| isolation of the individual structural elements of bacteria of the genus bordetella and a study of their properties. i. the formation of mureinoplasts and true protoplasts from b. pertussis. | b. pertussis suspension was tested by de voe et al. method (1970) and its modification with the solutions of a definite ionic composition and a lysozyme. the best results were obtained by the following modification elaborated by the authors. the microbes were grown on the casein-carbon agar for 36 hours and were washed with chilled 0.5 m nacl. the suspension was washed 4 times with the same solution and then the precipitate was suspended in saccharose solution (0.5 m). in 2 hours the saccharose ... | 1975 | 875 |
| the effect of bordetella pertussis on the antibody response in mice to type iii pneumococcal polysaccharide. | the effect of an i.p. injection of bordetella pertussis on the primary humoral immune response in mice to the thymus-independent antigen siii has been studied. suppression of the antibody response occurred when pertussis cells were injected at the same time as an optimal immunizing dose of siii. in contrast, the antibody response to high doses of siii was enhanced by b. pertussis. when siii alone was injected, only 19s antibody was detected. however, when b. pertussis was administered with eithe ... | 1976 | 3610 |
| some factors influencing the haemolysis of bordetella bronchiseptica. | strain-dependent variations in the ability of bordetella bronchiseptica to produce haemolysis on solid media exist. haemolysis is strongest at an acid reaction and will not take place if the reaction is too alkaline. peptone and glutamine inhibit haemolysis and favour growth. the vigorous growth rapidly produced an alkaline reaction which inhibits the haemolysis. | 1976 | 5844 |
| the influence of growth medium on the interactions between bordetella pertussis and staphylococcus aureus. | previous observers showed that many strains of staphylococcus aureus stimulated the growth of bordetella pertussis but we have found the reverse: the growth of all available strains of b. pertussis on charcoal-agar medium was inhibited by a standard strain of s. aureus; and 17 of 18 strains of s. aureus (as well as several other organisms) inhibited the growth of a standard strain of b. pertussis. all inhibiting colonies had an unusual brown colouration on the charcoal agar used in the investiga ... | 1976 | 6798 |
| histamine hypersensitivity in mice induced by bordetella pertussis or pharmacologic beta adrenergic blockade. effects of adrenergic, cholinergic, and other drugs. | the effects of prostaglandin e1, e2, f2alpha (pge2 pgf2alpha), isoproterenol, epinephrine, norepinephrine, salbutamol, practolol, atropine, aminophylline, and corticosterone on the hypersensitivity to anaphylaxis, histamine, and serotonin in bordetella pertussis-treated mice and propranolol-treated mice were investigated. female hla-sw (icr) mice, 27-29 gm, were injected with pertussis vaccine intravenously 4 days before challenge with antigen, histamine, or serotonin. alternatively, instead of ... | 1976 | 9437 |
| biologically active components and properties of bordetella pertussis. | | 1976 | 11644 |
| the effects of bordetella pertussis vaccine on cerebral vascular permeability. | the effect of bordetella pertussis vaccine on the cerebral vascular permeability in the mouse was studied by a radio-isotope method (131i-labelled hsa). intravenous injection of 4 x 1010 heat-killed pertussis organisms caused a measurable increase in permeability in normal mice. cryoinjury to the cerebral hemispheres resulted in a striking increase in vascular permeability at 24 h. this declined within 48 h and stabilized at a level fractionally higher than normal at 7 days ("healed lesion"). wh ... | 1976 | 12780 |
| otitis media of guinea pigs. | otitis media occurred in 177 of 1373 guinea pigs necropsied during a six-year period. streptococcus pneumoniae (20%), streptococcus zooepidemicus (15%), bordetella bronchiseptica (12%), and pseudomonas aeruginosa (11%) were the most common bacteria isolated from affected tympanic bullae. radiology and otoscopy were tested as means of antemortem screening for affected guinea pigs. radiology gave 96% accuracy in diagnosing otitis media and proved to be a more satisfactory technique than otoscopy. | 1976 | 14279 |
| adenyl cyclase in bordetella pertussis vaccines. | brodetella pertussis organisms have a large amount of extracytoplasmic adenyl cyclase, part of which is found in the supernatant culture medium during exponential growth. the enzyme differs from previously studied bacterial adenyl cyclases in biochemical characteristics as well as in location. several commercial pertussis vaccines were found to contain adenyl cyclase activity; this activity is probably due to the extracytoplasmic enzyme associated with and released from the whole cells in the va ... | 1977 | 19542 |
| the insulin-like action of bordetella pertussis vaccine in rats. | treatment of rats with bordetella pertussis vaccine significantly lowered the blood sugar level 4 days later but the vaccine did not alter the level in diabetic rats. the vaccine, like insulin, raised glycogen levels in liver, skeletal muscle and heart and reduced the plasma free fatty acid concentration. the action of a beta-adrenoceptor blocker was potentiated by the vaccine but not by insulin. part of the hypoglycaemic action of the vaccine is probably due to beta-adrenoceptor blockade. | 1977 | 22497 |
| mannitol and delayed hypersensitivity in the rat. | | 1978 | 27619 |
| action of chloroquine on pleurisy due to bordetella pertussis hypersensitivity. | | 1978 | 29110 |
| subunit structure of islets-activating protein (iap), a new protein isolated from the culture media of bordetella pertussis. | the subunit structure was studied of islets-activating protein (iap), a new protein recently isolated from the culture media of bordetella pertussis and possessing a unique action, i.e., potentiating insulin secretory responses of animals, iap dissociated into three subunits, f-1, f-2, and f-3, when incubated in 8m urea. three subunits isolated by chromatography on cm-sepharose and deae-sepharose columns showed different molecular weights (f-1: 44,000, f-2: 20,000, f-3: 11,000) and different iso ... | 1978 | 29892 |
