| pathways of nadph formation in escherichia coli. | | 1977 | 16899 |
| calf liver nuclear n-acetyltransferases. purification and properties of two enzymes with both spermidine acetyltransferase and histone acetyltransferase activities. | calf liver contains two nuclear n-acetyltransferases which are separated by chromatography on hydroxylapatite. both acetyltransferase a and acetyltransferase b will transfer acetate from acetyl-coa to either histone or spermidine. the same protein catalyzes the reaction with both substrates; this is shown by a constant ratio of spermidine to histone activity over a 5,000-fold purification and identical heat denaturation kinetics for both spermidine and histone acetyltransferase activity with eac ... | 1978 | 22543 |
| compartmentalization of cyclic nucleotides and cyclic amp-dependent protein kinases in rat liver: immunocytochemical demonstration. | | 1978 | 27084 |
| absorption, elimination and metabolism of a new neuroleptic agent (flo 1347) in the rat dog and man (author's transl). | | 1978 | 30386 |
| antigenic specificity of cell-mediated antitumor reaction in the msv system. | | 1975 | 60997 |
| dietary fibre and experimental colon cancer. | | 1979 | 85018 |
| comparative light- and electron-microscopical study of the normal adenohypophysis in the human. | the pars distalis of 1 girl and of 3 sexually mature women was studied. the glands were dissected out and fixed within a period of 30 min following death; in the aldehyde fixative, each gland was systematically divided into ten pieces. before fixation in osmium tetroxide, each piece was again divided into several blocks. at least 60 blocks were obtained from each gland. semi-thin sections obtained from all the blocks were stained and studied under the light microscope. ultrathin sections were ob ... | 1979 | 85403 |
| observations on the m-wave and the cnv in the squirrel monkey. | a typical cnv paradigm, with food as reward, evokes in the squirrel monkey's post-arcuate and post-central cortices both m-waves in response to the cues and what appears to be a cnv in the interstimulus interval. both wave forms appear to be generated locally in cortex and to be more closely related temporally to the cues than to the animal's behavioral response. the cnv, like the m-wave, appears to reflect the animal's level of interest in obtaining the reward. it is smaller when the animal mis ... | 1979 | 85525 |
| in vitro synthesis of infectious transforming dna by the avian sarcoma virus reverse transcriptase. | infectious dna molecules, capable of transforming chicken embryo fibroblasts, can be synthesized by the rous sarcoma virus-associated reverse transcriptase in vitro. the optimal enzymatic conditions employed for infectious dna synthesis also facilitate maximum synthesis of genome length dna. analysis of the dna product synthesized by detergent-disrupted rous sarcoma virus under these conditions indicates that dna complementary to viral rna (minus-strand dna) is genome length in size, whereas dna ... | 1979 | 85719 |
| cytotoxic macrophages induced in hamsters by vaccinia virus: selective cytotoxicity for virus-infected targets by macrophages collected late after immunization. | | 1979 | 87476 |
| denaturization of allergen p: effect on allergenicity, antigenicity and immunogenicity. | when allergen p was denatured by 8m urea, the modified molecule still reacted with ige specific for the native allergen but not with hemagglutinating antibodies. heating at 100 degrees c abolished the reaction in both cases. the results suggested differences between allergenic and antigenic capacities which may be based on structural differences of the antigenic determinants. | 1979 | 88195 |
| the role of p23,30-bearing human macrophages in antigen-induced t lymphocyte responses. | | 1979 | 88270 |
| differentiation between cyclic amp level and allergic histamine release in mast cells [proceedings]. | | 1979 | 88891 |
| trasylol prevents trypsin-induced shock in dogs. | the effect of simultaneous intravenous administration in the dog of bovine trypsin and trasylol followed by continued infusion of trasylol was studied. special attention was paid to the interchange between the dominating plasma protease inhibitors alpha1-antitrypsin and a-macroglobulins and to the disappearance of trasylol and its trypsin complexes from the circulation. the following results were obtained: 1) trypsin was preferentially bound by the alpha-macroglobulins, though trasylol is a stro ... | 1979 | 89067 |
| monkey antiserum to mlc-primed human t lymphocytes. | | 1979 | 89737 |
| steroid secretion by in vitro perfused testes: inhibitors of testosterone biosynthesis. | | 1979 | 89816 |
| detection by antihapten antibodies of liver-bound compounds related to azocarcinogens or their metabolites. | the localization of known azocarcinogens and metabolites such as p-aminoazobenzene and n-methyl-p-aminoazobenzene bound to components of liver cells of rats fed single or multiple doses of 3'-methyl-p-dimethylaminoazobenzene has been determined with the use of antibodies raised against p'-azo-p-aminoazobenzene and p'-azo-n-monomethyl-p-aminoazobenzene in the indirect fluorescent antibody procedure. these 2 antisera reacted with liver cells of rats fed 3'-methyl-p-dimethylaminoazobenzene, p'-amin ... | 1979 | 90352 |
