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purification and characterization of a plasminogen activator secreted by cultured human pancreatic carcinoma cells.a plasminogen activator secreted by cultured human pancreatic carcinoma (mia paca-2) cells has been purified to apparent homogeneity by procedures including sepharose-l-arginine methyl ester affinity chromatography, sephadex g-200 gel filtration, isoelectric focusing, and sodium dodecyl sulfate gel electrophoresis. the plasminogen activator shares many properties with urokinase including: molecular weight (55 000), isoelectric point (8.7), heat stability (60 degrees c, 30 min), ph stability (1.5 ...197715590
hormonal control of zinc uptake and binding in the rat dorsolateral prostate.the zinc uptake in the dorsolateral prostate of rats was studied after different hormonal manipulations. orchiectomy reduced the uptake of 65zn. administration of estradiol benzoate to orchiectomized rats doubled the 65zn uptake, a phenomenon which was not observed in orchiectomized-adrenalectomized rats. adrenalectomy in orchiectomized rats had no effect on the concentration of radioactivity beyond the castration-induced decrease. a prolactin release inhibitor, 6-methyl-8-erogelenylacetamide, r ...197715955
acute bacteremia in asplenic renal transplant patients.four cases of overwhelming bacteremia were observed in asplenic renal transplant patients 12 to 20 months after transplantation. the bacteriologic findings and presentation of these infections are characteristic of post-splenectomy sepsis reported in nontransplant patients. it is suggested that the absence of the spleen, more than immunosuppression with azathioprine and prednisone, predisposes to these late, uncommon infections after transplantation.197716144
biochemical and behavioral changes in rats exposed to ethanol in utero. 197618974
cardiomegaly produced by chronic beta-adrenergic stimulation in the rat: comparison with alpha-adrenergic effects. 197720543
pharmacological study of chicken airway smooth muscle.isolated chicken bronchus contracts to carbachol, pgf2alpha, histamine, 5-ht, bradykinin and phenylephrine. the bronchial strips from the horse plasma sensitized domestic fowl contracted to specific sensitizing antigen in vitro (schultz-dale anaphylactic reaction) and were 5 to 10 fold more reactive to pgf2alpha, histamine and 5-ht compared with the bronchi from normal chickens. second antigen challenge was inactive or produced a weak response (desensitization). allowing the bronchi to rest for ...197827609
chronic effects of oxypertine on the isolated vas deferens of the rat. 197829822
(exo, exo)-2-aryltropane-3-carboxylic esters, hypoglycemic agents with accompanying analgesic activity.(exo, exo)-2-aryltropane-3-carboxylic esters of types 6, 7, and 10 lower circulating blood glucose levels by 60--80%. this activity is accompanied by an analgesic activity roughly equal to that of codeine. both of these activities reside in the 1r enantiomer and extensive structure-activity studies failed to separate them. the specific opioid antagonist nalorphine blocks the analgesic activity but does not diminish the hypoglycemic action. conformational integrity afforded by the ethylene bridge ...197831482
kinetic studies in isolated organs: tools to design analgesic peptides and to analyze their receptor effects.the opioid activities of peptide and non-peptide narcotics were studied in longitudinal muscle strip of guinea pig ileum (gpi) and in mouse vas deferens (mvd). the comparison of agonist activities of peptides found in gpi and mvd offered the opportunity to predict the presence but not the magnitude of potential analgesic activity. the kinetics of the antagonism between naltrexone and different types of agonists were also determined in these systems. using c-6 epimers of naltrexone, it was found ...197933396
factors affecting the incidence and anti-salmonella activity of the anaerobic caecal flora of the young chick.thirty-two different types of anaerobic bacteria isolated from chickens have been tested for anti-salmonella activity in vitro. under the conditions of the test only bacteroides hypermegas and a bifidobacterium sp. were shown to inhibit the salmonellas and this was attributed to the production of volatile fatty acids (vfa's) coupled with a low ph. when these organisms were tested in newly hatched chicks no inhibition of s. typhimurium occurred. possible explanations for this observation are cons ...197934658
the stimulatory effect of 5ht and the role of the paraventricular nucleus on pms induced ovulation in the immature rat.immature rats can be induced to ovulate with pregnant mare serum (pms) as long as they weigh over 60 g. in the rats weighing less than 60 g 5-hydroxytryptamine (5ht)-60 micrograms/rat intraventricularly or 2 micrograms/rat in the paraventricular nucleus (pvn)-stimulated ovulation. injections into several other hypothalamic nuclei were ineffective. in rats weighing greater than 60 g, lesions of the pvn or injection of 10 micrograms/rat p-chlorophenylalanine into the pvn inhibited ovulation. the h ...197937456
