| different allotypic susceptibility of mice to rickett-sia tsutsugamushi. | some lines of mice and random-bred mice show different susceptibility to infection with rickettsia tsutsugamushi, displayed mainly in the development of overt infection. the latter is most markedly manifested in random-bred and swiss mice, causing high death rates and massive accumulation of rickettsiae in the peritoneum. black mice respond to inoculation with asymptomatic infection with no microscopically detectable rickettsiae. the infection is accompanied in either case by immunological respo ... | 1976 | 5869 |
| cytological investigation of rickettsia tsutsugamushi infection of mice with different allotypic susceptibility to the agent. | cytological and cytochemical studies on swiss and random-bred white mice susceptible to rickettsia tsutsugamushi infection as well as resistant c57 black 6 and cba mice revealed a clear-cut relationship between the severity of infection and the pattern of macrophage reaction. in highly susceptible mice the fatal infection was accompanied by death of macrophages and necrotisation of the peritoneal exudate cells. the resistant mice showed no clinical signs but developed an intensive macrophage rea ... | 1976 | 5870 |
| cellular factors. immunologic tolerance: irradiation and bone marrow transplantation in induction of canine allogeneic unresponsiveness. | | 1977 | 17203 |
| enzymatic activity of blood lymphocytes experimental tsutsugamushi fever in mice. | the influence of tsutsugamushi fever infection on the metabolism of blood lymphocytes of mice differing in susceptibility to rickettsia tsutsugamushi and of rifampicine and tetracycline treatment was studied. in susceptible mice, the activity of oxidation-reduction processes in lymphocytes increased at 7--10 days of the disease and became normal upon recovery of the animals. in mice with low susceptibility this increase of the activity began and terminated much earlier, at 3--5 days. treatment o ... | 1977 | 17284 |
| serologic classification of scrub typhus isolates from pakistan. | detailed serologic characterization of 79 isolates of rickettsia tsutsugamushi from pakistan was performed by using complement fixation and direct immunofluorescence techniques for comparison with three prototype strains. seventy-one were of the karp serotype and one was of a gilliam serotype. seven isolates were multiply-reactive: one with karp and gilliam, 3 with karp and kato, and 3 with karp, gilliam and kato, no strain failed to react with at least 1 of the 3 prototype antisera. no correlat ... | 1975 | 46135 |
| plaque assay and cloning of scrub typhus rickettsiae in irradiated l-929 cells. | it was demonstrated that gamma-irradiated l-929 cells support plaque formation by three strains of rickettsia tsutsugamushi and representative species of the spotted fever and typhus group rickettsiae. sensitivity of the plaque assay for detection of viable scrub typhus rickettsiae was similar to that achieved with intraperitoneal inoculation of random-bred mice. the concentration of irradiated cells and the temperature and length of incubation were all found to affect plaque size. a technique c ... | 1977 | 69632 |
| campylobacter urinary infection. | | 1979 | 86820 |
| on the mechanism of p-piperidyl and p-benzyl sulfamyl benzoic acids transport by renal tissue. | the uptake of cyclic analogues of probenecid by kidney cortical slices has been studied in detail, in order to obtain more information on the secretory system for these compounds. both p-piperidyl sulfamyl benzoic acid and p-benzyl sulfamyl benzoic acid were accumulated against concentration gradient, by renal tissue under aerobic as well as anerobic conditions. pah, phenol red and probenecid competitively inhibited the active accumulation of these compounds by kidney tissue. aerobic uptake of p ... | 1978 | 87158 |
| [allergy and lectins: action between ige-mediated histamine release and glycoproteins from viscum album l. (mistletoe)]. | low-molecular constituents from viscum album (toxic) release, in irritatively toxic manner, histamine from human leukocytes without destroying the cells (cytotox test). this histamine release is prevented by preincubation with viscum lectins. the viscum lectin blocks the fc-portion of allergen-specific ige against anti-ige [125i]. lectin also inhibits the allergen-specific histamine release from human leukocytes occurring through ige; this can be demonstrated on leukocytes from patients with ato ... | 1978 | 88141 |
| use of antibodies for studying the sidedness of membrane components. | | 1979 | 88659 |
| in-phase brain activities during arousal and sleep. | eeg of sensorimotor area, emg of neck muscles and unit activity in lateral geniculate (lg) nucleus, recorded in freely moving cats, were analysed for the presence of correlations between them. the 3 activities were first integrated with a 2 sec time constant, then a correlation coefficient was assessed between time-linked points of the 3 records for periods of 40 sec. the average vlaues of the correlation coefficients were found to increase from arousal through slow synchronized sleep (s sleep), ... | 1979 | 89948 |
| [effect of soviet bleomycin-bleomycetin on the body of animals in multiple parenteral administration]. | toxicity of bleomycetin was studied on 3 animal species (rats, rabbits and dogs). the antibiotic was administered intramuscularly and intravenously in various doses for a prolonged period of time. the death of the rats, rabbits and dogs treated with repeated lethal doses of bleomycetin was due to its toxic effect on the kidneys and probably lungs. the level of urea in the blood of the animals before death increased up to 300--400 mg %. histological examination of the kidneys revealed the picture ... | 1979 | 92213 |
