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resistance to levomycetin and activity of several enzymes in escherichia coli and the agent of plague.the authors compared the activity of acetyl-coa-synthetase and of the enzymes belonging to the group of asparaginic acid in levomycetin sensitive and resistant strains of y. pestis and e. coli. there were revealed marked differences in the activity of aspartase, fumarase, synthetase and desamidase of l-asparagin, and also of the enzyme activated by acetate in the e. coli strains with plasmide resistance. transmission of r-factor to the pestis was accompanied by decomposition of l-asparadein, for ...19768940
purification and properties of the methane mono-oxygenase enzyme system from methylosinus trichosporium ob3b.1. a three-component enzyme system that catalyses the oxidation of methane to methanol has been highly purified from methylosinus trichosporium. 2. the components are (i) a soluble co-binding cytochrome c, (ii) a copper-containing protein and (iii) a small protein; the mol. wts. are 13 000, 47 000 and 9400 respectively. the cytochrome component cannot be replaced by similar cytochrome purified from pseudomonas extorquens or by horse heart cytochrome c. 3. the stoicheiometry suggests a mono-oxyge ...197715544
an investigation of heavy meromyosin-adp binding equilibria by proton release measurements.the interaction of magnesium-adp with skeletal muscle heavy meromyosin has been studied by measuring the accompanying release of protons. total ph changes of the order of 0.03 were involved, and measurements were performed with a discrimination of some ten-thousandths of a ph unit. at ph 8.0 and 25 degrees c about 0.5 mol of protons per mol of heavy meromyosin is released at saturation. a stoichiometry of binding close to 2 mol of adp per mol of protein was found, with a binding constant, obtain ...197715588
prominent role of lysosomes in the proteolysis of rat liver mitochondria at neutral ph. 197715866
hormonal control of zinc uptake and binding in the rat dorsolateral prostate.the zinc uptake in the dorsolateral prostate of rats was studied after different hormonal manipulations. orchiectomy reduced the uptake of 65zn. administration of estradiol benzoate to orchiectomized rats doubled the 65zn uptake, a phenomenon which was not observed in orchiectomized-adrenalectomized rats. adrenalectomy in orchiectomized rats had no effect on the concentration of radioactivity beyond the castration-induced decrease. a prolactin release inhibitor, 6-methyl-8-erogelenylacetamide, r ...197715955
ammonia toxicity in cattle. ii. changes in carotid and jugular blood components associated with toxicity. 197715959
the transport of l-leucine into the brain of the rat in vivo: saturable and non-saturable components of influx. 197716270
vibrio background in the city of frunze. 197717976
testicular androgen binding protein (abp) - a parameter of sertoli cell secretory function.using abp as an index of sertoli cell secretory function, several important features of the sertoli cell have emerged: 1. the stimulation of abp production by fsh clearly points to the sertoli cell as a target cell for fsh (3,4,9-16,21,24). 2. the dramatic effects of androgens on abp production both in immature and mature rats also suggest that the sertoli cell is a target cell for androgen (3,12,14,16,25). 3. the striking reduction in abp production in the cryptorchid testis raises the question ...197518322
value of sputum culture in diagnosis of pneumococcal pneumonia.in our laboratory, culture of sputum was extremely useful in diagnosing the etiology of pneumococcal pneumonia. of 31 consecutive patients with bacteremic pneumococcal pneumonia, 29 (94%) had streptococcus pneumoniae cultured from sputum. recovery of pneumococci in culture was enhanced by anaerobic incubation as well as by a plate bile test and an optochin disk on a primary blood agar plate.197718489
participation of gaba receptors in the short-term activation of striatal tyrosine-3-monooxygenase elicited by neuroleptics. 197718893
occurrence and distribution of western equine encephalomyelitis in florida.research and surveillance programs relating to the occurrence and distribution of western equine encephalomyelitis virus in florida, conducted between 1955 and 1976, suggest that the virus is (1) an endemic arbordae, (2) transmitted in a continuous cycle throughout the year by culiseta melanura mosquitoes, and (3) restricted to fresh water swamps and waterways in central, north, and northwest florida.197823372