antigenic analysis of chlamydiae by two-dimensional immunoelectrophoresis. ii. a trachoma-lgv-specific antigen.two-dimensional immunoelectrophoresis was utilized to study precipitins in hyperimmune rabbit serum made against chlamydiae and from patients with chlamydial infections. an antigen of triton x-100-solubilized l2/434/bu organisms with an electrophoretic mobility of 0.65 relative to bovine serum albumin at ph 8.6 was excised from the agarose gel of electrophorograms as antigen-antibody complexes and used to immunize rabbits. a monospecific antiserum to antigen 0.65 was obtained that reacted with t ...197551883
[identification of the causative agents of trachoma and paratrachoma by the method of direct immunofluorescence and staining by the romanovskiÄ­-giemsa method]. 197656498
fetal syphilis in the first trimester.evidenc of first-trimester fetal syphilis was sought in the products of conception in a therapeutic abortion clinic. during two collection periods of one week, five patients with serologic and clinical data consistent with recent syphilitic infection were identified. their conceptuses were carefully examined by silver and immunofluorescent stains for the presence of treponema pallidum. two of these five conceptuses (9 and 10 weeks' gestation) were found to contain t. pallidum by these methods. t ...197656895
letter: growth of chlamydia trachomatis in cell culture. 197657430
a serial study of pregnancy proteins in primigravidae.the plasma concentrations from four 'pregnancy proteins' and three steroid hormones have been measured throughout pregnancy in 15 primigravidae. two of the proteins, human placental lactogen (hpl) and pregnancy-specific beta1-glycoprotein (psbetag), are specific for pregnancy and correlate well with the stage of gestation. it is suggested that measurement of psbetag may be useful in assessing feto-placental wellbeing. neither of the pregnancy-associated proteins, steriod-binding beta-globulin (s ...197657799
comparison of chlamydia subgroup a detection from clinical specimens after 40 and 64 hours of incubation in 5-iodo-2-deoxyuridine-treated mccoy's cells.the time course of formation of inclusion bodies produced by chlamydia in 5-iodo-2-deoxyuridine (iudr)-treated mccoy's cells was studied with the use of a known isolate of chlamydia trachomatis d/uw-184/ur and 47 frozen clinical urethral specimens previously shown to be either positive or negative for chlamydial inclusions after 3 days of incubation. subsequent examination of 369 clinical specimens from the genitourinary tract over a 6-month period revealed 47 (13%) chlamydia-positive cultures, ...197657968
isolation of chlamydia trachomatis in tissue-culture of human thyroid. 197661387
differential response of chlamydial and ureaplasma-associated urethritis to sulphafurazole (sulfisoxazole) and aminocyclitols.91 men with non-gonococcal urethritis (n.g.u.) were randomly treated with either sulphafurazole (sulfisoxazole), 500 mg orally q.i.d. for 10 days, or an aminocyclitol (streptomycin or spectinomycin), 2 g intramuscularity for 1 to 3 doses at 12 h intervals. initial urethral cultures were positive for chlamydia trachomatis (c) in 36 (40%). ureaplasma urealyticum (u) was isolated from the urethra or urine from20 (95%) of 21 white men in a first episode of n.g.u. who had negative chlamydia cultures. ...197663748
[the effect of increased intracranial pressure and subarachnoid hemorrhage on the sympathetic vasoconstrictor nerve activity (author's transl)]. 197664942
chlamydia trachomatis and the respiratory tract. 197766577
aetiology of acute epididymitis.24 patients with acute epididymitis were examined and underwent urethral and urine cultures for neisseria gonorrhoeae, ureaplasma urealyticum, herpes-simplex virus, chlamydia trachomatis, cytomegalovirus, and gram-negative aerobic bacteria. the results suggest that in young men the sexually transmitted organisms which cause urethritis (n. gonorrhoeae, c. trachomatis, and possibly u. urealyticum) may also lead to acute epididymitis, whereas in older men coliforms and pseudomonas are the predomina ...197767333
treatment of chlamydia trachomatis infections. 197874613
antichlamydial antibody in genital exudates of men and women with non-gonococcal genital infections. 197876057
axoplasmic flow during chronic experimental glaucoma. 1. light and electron microscopic studies of the monkey optic nervehead during development of glaucomatous cupping.the anterior optic nerve and the macular region of the retina of glaucomatous eyes of five rhesus monkeys (macaca mulatta) have been examined by light and electron microscopy. the experimental glaucoma had been induced by argon laser treatment of the anterior chamber angle. the eyes were examined 3 to 11 weeks after the onset of sustained elevation of intraocular pressure above 20 mm hg. severe degenerative changes were seen in eyes with higher intraocular pressure and longer duration of glaucom ...197881192