| [clinical and biochemical contributions on the effect of maprotiline and clomipramine in depressive states (preliminary observation)]. | this study has been conducted on 17 patients suffering from neurotic and psychotic depressions, who had not received a pharmacological antidepressive therapy since at least 1 month. 6 patients suffering from psychotic depression were treated with 100 mg clomipramine i.v. daily for 20 days; 11 patients, 7 of whom suffered from psychotic depression and 4 from neurotic depression, were treated with 150 mg maprotiline i.v. daily for 20 days. in both groups the therapy has been continued orally. in ... | 1979 | 94169 |
| effect on rats and mice of a diet with low tryptophan content (maize flour). | female wistar rats when crowded together become aggressive if fed a diet with low tryptophan (trp) content (maize, flour, mf). when isolated during 30 days and fed mf they show a decrease of weight, of total plasma trp, and of trp and 5-hydroxytryptamine (5-ht) in brain stem, but 5-hydroxyindolacetic acid (5-hiaa) of the same cerebral area does not change. these results partially agree with other authors observations. mice isolated during 47 days and fed with mf do not show any significant weigh ... | 1979 | 95611 |
| verification of human fetal breathing with phased array ultrasound imaging. | continuous observation of fetal movement patterns is a novel and useful capability of new high-speed ultrasound imaging systems. confirmatory documentation of human fetal breathing as a component of these movement patterns has been achieved using a phased-array real time ultrasound sector scanning system. this system permits direct visualization of fetal breathing movements. permanent recordings can be made on videotape. recordings can also be made as a time-motion echocardiograms during continu ... | 1978 | 96144 |
| the organization, composition and matrix of hepatocyte nuclei exposed to alpha-amanitin. | alterations in the structure and molecular composition of avian hepatocyte nuclei were compared following administration in vivo of lethal and sub-lethal doses of alpha-amanitin. this toxin interferes with extranucleolar transcription by direct inhibition of rna polymerase ii activity. the resultant effects include: extensive condensation of chromatin, displacement of nucleoplasmic contents and fragmentation of nucleoli. changes in nuclear morphology were quantitated by stereometry and related t ... | 1978 | 96580 |
| quantitative electron microscopic studies of the changes in rat hepatocytes following halothane induced anaesthesia. | | 1977 | 98410 |
| stylostome formation by leptotrombidium mites (acari: trombiculidae). | the modes of stylostome formation by larvae (chiggers) of leptotrombidium intermedium, l. fletcheri, l. arenicola, and l. deliense in parasitized mouse skin were studied histologically in relation to their capacity to transmit rickettsia tsutsugamushi. three types of stylostome formation were recognized among the different species: the epidermal stylostome formed by the larva of l. intermedium; the mesenchymal stylostome formed by the larva of l. fletcheri; and, the mixed stylostome formed by th ... | 1978 | 98623 |
| control of cell multiplication: preparation and immunological comparison of inhibitory factors in the homogenate and perfusate of the adult rat liver. | the control of organ cell multiplication by a negative feed-back mechanism implies that factors of the inhibitory mechanism are present in the blood and are produced by the target organ itself. we have examined the inhibitors which are present in the cytosol of adult rat liver as well as in efferent fluid from an isolated perfused organ. these two materials yielded predominantly protein molecules having in common a molecular weight of approximately 80 000 daltons and an isoelectric point between ... | 1978 | 100149 |
| early detection of rickettsia tsutsugamushi in peripheral monocyte cultures derived from experimentally infected monkeys and dogs. | rickettsia tsutsugamushi organisms were identified in giemsa and fluorescent antibody stained monocyte cell cultures derived from experimentally infected monkeys and dogs. the identification of organisms in monocyte cell cultures compared favorably with the standard technique of mouse inoculation. | 1978 | 100887 |
| comparative ultrastructural study on the cell envelopes of rickettsia prowazekii, rickettsia rickettsii, and rickettsia tsutsugamushi. | rickettsia tsutsugamushi differs from other rickettsiae in its cell envelope organization. the differences were made evident through a comparative study of the outer envelope of r. tsutsugamushi, r. prowazekii, and r. rickettsii by electron microscopy. | 1978 | 101465 |
| identification and antigenic typing of rickettsia tsutsugamushi in naturally infected chiggers (acarina: trombiculidae) by direct immunofluorescence. | rickettsia tsutsugamushi organisms were detected and typed antigenically by direct immunofluorescence in mites from laboratory-maintained infected colonies of leptotrombidium (leptotrombidium) fletcheri and l. (l.) arenicola. rickettsiae were identified most readily in unengorged larvae, but were also discernable in engorged larvae and all post-larval stages of the vectors. | 1978 | 103449 |
| effects of temperature on the stability of rickettsia tsutsugamushi and gamma-irradiated scrub typhus immunogens. | unirradiated rickettsia tsutsugamushi and a component of gamma-irradiated karp immunogen required for homologous immunity were more stable than the immunogen component that elicited heterologous (kato strain) protection. | 1978 | 103827 |
| gamma-irradiated scrub typhus immunogens: development and duration of immunity. | the development and duration of immunity to lethal scrub typhus infection was studied in balb/c mice vaccinated with gamma-irradiated rickettsia tsutsugamushi, strain karp. one intraperitoneal injection containing approximately 10(8) 50% mouse lethal doses (mld(50)) of irradiated organisms elicited an immune response protective against challenge with 10(5) mld(50) of viable karp. the same mass of immunogen given in three injections at 5-day intervals increased homologous (karp strain) protection ... | 1978 | 103828 |
