 |
| [the effects of bleomycin on chemically induced squamous cell carcinoma in oral membrane of rats (author's transl)]. | | 1978 | 95058 |
| metabolism of histamine during anaphylactic shock in guinea-pigs [proceedings]. | | 1978 | 98974 |
| improved safety of splenoportography by plugging of the needle tract. | splenoportography, a useful preoperative diagnostic procedure in patients with portal hypertension, has been largely discontinued because of the risk of hemorrhage. we have used both ivalon and gelfoam in particle and plug form to plug the needle tract after splenoportography. initial studies were conducted on six dogs. plugging of the needle tract by injection of suspensions of small gelfoam or ivalon particles resulted in intravasation of these particles into the splenic vein. this was demonst ... | 1978 | 98987 |
| genetic studies of the lac repressor. vi. the b116 repressor: an altered lac repressor containing amino acid specified by both the trp and laci leader regions. | | 1978 | 99520 |
| the isolation and partial characterization of the serum lipoproteins and apolipoproteins of the rainbow trout. | 1. vld (very-low-density), ld (low-density) and hd (high-density) lipoproteins were isolated from the serum of trout (salmo gairdneri richardson). 2. each lipoprotein class resembled that of the human in immunological reactivity, electrophoretic behaviour and appearance in the electron microscope. trout ld lipoprotein, however, was of greater density than human ld lipoprotein. 3. the trout lipoproteins have lipid compositions which are similar to those of the corresponding human components, exce ... | 1978 | 100102 |
| comparison of antigens of pneumonia-associated mycoplasma species by gel diffusion. | comparison of fluorocarbon-extracted antigens of six mycoplasma species by double immunodiffusion and counterimmunodiffusion techniques revealed a close reciprocal relationship among mycoplasma dispar, m. ovipneumoniae, and m. hyopneumoniae. a lesser degree of cross-reaction was also demonstrated between these three species and m. hyorhinis and m. bovoculi. the interrelationships were more clearly demonstrated by double immunodiffusion than by counterimmunodiffusion. | 1978 | 101469 |
| a new sequence-specific endonuclease from anabaena cylindrica. | | 1978 | 103749 |
| detailed monitoring of the effects of mannitol following experimental head injury. | the experimental model of a cerebral missile injury developed by crockard was used in three groups of rhesus monkeys treated with mannitol. one group received mannitol 15 minutes after being injured with a bb pellet at 90 m/sec impact. another group was wounded identically, but mannitol treatment was delayed until 1 hour after injury. the last group was wounded with the missile traveling at 180 m/sec, and mannitol was started 15 minutes after trauma. the data were contrasted with the results fro ... | 1979 | 106095 |
| [bacillus cereus septicemia (author's transl)]. | | 1978 | 106146 |
| absence of mutagenicity of praziquantel, a new, effective, anti-schistosomal drug, in bacteria, yeasts, insects and mammalian cells. | praziquantel (embay 8440, droncit) a new, effective anti-schistosomal drug, was tested in various short-term assays that have shown a predictive value for the detection of potential carcinogens. indicator organisms s. typhimurium strains, s. pombe, s. cerevisiae, cultured v79 chinese hamster cells or human heteroploid cells and drosophila melanogaster were treated with praziquantel. the induction of reverse and forward mutations, mitotic gene conversions, x-linked recessive lethals, sister-chrom ... | 1978 | 106268 |
| [effects of chemotherapeutic agents on strains of neisseria meningitidis isolated in bohemia during 1970-1976]. | | 1979 | 106970 |
| glycogen synthase kinase-2 from rabbit skeletal muscle is activated by the calcium-dependent regulator protein. | | 1979 | 107045 |
| pulmonary megakaryocyte increase after phlebotomy in rabbits. | | 1978 | 107073 |
| effect of communal housing on the development and behaviour of malnourished rats [proceedings]. | | 1979 | 107715 |
| diagnosis and management of tuberculosis. | | 1979 | 111269 |
| comparison of the 10 000 and 43 000 dalton polypeptide populations isolated from the water soluble and insoluble fractions of human cataractous lenses. | | 1979 | 118040 |
| gastrin-related compounds and their effect on gastric-acid and gastrin output in the dog. | | 1975 | 123975 |
| [relationship between chemical constitution and theraeutic activity of alpha, beta-unsaturated aldehydes in the ehrlich-solid-tumor of the mouse]. | biochemical and biological effects and chemical properties of three alpha,beta-unsaturated aldehydes [acrolein (i), 4-hydroxypentenal (ii), and 4-hydroxyundecenal (iii)] were compared. these three substances inhibited the incorporation of -3h-thymidine in ehrlich-ascites-tumor cells in vitro in the following order: i is greater than iii is greater than ii. for reactivities with glutathion in vitro the order was: i is greater than ii is greater than iii is greater than. we concluded there from th ... | 1975 | 125002 |