antibodies against chlamydia of lymphogranuloma-venereum type in crohn's disease.antibodies against chlamydia of lymphogranuloma-venereum type were detected by the micro-immunofluorescence technique in 38 (69%) of 55 patients with crohn's disease. weak positive reactions were seen in only 2 or 21 patients with other gastrointestinal disorders and 1 of 50 healthy blood-donors.197983465
isolation of a type-specific antigen from chlamydia trachomatis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.this report describes the isolation of a type-specific antigen of a serotype a strain of chlamydia trachomatis. the antigen could be identified in sodium dodecyl sulfate-polyacrylamide electrophoretic (sds-page) analysis of immunoprecipitates of homologously reacted lysates from bolton-hunter 125i-labeled elementary bodies, solubilized by sonication and treatment with nonidet p40. the electrophoretic pattern of this precipitate revealed a peak of unique mobility that was not reproduced by hetero ...197984016
growth-stimulating factor in regenerating canine liver.extracts from dog livers which had been regenerating for 24, 48, and 72 h after hepatectomy were infused for 6 h into the left portal vein of animals which had fresh portacaval shunts (eck fistula) and which were killed 2 and 3 days later. the brief exposure to the 48-h and especially the 72-h regenerating liver extracts induced a delayed proliferative response predominantly in the left liver lobes, with a slight spillover effect to the right liver lobes but none to the kidney. the response reac ...197984151
diisopropylfluorophosphate-evoked inhibition of anaphylactic histamine release from human skin: decrease of the inhibition by storing the skin specimens.antigen-induced histamine release from human skin slices passively sensitized with reaginic serum in vitro was inhibited by dfp, suggesting involvement of serine esterase activation in the reaction. the magnitude of dfp-evoked inhibition of the histamine release was not the same in each skin sample and no correlationship was observed between the magnitude of the dfp-evoked inhibition of the histamine release and that of the histamine release in the absence of dfp. the magnitude of the histamine ...197984487
induced metabolic sequelae of tularemia in the rat: correlation with tissue damage.serum and liver zinc concentration, amino acid uptake by liver, seromucoid content, and alpha2-macrofetoprotein production were measured in vaccinated as well as nonimmune rats exposed to either virulent (schu s4) or attenuated (lvs) strains of francisella tularensi. it appears that liver damage (pyogranulomatous lesions) must occur before there is any alteration in the above variables. the presence of bacteria in the liver is not of itself sufficient to lead to the onset of systemic, induced me ...197551592
the effect of mixed phosphatidylcholine liposomes on beef heart cytochrome c oxidase [proceedings]. 197884573
membraneous and cytosolic cyclic-nucleotide phosphodiesterases in beef aorta: substrate specificity, endogenous inhibition and activation [proceedings]. 197884582
staining of legionella pneumophila. 197985128
cellular and humoral immunity in viral hepatitis.cellular and humoral immunity combine to determine the outcome following exposure to hepatitis virus and are implicated in the proposed pathogenetic mechanism for acute and chronic hepatitis. although antibody to hbsag is found in virtually all following recovery from hepatitis b, a cell-mediated response to hbsag can be detected in most patients during the acute phase, and it has been suggested that this may cause the acute hepatic damage by an attack on virus-infected cells. patients who have ...197685410
subarachnoid space of the cns, nasal mucosa, and lymphatic system.we have briefly reviewed the literature pertaining to the movement of tracer molecules and infectious organisms within the olfactory nerve. there is a body of evidence indicating that tracers placed in the csf will quickly move via the olfactory nerve to the nasal mucosa and then to the cervical lymph nodes. organic and inorganic tracer materials and organisms as diverse as viruses, a bacillus, and an amoeba, when placed in the nasal cavity, have been shown to move from the nasal mucosa via the ...197985446
evidence for two forms of rna-dependent dna polymerase in visna virus.the visna viral rna-dependent dna polymerase has been resolved into two forms by affinity chromatography. glycerine gradient centrifugation of the two forms showed that one form sedimented at 6.9 s corresponding to an apparent molecular weight of 135 000 and the other at 6.3 s corresponding to 118 000. sodium dodecyl sulfate (sds)-polyacrylamide gel electrophoresis of the two forms indicated that the 6.9 s enzyme is composed of 2 molecules of 68 000 mol. wt. chain and the 6.3 s is a single chain ...197985464