| analysis of antigens in mycobacterium paratubercuolsis. | | 1979 | 90456 |
| [animal experimental studies on the volume expanding effect of hydroxyethyl starch 40000 in the dog acute hemorrhagic shock]. | after acute hemorrhagic shock in dogs the hemodynamics of hydroxyethyl starch (mw: 40,000) are studied. the experiment shows that this plasma expander has a good efficiency for 3 to 4 hours. the indications of application of this colloidal solution are discussed. | 1979 | 90651 |
| maternal blocking factors in human pregnancy are found in plasma not serum. | pregnancy plasma and sera were evaluated for differential blocking effects in mixed lymphocyte culture reactions. autologous pregnancy plasma, but not serum was found to contain a specific allogeneic inhibitor for paternal lymphocytes. | 1979 | 90919 |
| inhibition of anaphylactic histamine release by complexes of lidocaine with zinc. | | 1979 | 91376 |
| comparative morphology and mucus histochemistry of the ruminant cervix: differences between crypt and surface epithelium. | | 1979 | 91389 |
| occurrence of beta 2-microglobulin in mammalian lymphocytes and erythrocytes. | cell-associated beta 2-microglobulin (beta 2m) has been studied by quantitative techniques in lymphocytes and erythrocytes of guinea pig, rabbit, rat and man. beta 2m was solubilized by sonication followed by treatment with acid, deoxycholate or thiocyanate, and then determined by radioimmunoassay. the average number of beta 2m molecules per lymphocyte, estimated after acidification, varied between 0.89 x 10(5) and 7.1 x 10(5). rat erythrocytes contained 3.0 x 10(3) molecules per cell, whereas n ... | 1979 | 91519 |
| antigen specific t cell-mediated suppression. vi. properties of in vitro generated l-glutamic acid60-l-alanine30-l-tyrosine10 (gat)-specific t-suppressor factor(s) (gat-tsf) in responder mouse strains. | | 1979 | 91643 |
| viral specificity of h-2-restricted t killer cells directed against syngeneic tumors induced by gross, friend, or rauscher leukemia virus. | cytolytic t lymphocytes (ctl) were generated against murine tumors induced by gross, friend, or rauscher leukemia virus (lv) in syngeneic mixed leukocyte-tumor cell cultures. analogous to the patterns of specificity observed with antibodies to lv-induced cell surface antigens, ctl could be classified into two major groups of specificity. tumor cells induced by friend, moloney, or rauscher virus and positive for the fmr antigen were killed by syngeneic ctl immune to any one of these three lv; the ... | 1979 | 91655 |
| decline in hypernatraemia. | | 1979 | 91864 |
| response to immunological or cholinergic stimulation of isolated mast cells from man, guinea pig and rat. | | 1979 | 91954 |
| [ultrastructural cytochemistry of the mouse juxtaglomerular apparatus (author's transl)]. | the ultrastructural cytochemistry of the mouse juxtaglomerular apparatus has been studied. the specific granules of the juxtaglomerular cells were found to be argentaphobic when ultrathin sections of araldite-embedded renal cortex were stained according to the periodic acid-thio-carbohydrazide-silver proteinate technique of thiery. this technique revealed an abundant glycogen of type beta in the specific granules and in the cytosol of these cells. the rim of specific granules was positive when u ... | 1979 | 92002 |
| relations between statistical properties of spontaneous activity of lateral geniculate neurons and their anatomo-physiological features [proceedings]. | | 1979 | 92234 |
| the antagonistic effect of dexamethasone and insulin on alpha-fetoprotein secretion by cultured h4-ii-e-c3 cells derived from the reuber h-35 hepatoma. | | 1979 | 92316 |
| [a comparison of the immunosuppressive effect of normal and purified alpha-globulin fraction of human plasma]. | | 1979 | 92373 |
| antiviral agents: action and clinical use. | the development of antiviral agents has been hindered by a variety of problems. there are fundamental biological differences between viruses and other infectious agents. viruses are strictly dependent on cellular metabolic processes and possess very limited intrinsic enzyme systems and building blocks which may serve as targets for drugs. antiviral drugs must also possess the ability to enter the host cell. viral replication consists of a series of events, each of which can be interfered with, l ... | 1979 | 92398 |
| nonspecific light loss and intrinsic dna variation problems associated with feulgen dna cytophotometry. | nonspecific light loss by the cell-wall-plus-cytoplasm (cwc) can cause a 50% increase in feulgen absorption units in peanut root-tip nuclei as determined by scanning at 450 nm, whereas this phenomenon is not evident with chicken erythrocytes. a two wavelength scanning method of subtracting nonspecific 450 nm absorption from 550 nm feulgen absorption values eliminated the nonspecific light loss in cwc, however, the two wavelength scanning method is time consuming and somewhat impractical with a r ... | 1979 | 92496 |