| [mechanism of noradrenaline release from the rat brain under the action of nicotine]. | | 1975 | 126707 |
| the effect of circulatory hypoxia on the activity of hexokinase, phosphofructokinase and pyruvate kinase. | | 1976 | 134758 |
| the influence of age on the wound healing of experimental myocardial infarction in rats. | in 6-weeks-old, 5-months-old and 21-months-old rats myocardial infarction was induced by coronary artery ligature. after performing the ligature the animals were administered 3h-thymidine, 3h-proline or 35s-sulphate at different times. the following parameters were determined: number of dna- and tropocollagen-synthesizing connective tissue cells at the infarction border and at the infarction site; mean silver grain density above the nuclei or cells; duration of a cycle; number of mitoses, and in ... | 1975 | 134906 |
| dysplasia of the tricuspid valve in the dog and cat. | dysplasia of the tricuspid valve in 14 dogs and 13 cats was studied. the clinical, electrocardiographic, radiographic, hemodynamic, angiocardiographic, and pathologic findings were reviewed in each species. alterations of the tricuspid valve complex included long, thick septal leaflets adhered to the septum; absent or short, stout fused chordae tendineae; hypertrophic fused papillary muscles; insertion of papillary muscles directly into the lateral leaflets; incomplete development of the valvula ... | 1976 | 134984 |
| [identification and determination of age of needle tracks in human skin (author's transl)]. | examination of enzymic activities and histochemical reactions on needle pricks can be used to determine the age of micro-injuries with sufficient exactness. well preserved skin shows patterns of enzymes which also appear with other skin injuries and which were described in detail especially by raekallio (1970, 1972). in autolytical changes of the skin the adenosinetriphosphatase-reaction is still reliable and can be successfully estimated. if one has sufficient experience it is possible to fairl ... | 1977 | 141827 |
| a light and electron microscopic study of developing bovine sympathetic ganglia. | | 1978 | 151516 |
| macrophage-t cell interactions in the con a induction of human suppressive t cells. | macrophage-t interactions are required for the con a-induced generation of human ts capable of inhibiting pha-induced blastogenesis among autologous pbmc. con a treatment of adherent cell-depleted pbmc, or pbmc recovered after a 7-day incubation in fcs, failed to generate ts. addition of adherent cells to either of these populations restored con a inducible ts. discontinuous density gradient fractionation of adherent cells demonstrated that the required accessory cell was a low density macrophag ... | 1978 | 152792 |
| comparison of the effects of ethane-1-hydroxy-1,1-diphosphonate and dichloromethylene diphosphonate upon periodontal bone resorption in rice rats (oryzomys palustris). | | 1979 | 161500 |
| early cellular events in the response of mice to sheep red blood cells reflected by changes in the spleen level of cyclic amp. | | 1975 | 165767 |
| oxygen control of cytochrome c oxidase synthesis in isolated mitochondria from saccharomyces cerevisiae. | | 1975 | 167283 |
| cytoplasmic inclusions of neurons in the monkey visual cortex (area 19). | several unusual neuronal inclusions were found in certain cells of the rhesus monkey visual cortex (area 19): 1. filamentous bodies, present in the small stellate cells of layer iv, globoid, 0.3-0.6 mum in diameter, consisting of fine 50 a filaments in a hexagonal meshwork. these are often associated with the labyrinthine bodies. 2. labyrinthine bodies found exclusively in the small stellate cells of layer iv, including certain neurons with dispersed ribosomes. these are 0.4-0.7 mum in diameter ... | 1975 | 170843 |
| considerations on structure-activity relationships with mengovirus of substituted 5-amino-4-cyanopyrazoles. | in a screening program using the agar diffusion-plaque inhibition test, 22 out of 27 substituted aminopyrazoles tested showed marked antiviral activity against mengovirus in fl cell cultures. the efficacy of the different derivatives was compared by determining their effect on the yield of infectious virus after a one-step growth cycle. the antiviral activity against mengovirus correlated with the chain length of the substituents and increased or decreased according to the position of the side c ... | 1976 | 176931 |
| activation of intestinal mucosal adenylate cyclase by shigella dysenteriae i enterotoxin. | because the mechanism whereby shigella dysenteriae i enterotoxin induces intestinal secretion is unclear, the effect of this toxin on adenylate cyclase activity in rabbit ileal mucosa was studied under various in vitro and in vivo conditions. activation of adenylate cyclase by shigella enterotoxin was observed only when substrate (atp) concentrations above the km of adenylate cyclase were employed. these concentrations of atp are greater than those required to demonstrate activation of adenylate ... | 1976 | 178569 |