isolation of a nucleocapsid polypeptide of herpes simplex virus types 1 and 2 possessing immunologically type-specific and cross-reactive determinants.a polypeptide (p40) of approximately 40,000 molecular weight was isolated from herpes simplex virus type 1 and 2 nucleocapsids by gel filtration and ion exchange chromatography. this protein appears to be the same as protein 22a described previously (gibson and roizman, j. virol. 10:1044--1052, 1972). competition immunoassays were developed by using purified p40 and antisera prepared in guinea pigs. the assays indicated that the p40's from herpes simplex virus types 1 and 2 possess both type-spe ...197985720
isoelectric focusing of chlamydia trachomatis.hela-229 cells and the elementary bodies of chlamydia trachomatis had a net negative electrical surface charge at neutral ph when measured by isoelectric focusing. inclusion-forming and non-inclusion-forming elementary bodies focused in one band at pi 4.64.197944706
is trachoma an ocular component of a more generalised chlamydial infection?in industrialised countries, inclusion conjunctivitis of the newborn is now known to be just one manifestation of a more generalised infection with chlamydia trachomatis. pneumonia and enteric infection can develop in perinatally infected infants. it is possible that trachoma in developing countries may reflect extraocular infection that may contribute to the high frequency of pneumonia and diarrhoea in infants in these countries. if true, this would explain the short-term effects of topical tre ...197985939
identification of gallbladder typhoid carriers by a string device.the efficiency of a gelatin capsule containing a nylon string for collection of duodenal specimens was investigated in carriers of salmonella typhosa (typhi). cultures of duodenal specimens obtained by means of the string capsule were compared with cultures of duodenal specimens obtained by a conventional duodenal tube and with stool cultures duodenal contents obtained with either the string or tube were more often positive for s. typhosa than were stool cultures. the string, which is as efficie ...197986040
the isolated human cortex. a golgi analysis of krabbe's disease.the clinical course of a child with krabbe's leukodystrophy was characterized by clinical seizures, startle myoclonus, and paroxysmal activity recorded by eeg. at autopsy in the fourth year, myelinated subcortical axons were destroyed, virtually completely. despite isolation from major subcortical and interhemispheric connections, the cell and fiber pattern of the cortex appeared remarkably normal in routine histologic preparations. the normal range of pyramidal and stellate interneurons were al ...197986346
low dose lithium-carbimazole in the treatment of thyrotoxicosis.fifteen patients with thyrotoxicosis were treated with low dose sustained release lithium carbonate 400 mg, combined with carbimazole 40 mg daily, and the therapeutic response was followed over a two week period. this response was compared with that obtained in a similar group of patient treated with carbimazole alone. li-carbimazole treatment brought about a fall in the mean total serum t4 of 57.4% compared with a drop of 32.8% in patients treated with carbimazole alone. the mean serum t3 fell ...197886350
normal immunosuppressive protein inhibition of human and murine lymphoblastoid cell line proliferation.normal immunosuppressive protein, prepared from human plasma by deae-cellulose chromatography, inhibits dna synthesis in human cell lines of lymphocytes of both t and b origin. it also inhibits [3h]thymidine incorporation in mouse cell lines. normal immunosuppressive protein was able to inhibit the proliferation of these cells, although they were already transformed and had a high rate of dna synthesis. on the other hand, it does not inhibit myeloid cells or fibroblasts.197986450
tryptic digestion of immobilized d-amino acid oxidase. 197825787
[significance of serum digoxin concentration and its influencing factors].in recent years it has become possible by means of a radioimmunoassay to measure digoxin concentration in the serum of digitalized patients. with this method it could be shown that the resorption of digoxin is decreased by partial resection of the samll intestines, by malabsorption syndromes, after ingestion of neomycin, colestyramine and antacids. in renal insufficiency, however, the elimination half-life period of digoxin is increased conspiciously (from about 35 hours up to about 120 hours). ...197661153