| evaluation of the validity of the histochemical lead nitrate technique for alkaline and acid deoxyribonuclease. | the results of several tests and the characteristic morphological distribution of the enzymatic activity appeared to be in favor of the validity and specificity of the histochemical lead nitrate technique for alkaline and acid deoxyribonuclease (dnase) detection. these tests included thermal inhibition, omission of substrate, use of different chemical inhibitors and the reproduction of histochemical staining on coujard's slides. most of these results were in conformity with the biochemical data ... | 1979 | 92502 |
| specificity and t-lymphocyte dependence of the humoral immune response in the rat to purified ovine and porcine mucins. | | 1979 | 92759 |
| penicillin and cephalosporin immunogenicity in man. | whether cross-allergenicity exists between the penicillin and cephalosporin antibiotics is controversial. a solid-phase radioimmunoassay was adapted to detect drug-specific igg, igm and ige antibodies. penicillin and cephalothin-specific serum immunoglobulins were determined in patients' serum before and after a therapeutic course of sodium cephalothin. changes in igg, igm and ige antipenicillin and anticephalothin antibodies, respectively, occurred and were closely correlated to one another (r ... | 1979 | 92902 |
| influence of an oversulphated heparinoid upon hyaluronate metabolism of the human synovial cell in vivo. | glycosaminoglycans appear to affect proteoglycan metabolism of fibroblasts, human synovial cells, and chondrocytes under in vitro conditions. the influence of an oversulphated heparinoid (arteparon) on hyaluronate metabolism of the human synovial lining cell was studied by in vivo experiments on human volunteers. a higher production of better polymerized hyaluronic acid was observed after repeated intraarticular injections of this heparinoid into the knees of 2 osteoarthritic patients. after a s ... | 1979 | 93148 |
| from the nichd. national institute of child health and human development. predictors of hereditary disease or congenital defects. | | 1979 | 93264 |
| effects of exogenous gonadotropic and steroid hormones on the social behaviour and gonadal maturation of male domestic ducklings anas platyrhynchos l. | male domestic ducklings were injected during their first month of life with mammalian gonadotrophins (ovine lh or fsh, hmg) or gonadal steroids (testosterone or oestradiol). lh and testosterone stimulated sexual behaviour while oestradiol inhibited the increase of aggression observed in control birds during the experiment. the mammalian gonadotrophins did not increase plasma testosterone but nevertheless they all stimulated the testis growth. several hypotheses which could explain this finding ( ... | 1979 | 93890 |
| albumin synthesis in isolated hepatocytes of control and diethyl-nitrosamine-treated rats, maintained in suspension or in monolayer culture [proceedings]. | | 1979 | 93933 |
| study of effectiveness of bleomycin in rat brain tumor model intravenously and intracerebrally. | | 1979 | 94056 |
| chemotherapy of herpes simplex virus encephalitis in mice by direct intracerebral injection. | the effects of 9-beta-d-arabinofuranosyladenine-5'-phosphate (ara-a-5'-p) on herpes simplex virus encephalitis in mice were studied. this drug is a monophosphate derivative of adenine arabinoside (ara-a). when administered by the intracerebral (ic) route, ara-a-5'-p was highly effective in virus-infected mice in the 17-20 g weight range provided therapy was begun before clinical symptoms of encephalitis appeared. the most effective dose schedule was found to be three daily ic injections totaling ... | 1979 | 94338 |
| chlamydia psittaci: growth characteristics and enumeration of serotypes 1 and 2 in cultured cells. | the growth characteristics of chlamydia psittaci serotypes 1 and 2 (ovine and bovine origin) were studed in mouse l cells. formation of inclusions and yield of infectious progeny for serotype 1 were maximal when host cells were treated with cycloheximide and the ph in the cell culture medium was 7.2-7.4. the number of cells that contained inclusions and the infectivity yield for serotype 2 were maximal when the ph was 6.6-7.0. treatments with diethylaminoethyl dextran and cycloheximide increased ... | 1979 | 94339 |
| characterization of 40,000- and 25,000-dalton intermediate precursors to rauscher murine leukemia virus gag gene products. | under steady-state labeling conditions, rauscher murine leukemia virus-infected nih swiss mouse cells contain at least three major polyproteins derived from the viral gag gene. they have molecular weights of 65,000, 40,000, and 25,000. they have been termed ppr65gag, pr40gag, and ppr25gag. ppr65gag has been shown by a number of laboratories to be composed of all four core proteins (p15, pp12, p30, and p10). in this paper, pr40gag was found to contain p30 and p10 antigenic determinants and peptid ... | 1979 | 94357 |