| inbred mice and their hypbrids as an animal model for atherosclerosis research. | 1. the inbred strain of mouse is a relatively inexpensive and easily controlled animal that produces consistent results within each of the p1, p2, f1, f2, b1 and b2 generations. 2. the mother and father exert an equal influence on the development of fatty deposits in the aortic sinus wall and on serum total cholesterol levels. 3. different strains of inbred mice react to the high-fat, high-cholesterol diet in different ways. 4. the control mice of the cba/j (p2) strain had significantly lower va ... | 1976 | 179298 |
| the release of endogenous amino acids from the rat visual cortex. | the release of endogenous taurine, gaba, glycine, aspartate, glutamate, glutamine and alanine from the rat visual cortex was measured using a cortical cup technique. the electrocorticogram (ecog) was monitored throughout most experiments. 2. spreading depression, evoked by the dropwise placement of 10% kcl solution on to the brain outside the cup was associated with a significant increase in the release of gaba and glutamine but a marked fall in that of glutamate. the evoked release of gaba and ... | 1976 | 186588 |
| the storage lipids in tangier disease. a physical chemical study. | the physical states and phase behavior of the lipids of the spleen, liver, and splenic artery from a 38-yr-old man with tangier disease were studied. many intracellular lipid droplets in the smectic liquid crystalline state were identified by polarizing microscopy in macrophages in both the spleen and liver, but not in the splenic artery. the droplets within individual cells melted sharply over a narrow temperature range, indicating a uniform lipid composition of the droplets of each cell. howev ... | 1977 | 193870 |
| turnover of cellular carbohydrates in normal and rous sarcoma virus-transformed cells. | we have analyzed the distribution of glucosamine-labeled polymers on the cell surface, in the growth medium, and inside the cell and the net turnover of these polymers during the process of malignant transformation of chick embryo fibroblasts by rous sarcoma virus. the distribution of label and the turnover kinetics for hyaluronic acid, total glycoproteins, and chondroitins were found to be identical in both normal and transforming cultures. we conclude that nonspecific degradative processes are ... | 1978 | 201373 |
| asymmetric okazaki piece synthesis during replication of simian virus 40 dna in vivo. | | 1977 | 202391 |
| virus infections. | | 1977 | 202429 |
| effect of starvation on hepatic glycogen metabolism and glucose homeostasis. | the effects of starvation on the hepatic glycogen synthase and phosphporylase systems were sequentially assessed in fed and 24-120-hr-fasted rats. enzymic changes before and after glucose were correlated with simultaneous measurements of hepatic cyclic amp and glycogen concentrations and glucose, insulin, and glucagon concentrations in the portal vein plasma. fasting caused parallel changes in plasma glucose and hepatic glycogen concentrations with decreases by 24 hr and subsequent increases, wh ... | 1978 | 203823 |
| multiple forms of sarc gene proteins from rous sarcoma virus rna. | in a previous study we were able to identify two proteins of 25,000 and 18,000 daltons that were made from rna of transforming virions of rous sarcoma virus (rsv) and that were missing from the translation products of a transformation-defective deletion mutant of rsv. in the present study we have separated rsv virion rna on sucrose gradients and have determined that the two putative sarc gene products are synthesized as doublets from an mrna of approximately 18 s. there also appear to be several ... | 1978 | 203938 |
| [cell biological studies on the development of drug induced crystalloid inclusion bodies in the pigment epithelium of the retina of albino rats]. | | 1977 | 205056 |
| [division of labor and adaptive total performance of the liver parenchyma. histochemical and biochemical studies of carbohydrate metabolism]. | | 1977 | 205057 |
| [formation of postvaccinal immunity in infectious rhinotracheitis]. | | 1978 | 209606 |
| synthesis and packaging of herpes simplex virus dna in the course of virus passages at high multiplicity. | herpes simplex virus type 1 (hsv-1), strain ang, was passaged serially at high moi or undiluted on rc-37 cells. the yields of infectious virus decreased and increased periodically with a maximum of about 3 log units variation in titer. the amount of newly synthesized hsv-1 dna, however, did not vary by more than a factor of 2. on the other hand, the fraction of total hsv-1 dna associated with virions was reduced at passage numbers coinciding with the minima in the yields of infectious progeny vi ... | 1978 | 210139 |