prostacyclin: a solution to some problems of extracorporeal circulation. experiments in greyhounds.in cardiopulmonary-bypass experiments in greyhounds the effects of adding prostacyclin, prostacyclin plus heparin, and heparin alone to the extracorporeal circulation were compared. with heparin alone platelet count and function were reduced, the pressure differential across the arterial filters rose, platelet deposits were found on the arterial filters, and plasma-fibrinogen levels fell. plasma from these dogs was toxic to fetal-mouse hearts in culture. with prostacyclin alone, fibrinogen level ...197986720
inclusion bodies in paneth cells. 197986743
low frequency of chlamydial antibodies in patients with crohn's disease and ulcerative colitis.serum samples from 55 patients with crohn's disease and from 23 patients with ulcerative colitis were tested for antibodies to chlamydia trachomatis immunotypes by a micro-immunofluorescence technique. antibody titres of 1:8 or greater against several immunotypes were detected in 14.5% of patients with crohn's disease and in 21.7% of those with ulcerative colitis. these figures resemble the incidence in a healthy, non-venereal-disease population. furthermore, there was no correlation between the ...197986884
antigenic variation in three distinct determinants of an influenza type a haemagglutinin molecule. 197986955
erythromycin and lymecycline treatment in chlamydia-positive and chlamydia-negative non-gonococcal urethritis--a partner-controlled study.a group of 213 men with non-gonococcal urethritis and their sexual partners were treated either with erythromycin stearate 500 mgx2 for 15 days or with lymecycline 300 mgx2 for 10 or 20 days. chlamydia trachomatis was isolated from 40% of the men, from 26% of their female partners and from 56% of the partners of men with chlamydia-positive urethritis. one hundred and eighty-one men were available for evaluation of therapy. there were no significant differences between the treatment schedules. th ...197987096
histological and histochemical changes of the skeletal muscle in human chronic chagas' disease.gastrocnemius muscle biopsies were performed in 7 subjects with chronic chagas' disease. on clinical and laboratory grounds the selected patients were judged to be healthy, being the only abnormality found the presence of positive serum tests for chagas' disease. fibre type grouping of either type i or type ii was observed in 5 of the 7 patients. furthermore, in 2 of the 5 patients showing muscle fibre groupings, angular fibres reacting with nadh and non-specific sterase were also found. these o ...197887186
the fine specificity of regulatory t cells. i. hen egg-white lysozyme-induced suppressor t cells in a genetically nonresponder mouse strain do not recognize a closely related immunogenic lysozyme. 197987419
lipid-modified antigens. i. specificity of guinea pig t lymphocyte responses and i-region restriction. 197987434
anatomical organization of the phasic activity produced by reserpine at the level of the oculomotor system.the organization of the pathways responsible for the transmission of phasic electrical activity at the level of the oculomotor system was studied in the encéphale isolé cat which was injected with reserpine or exhibited spontaneous phases of paradoxical sleep. at the level of the vith nuclei there are both ipsilateral and contralateral connections deriving from each generator. the ipsilateral pathway transmits an "inhibiting" potential eliciting electromyographic inhibition of the ipsilateral re ...197655344
receptor cross-linking and histamine release. ii. interpretation and analysis of anomalous dose response patterns. 197987458
thymic control of secretory antibody responses in the rat.the effect of neonatal thymectomy on salivary and serum antibody responses was studied in rats. local immunization of thymectomized rats with a t-dependent antigen (dnpbgg) elicited negligible amounts of iga anti-dnp antibody in saliva. in contrast, both normal and sham-thymectomized animals demonstrated substantial levels of salivary iga antibody. all thymectomized rats locally injected with a t-independent antigen (dnp-lys-ficoll) exhibited salivary iga antibody production. salivary igg antibo ...197987472
some properties of the polysaccharide from cell cultures infected with tric agent (chlamydia trachomatis).the polysaccharide, elaborated in trachoma-inclusion conjunctivitis (tric) agent inclusions, was isolated from baby hamster kidney (bhk) cells grown and infected in suspension cultures. it was characterized by physical, chemical and enzymic methods as a glycogen with an average chain length of 14 to 16 glucose units.197551905
limited immunodeficiency. 197887559