| serial prolactin and thyrotropin responses to thyrotropin-releasing hormone throughout normal human pregnancy. | | 1979 | 107178 |
| sensitive microplate enzyme-linked immunosorbent assay for detection of antibodies against the scrub typhus rickettsia, rickettsia tsutsugamushi. | a microtiter enzyme-linked immunosorbent assay (elisa) has been developed for the titration of antibodies against scrub typhus in human and animal sera. scrub typhus rickettsiae were grown in monolayers of irradiated mouse lm3 cells and separated from host cell materials by differential centrifugation, filtration through a glass filter (ap-20, millipore corp.), and isopycnic banding in renografin density gradients. the scrub typhus elisa antigens were obtained from the purified viable rickettsia ... | 1979 | 107185 |
| sero-epidemiological survey of scrub typhus. | a total of 1017 human sera from ecologically different areas in the states of rajasthan and jammu & kashmir were subjected to the cf test using the gilliam strain antigen of r. tsutsugamushi. results revealed that 2.4% and 3.5% of the populations examined in the two states respectively, were found to possess antibodies to the test antigen. the titres of positive sera varied from 1:8 to 1:32. findings of this survey could be correlated with the local topography, presence or absence of vector and ... | 1978 | 107239 |
| rickettsia tsutsugamushi infections in chiggers and small mammals on a mature oil palm estate. | an epidemiological study in a mature oil palm estate in peninsular malaysia has demonstrated a low prevalence of r. tsutsugamushi infection in small mammals. the direct fluorescent antibody technique for assaying infections in chiggers proved more sensitive than mouse inoculation. most infections in both chiggers and rodents were caused by the karp strain. | 1978 | 107596 |
| isolation of listeria monocytogenes from animals in the sudan. | | 1979 | 107996 |
| interference of iodine-125 ligands in radioimmunoassay: evidence implicating thyroxine-binding globulin. | although there is abundant published evidence that radioiodinated antigens interfere in digoxin radioimmunoassays, other radioimmunoassays are similarly affected. we investigated the relationship of radioiodinated antigen structure to its function in the immunoassay. carrier-free 125i-labeled iodotyrosine and iodohistamine derivatives were incubated with human serum, and the bound and free fractions were separated. we demonstrated that diiodotyrosyl analogs bind avidly to serum proteins. because ... | 1979 | 108034 |
| 3'-terminal nucleotide sequence of alfalfa mosaic virus rna 4. | the sequence of the 3'-terminal 91 nucleotides of alfalfa mosaic virus rna 4, the messenger for the viral coat protein, has been elucidated. a fragment containing the 3' terminus of the rna was obtained by mild digestion with rnase t1. the primary structure of the fragment was deduced by labeling it in vitro at its 5' terminus and application of rna sequencing techniques. the sequence is completely extracistronic and is believed to contain the binding sites for the viral coat protein and replica ... | 1979 | 108677 |
| [history of bacteriology in japan (32)]. | | 1979 | 112271 |
| intracellular localization of rickettsia tsutsugamushi in polymorphonuclear leukocytes. | rickettsia tsutsugamushi (gilliam strain) was serially propagated in bhk-21 cell cultures and incubated with guinea pig peritoneal polymorphonuclear leukocytes to study the ultrastructural features of rickettsial uptake and entry into the leukocytes. significant numbers of rickettsiae were phagocytized selectively by these leukocytes within 30 min. about one-half of these rickettsiae remained sequestered in phagosomes but the other one-half were free from the phagosome and localized directly in ... | 1979 | 113480 |
| [current remarks on rickettsiae and rickettsiosis--studies on virulence and prevalence of tsutsugamushi disease rickettsia (author's transl)]. | | 1979 | 114685 |
| gamma-irradiated scrub typhus immunogens: broad-spectrum immunity with combinations of rickettsial strains. | scrub typhus immunogens were prepared from rickettsia tsutsugamushi strains karp, kato, gilliam, kostival, and buie by exposing frozen infected yolk sac suspensions to 300 krad of gamma radiation. mouse protection tests showed that each of the irradiated immunogens protected c3h/hedub mice against high challenge levels of karp and gilliam, but that none of these single-strain immunogens were capable of protecting against all five of the challenge strains. broad-spectrum protection was achieved b ... | 1979 | 115796 |
| macrophages in resistance to rickettsial infection: macrophage activation in vitro for killing of rickettsia tsutsugamushi. | rickettsia tsutsugamushi, strain gilliam, replicates in cultures of resident peritoneal macrophages from balb/c mice. macrophage cultures treated with culture supernatants of spleen cells from rickettsial-infected mice stimulated with heat-killed rickettsiae markedly suppressed macrophage infection by rickettsiae. rickettsiacidal activity of activated macrophages was dependent upon both lymphokine concentration and time of incubation in lymphokines. treatment of macrophage cultures with lymphoki ... | 1979 | 115917 |
| clinical responses of silvered leaf monkeys to infection with selected strains of rickettsia tsutsugamushi. | minimal clinical and hematologic signs were observed in silvered leaf monkeys inoculated intradermally with four strains of rickettsia tsutsugamushi, both virulent and avirulent for laboratory mice. the clinical response of the monkeys to the infection was related to neither the virulence of the strains in mice nor the antigenic characteristics of the strains. | 1979 | 119001 |