| effect of subminimal inhibitory concentrations of mecillinam on the synthesis of dna, rna, and protein of salmonella typhimurium: a proposed mechanism of action. | salmonellae alter their rod-like morphology to become large ovals within 3-5 hr after being exposed to concentrations of mecillinam below the minimal inhibitory concentration. before this overt morphologic change occurs, synthesis of dna increases, with a concomitant decrease in total protein synthesis. incorporation of [3h]leucine into cell wall protein is markedly inhibited by mecillinam, whereas incorporation of leucine into soluble intracellular proteins is enchanced by the drug. electrophor ... | 1979 | 94451 |
| placental alkaline phosphatase, alphafetoprotein and carcinoembryonic antigen in testicular tumors. tissue typing by means of cytologic smears. | indirect immunofluorescence and radioimmunoassay with specific rabbit antisera demonstrated the occurrence of alphafetoprotein (afp), carcinoembryonic antigen (cea) and placental alkaline phosphatase (plap) in primary testicular tumor cells. embryonal carcinomas had afp- and cea-containing cells, sometimes plap. plap and sometimes cea were found in seminoma cells. sera from patients with advanced non-seminomatous tumors could contain any of these antigens or any combination of them. sera from pa ... | 1979 | 94592 |
| quantitative study of the energy conversion in halobacterium halobium [proceedings]. | | 1979 | 94791 |
| [faecal enzyme diagnostic (author's transl)]. | the hitherto existing results of determinations of enzymatic activities in stool are presented in this review. the chymotrypsin activity is diminished in advanced exocrine pancreatic insufficiency. the faecal alpha-amylase activity has up to now no significance in the diagnosis of pancreatic diseases. up to five amylolytic enzyme activities are detectable. the alkaline phosphatase is mostly of intestinal origin. up to 4 enzyme bands can be exhibited with the disc electrophoresis in polyacrylamid ... | 1979 | 94852 |
| [the heterogeneity of streptokinases]. | purified streptokinases of some strains of different types of strep. pyrogenes (group a) as well as streptokinases of a strain of group c or group g streptococci, resp., were studied in regard of their heterogeneity. differences of the streptokinases were found in their amino acid compositions and in isoelectric points. serological differences were detected by a quantitative precipitation reaction with fluorescein-coupled antistreptokinase antisera from the goat as well as by neutralization reac ... | 1979 | 94885 |
| role of interferon in mice in protection against influenza a virus by bacterial ribosomes together with membranal glycoproteins of klebsiella pneumoniae as adjuvant. | nonspecific protection against infectious aerosols of influenza a virus was obtained in swiss mice after vaccination by aerosols of bacterial ribosomes together with membranal glycoproteins extracted from klebsiella pneumoniae as the adjuvant. it was shown that repeated stimulant aerosols were necessary to obtain this protection. routine estimation of serum interferon levels after administration of the association of ribosomes plus membranal glycoproteins to the animals by aerosol or intravenous ... | 1979 | 94908 |
| study of the interaction between phosphorylase and hydrophobic groups by means of affinity electrophoresis. | a homologous series of water-soluble alkyl-dextrans varying in the length of their hydrocarbon side-chain [-nh-(ch2)n-ch3; n = 1-5] were synthesized. when alkyl-dextrans were entrapped in polyacrylamide gel, the electrophoretic mobility of phosphorylase was retarded by hydrophobic interaction between phosphorylase and the immobilized alkyl groups. the dissociation constants of rabbit brain phosphorylase, rabbit skeletal muscle phosphorylase a and b and potato glycogen and starch phosphorylases w ... | 1979 | 94915 |
| lower levels of thyrotropin-releasing hormone-degrading activity in human cord and in maternal sera than in the serum of euthyroid, nonpregnant adults. | thyrotropin-releasing hormone (trh)-degrading activity was investigated in human cord, maternal, and euthyroid adult sera by measuring (a) the rate of disappearance of trh and (b) the rate of formation of degradation products. the rate of trh degradation in cord and maternal sera was 25-33% of that in euthyroid adult serum. concomitantly, in cord and maternal sera, the rate of formation of proline, a major trh degradation product in serum, was one-quarter to one-third that in euthyroid adult ser ... | 1978 | 96140 |
| the significance of antidromic potentiation and induced activity in the retina. | it is argued that "the significance of antidromic potentiation and induced activity in the retina" (the title of this article) concerns two identical effects and that both are the outward sign of the existence of a specific organization in the retina. for this reason they can serve as a valuable criterion for identifying activity in this organization. this activity is assumed to be in the nature of a self-excitation by positive feedback in the amacrine circuits of certain y-cells. relevant liter ... | 1978 | 96310 |