mitochondrial atpase of zajdela hepatoma. v. mitochondria of zajdela hepatoma contain membrane sectors of atpase complex unassociated with f1.relative content of membrane sectors of atpase complex in rat liver and zajdela hepatoma mitochondria and the ability of mitochondrial membrane of the two sources to bind isolated soluble (f1) atpase were examined. approximately equal concentrations of oligomycin were required for 50% inhibition of atpase activity in submitochondrial particles of rat liver and zajdela hepatoma indicating practically identical content of membrane sectors of atpase complex in both types of mitochondria. as detecte ...197888020
abstracts of an international symposium on viral hepatitis, 5-7 april 1979, munich. 197941810
the effect of eating some british snacks upon the ph of human dental plaque. 197828741
evidence for antigenic variation in influenza a nucleoprotein. 197988124
anaphylatoxin-induced shock and two patterns of anaphylactic shock: hemodynamics and mediators.in the dog, different cardiorespiratory reactions were identified in two types of anaphylactic shock and in c5a-at (anaphylatoxin)-induced shock. all three types had in common a portal blood pooling with consequent decrease in the venous return, cardiac output, and arterial pressure. in anaphylaxis (a) of the first type, at a low titer of hemagglutinating antibodies, the latent period was 68 s and heart and lung function was unchanged. in the second type, at high titer, the latency was 19 s and ...197988165
ethical considerations in cancer chemotherapy.cancer treatment has improved dramatically in the recent past. as a consequence, the range of choices has been greatly broadened. with a much larger range of choices and a larger range of treatment disciplines available, decisions regarding treatment create major ethical burdens for the physician and for the patient. the participation of the patient in such choices improves the ethical posture of the therapist, whenever that is possible, and also improves the probability that the best treatment ...197988204
4th international workshop on human gene mapping. report of the committee on the genetic constitution of the x and y chromosomes. 197888299
automatic recognition of inter-ictal epileptic activity in prolonged eeg recordings.a method of automatic recognition and quantification of inter-ictal epileptic activity in the human eeg had previously been developed and tested using short recordings from awake subjects. this paper describes the adaptation of the method for use during overnight recordings in free-moving unattended patients, in combination with the already existing seizure monitoring system. eeg s were recorded from scalp and sphenoidal electrodes, using cable telemetry and a pdp-12 computer. the spike and shar ...197988339
hippocampal evoked potentials and eeg changes during classical conditioning in the rat.hippocampal evoked potentials (eps) and eeg responses were studied in rats, using a classical conditioning paradigm (water, us), with a spatially discontiguous cs-us arrangement in order to separate the cs and goal-related responses. in early training, when the orienting score was high, the tone cs, instead of eliciting a definite ep, usually reset hippocampal theta activity in phase, i.e. theta rhythm became time-locked to cs. with further training, orienting activity (ori) decreased to the pre ...197988362
passive sensitization of human basophils: evidence for heterogeneity in the ige molecule.possible functional heterogeneity of human ige antibody was studied by passively sensitizing human basophils for antigen-induced histamine release. six sera of known ige anti-ragweed antigen e and total ige content were diluted to contain 10 ng of antibody but differed with respect to the ratio of specific/total ige. the relative ability of the sera to passively sensitize generally reflected the specific/total ige ratio but one serum was 2.5 times more active than the remainder. this ability did ...197988417
the effects of acridine orange on deoxyribonucleic acid in escherichia coli.1. acridine orange inhibits growth of escherichia coli k12 when incubated at ph 7.9, but not at ph 7.4.2. at a non-permissive temperature for dna polymerase i, acridine orange inhibits growth of a temperature-sensitive strain and also increases the rate of elimination of the f'-lac plasmid. 3. dna isolated from cells treated with acridine orange under conditions that inhibit growth contains material of low molecular weight, which is absent from dna isolated from cells treated under conditions in ...197827167
in vitro testosterone synthesis by testicular tissue of old mouse: the metabolism of 3beta-hydroxy-5-ene steroids. 197718359
remote-site stimulation of secretory iga antibodies following bronchial and gastric stimulation. 197884519
update: drugs in breast milk.drugs found in a woman's blood can be detected in her milk. the concentration in milk depends on the amount of drug in maternal blood, its lipid solubility and degree of ionization, whether it is actively secreted into the milk, and status of maternal renal function. alcohol concentration in the mother's milk is generally about equal to that in her blood; it is not known however, how large a daily dose can be tolerated by an infant. anticoagulants may or may not appear in breast milk. no sig ...197984332