| [immunological studies of rickettsial infection--analysis of lymphoid cell subpopulations of the spleens of the mice infected with rickettsia sennetsu and rickettsia tsutsugamushi (author's transl)]. | | 1979 | 119018 |
| studies on soluble complement fixing antigen of rickettsia tsutsugamushi. | | 1979 | 120318 |
| experimental rickettsia tsutsugamushi infections in dogs. | dogs were infected intravenously and intradermally with the gilliam and karp strains of r. tsutsugamushi. although the development of clinical signs was related to the dose of the organism, gilliam-infected dogs developed severer infections than those infected with karp. specific antibodies were demonstrated in sera of experimentally infected dogs. | 1979 | 120457 |
| persistence and reactivation of rickettsia tsutsugamushi infections in laboratory mice. | the persistence of r. tsutsugamushi in tissues of experimentally infected mice for 565 days was demonstrated. reactivation of apparently dormant infections was accomplished by inoculating the mice with a heterologous strain of the organism or treatment with cyclophosphamide. | 1979 | 120458 |
| antigenic analysis by direct immunofluorescence of 114 isolates of rickettsia tsutsugamushi recovered from febrile patients in rural malaysia. | one hundred and fourteen rickettsia tsutsugamushi isolates, recovered from febrile patients in central peninsular malaysia, were antigenically analyzed by direct immunofluorescence using eight prototype strains. twenty-nine antigenic types were detected. the ta763, ta716, karp and ta686 strains were the most common and occurred singly or in combination with each other or other strains in 86% of the isolates. | 1979 | 120901 |
| comparison of experimental rickettsia tsutsugamushi infections in silvered leaf (presbytis cristatus) and cynomolgus (macaca fascicularis) monkeys. | both silvered leaf and cynomolgus monkeys were infected with the gilliam, karp and kato strains of rickettsia tsutsugamushi. the two species developed similar clinical syndromes, but the antibody responses were greater in cynomolgus monkeys. in both species of monkeys, the gilliam strain induced more severe clinical manifestations. at 10 months post-infection, silvered leaf monkeys were immune to homologous intradermal (id) challenge. cynomolgus monkeys, at 15 months post-infection, were relativ ... | 1979 | 120902 |
| changes in immunoferritin labeling of rickettsia tsutsugamushi after serial cultivation in 60co-irradiated bhk cells. | the immunolabeling characteristics of rickettsia tsutsugamushi (gilliam strain) were examined by using a purified immunoglobulin g fraction of antibody to r. tsutsugamushi raised in rabbits. formalin-fixed rickettsiae were reacted with this antibody and then with ferritin-conjugated goat anti-rabbit fc antibody. r. tsutsugamushi cultivated in yolk sacs was used to raise antibody for this study. when rickettsiae in bhk-21 cells infected from yolk sac seed material were immunoferritin labeled, the ... | 1979 | 121111 |
| host defenses in experimental scrub typhus: role of normal and activated macrophages. | resident peritoneal macrophage from balb/c mice were infected in vitro with rickettsia tsutsugamushi strain gilliam, and rickettsial growth was estimated by microscopic examination of giemsa-stained cells. both number of infected macrophage per culture and number of intracellular rickettsiae per cell increased with time during culture. treatment of rickettsiae with immune serum before infection macrophage cultures reduced the number of infected macrophage by 50%. macrophage treated in vitro with ... | 1979 | 121116 |
| the manufacture of moulded supportive seating for the handicapped. | the wheelchair-bound population often have difficulty in obtaining a correct or comfortable posture in their chairs and sometimes develop pressure sores from long-duration sitting. this problem is being solved by manufacturing personalised, contoured seats which support the patient over the maximum area possible thereby reducing the pressure on the body and the incidence of pressure sores. a cast is obtained of the patient in a comfortable, medically correct posture and from this cast the seat i ... | 1975 | 126704 |
| in vitro proliferative response of balb/c mouse spleen cells stimulated with trinitrophenylated syngeneic spleen cells. | spleen cells from normal balb/c mice showed in vitro proliferative response against hapten-conjugated syngeneic spleen cells. trinitrophenylated (tnp) spleen cells were prepared by treating normal spleen cells with sodium 2,4,6-trinitrobenzenesulphonate (tnbs). four-day cultures of tnp-labelled spleen cells incorporated 2.5-7.4 times more [3h]thymidine than similar cultures of untreated spleen cells. an obviously positive mixed lymphocyte reaction (mlr) by normal spleen cells against mitomycin c ... | 1975 | 127744 |
| [action of hemocoagulase on the cicatrization of the dura mater in rabbits. preliminary results]. | the present study compares the cicatrization of the dura by administration of i.m. hemocoagulase. this study was done on 6 rabbits and 6 control animals. the authors think that the cicatrization is a little slower but of better quality. the hemocoagulase seems to favorize the vasculo-exsudative process of cicatrization. the fibrinous deposits are more important too. perhaps the occlusion of c.s. fluid fistulas could be favorized by means of the used product. definitive conclusions are not possib ... | 1978 | 154952 |
| muscle fiber and motor end plate involvement in the extraocular muscles of the myotonic mouse. | the extraocular muscles of the c57bl/6jdy-2j myotonic mouse were studied by phase and electron microscopy. the most susceptible ocular muscle was the levator palpebrae; the other muscles manifested scattered abnormalities to varying degrees. central nucleation and fiber splitting were prominent. junctional abnormalities consisted of a reduction in post-junctional folding, excessive numbers of axonal terminals on hypertrophic fibers, and the presence of dense granules between axon and muscle. thi ... | 1975 | 166048 |