aerobic glycolysis in bone: lactic acid production by rat calvaria cells in culture.considerable data have been accumulated on aerobic glycolysis of intact bone preparations. to test whether aerobic glycolysis is a feature of the bone cells themselves or of the localized conditions within an intact bone, cells isolated from rat calvaria were cultured and the effect of several factors on lactate production was determined. these cells drastically decreased lactate production when the ph in the culture medium was lowered, changing from 100 to 20 percent for a ph shift from 7.4 to ...197823680
dipeptidylaminopeptidase and carboxypeptidase activities of the brush border of rabbit small intestine. 197830675
the ph-dependence of the non-specific esterase activity of carboxypeptidase a.the hydrolysis of the following 6 esters by bovine pancreatic carboxypeptidase a (peptidyl-l-amino-acid hydrolase, ec 3.4.12.2) has been investigated over the range ph 5--10 at 25 degrees c, ionic strength 0.2: ch3co2chrco2h (r = c6h5 (ester 3), c6h5ch2 (ester 4), 4-no2c6h4co2chrco2h (r = c6h5 (ester 5), c6h5ch2 (ester 6), ch3(ch2)2 (ester 7)), ch3ch2co2ch(ch2c6h5)-co2h (ester 9). for each ester the ph dependence of kcat/km indicates that substrate binding is controlled by an acid of pkeh = 9.2 ...197831187
[study of the dynamics of acid formation in the stomachs of dogs under the influence of thyroidin by the method of intragastric ph-graphy].intragastral ph-graphy was applied to the study of the dynamics of acid production in the stomach of dogs with fistulae of the fundal portion of the stomach out of and during digestion, and also before and after the thyroidin prescription. biphasic character of the changes in acid production in the stomach under the effect of the hormonal preparation was revealed.197831210
proceedings of the fifteenth congress of the european dialysis and transplant association, istanbul, turkey, 1978. 197833380
[phenomenon of parental resistance and its genetic regulation].lymphocytes of mice f1 (cba x m523) and f1 (a x m523) transplanted to 1000 r irradiated cba or a mice responded to the test antigens--srbc or s. typhi vi-antigen--by formation of 100--1000 times less antibody forming cells than in syngeneic recipients. an intermediate result is achieved when the lymphoid cells are transplanted to the irradiated m523 mice. lymphocytes of mice f1 (a x cba), f1 (cba x c57bl/6), or f1 (a x a.ca) developed a similar immune response in the irradiated syngeneic mice an ...197934452
kitasato, yersin, and the plague bacillus. 197554239
cell-mediated immune response in mice treated with steroidal contraceptives.the splenomegaly assay (simonsen, 1962) was standardized using different strains of rats and mice. male wistar rat (donor)-female swiss mouse (host) was found to be the suitable combination that could be employed in subsequent experiments to study the potential of contraceptive steroids to alter cmir. the index of splenomegaly appeared to increase in case of mice treated with combination oral contraceptives (ovulen, ovral or enovid). the differences observed, however, neared significance only in ...197555327
retrograde axonal transport of antibody to dopamine-beta-hydroxylase. 197656975
a serial study of pregnancy proteins in primigravidae.the plasma concentrations from four 'pregnancy proteins' and three steroid hormones have been measured throughout pregnancy in 15 primigravidae. two of the proteins, human placental lactogen (hpl) and pregnancy-specific beta1-glycoprotein (psbetag), are specific for pregnancy and correlate well with the stage of gestation. it is suggested that measurement of psbetag may be useful in assessing feto-placental wellbeing. neither of the pregnancy-associated proteins, steriod-binding beta-globulin (s ...197657799
[effects of the electric current on the fundamental processes of stimulation in the heart].on the basis of experimental studies on isolated preparations from different regions of the heart and on perfused hearts of animals, it was possible to distinguish at least four basic actions of an electric current: 1. the release of excitations, 2. with continuous current, an electro-tonic influence on the pacemaker activity in the sense of a cathodic advancement, or an anodic inhibition 3. with alternating current, stimulation of the vegetative nerves of the heart, 4. a direct, reversible dama ...197558696