immunologic methods for the identification of cell types. ii. expression of normal mouse mammary epithelial cell antigens in mammary neoplasia.mouse mammary epithelial (mme) cell antigens were cell type-specific and were retained, to a large extent, by mme cells after neoplastic transformation. these mme cell antigens were expressed in mammary tumors of balb/c, c3h, grs/a, riii, and is/bi mice tested and were not expressed in tumors whose normal counterpart was other than mammary tissue. they were not dependent on cell culture conditions or on the presence of murine mammary tumor virus; therefore, they can be used in an ubiquitous cell ...197880454
antibody to early antigens of varicella-zoster virus during varicella and zoster.igg antibody to the early antigens of varicella-zoster virus (vzv) was studied during both varicella and zoster by the indirect immunoperoxidase antibody technique. in parallel, complement-fixing, immune-adherence hemagglutinating, igg, and igm antibodies to vzv were studied. in both varicella and zoster infections, antibody to the early antigens of vzv appeared three to five days after onset of infection, reached a peak during the second week, and progressively decreased in titer until it disap ...197988490
preparation and antigenic properties of testosterone-4-bovine serum albumin conjugates. 197988547
chronic cryptic q-fever infection of the heart.evidence of chronic coxiella burneti infection of the heart, a disease previously considered peculiar to patients with valvular heart-disease, was found in a patient during routine serological tests before resection of a ventricular aneurysm and also by isolation of the rickettsia from the resected tissue. the patient had no symptoms or signs of q-fever endocarditis and none of the laboratory evidence usually associated with it.197988607
[partial monosomy 21 in familial cystic fibrosis and ectodermal dysmorphias]. 197988707
the influence of cyclic nucleotides on histamine release from rat peritoneal mast cells [proceedings]. 197988893
a simple and sensitive method for the quantitative estimation of collagen. 197988913
systemic hyalinosis (juvenile hyaline fibromatosis). ultrastructure of the hyaline with particular reference to the cross-banded structure.systematic hyalinosis (juvenile hyaline fibromatosis) is characterized by hyalinized skin lesions. electron microscopic examination of a hyalinized skin tumor from a 19-year-old man with this syndrome revealed that the hyaline was composed of ruthenium red-positive ultrastructures (granules, filaments, and a kind of cross-banded structure), indicating the presence of glycosamino-glycan or glycoprotein, and a small number of thin collagen fibrils. using a new ruthenium red staining method combine ...197988923
a reliable golgi-kopsch modification.a reliable golgi-kopsch variant is described. tissue is fixed with 1% paraformaldehyde, 1% glutaraldehyde in 0.1 m phosphate buffer, ph 7.2. tissue slabs (2.5--4 thick) are immersed for 5--7 days in a solution containing 3.5 g potassium dichromate, 15 g sucrose, 1.65 ml formaldehyde in 100 ml distilled water, washed briefly in 0.75% silver nitrate, and immersed in 0.75% silver nitrate for 2--3 days. procedures for cutting, counterstaining, and handling sections are described.197989002
preparative isolation of the cell receptor for immunoglobulin e. 197989114
simplified rubella haemagglutination inhibition test not requiring removal of non-specific inhibitors. 197989304
prospective study of chlamydial infection in neonates.chlamydia trachomatis was recovered from the cervices of 4% (36/900) of pregnant women tested. 20 infants born through chlamydia-infected cervices were followed up for a year, as were 18 infants born to chlamydia-negative mothers. a statistically significant excess of conjunctivitis and pneumonia was found in infants exposed to chlamydia. the attack-rate for inclusion conjunctivitis was 35% (7/20) and for chlamydial pneumonia it was 20% (4/20). chlamydiae were recovered from 10 of the 20 (50%) e ...197989446
failure to isolate a transmissible agent from the bone-marrow of patients with multiple sclerosis. 197989469
carcinomas of the liver in rats ingesting kepone.young male and female albino rats ingested 0, 1, 5, 10 or 25 ppm kepone, an organochlorine pesticide, in the diet for two years. carcinomas of the liver, as well as hyperplastic nodules and moderate and severe diffuse hyperplasia were observed in kepone-treated rats. such hepatic lesions were not seen in control rats. female rats ingesting kepone were more susceptible than male rats to hepatic carcinogenesis. rats ingesting 50 or 80 ppm kepone developed severe diffuse hepatic hyperplasia and did ...197989631