| a method of isolating enteroviruses from meat]. | a method of isolating the virus echo ii in specimens of stewed beef and cutlets is assessed. the procedure involves obtaining extracts of the meat with the saline (in ratios of 1:2 and 1:4) in combination with processing with freon 113. this method failed to detect in the meat samples analyzed 20-30 cpd50 of the virus in 1 g. experiments demonstrated that eluation of the poliovirus from the meat into an aqueous saline depended on the proportion of meat and the eluating solution. it was shown tha ... | 1975 | 174319 |
| five steps in the conversion of a large precursor rna into bacteriophage proline and serine transfer rnas. | | 1975 | 175167 |
| fine structure of the pancreatic islets in domestic fowl with special reference to the cell type and secretion. | the pancreatic islets of domestic fowl were investigated by electron microscope. the following results were obtained. 1. the a islet is composed of a great many a cells and a few d cells. it also contained only a few b cells which are situated mainly along capillaries. 2. on the contrary, the b islet is composed of a great many b cells and a few d cells. it also contained only a few a cells in its periphary. 3. immature secretory granules within the golgi complex are almost the same in size, sha ... | 1975 | 175756 |
| immunofluorescence on avian sarcoma virus-transformed cells: localization of the src gene product. | the localization of the avian sarcoma virus src gene product (termed p60src) was examined by indirect immunofluorescence in cells transformed by the schmidt-ruppin strain of rous sarcoma virus, subgroup d (sr-rsv-d). antiserum to p60src was obtained from rabbits bearing sr-rsv-d-induced tumors, and immunofluorescence was performed on chicken embryo fibroblasts (cef) transformed with sr-rsv-d, as well as normal rat kidney (nrk) cells transformed by the same virus (termed sr-rk cells). both aceton ... | 1979 | 217542 |
| diffusion-controlled reactions on spherical surfaces. application to bacteriophage tail fiber attachment. | we have explored the kinetic implications of a model that may account for the acceleration of tail fiber (f) attachment to baseplates (b) by whiskers (w) on bacteriophage t4. the model assumes that a w-f complex is formed initially, and that the tethered fiber then undergoes rotational diffusion until a b-f encounter takes place. in the absence of whiskers, b-f complexes must form unassisted. formation of a w-f intermediate will accelerate f attachment to b if (a) the bimolecular rate constant f ... | 1979 | 262439 |
| [radioprotection of 2, 2-dimethylthiazolidine hydrochloride (author's transl)]. | | 1979 | 262827 |
| a soluble atp-dependent proteolytic system responsible for the degradation of abnormal proteins in reticulocytes. | reticulocytes, like other cells, selectively degrade certain abnormal proteins by an energy-dependent process. when isolated rabbit reticulocytes incorporate the valine analog 2-amino-3chlorobutyric acid (clabu) in place of valine, they produce an abnormal globin that is degraded with a half-life of 15 min. normal hemoglobin, in contrast, undergoes little or no breakdown within these cells. cell-free extracts from reticulocytes have been shown to rapidly hydrolyze these abnormal proteins. the de ... | 1977 | 264694 |
| [experimental malocclusion and growth of the condylar cartilage in young rats]. | | 1977 | 265595 |
| [cytotoxic antibodies to leukemia cells in normal human sera]. | antibodies cytotoxic for human leukemia cells were demonstrated in 7 parents of leukemia children and in 2 normal donors whose blood had induced a partial remission in leukemia and lymphoma patients. none of these sera were cytotoxic to remission cells nor to normal lymphocytes. these sera appear to be relatively specific for acute lymphoblastic leukemia cells; however, several antigenic specificities appear to be detected by these sera. | 1977 | 265695 |
| ld50 of snf2, naf, and na2po3f in the mouse compared to the rat. | | 1978 | 272954 |
| purification of adp-ribosylated nuclear proteins by covalent chromatography on dihydroxyboryl polyacrylamide beads and their characterization. | nuclear proteins modified by mono or poly adp-ribosylation were selectively isolated and purified by covalent chromatography on a dihydroxyboryl polyacrylamide bead column that specifically interacts with cis-diol-containing compounds. from rat liver nuclei that had been incubated with nad+, histones and some nonhistone proteins were extracted with 0.25 m hcl. approximately 60% of the adp-ribose incorporated into 20% trichloroacetic acid-precipitable material was recovered in this extract. the a ... | 1978 | 274702 |
| some effects of n-methylnitrosourea on the oral and odontogenic tissues of the syrian golden hamster. | | 1978 | 281195 |
| cytotoxic activities of normal cultured human t cells. | normal human t cells grown in continued cultures in medium containing conditioned medium (cm) from pha-stimulated lymphocytes were studied for their ability to manifest three known forms of cell-mediated cytotoxicity: lectin-induced cellular cytotoxicity (licc), natural killer cell (nk) activity, and antibody-dependent cellular cytotoxicity (adcc). the cultured t cells (ctc) were very effective mediators of licc, being cytotoxic even at very low attacker-target cell ratios in the presence of dif ... | 1978 | 308961 |
| effects of human thymic epithelial-conditioned medium on mitogen responsiveness of human and mouse lymphocytes. | | 1979 | 313294 |
| immunotherapy from malignant disease. | | 1978 | 348035 |