[the cytobacteriological coloring substance bf (methylene blue and basic fuchsin)].the authors have set up a cytobacteriological colouring matter for the reading of the figured elements of liquor, urine, exudats, and trasudats. the colouring solution is steady, it colours and fixes at the same time and is composed by blue methylene and basic fuchsine. there is abready a combination of both colouring matters in wayson's formula for the bipolar colouring matter of the pasteurella pestis and in pick's and jacobson's formula to point out the intercellular neisserie.197559579
transient inhibition of initiation of s-phase associated with dimethyl sulfoxide induction of murine erythroleukemia cells to erythroid differentiation.the murine erythroleukemia cell (melc) line in suspension culture can be induced to differentiate to erythroid cells by various compounds, including dimethyl sulfoxide (me2so). analysis of the cell cycle, during differentiation induced by me2so, using thymidine incorporation, thymidine labeling index, and relative dna content per cell as measured by flow microfluorometry, demonstrates a transient inhibition of entry of cells into s-phase of the cell cycle which is detected as early as 5 hr and i ...197764982
[use of the method of macrophage migration inhibition for titration of toxic activity in microbial fractions]. 197775324
ultrastructure of peptidergic neurosecretory axons in the developing neural lobe of the rat. 197886479
palliation of massive hemoptysis from unresectable carcinoma of the lung.unresectable carcinoma of the lung has traditionally been recognized as a contraindication to surgery in massive hemoptysis. a 60-year-old man had massive hemoptysis. at surgery an unresectable neoplastic mass invading the mediastinum and great vessels was encountered. subtotal resection was accomplished using a stapler (autostapler). the margins of the bronchial and vascular staples were of necessity placed directly through the tumor. the patient had an uneventful recovery and has survived six ...197988310
[spontaneous rosette forming, fc and complement receptor bearing lymphocytes in pediatric diseases].investigations with lymphocyte subpopulations were made in 51 children aged from 1-14 years with infections of the upper airways, with acute leukaemias, and other malignant diseases. t-lymphocytes were registered by means of the spontaneous rosette test. the attempt of proving b-lymphocytes was made by means of an eac test with human erythrocytes, anti-d-immunoglobulins and human complement. the results were compared with those obtained by an eac test with sheep erythrocytes, sheep haemolysin an ...197988386
a simple and sensitive method for the quantitative estimation of collagen. 197988913
cell differentiation in human gastric gland as revealed by nuclear binding of tritiated actinomycin.the nuclear binding of h3 actinomycin, which is closely linked to the differentiation phenomenon, was studied in human normal gastric mucosa. actinomycin binding decreases in cells which differentiate and becomes very low in fully differentiated cells. in the gastric pits, there is a decreasing gradient of labelling from the deeper stem cells to the well-differentiated superficial cells. this indicates that migration and renewal of the surface epithelium occurs following a 'pipe-line' system. al ...197990638
prolonged survival of corneal allografts in rabbits treated with cyclosporin a. 197990771
soluble immune complex disease associated with antigen heterogeneity an hla related disorder.it is suggested that soluble immune complex diseases arising after infections may result from the liberation of partially synthesized bacterial polypeptide or viral nucleic acid antigens. these disrupted antigens will have heterogeneous molecular weights due to antigenic material which is incomplete as a result of premature termination of synthesis. antigens of this type have been shown to result in significant soluble complex formation in vitro when reacted with antisera from many individuals. ...197991086
procaine-induced seizures in epileptic monkeys with bilateral hippocampal foci.intravenous procaine hcl given at low doses (0.5-2.5 mg/kg) to two monkeys with bilateral alumina hippocampal foci depressed interictal spiking or had little effect. at 5.0 mg/kg unilateral limbic activation occurred. at 10.0 mg/kg unilateral or bilateral limbic activation and generalized seizures could be evoked within 3-10 min. at higher doses (15 and 20 mg/kg) bilateral limbic activation or brief (one min) generalized seizures occurred. the unilateral-onset psychomotor seizures were not ident ...197991502
[method of obtaining a y. pestis fraction containing heterogenetic antigens]. 197991715
immunofluorescence testing for chlamydial antibodies. 197991742