chlamydia trachomatis urethritis in men attending a venereal disease clinic: a culture and therapeutic study.urethral specimens from 459 male patients attending a venereal disease clinic were studied for presence of chlamydia trachomatis and neisseria gonorrhoeae. of the 459 patients, 362 had symptoms suggestive of urethritis. in these 362, gonorrhoea was diagnosed in 78 (22%), while 88 (24%) harboured c. trachomatis; 15 harboured both organisms. of those patients from whom c. trachomatis was isolated, 17% had no subjective symptoms of urethritis; the same percentage of symptomless carriers of gonococc ...197876400
a method for continuously monitoring the electrical threshold of single intraspinal nerve fibers.a method is described for the determination and continuous monitoring of the electrical threshold of single primary afferent fibres within the spinal cord of the cat. the centre barrels of multibarrel micropipettes, filled with 3.6 m nacl, were used as stimulating electrodes, impulses in single afferents were recorded peripherally and a firing index of 50% was maintained by using a feedback circuit to regulate the amplitude of the stimulating pulses (0.2-0.3 msec duration, less than 2 microa).197989955
[phospholipids and blood coagulation].after a simplified survey of the chemistry of phospholipids (pl) their presence in the lipid part of thromboplastin is dealt with, the significance of this structure being stressed. in addition, the condition, mode of action and synthesis of pl in blood platelets are extensively discussed and the impact of the composition of thrombocytic pl in the membrane and granular fraction by plasma lipid substances is referred to. the relations between single forms of pl and those proteins activating coagu ...197989981
the immune response of lewis rats to peptide 68-88 of guinea pig myelin basic protein. i. t cell determinants.a series of peptides, produced from peptide 68-88 by selective enzyme cleavage, were used to define the amino acid sequences required for the induction of experimental allergic encephalomyelitis (eae), an in vitro lymphocyte proliferative response (lpr), and serum antibody by peptide 68-88 in the lewis rat. here we present data that indicate that the t cell determinants for induction of eae, an lpr, and helper function in the production of antibody are located in the same region of the molecule ...197990087
involvement of host fc receptors in antibody-mediated cutaneous basophil hypersensitivity reactions.cutaneous basophil hypersensitivity (cbh) reactions are heterogeneous delayed time course basophil-rich responses that can be mediated by either t cells, b cells, or serum antibodies. the current study examined the mechanism by which antibodies mediate cbh in guinea pigs. fc competition experiments were constructed by passively transferring mixtures of anti-klh serum and normal heterologous gamma-globulins. it was found that rabbit igg and its isolated and purified fc fragment [but not the (fab' ...197990094
[schiff's test in diagnosis of ophthalmogalprovioses (chlamydioses)]. 197774054
[value of the method of quantitative bacterial counts for etiological diagnosis of pneumonia]. 197990194
effect of camp on acrosome reaction and fertilization. 197990530
the intra-nucleolar localization of amplified rdna in xenopus laevis oocytes.a fluorescent feulgen-stain was adapted in order to demonstrate dna-containing structures inside the amplified nucleoli of xenopus laevis. at all stages of oogenesis this method reveals granules or complex structures of dna in each nucleolus. the micronucleoli which do not stain with this method and which do not reveal an internal structure in low molarity saline, unlike real nucleoli are considered as nucleolus-like bodies. the dna-containing structures in the nucleoli can be composed of one or ...197990588
identification of malondialdehyde as the tba-reactant formed by bleomycin-iron free radical damage to dna. 197990623
prolonged survival of corneal allografts in rabbits treated with cyclosporin a. 197990771
preparation of antigens for microimmunofluorescence testing for antichlamydial antibodies. 197990960
procaine-induced seizures in epileptic monkeys with bilateral hippocampal foci.intravenous procaine hcl given at low doses (0.5-2.5 mg/kg) to two monkeys with bilateral alumina hippocampal foci depressed interictal spiking or had little effect. at 5.0 mg/kg unilateral limbic activation occurred. at 10.0 mg/kg unilateral or bilateral limbic activation and generalized seizures could be evoked within 3-10 min. at higher doses (15 and 20 mg/kg) bilateral limbic activation or brief (one min) generalized seizures occurred. the unilateral-onset psychomotor seizures were not ident ...197991502
immunofluorescence testing for chlamydial antibodies. 197991742
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