| enzyme immunoassay of antibody to rochalimaea quintana: diagnosis of trench fever and serologic cross-reactions among other rickettsiae. | enzyme immunoassay (eia) tests were used to diagnose trench fever and to determine cross-reactions of rochalimaea quintana with other rickettsiae. the results were compared with those obtained by counterimmunoelectrophoresis (cie). all sera from cases of primary or relapsed forms of trench fever were positive both in eia, with serum antibody titers of 1:20-1:640, and in cie, giving one to three precipitin lines. sera from patients with other rickettsial infections were also tested for reactivity ... | 1978 | 351072 |
| biosynthetic relationships of big and little gastrins. | | 1978 | 351420 |
| alteration in local and systemic immune capacity after exposure to bursts of co. | | 1979 | 387409 |
| experimental scrub typhus immunogens: gamma-irradiated and formalinized rickettsiae. | scrub typhus immunogens were prepared by exposing infected yolk sac suspensions of rickettsia tsutsugamushi to various doses of gamma radiation. mouse lethality was abolished at doses greater than 200 krads, whereas immunogenicity of the suspensions, as shown by mouse protection tests, was diminished relatively little by radiation doses in the 200- to 400-krad range. using a 300-krad gamma dose to provide a safety factor, immunogens were prepared and their protective capacity was contrasted with ... | 1977 | 401770 |
| failure of cyclophosphamide to significantly enhance isolation of rickettsia tsutsugamushi from wild philippine rats. | treatment of wild rats from a known scrub typhus focus in the philippines with cyclophosphamide did not significantly enhance the isolation rate of rickettsia tsutsugamushi using mouse inoculation techniques. similarly, cyclophosphamide treatment of mice inoculated with organs of wild rats did not increase the recovery of rickettsiae, and isolation of rickettsiae was about equal from biopsies obtained before and after immunosuppression of wild rats. | 1977 | 401830 |
| scrub typhus: a common cause of illness in indigenous populations. | an explanation was sought for the disparity between the low reported incidence of scrub typhus and the high prevalence of antibody to rickettsia tsutsugamushi in the rural population of malaysia. a combination of isolation of the organism, titration of antibody by indirect immunofluorescence, and the weil-felix test was used to confirm infections. scrub typhus was found to be very common, causing 23% of all febrile illnesses at one hospital. the infection was particularly prevalent in oil-palm w ... | 1976 | 402722 |
| efficiency of transovarial transmission of rickettsia tsutsugamushi in leptotrombidium arenicola (acari: trombiculidae). | | 1977 | 403286 |
| indirect immunofluorescence antibodies in natural and acquired rickettsia tsutsugamushi infections of philippine rodents. | antibodies against rickettsia tsutsugamushi detected by the indirect fluorescent-antibody test (ifat) were present in most rats trapped from a human focus of scrub typhus in the philippines. rickettsiae were isolated only from rats with positive ifats. naturally acquired antibodies persisted for at least 11 months, and antibodies resulting from experimental infections of rats persisted for at least 7 months. a common philippine rodent, rattus mindanensis, tolerated experimental infections with b ... | 1977 | 404245 |
| patterns of rickettsemia and antibody response in silvered leaf monkeys (presbytis cristatus) after inoculation with virulent and avirulent strains of rickettsia tsutsugamushi. | most silvered leaf monkeys inoculated with selected strains of rickettsia tsutsugamushi developed rickettsemia. the time of onset and the duration of rickettsemia were related to the infecting strains, but these parameters could not be correlated with the virulence of the strain. the rickettsemia was not terminated by the appearance of humoral antibody, as detected by the indirect fluorescent antibody test. the specificities of the antibody responses were related to the antigens present in the i ... | 1977 | 404364 |
| host defenses in experimental scrub typhus: role of spleen and peritoneal exudate lymphocytes in cellular immunity. | lymphocytes obtained from spleens or peritoneal exudates of immune donor mice were evaluated for their ability to passively confer protection on recipients subsequently challenged with virulent scrub typhus rickettsiae. peritoneal exudate lymphocytes (pels) injected intraperitoneally were able to transfer complete protection against rickettsial challenge by 5 days after immunization, whereas splenic lymphocytes (spl's) required 15 days to exhibit similar resistance. when immune lymphocytes were ... | 1977 | 409681 |
| sex ratios in rickettsia tsutsugamushi-infected and noninfected colonies of leptotrombidium (acari: trombiculidae). | | 1977 | 409845 |
| chigger (acarina:trombiculidae) surveys of the west coast beaches of sabah and sarawak. | leptotrombidium (leptotrombidium) arenicola traub, a vector of scrub typhus, had previously been found to occur in the coastal vegetation behind the edge of open sand along the beaches of peninsular malaysia. surveys of the west coast beaches of sabah and sarawak were conducted to determine if this species occurs in similar habitat in east malaysia on the island of borneo. leptotrombidium (l.) arenicola was not collected from the eighteen sites studied. of the 11,982 mite larvae collected, 55 pe ... | 1977 | 411176 |
| numbers of leptotrombidium (leptotrombidium) deliense (acarina: trombiculidae) and prevalence of rickettsia tsutsugamushi in adjacent habitats of peninsular malaysia. | numbers of l. (l.) deliense larvae were determined in adjacent habitats over a 16 month period. both r. argentiventer and r. tiomanicus were highly efficient hosts for l. (l.) deliense. r. argentiventer was host to significantly greater numbers of chiggers per rat than was r. tiomanicus. the 2 habitats were similar in numbers of chiggers collected. no consistent correlation was apparent between numbers of chiggers and any single weather factor, but the chigger population seemed to be adversely a ... | 1977 | 411177 |