viability assessment by dye exclusion. a fluorescent method for fungal cells.a new fluorescent staining technique for fungi utilizes the differential affinity of dead cells for rhodamine b. a mounting medium has been devised that includes the dye. this medium allows direct processing of cells from a broth and provides optimal conditions for fluorescence intensity. comparison with the standard methylene blue exclusion test as applied to the candida albicans yeast phase indicates similar specificity. various pseudohyphae and several fungi also exhibited selective uptake of ...197992216
effects of painful footshock on self-stimulation behaviour of rats and influence of naloxone on this behaviour [proceedings]. 197992231
processing of 19 s thyroglobulin in vitro [proceedings]. 197992247
immunologic regulation in pregnancy.theories to explain the failure of rejection of the fetus by the mother during pregnancy include immunologic privilege of the uterus as a graft site, lack of transplantation antigen expression on the trophoblast, weakening of maternal cellular immunity during pregnancy, and separation of maternal and fetal circulations. evidence for and against each of these theories is discussed. local concentration of a variety of hormones, including human chorionic gonadotropin (hcg), sex steroids, alpha-feto ...197992318
guinea-pig alpha 1 microglobulin. isolation and properties in comparison with human alpha 1 microglobulin. 197992407
ia determinants on human t-cell subsets defined by monoclonal antibody. activation stimuli required for expression.the nature of ia antigens which appear on human t cells after activation and the stimuli required for their expression was examined utilizing a monoclonal antibody reactive with the ia antigen framework. t cells were purified using monoclonal antibodies directed either at the entire t-cell population (okt3) or the t-cell inducer subset (okt4). by indirect immunofluorescence, it was shown that the human t-cell population contains no detectable ia+ cells in the resting state. in contrast, in exces ...197992523
[physicochemical properties of neurospecific basic protein (scp) of the spinal cord].basic protein (scp) known as antiencephalytogenic was isolated from the bull spinal cord and spinal roots. the protein is purified to a molecular homogeneous state, some of its physicochemical properties are studied. molecular homogeneity of the protein is established by the method of disk electrophoresis in 15% polyacrylamide gel with sodium dodecyl sulphate present and by analytic ultracentrifugation. during electrophoresis in 15% polyacrylamide gel at ph 4.0 the protein movement occurs only i ...197992837
[determination of the internal association constant as a measure of the affinity of erythocyte-fixed antibodies that interact with mono- and multivalent antigens].the fraction of antibody-bound determinants of a polyvalent antigen is determined by the fraction of free antigen molecules and the valence of the antigen. the internal association constant for antibodies fixed onto erythrocytes can be found by the suspension method, the index obtained in this process being similar when both monovalent and polyvalent antigens are used. the sensitivity of the antibody-erythrocyte diagnostic preparation in the passive hemagglutinin test depends on the affinity of ...197992866
antigenic determinants of horse cytochrome c for lymphocyte transformation: identification of an immunodominant peptide. 197993078
delayed hypersensitivity to staphylococcus aureus in mice: in vivo responses to isolated staphylococcal antigens.the development of delayed hypersensitivity (dh) to staphylococcus aureus in swiss mice was evaluated by the footpad (fp) assay. in order to determine which component of the bacteria was responsible for the in vivo immune reactivity, purified staphylococcal cell wall, cell membrane, protein a, lipoteichoic acid, teichoic acid, as well as lipid-free membrane proteins were isolated. the immune responses of mice receiving one to eight s. aureus injections indicated that the first dh peak, following ...197993087
biosynthesis of human blood group t-, n- and m-specific immunodeterminants on human erythrocyte antigens.we synthesized on tn erythrocytes with human sera, udp-gal, and activators t-specific haptenic structures in satisfactory yield. the specificity of this biosynthesis was ascertained by agglutination with human and animal anti-t, by specific absorption of human anti-t as well as by agglutination inhibition assays. with isolated human erythrocyte t antigen as substrate we synthesized n- and m-specific structures with sera from individual human donors in presence of cmp-sialic acid by incubation fo ...197993134