| current concepts in ophthalmology. ocular infections. | | 1978 | 96339 |
| pseudomonas cytochrome c551 at 2.0 a resolution: enlargement of the cytochrome c family. | the structure of respiratory cytochrome c551 of pseudomonas aeruginosa, with 82 amino acids, has been solved by x-ray analysis and refined to a crystallographic r factor of 16.2%. it has the same basic folding pattern and hydrophobic heme environment as cytochromes c, c2, and c550, except for a large deletion at the bottom of the heme crevice. this same "cytochrome fold" appears to be present in photosynthetic cytochromes c of green and purple sulfur bacteria, and algal cytochromes f, suggesting ... | 1978 | 96440 |
| immunochemical comparison between an oxacillin-hydrolyzing penicillinase of aeromonas hydrophila and those mediated by r plasmids. | antiserum against an oxacillin-hydrolyzing penicillinase of aeromonas hydrophila did not show immunochemical cross-reaction with four oxacillin-hydrolyzing penicillinases mediated by r plasmids. | 1978 | 97272 |
| studies on the low-molecular weight glycoprotein gp-350: molecular and immunological heterogeneity. | | 1978 | 97368 |
| meningitis caused by neisseria meningitidis type w-135. | | 1978 | 97374 |
| long term effects of myochrysine in articular cartilage. | intra-articularly administered sodium aurothiomalate (myochrysine) produced aurosomes containing characteristic electron dense contents (indicating the presence of gold), in the chondrocytes of rabbit articular cartilage. at first the aurosomes were bounded by a membrane but later the electron dense contents were seen lying free in the cytoplasmic matrix. such deposits were detectable up to 14 months after injection of myochrysine but none were found at later time intervals (18 months and 2 year ... | 1978 | 97856 |
| purification of a specific antigen of trypanosoma cruzi from culture forms. | a monospecific rabbit antiserum was prepared against a specific component of tryanosoma cruzi epimastigote culture forms (designated antigen 5). rabbits were immunized intradermally in 30-50 sites with the zone of agarose gel in which the component 5:anti-5 complex was visualized after two-dimensional immunoelectrophoresis. with this appropriate antiserum and the total epimastigote soluble extracts, the specific component of t. cruzi was purified by immunoadsorption. purity and specificity contr ... | 1978 | 98064 |
| [alteration of the construction and cellular composition of ileo-colonic lymph nodes of rhesus macaques after administration of salmonella vaccine]. | in stained histological sections, percentage ratio of areas to different cellular elements in structural components of the ileocolonic lymph nodes was studied in mature macaca rhesus, normal and after injection of salmonella vaccine. a rather considerable reaction in all structural components and cell composition of the lymph nodes was demonstrated as a response to immunization of the animals. these changes were demonstrated in decreased area occupied by the cortical substance and in increased a ... | 1978 | 98134 |
| biochemical changes in guinea pig lungs due to amosite asbestos. | | 1978 | 98326 |
| isolation of immunoglobulin from splenic lymphocytes of inbred rats by triton x-100 solubilization. | | 1978 | 98589 |
| catecholamine-induced alterations in glucose homeostasis in baboons, dogs, rabbits, and rats: comparative effects of somatostatin. | | 1978 | 98685 |
| changes in composition of tears of malnourished children. | | 1978 | 98738 |
| [immunological relations between mother and child during pregnancy (author's transl)]. | the relations between the maternal and foetal organisms during pregnancy are partly very complicated and remain inexplicable. blastocyst, trophoblast, embryo and foetus have membrane antigens at a very early stage, and the immunocompetence of the foetus develops already during the second third of the pregnancy period. many non-specific factors are involved in preventing the castingoff reaction of the foetal organism. the trophoblastic tissue is probably of central importance. the focal point of ... | 1978 | 98927 |
| immune control in experimental subacute sclerosing panencephalitis. | | 1978 | 99024 |
| jaundice and breast-feeding among alaskan eskimo newborns. | the course, incidence, and severity of neonatal jaundice was studied in 95 alaskan eskimo infants. breast-fed infants had higher bilirubin concentrations than bottle-fed babies. both groups experienced high bilirubin levels, similar to those previously reported in navajo and oriental infants but greater than those observed in whites and blacks. a marked capacity to inhibit hepatic glucuronyl transferase was observed in breast-milk specimens but only partly accounted for the bilirubin differences ... | 1978 | 99026 |