| the life history of a colony of leptotrombidium (leptotrombidium) fletcheri (womersley & heaslip) infected with rickettsia tsutsugamushi. | the life cycle of 5 generations of leptotrombidium (l.) fletcheri infected with rickettsia tsutsugamushi and reared under ambient temperatures in malaysia was presented and compared with a colony reared at a constant 27 degrees c (neal and barnett, 1961). in general our colony had a longer generation time (average of 54 days from engorged larvae to adult compared with 37 days) and produced fewer eggs (average of 127.9 compared with 900.0) than the comparison colony. possible factors causing thes ... | 1977 | 411178 |
| virulence and antigenic properties of rickettsia tsutsugamushi in a naturally infectei laboratory colony of leptotrombidium (leptotrombidium) arenicola. | over 1,200 isolations of r. tsutsugamushi were obtained over 7 generations of l. (l.) arenicola and no reproducible differences in virulence or antigenic markers could be detected among these isolations. the f8 generation yielded rickettsia with the same antigenic makeup and virulence properties as the original female parent mite. when these isolates were inoculated into mice they elicited the same predominant antibody specificities, i.e. they all produced antibody which reacted with the ta 763 ... | 1977 | 411179 |
| presence of antibodies to scrub typhus and murine typhus in dogs from selangor, peninsular, malaysia. | dog sera, collected from different communities throughout selangor, peninsular malaysia, were investigated for the presence of antibodies to r. tsutsugamushi and r. typhi. scrub typhus antibodies were present in animals from the rural areas only, whereas murine typhus antibodies were observed in equal numbers of dogs from both rural and metropolitan areas. greater percentage of dogs from suburban areas had demonstrable antibody titers to murine typhus than from the urban area. | 1977 | 411180 |
| host defenses in experimental scrub typhus: effect of chloramphenicol. | the effect of chloramphenicol treatment on the development of immunity to scrub typhus in mice was studied. chemotherapy was administered either shortly before infection and for 14 days thereafter (group i), or from 7 to 21 days postinfection (group ii). although the full course of either regimen resulted in complete protection of the mice against subsequent challenge with the homologous strain of rickettsia tsutsugamushi, initiation of chemotherapy at 7 days postinfection resulted in more rapid ... | 1977 | 411755 |
| improved chicken embryo cell culture plaque assay for scrub typhus rickettsiae. | the plaque technique for three strains of rickettsia tsutsugamushi in chicken embryo cell cultures was greatly improved by modifying the trypsinizing procedure and employing homologous chicken serum in the overlay medium. | 1977 | 412863 |
| epidemiological and serological study of scrub typhus among chinese military in the pescadores islands of taiwan. | an outbreak of 69 cases of scrub typhus occurred among chinese military personnel stationed in the pescadores islands, taiwan province, republic of china between may and november 1975. a retrospective epidemiological study of this outbreak indicated that military personnel over 40 were more likely to have scrub typhus than those under 40. high risk groups included the garrison force (home guard), anti-aircraft gunners and infantry and armoured units stationed at hsing-jen. the onset of symptoms ... | 1977 | 413217 |
| restoration of the infectivity of rickettsia tsutsugamushi to susceptible animals by passage in athymic nude mice. | restoration of the infectivity of three prototypes of rickettsia tsutsugamushi (i.e., gillium, karp and kato strains) was examined to obtain each antiserum for the diagnosis of rickettsiosis and to prepare target antigens. when successively passed in embryonated yolk sac, rickettsiae gradually lost their infectivity to susceptible animals; after several passages in mice only kato strain retained infectivity and others became completely avirulent. when these strains were passaged in athymic nude ... | 1977 | 413961 |
| scrub typhus infection in rats in four habitats in peninsular malaysia. | rickettsia tsutsugamushi isolations were attempted from blood samples obtained from rats captured in four adjacent habitats near kuala lumpur, malaysia. antibody surveys were also made. rickettsial infections were most frequent in rats captured in the forest and in lalang grass (imperata cylindrica) and least frequent in the most extensively disturbed habitat, an orang asli (aborigine) village. forest rats such as rattus sabanus (31%), as well as rats in the subgenus r. (rattus), i.e. r. tiomani ... | 1977 | 415390 |
| serological evidence for a high incidence of transmission of rickettsia tsutsugamushi in two orang asli settlements in peninsular malaysia. | two communities of orang asli (aborigines) in peninsular malaysia were observed for evidence of rickettsia tsutsugamushi infection over periods of 1-8 mo. sequential sera were examined for antibody by the indirect immunofluorescence test. the incidence of infection in the two self-selected populations in the two communities was calculated to be 3.9% per month and 3.2% per month. | 1978 | 415625 |
| host defenses in experimental scrub typhus: genetics of natural resistance to infection. | genetic resistance to lethal infection with rickettsia tsutsugamushi was studied in over 30 inbred strains, inbred hybrids, and outbred stocks of mice. inbred mice infected intraperitoneally with the gilliam strain of r. tsutsugamushi showed three patterns of response: susceptible (a/hej, c3h/hedub, c3h/hej, c3h/hen, c3h/st, cba/j, dba/1j, dba/2j, and sjl/j), resistant (akr/j, balb/cdub, balb/cj, c57bl/6j, c57l/j, and swr/j), and selectively resistant (a/j). the selectively resistant pattern was ... | 1978 | 415980 |