anomalous alpha 2-macroglobulin-protease complexes in cystic fibrosis: decreased uptake of the complexes by fibroblasts in culture.immunochemical and functional properties of control and cystic fibrosis (cf) alpha 2-macroglobulin (alpha 2m) are compared. crossed immunoelectrophoresis and ouchterlony double diffusion revealed no qualitative differences between the two alpha 2-m preparations. trypsin-esterase activity assayed with bapna as a substrate, in the presence of an excess sti, gave similar ratios between total and active alpha 2m. these alpha 2m-trypsin complexes were equally stable under various experimental conditi ...197993265
effect of azacytidine on simian virus 40 nucleoprotein complexes.simian virus 40 nucleoprotein complexes synthesized in the presence of 5-azacytidine showed small differences in sedimentation rate on neutral sucrose and buoyant density in metrizamide and cesium chloride. simian virus 40 deoxyribonucleic acid (dna) i, isolated from the nucleoprotein complexes of drug-treated cultures, was found to band at a higher buoyant density and therefore had a decreased ability to bind ethidium bromide. the data indicated that these molecules were deficient in superhelic ...197993427
a novel class of schizosaccharomyces pombe mutants, phenotypically unable to grow on glycerol, a respiratory substrate, but still able to oxidize glycerol aerobically [proceedings]. 197993469
antigenic heterogeneity of the non-serogroup antigen structure of neisseria gonorrhoeae lipopolysaccharides.studies of the antigenic structure of the polysaccharide component of gonococcal lipopolysaccaride (lps) indicated that the non-serogroup antigen structure is antigenically heterogeneous. immunodiffusion studies of gc4 strain 8551 indicated that in addition to the gc serogroup determinent, this polysaccharide contains two other sets of determinants, one which is shared with the other five gc serogroups and a second which is shared by the gc1 and gc3 serogroups. enzyme-linked immunosorbent assay ...197993575
double staining technique for rat foetus skeletons in teratological studies.cartilage and bone were differentiated using alcian blue and alizarin red s respectively. anomalies of both cartilaginous and bony parts of the skeleton could be examined.197993666
1-isoamyl-3-isobutylxanthine: a remarkably potent agent for the potentiation of norepinephrine, histamine, and adenosine-elicited accumulations of cyclic amp in brain slices. 197993674
in vivo release of substance p in the cat substantia nigra.push-pull cannuale were implanted into the substantia nigra (sn) and the caudate nucleus (cn) of the cat to study the in vivo release of substance p (sp), using a radioimmunoassay and high pressure liquid chromatography (hplc) analysis. the spontaneous release of sp could be detected in the sn and the cn. potassium (50 mm) locally applied stimulated sp release in both structures. furthermore an important evoked release of sp was observed in the sn during depolarization of striato-nigral sp fiber ...197993729
in vitro primary immunization of human peripheral blood lymphocytes to klh: evidence for hla-d-region restriction. 197993813
receptive field organization in areas 17 and 18 of the cat [proceedings]. 197993893
mutagenicity of n-nitrosodiethanolamine and its acetyl-derivatives [proceedings]. 197993920
integration site of bovine leukemia virus dna in the bovine genome [proceedings]. 197993923
the effects of pesticin on yersinia enterocolitica and y. pseudotuberculosis. 197994002
interactions of lysophospholipids and mast cells. 197986956
vidarabine monophosphate in viral encephalitis. 197986765
a developmental model for studying choline acetyltransferase transport in chick motoneurons.the proximodistal axonal transport of choline acetyltransferase (chac) has been studied in the chick sciatic nerve in the absence of any experimental manipulation. the phenomenon utilized by us is a physiological transient fall in the activity of chac. this fall occurs in most areas of the chick central nervous system after hatching, and moves toward the periphery along the nerves. having ruled out the presence of transient inhibitors, the movement of the fall towards skeletal muscles has been c ...197994010