| [slow virus infection]. | | 1978 | 99538 |
| bacterial metabolism of anthracycline antibiotics. steffimycinone and steffimycinol conversions. | streptomyces nogalater, uc-2783, and streptomyces peucetius var. caesius, imru-3920/uc-5633, catalyze ketonic carbonyl reduction of steffimycinone (1, scheme 1). using cell-free preparations of s. nogalater, the process of ketonic carbonyl reduction has been shown to be tpnh linked. the product, steffimycinol (2), is reduced further by aeromonas hydrophila, 2c/uc-6303, by the process of microaerophilic conversion of anthracyclinones previously reported1,2) with the result being the formation of ... | 1977 | 20436 |
| bacteroides fragilis septicemia. | on the basis of eight cases of bacteroides fragilis septicaemia, the authors review recent data from the literature related to this topic. they first note the increasing prevalence, accounting for approximately 10 per cent of all septicaemias at the present time. they note that the most frequent portals of entry are sites of localised suppuration, related on the one hand to digestive or gynaecological surgery and, secondly, to the post-partum or post-abortum period. from a therapeutic standpoint ... | 1977 | 23026 |
| bacterial 2,3-butanediol dehydrogenases. | enterobacter aerogenes, aeromonas hydrophila, serratia marcescens and staphylococcus aureus possessing l(+)-butanediol dehydrogenase produced mainly meso-butanediol and small amounts of optically active butanediol; acetobacter suboxydans, bacillus polymyxa and erwinia carotovora containing d(-)-butanediol dehydrogenase produced more optically active butanediol than meso-butanediol. resting and growing cells of these organisms oxidezed only one enantiomer of racemic butanediol. the d(-)-butanedio ... | 1978 | 25056 |
| prevalence and distribution of aeromonas hydrophila in the united states. | the abundance of aeromonas hydrophila was measured in 147 natural aquatic habitats in 30 states and puerto rico. viable cell counts were used to estimate density at all sites by using rimler-shotts medium, a differential presumptive medium for a. hydrophila. temperature, ph, conductivity, salinity, and turbidity were measured simultaneously with water sample collection. the density of a. hydrophila was higher in lotic than in lentic systems. saline systems had higher densities of a. hydrophila t ... | 1978 | 31839 |
| enterotoxicity of aeromonas hydrophila: skin responses and in vivo neutralisation. | culture filtrates and partially purified enterotoxins of 6 strains of aeromonas hydrophila isolated from faeces of diarrhoeic and healthy persons, drinking water, sewage and faeces of domestic animals caused induration and increased capillary permeability in skin of adult albino rabbits. the activities were less in crude enterotoxins indicating partial loss during purification. heat treatment for 30 min at 60 degrees c and 56 degrees c inactivated the induration and permeability effects of cultu ... | 1978 | 34953 |
| characterisation and neutralisation of aeromonas hydrophila enterotoxin in the rabbit ileal-loop model. | cell-free culture filtrates and crude enterotoxin preparations from six strains of aeromonas hydrophila caused the accumulation of fluid in rabbit ileal loops. this activity was due to a non-dialysable, heat and acid-labile antigenic protein and was lost when culture filtrates and crude enterotoxin preparations were heated at 60 degrees c for 20 min. or 56 degrees c for 30 min. respectively. maximum activity was observed at ph 8.0-10.0; there was a gradual loss at lower ph and activity was aboli ... | 1979 | 38341 |
| biosynthesis of ethylene from methionine. isolation of the putative intermediate 4-methylthio-2-oxobutanoate from culture fluids of bacteria and fungi. | methods are described for identifying the 2,4-dinitrophenylhydrazones of 4-methylthio-2-oxobutanoate by means of t.l.c., n.m.r. and mass spectroscopy. by using these methods 4-methylthio-2-oxobutanoate, a putative intermediate in the biosynthesis of ethylene from methionine, has been identified in culture fluids of aeromonas hydrophila b12e and a coryneform bacterium d7f grown in the presence of methionine. relative to 4-methylthio-2-oxobutanoate, the yield of 3-(methylthio)propanal (methional) ... | 1979 | 42392 |
| current questions on the tumour-associated antigens of chemically-induced tumours ii. in search of practical uses. | with special reference to tumours which were chemically-induced in animals, we present a brief review on the applicability of the results obtained, as to immunoprophylaxis and to immunotherapy. a search is made onto what are the mostly representative animal models for human studies. from the present available data, experimental chemically-induced bladder and colonic tumours seem to be the "best" models for human counterparts. | 1976 | 57809 |
| letter: paramyxovirus-like inclusions in brain of patient with severe multiple sclerosis. | | 1976 | 59881 |