| role of cyclic amp and protein kinase on the steroidogenic action of acth, prostaglandin e1 and dibutyryl cyclic amp in normal adrenal cells and adrenal tumor cells from humans. | the role of the cyclic amp-protein kinase system in mediating the steroidogenic effect of acth, prostaglandin e1 and dibutyryl cyclic amp, induced similar stimulations of protein kinase activity, cyclic amp was studied using human adrenal cells isolated from normal and adrenocortical secreting tumors. at high concentrations of acth, complete activation of protein kinase of normal adrenal cells was observed within 3 min, at the time when cyclic amp production was slightly increased and there was ... | 1978 | 214468 |
| outbreaks of classical swine influenza in italy in 1976. | | 1978 | 217205 |
| protective action of amiodarone against ventricular fibrillation in the isolated perfused rat heart. | the pretreatment of rats with amiodarone for 2 minutes to 3 weeks before the excision of their hearts caused a dose-related decrease in heart rate and an increase in the ventricular fibrillation threshold both before and after coronary arterial ligation. similarly, amiodarone decreased the incidence of ventricular premature extrasystoles, ventricular tachycardia and fibrillation during the period of regional ischemia after coronary arterial ligation and also after reperfusion of the ischemic myo ... | 1979 | 217261 |
| immunodeficiencies of man and the new immunobiology. | | 1975 | 238673 |
| phospholipase a2 in experimental hypertension. | an assay method has been developed to measure phospholipase a2 (pla2) in ratserum and to study the possible role of this enzyme in experimental hypertension. experiments with rat serum following 48 h of bilateral nephrectomy indicated a decrease inpla2 activity, suggesting that kidneys might be playing an important role in regulating serum pla2 activity and that kidneys might be a source of this enzyme. experiments with renal hypertensive rats, spontaneously hypertensive rats, and rats receivi ... | 1975 | 239601 |
| isolation and properties of type ii alveolar cells from rat lung. | type ii alveolar cells can be isolated and partially purified from adult rat lung by a series of steps that includes enzymatic digestion of the lung with trypsin and separation of cells on a discontinuous albumin density gradient. the yield of the isolated type ii cells depends on the supplier and the housing of the rats used to prepare the cells. with specific pathogen-free rats housed in a laminar flow hood, the yield was 20.3 x 10(6) cells per rat, of which 50 per cent were type ii cells. wit ... | 1977 | 262096 |
| intraoral leukoplakia, abrasion, periodontal breakdown, and tooth loss in a snuff dipper. | dentists should be aware that snuff dipping or chewing is increasing in southern states and perhaps in other sections of the united states. these habits can lead to clinical leukoplakia, gingival recession, tooth abrasion, and periodontal bone destruction. the possibility also exists that a malignant transformation of leukoplakia can develop in persons who use snuff and other forms of tobacco. | 1979 | 285136 |
| a method of rapid wetting and synchronous germination of streptomycete spores. | | 1977 | 321309 |
| rapid identification of infectious pancreatic necrosis virus in infected cell cultures by immunoperoxidase techniques. | direct and indirect immunoperoxidase (ip) techniques were evaluated for their potential in identifying infectious pancreatic necrosis (ipn) virus. both techniques were shown to offer a relatively simple, rapid and efficient means for the specific identification of ipn virus in infected cells. the direct ip method resulted in less nonspecific staining; however, the indirect method was clearly specific and utilized commercially available reagents. | 1978 | 368352 |
| synthesis and properties of fluorescent nucleotide substrates for dna-dependent rna polymerases. | a new class of fluorescent nucleotide analogs which contain the fluorophore 1-aminonaphthalene-5-sulfonate attached via a gamma-phosphoamidate bond has been synthesized. both the purine and pyrimidine analogs have fluorescence emission maxima at 460 nm. cleavage of the alpha-beta-phosphoryl bond produces change in both the absorption and fluorescence emission spectra. the fluorescence of the pyrimidine analogs is quenched; cleavage of the alpha-beta-phosphoryl bond of the utp analog produces abo ... | 1979 | 387781 |
| incidence and pathological features of spontaneous tumors in athymic nude mice. | systematic observation of 1141 nude mice (swiss background [corrected] strain) that received human tumor transplants revealed 24 spontaneous tumors, 18 of lymphoreticular origin and 6 pulmonary adenomas. spontaneous tumors were seen at an average age of 9.1 months, and 22 of the tumors were seen only in that fraction of our group (324 mice) surviving for 5 months or more (22 of 324 x 100 = 6.8%). transplantation of these tumors to other nude mice was successful in three of five cases. mice trans ... | 1979 | 427772 |