alien h-2 allospecificities in murine chemically-induced tumors.sera from c3h/heha mice immunized with syngeneic methylcholanthrene-induced sarcoma react with allogeneic thymus, lymphoma and leukemia cells. the presence on leukemia and lymphoma cells of h-2 specificities expressed on normal cells of other h-2 haplotypes from the one in which the tumor originates is described. it was observed that the reaction of antisera to h-2 specificities with lymphoma cells was blocked by anti-mca sarcoma sera. the cross-reactivity between mc sarcomas, thymus, leukemia a ...197994037
demonstration of specific antigenecity of various fractions of human liver homogenate. 197994039
antigenicity of casein enzymatic hydrolysate.an enzymatic hydrolysate of bovine casein were studied for molecular size and antigenic properties. as determined by sephadex g-25 gel filtration, polypeptide fractions having molecular weights greater than 1,000 were not detected in the soluble fraction of the casein hydrolysate. antigenicity of the fraction was not detected by heterologous passive cutaneous anaphylaxis in guinea pig-rabbit antiserum system mediated by immunoglobulin g types of antibody (guinea pig passive cutaneous anaphylaxis ...197994065
studies on the oxidation of muscle triglycerides. 197994070
[criterion of the comparative sensitivity of plague antigenic and antibody erythrocyte diagnostica in detecting antibodies]. 197994132
[electrophoretic mobility test in the early diagnosis of malignant tumors; findings in the prestages of cervical and breast cancers].a double-blind pilot study of 130 female patients was carried out to determine the feasibility and significance of the em test in the early diagnosis of carcinoma of the female genital organs and breast. early stages of cervical carcinoma (carcinoma in situ) as well as fibroid adenoma, mastopathy and breast tumors were tested and compared with the results of their manifest forms. positive results were recorded in 87.5% of the cases of middle-grade to severe epithelial dysplasia (papanicolaou iii ...197994155
[clinical and biochemical contributions on the effect of maprotiline and clomipramine in depressive states (preliminary observation)].this study has been conducted on 17 patients suffering from neurotic and psychotic depressions, who had not received a pharmacological antidepressive therapy since at least 1 month. 6 patients suffering from psychotic depression were treated with 100 mg clomipramine i.v. daily for 20 days; 11 patients, 7 of whom suffered from psychotic depression and 4 from neurotic depression, were treated with 150 mg maprotiline i.v. daily for 20 days. in both groups the therapy has been continued orally. in ...197994169
[vascularization of malignant melanoma in golden hamster]. 197994247
endotoxin shock in the beagle dog. 197994472
the human ia system. 197994505
possible role of the friend virus life cycle in differentiating friend leukemia cells treated with interferon. 197994575
prostaglandin synthesis inhibition and monoamine metabolites in the rat brain.the effect of indomethacin 3 mg/kg on levels of homovanillic acid (hva), 4-hydroxy-3-methoxy phenyl ethylene glycol (hmpg) and 5-hydroxy indol acetic acid (5hiaa) was studied in rat striatum and olfactory tubercle with and without pretreatment with morphine 10 mg/kg. indomethacin caused a small decrease in resting levels of hva in striatum but not in olfactory tubercle. no effects were seen on resting or morphine induced changes in the levels of these monoamine metabolites. likewise indomethacin ...197994946
properties and usefulness of the original k-562 human myelogenous leukemia cell line. 197995026
biochemical effects of the modification of nucleic acids by certain polycyclic aromatic carcinogens. 197995052
comparison of antigenic properties among various strains of treponema hyodysenteriae.agglutinin-absorption and precipitin-absorption studies demonstrated that three strains of treponema hyodysenteriae isolated from cases of swine dysentery were antigenically different from each other and also from a spirochete isolated from a clinically normal dog. each of the strains of t. hyodysenteriae also possessed two common antigens.197995077
separation of t and b lymphocytes from various mouse strains by density gradient electrophoresis.t and b mouse spleen lymphocytes were separated by density gradient electrophoresis on the basis of their surface charge. in all strains examined, the t lymphocytes were found in the high mobility fractions and the b in the low. the t and b cells were separated completely in most fractions, with some overlapping in the middle. significant differences were found in the electrophoretic distribution profiles between the strains: c57bl/6j, c57bl/10j, (balb/cxc57bl/6j)f1, and all the following: b6.c- ...197995175