| vole agent identified as a strain of the trench fever rickettsia, rochalimaea quintana. | the vole agent described by baker in 1946 was studied as an example of a bacterium that has been mistakenly regarded a rickettsia. unlike rickettsiae, the vole agent killed chicken embryos with great irregularity, multipled primarily at the surface of avian or mammalian cells and not intracellularly, produced colonies rather than plaques on chicken embryo monolayers under agar, and developed small colonies after 4 to 7 days of cultivation on blood plates. it was most conveniently cultivated on m ... | 1978 | 417026 |
| experimental infection of mouse peritoneal mesothelium with scrub typhus rickettsiae: an ultrastructural study. | the infection cycle of rickettsia tsutsugamushi in mouse peritoneal mesothelial cells, observed late in the course of an established infection, intimately involved the host cell plasma membrane. organisms multiplied in the cytoplasm, moved to the cell periphery, and acquired a host-membrane coat as they budded from the cell surface. rickettsiae enveloped by this membrane entered other mesothelial cells, apparently by a phagocytic mechanism. organisms escaped from the phagocytic vacuole as the va ... | 1978 | 417027 |
| isolation of rickettsia tsutsugamushi from mammals and chiggers (fam. trombiculidae) in the pescadores islands, taiwan. | | 1978 | 418538 |
| [the fertility status following puerperal diseases in cattle]. | | 1979 | 420689 |
| pharmacokinetic study of cis-dichlorodiammineplatinum(ii) (ddp) in the beagle dog: thermodynamic and kinetic behavior of ddp in a biologic millieu. | | 1979 | 421234 |
| [an experimental study on myocardial involvement in disseminated intravascular coagulation (author's transl)]. | | 1979 | 422119 |
| changing risk of scrub typhus in relation to socioeconomic development in the pescadores islands of taiwan. | long term changes in risk of rickettsia tsutsugamushi infection among civilian residents of the pescadores islands of taiwan were associated with changing social conditions. age specific incidence rates of scrub typhus in the pescadores before 1940 were highest among children under 5 years of age. rickettsiae can be demonstrated in vectors, wild animals continue to be infected and scrub typhus occurs in military personnel. a serologic survey for antibody to r. tsutsugamushi was conducted during ... | 1979 | 425961 |
| autoradiographic studies on the incorporation of tritiated uridine, leucine and methionine into gomori-positive glia of rat hypothalamus. | the relative level of metabolic activity in gomori-positive (gp) glia was estimated by comparing the incorporation rates of 3h-uridine, 3h-leucine and 3h-methionine into the nuclear macromolecules of the glia, neurons, ependyma and subcommissural organ (sco). the uptake of 3h-uridine by gp glia was somewhat lower than that by neurons and sco but higher than that by ependyma. the incorporation of 3h-leucine was about the same in all studied types of cells, except for a lower uptake by ependyma. t ... | 1979 | 525236 |
| forecasting the onset of a scrub typhus epidemic in the pescadores islands of taiwan using daily maximum temperatures. | daily maximum atmospheric temperatures were used to forecast the seasonal onset of scrub typhus in the pescadores islands of taiwan. the day of the year on which the temperature first reached 30 degrees c was selected as the predictive base. predictions for 1977 closely matched observed events. the model provides an easy and effective means to forecast the start of scrub typhus epidemics in the pescadores islands and could be used for such practical purposes as determining when prophylactic anti ... | 1979 | 542987 |
| single dose doxycycline therapy for scrub typhus. | a single dose of 200 mg of doxycycline was shown to be as effective as a seven day course of tetracycline, in patients suspected of having scrub typhus. 65 (44%) of the 149 patients studied fulfilled the criteria for definite diagnosis of scrub typhus; 10 had an additional diagnosis. rickettsia tsutsugamushi was isolated from 49 (75%) patients. there was no difference between the two treatment groups in time to defervescence, abolition of cough and headache, or in the time taken to recover well- ... | 1978 | 705848 |
| distribution of rats infected with rickettsia tsutsugamushi (scrub typhus) in an edge habitat. | no focalization of rats (rattus tiomanicus and r. argentiventer) infected with rickettsia tsutsugamushi could be discerned over a 500 m trapping transect at the border between a forest and lalang grass (imperata cylindrica). r. tiomanicus appeared to occupy 250 m of the transect on the average and had periods during which infections were observed which averaged 97 days. calulations indicated that more than 50% of individuals become infected over their life-time. the high rate of infection in thi ... | 1978 | 751214 |
| mammals and scrub typhus ecology in peninsular malaysia. | the overall comparisons of habitats are given in (table iii). the habitats are arranged in order of extent of alterations by man, with the least disturbed at the top. the highest average blood isolation rates came from the least disturbed areas. the highest monthly maximal rickettsial isolation rates from blood and maximal prevalence rates of antibody per month were also obtained at bukit lanjan, the habitat least altered by activities of man. the lowest average blood isolation rate (6%) and the ... | 1975 | 806995 |
| distribution of rickettsia tsutsugamushi in organs of leptotrombidium (leptotrombidium) fletcheri (prostigmata: trombiculidae). | | 1975 | 810585 |