| diagnostic dilemma of a 13-month-old boy with 'late-onset' combined immunodeficiency. | a 13-month-old boy had a "late-onset" form of combined immunodeficiency and a fulminant pneumocystis carinii pneumonia of one month's duration. there was no evidence of cutaneous-delayed hypersensitivity responses to diphtheria-tetanus toxoids, candida albicans, or streptokinase-streptodornase, or of lymphocyte dna synthesis after in vitro stimulation with the mitogens phytohemagglutinin and concanavalin a, and only 2% to 4% of peripheral blood e-rosetted t lymphocytes. the serum igm level was n ... | 1979 | 88898 |
| observations concerning the staining properties of the macroconidia of certain dermatophyton species. | staining of the macroconidia of several dermatophyton species by lactophenol-cotton blue was investigated. young macroconidia stain variably; their cytoplasm may appear homogeneous or inhomogeneous. the possible explanation seems to be variation in the composition of the cytoplasm. in some macroconidia dark-staining filament was seen along the longitudinal axis. mature macroconidia showed basal or basal+apical homogeneous deep staining. the intensive apical staining suggests that the apical stru ... | 1978 | 89788 |
| strain differences in tolerance induction to human gamma-globulin subclasses: dependence on macrophages. | | 1979 | 90559 |
| cell differentiation in human gastric gland as revealed by nuclear binding of tritiated actinomycin. | the nuclear binding of h3 actinomycin, which is closely linked to the differentiation phenomenon, was studied in human normal gastric mucosa. actinomycin binding decreases in cells which differentiate and becomes very low in fully differentiated cells. in the gastric pits, there is a decreasing gradient of labelling from the deeper stem cells to the well-differentiated superficial cells. this indicates that migration and renewal of the surface epithelium occurs following a 'pipe-line' system. al ... | 1979 | 90638 |
| macrophage oxygen-dependent antimicrobial activity. i. susceptibility of toxoplasma gondii to oxygen intermediates. | a sensitive method for evaluating extracellular parasite viability was used to determine the in vitro susceptibility of virulent toxoplasma gondii to selected oxygen intermediates. by acridine orange fluorescent staining criteria, toxoplasmas were resistant to up to either 10(-3) m reagent h2o2 or h2o2 generated by glucose-glucose oxidase. in keeping with a lack of sensitivity to h2o2, toxoplasmas contained endogenous catalase (5.7 x 10(-4) baudhuin units/10(6) organisms). the addition of a pero ... | 1979 | 92521 |
| immunological release of histamine from human lung. i. studies on the beta 2-sympathomimetic stimulator fenoterol. | human lung tissue passively sensitized with anti-grass pollen ige antibodies release histamine upon exposure to specific grass pollen antigen. fenoterol, a beta 2-sympathomimetic stimulator drug, is shown to be a potent inhibitor of antigen-induced release of histamine. this inhibitory effect occurred with fenoterol concentrations of 2 x 10(-8) to 1 x 10(-7) m, and was determined by 67 and 95%, respectively. thus, the beta 2-receptor stimulator fenoterol is a valuable drug for treating allergic ... | 1979 | 92803 |
| characterization of estrogen binding in the developing rat testis. ontogeny of the testicular cytoplasmic estrogen receptor. | the properties and physical characteristics of a steroid binding component present in the immature (7 to 35 day) rat were investigated and found to be different from those of the 17 beta-estradiol receptor in the mature rat testis. these properties include a binding capacity of 483 fmol estradiol/mg protein, a ka at equilibrium of 4.23 x 10(7)m-1, and broad steroid specificity as shown by interaction with several steroids; no binding was observed with diethylstilbestrol. the component, found in ... | 1979 | 92832 |
| the interaction of lanthanides with isolated sarcoplasmic reticulum vesicles from rabbit skeletal muscle. | the interaction of lanthanides with isolated sarcoplasmic reticulum (sr) vesicles from rabbit skeletal muscle and the effects of lanthanides on 45ca2+ uptake by the vesicles were studied. 153gd3+ was taken up by the vesicles in the absence of atp and oxalate in a time-dependent manner, reaching a maximum total accumulation of 380 nmol 153gd3+/mg protein after 20 min with 200 microm 153gd3+. this 153gd3+ accumulation was not washed out by 1 mm egta. the addition of atp induced the release of 87% ... | 1979 | 93439 |
| the messianic idea and messianic delusion. | the messianic delusional syndrome repeats an historical prototype that manifests itself in each patient with individual changes. the syndrome expresses a serious impairment of identity and reflects a social, cultural and religious reality through generations. the regularities of its clinical features comprise a delusional system, centered on the patient's conviction that he has been chosen by god for a special and intransferable mission. the patient has special powers for carrying out this missi ... | 1978 | 95508 |