effects of ovarian hormones on cell membranes in the rat uterus. i. freeze fracture studies of the apical membrane of the liminal epithelium.freeze fracture techniques have been used to study the apical membrane of cells of the luminal epithelium of the rat uterus under various hormonal regimes. in the ovariectomized but otherwise untreated rat, intramembranous particles (imps) occur at a density of 1395 +/- 122 per micron 2; they appeared spherical and uniformly distributed. after 3 days treatment with estrogen, no change in appearance or density was found, but 3 days of progesterone treatment produced a significant increase in imp ...197995176
immunodiffusion study on group-specific antigen of mc-29 chicken hepatoma.rabbit serum against crude mc-29 hepatoma extract does not contain anti-avian gs antibodies detectable by gel diffusion methods. rabbit serum containing antibodies against purified gs 1, gs 2, gs 3 and gs 4 antigens of avian myeloblastosis virus reveals gs 1 antigen in mc-29 hepatoma extract.197995333
k562 human leukaemic cells synthesise embryonic haemoglobin in response to haemin. 197995354
antigenic similarity between squamous cell carcinoma of horn (horn cancer) and normal bovine foetal tissues.normal bovine foetal (liver and skin) and horn cancer tissue antigens were examined using double diffusion agar gel precipitation and immuno-electrophoretic tests to detect any cross reactivity among them. rabbit horn cancer antisera absorbed with normal bovine liver, skin and horn core epithelium antigens, when tested with foetal skin and liver (4 to 6 months of gestation), revealed the presence of 2 foetal antigens in horn cancer. immuno-chemically 2 of the horn cancer antigens were found to b ...197995358
hearing thresholds with outer and inner hair cell loss.hearing impairment and related cochlear histopathologic changes were evaluated in experimental animals after treatment with aminoglycoside antibiotics or exposure to intense sound. in the course of treatment with kanamycin, neomycin, or dihydrostreptomycin, permanent hearing loss in monkeys and guinea pigs occurred first at the high frequencies and progressed toward the lows. exposure to different octave bands of noise at 120 db spl in monkeys and chinchillas produced permanent hearing loss at f ...197995382
immunological relationships among transaldolases in the genus bifidobacterium.antisera were prepared against electrophoretically homogeneous transaldolase (dihydroxyacetone transferase, e.c. 2.2.1.2.) of bifidobacterium thermophilum (b. ruminale) ru326 (atcc25866), b. cuniculi ra93 (atcc27916) and b. 'minimum' (homology group) f392 (atcc 27538). crude extracts of eighty six strains previously assigned to twenty one species of the genus bifidobacterium on the basis of deoxyribonouclelic acid (dna) homology (dna-dna hybridization), were compared by double diffusion tests on ...197995384
a case of a needle stick. 197995411
[antitumor activity and preclinical pharmacologic evaluation of pingyangmycin (author's transl)]. 197995444
[replacement solutions and hemodilution].by definition, haemodilution involves the use of filling solutions, but in this technique the role of different solutions has yet to be clearly defined. amongst the criteria of choice used at the present time, two would seem to be essential: good tolerance, limiting the risks of complication and side effects to an absolute minimum; and a sufficiently long intravascular half-life ensuring good control of blood volume. on this basis, amongst the crystalloids ringer lactate offers definite advantag ...197995461
[biosynthesis of penicillin upon periodic culturing of penicillium chrysogenum with an exponentially increasing glucose supply].penicillium chrysogenum was cultivated under controlled conditions and at constant specific growth rates regulated by glucose supply. the rate of penicillin synthesis (units/mg dry weight.hr) and pattern of time changes of the synthesizing capacity of the culture depended on the specific growth rate (hr-1). the arrest of penicillin synthesis was induced by the inherent changes of the culture rather than by external factors, e.g. use of substrates, changed limitation, accumulation of inhibitory m ...197995828
[levels of testosterone and dihydrotestosterone in guinea pig sex canals during embryonic life].at the undifferentiated stage, testosterone and dihydrotestosterone levels were comparable in sexual ducts of both sexes. an hormonal sexual dimorphism appeared at the time of differentiation: while testosterone rapidly decreased in the female ducts, it considerably increased in those of the male. testosterone rather than dht seems to be responsible for the wolffian duct stabilization in the male foetus.197895894