| neurectoderm markers retained in phenotypical skeletal muscle cells arising from a glial cell line. | | 1979 | 492321 |
| origin and early development of canine circumanal glands. | | 1979 | 517821 |
| alterations of lactate dehydrogenase isoenzymes with subacute adriamycin toxicity. | single doses of adriamycin (adr) and isoproterenol in cdf rats produce significant increases in total serum lactate dehydrogenase (ldh) activity, ldh isoenzymes, and ldh-1/ldh-2 ratio. isoproterenol produced significant increases in ldh-1, ldh-2, and ldh-3 and the ldh-1/ldh-2 ratio; adr produced significant increases in all isoenzymes, reflecting widespread toxicity, with peak levels of total ldh, ldh isoenzymes, and ldh-1/ldh-2 ratio at 48 hours after injection. while the increased ldh-1/ldh-2 ... | 1979 | 526938 |
| the effects of dopamine on neurones in the nucleus tractus solitarii and on the central control of blood pressure in the rat [proceedings]. | | 1979 | 529063 |
| hypothalamic sensitivity to leukocytic pyrogen of adult and new-born guinea-pigs. | 1. experiments were conducted to localize the hypothalamic site of action of microinjected leucocytic pyrogen and to compare the pyrogenic sensitivity of this locus in adult and new-born guinea-pigs.2. to identify the site reactive to leucocytic pyrogen, bilateral (0.8-1.0 mm from the mid line) injections of 1 microliter were made into conscious adult guinea-pigs via cannulas stereotaxically palced at 0.5 mm intervals and varying depths from the olfactory tegmentum to the mammillary bodies. inje ... | 1979 | 529081 |
| [human phrenic nerve: analysis of nerve fibre types on the base of their acetylcholinesterase activity (author's transl)]. | as marked differences in the acetylcholinesterase (ache)-activity of myelinated nerve fibres of ventral and dorsal spinal roots can be found also in human post mortem material (zenker et al. 1978), the karnovsky-method for histochemical demonstration of ache-activity has been used for differentiation of motor and sensory fibres in the human phrenic nerve. in cross sections of the phrenic nerve 1--2 cm above its entrance into the diaphragm, after an incubation period of 24 hours, 86% of the medul ... | 1979 | 543560 |
| lipid & growth changes in organs of chicks (gallus domesticus) during acute & chronic toxicity with disyston & folithion. | | 1979 | 546750 |
| synergistic protection against experimental cholera by immunization with cholera toxoid and vaccine. | rabbits were immunized with two parenteral injections of wellcome toxoid px389a, wyeth toxoid 20101, or merck bivalent vaccine. other groups of rabbits were immunized with combinations of the merck vaccine and each of the two toxoids. antitoxin responses were monitored in each group of rabbits before livecell challenge of each animal by the ligated intestinal loop assay. inaba and ogawa strains of vibrio cholerae were used for challenge experiments. basically, the data indicate that the toxoids ... | 1979 | 546785 |
| different calcium requirements for proliferation of conditionally and unconditionally tumorigenic mouse cells. | conditionally tumorigenic balb/3t3 mouse cells (which produce tumors in balb/c mice only under special conditions) cannot sustain dna synthesis and consequently stop proliferating in media containing low concentrations (0-0.02 mm) of physiologically available calcium. by contrast, cells that have been neoplastically transformed (tumorigenic in mice without special assistance) in vitro by different oncogens, can sustain dna synthesis and proliferate in such calcium-deficient media. the possible i ... | 1976 | 1064038 |
| a study of absorption of compounds from the rat biliary tree by retrograde intrabiliary injection (rii). | absorption of compounds from the biliary tree of rats was studied by a retrograde intrabiliary injection (rii) technique. after rii of a number of compounds in volumes that exceeded the maximum distended capacity of the biliary tree, only that volume of rii solution which corresponded to biliary tree capacity remained therein. furthermore, this latter portion of rii solution was absorbed by a first-order process when the duration of bile duct cannula occlusion was extended. thus, the present stu ... | 1975 | 1151745 |
| study on the efficiency of five antibilharzial drugs judged by she direct and serodiagnostic methods. | | 1975 | 1181175 |
| synchronization of the fission yeast schizosaccharomyces pombe using heat shocks. | | 1975 | 1196141 |
| [effect of inoculation on nitrogen fixation by chick pea, on its crop and protein content]. | active strains of rh. cicer were found to increase the crop of chick pea by 25--36%, the content of protein by 2--6%, and the content of total nitrogen in the roots by 1.7--2%. symbiotic fixation of nitrogen determined by a technique of "inoculation" varies within 40--60% depending on the activity of the strain. no correlation has been established between the effectiveness of the strains of nodule bacteria and the activity of their enzymes--dehydrogenases. | 1975 | 1214612 |