| association of diamine oxidase and ornithine decarboxylase with maturing cells in rapidly proliferating epithelium. | diamine oxidase and ornithine decarboxylase activities are shown to have a parallel distribution across rat small intestine mucosa; levels of both enzyme activities are sharply higher in mature cells in the villus tip region than in proliferating cells in the crypt areas. histidine decarboxylase levels were not measurable in the same cell preparations and aromatic-l-amino-acid decarboxylase activity was distributed in an opposite pattern to diamine oxidase and ornithine decarboxylase. the result ... | 1978 | 96870 |
| repression of biotin biosynthesis in escherichia coli during growth on biotin vitamers. | a strain of escherichia coli in which the lacz gene was fused to the bioa promoter was constructed. colonies of this strain formed lac(+) colonies on low-biotin agar (1.6 to 4.1 nm) and lac(-) colonies on high-biotin agar (41 nm). this lac-bio fusion strain was used to study the question of whether cells growing on the biotin vitamers d-biotin-d-sulfoxide (bds) and dethiobiotin (dtb) generate enough biotin to give maximal repression of beta-galactosidase synthesis. repression by high concentrati ... | 1978 | 97277 |
| passive immunization with an antibody to the beta-subunit of ovine luteinizing hormone as a method of early abortion--a feasibility study in monkeys (macaca radiata). | antiserum to the beta-subunit of ovine luteinizing hormone (olh-beta) raised in monkeys (macaca radiata) has been tested by a variety of criteria both in vivo and in vitro to establish its ability to neutralize olh, hlh, and human chorionic gonadotropin (hcg). passive administration of this antiserum caused inhibition of ovulation and termination of pregnancy in recipient monkeys as indicated by premature vaginal bleeding and a significant reduction in serum progesterone and estrogen levels. the ... | 1978 | 98358 |
| electrophoretic strand separation of long dnas with poly (u,g) in agarose gels. | we have found that binding of poly(u,g) to single-stranded dna decreases its mobility in 0.3% agarose gels. differential binding to the complementary strands of denatured duplex dna provides a simple method for strand separation. the method is shown to work with bacteriophage lambda dna, adenovirus dna and mtdna for tetrahymena pyriformis. in all cases the strand that binds more poly(u,g) in cscl gradients also binds more in gels. the separated strands can be directly blotted from the gel onto n ... | 1978 | 99728 |
| [proteins of human body--clinical and diagnostic aspects. practical clinical aspects of studies on protein metabolism]. | | 1978 | 99770 |
| serologic typing of rickettsiae of the spotted fever group by microimmunofluorescence. | | 1978 | 101593 |
| [studies on moraxella. i. a new selective medium for moraxella sp. (author's transl)]. | | 1977 | 101603 |
| dominant constitutive mutations in malt, the positive regulator gene of the maltose regulon in escherichia coli. | | 1978 | 101676 |
| clinical studies on pipemidic acid. | | 1978 | 101691 |
| ultrastruct of red-sore lesions on largemouth bass (micropterus salmoides): associattion of the ciliate epistylis sp. and the bacterium aeromonas hydrophila. | epizootic outbreaks of red-sore disease in several reservoirs in the southeastern united states have been reported to cause heavy mortality among several species of fish having sport and commercial value. the etiologic agent is said to be the peritrich ciliate epistylis sp.; secondary infection by the gram-negative bacterium aeromonas hydrophila produces hemorrhagic septicemia which results in death. however, in recent studies on the largemouth bass micropterus salmoides, epistylis sp. could be ... | 1978 | 102785 |
| high affinity uptake sites for taurine in the retina. | | 1978 | 104877 |
| transcription and translation in a pleiotropic streptomycin-resistant mutant of escherichia coli. | the role of the ribosomal protein s12 (streptomycin protein) in ribosome function and in other metabolic processes in the cell has been investigated. a spontaneous streptomycin-resistant strain of escherichia coli (sm3) carrying a mutation in the rpsl gene is deficient in its ability to induce the synthesis of the enzyme bets-galactosidase. it was demonstrated that the reduced rate of enzyme synthesis results from deficiencies in both the transcription of the lactose operon and translation of th ... | 1979 | 104958 |
| implications for adult roles from differential styles of mother-infant bonding: an ethological study. | ethological observations of maternal and infant behaviors of nine vervet monkey pairs (cercopithecus aethiops sabaeus) showed the effects of differential styles of early maternal responsiveness on later infant competence. those infants receiving the least amount of maternal responsiveness and the most time-off the mother in the first 3 months of development were more socially competent at 6 months of age. the results are discussed within current ethological "attachment" theories. the detachment ... | 1979 | 105083 |