molybdenum independence of nitrogenase component synthesis in the non-heterocystous cyanobacterium plectonema.the cyanobacterium plectonema boryanum (iu 594-utex 594) fixes n2 only in the absence of combined n and of o2. we induced nitrogenase by transfer to anaerobic n-free medium and studied the effect of mo starvation on nitrogenase activity and synthesis. activity was first detected within 3 h after transfer by the acetylene reduction assay in controls, increasing for at least 25 h. cells grown on nitrate and mo and then transferred to n-free, mo-free medium produced 8% of the control nitrogenase ac ...197896092
direct administration of methotrexate into the central nervous system of primates. part 1: distribution and degradation of methotrexate in nervous and systemic tissue after intraventricular injection.levels of methotrexate (mtx) measured by both 3h radioactivity and dihydrofolate reductase assays were determined in cerebrospinal fluid (csf), plasma, urine, and both neural and non-neural tissues at varying times after a single intraventricular injection into cynomolgus monkeys (macaca fascicularis). clearance of the mtx from csf was rapid after injection. a relatively constant level of 3hmtx was reached in plasma 2 1/2 hours after injection, and about 30% of the 3hmtx dose was excreted in the ...197896228
tissue tropism of different trypanosoma cruzi strains.a systematic study of the distribution of intracellular parasites in the organs and tissues was performed in groups of mice inoculated with 4 different trypanosoma cruzi strains. an extremely high parasitism of spleen, liver, and bone marrow was observed in mice inoculated with y and berenice strains; with cl strain, however, parasites were almost absent in those organs. bloodstream forms apparently present differences which facilitate or prevent their uptake by macrophages from the mononuclear ...197896243
variant of stiff-man syndrome provoked by alcohol: case report. 197896364
chromosomal locations of mouse immunoglobulin genes.the chromosomal locations of the structural genes coding for the constant portions of mouse heavy (h) and light chain immunoglobulins were studied by molecular hybridization techniques. complementary dna probes containing the constant-region sequences of kappa and lambdai light chain and alpha, gamma2b, and mu heavy chain mrnas were annealed to a large excess of dna from a series of eight mouse-human hybrid cell lines that are deficient for various mouse chromosomes. the lines were scored as pos ...197896442
effects of ethanol on pregnant rats and their offspring.pregnant rats were intubated with either 1.0 or 2.0 g/kg of ethanol daily throughout gestation. pair-fed vehicle-treated, and nontreated rats fed ad libitum, served as control groups for ethanol-treated animals. ethanol treatment reduced food and water consumption and attenuated the gain in body weight of pregnant animals relative to nontreated animals fed ad libitum. litter size, litter weight, and the mean weight per pup were reduced in both the ethanol-treated and pair-fed control groups. the ...197896469
[oesophageal diverticulum in a pony (author's transl)].a case of oesophageal diverticulum in a pony is reported. the diagnosis was established by clinical and x-ray examination (following administration of a contrast agent) and verified by post-mortem studies. the cause and pathogenesis are discussed.197896547
haplotype designations of various strains of guinea pigs. 197896556
[biological properties and mechanisms of development of bacteria resistant to fusidin, erythromycin and chloramphenicol]. 197896638
phospholipid content and activity of pure uridine diphosphate-glucuronyltransferase from rat liver.rat liver phospholipids were radioactively labeled in vivo before purification of udp-glucuronyltransferase to homogeneity. the pure enzyme contained very little phospholipid (approx. 0.7 mol of phospholipid/mol of protein). the solubilization detergent lubrol 12a9 appeared to act as a phospholipid substitute, capable of supporting udp-glucuronyltransferase activity. phospholipase c did not inhibit the pure enzyme activity and pure udp-glucuronyltransferase was stimulated by 40--100% by the addi ...197896816
5-thio-d-glucose is an acceptor for udp-galactose : d-glucose 1-galactosyltransferase. 197896819
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