| viruses and bacteria associated with acute respiratory illnesses in young children in general practice. | the results obtained and the laboratory methods used for the isolation of viruses and bacteria from malaysian children with acute respiratory illnesses seen in a private clinic are described. of the 65 children studied virus isolations were obtained from 26 children, bacteria from 10 and both virus and bacteria from another 5. the agents isolated were influenza viruses, parainfluenza viruses, adenoviruses, bordetella pertussis, streptococcus pneumoniae, haemophilus influenzae and staphylococcus ... | 1978 | 30173 |
| bordetella pertussis does not induce beta-adrenergic blockade. | bordetella pertussis organisms induce histamine sensitivity and diminish the normal hyperglycemic response to epinephrine in experimental animals. these effects have been attributed to beta-adrenergic blockade. however, under conditions in which the decrease in epinephrine-induced hyperglycemia after b. pertussis administration was demonstrable, there was no change in rat reticulocyte beta-adrenergic receptor number or affinity measured by iodohydroxybenzylpindolol binding or in isoproterenol-st ... | 1978 | 32138 |
| purification and crystallization of fimbrial hemagglutinin from bordetella pertussis. | a procedure to purify and crystallize fimbrial hemagglutinin from bordetella pertussis is described. redissolved crystals had the same specific activity as the original, purified solution of fimbrial hemagglutinin. about 97% of the weight of washed crystals was accounted for by amino acids. | 1979 | 39033 |
| fimbrial hemagglutinin in stationary and shake cultures of bordetella pertussis. | bordetella pertussis produced hemagglutinin in stationary cultures; in cultures kept under constant shaking, hemagglutinin was found only during the first 48 h of incubation but not after 3 to 5 days. the type of medium had a pronounced effect on production of hemagglutinin. strain differences in ability to produce hemagglutinin were also detected. | 1979 | 39897 |
| the presence of the heat-stable neurotoxin in the pertussis cells. | | 1978 | 41206 |
| a selective medium facilitating the isolation and recognition of bordetella bronchiseptica in pigs. | a medium was developed that in most instances allowed the isolation from pigs of bordetella (alcaligenes) bronchiseptica in pure, or virtually pure, culture from such sites as the nasal cavity, which contains many other bacteria. if not suppressed, some of the latter can inhibit, sometimes completely, the growth of the bordetellae on artificial media. besides being markedly selective, the new medium is simple to prepare, reasonably cheap and practically noninhibitory to b bronchiseptica. this or ... | 1979 | 42958 |
| polymorphonuclear leukocyte-inhibitory factor of bordetella pertussis. ii. localization in the outer membrane. | the outer and inner membranes and cytoplasm of spheroplasts of a strain of phase i b. pertussis were fractionated by density gradient centrifugation. the high density vesicles of the outer membranes isolated had the "pili" characteristic of the bacteria and the same antigenicty as the bacterial surface. activities for inhibition of polymorphonuclear leukocytes were also almost exclusively localized in this outer membrane fraction. the histamine-sensitizing activity was more dispersed, but its sp ... | 1979 | 43725 |
| immunization against nippostrongylus brasiliensis in the rat. a study on the use of antigen extracted from adult parasites and the parameters which influence the level of protection. | it was found that protective immunity in excess of 90% reduction in worm burden could be stimulated against nippostrongylus brasiliensis in rats by using an extract of adult nippostrongylus worms. the level of protection achieved was influenced by several factors. thus, the use of bordetella pertussis as adjuvant significantly increased the level of protection which, in addition, was shown to be influenced by the amount of worm antigen used. furthermore, antigen administered in multiple doses wa ... | 1979 | 44095 |
| non-specific induction of increased resistance in mice to trypanosoma congolense and trypanosoma brucei by immunostimulants. | administration of the immunostimulants corynebacterium parvum, bacillus calmette-guérin (bcg) or bordetella pertussis prior to, or at the same time as, challenge with trypanosoma congolense significantly increased survival times in mice, both of trypano-susceptible (a/j) and trypano-resistant (c57bl) strains. the increased survival time was associated with significant alterations in parasitaemia, which included lengthening of the pre-patent period, a delay in the time taken to reach the first pe ... | 1979 | 44360 |
| the whooping cough syndrome: a continuing pediatric problem. | | 1975 | 46190 |
| spontaneous and methylcholanthrene-enhanced thyroiditis in buf rats. ii. induction of experimental autoimmune thyroiditis without completed freund's adjuvant. | the immunization of buffalo strain (buf) rats with rat thyroid extract and bordetella pertussis vaccine without complete freund's adjuvant resulted in experimental autoimmune thyroiditis (eat) in 90% of the rats by the 10th day after immunization. the treatment did not elicit thyroiditis in lewis strain (lew) rats. this susceptibility to the induction of eat without the use of complete freund's adjuvant was inherited by f1 hybrids of buf and lew. neither histamine sensitizing factor from b. pert ... | 1975 | 46238 |
| immunologic and biochemical properties of the histamine-sensitizing factor from bordetella pertussis. | a highly potent extract of the histamine sensitizing factor (hsf) of bordetella pertussis was isolated by extraction of bacterial cells with urea buffer and subsequent gel filtration. this preparation of hsf also contained leukocytosis-promoting activity and adjuvant activity for reaginic and hemagglutinating antibodiesl digestion of this extract with pronase or trypsin partially destroyed histamine-sensitizing activity, leukocytosis-promoting activity, and adjuvant activity for reaginic antibod ... | 1975 | 46244 |
| letter: effect of bordetella pertussis vaccine on growth of hepatoma. | | 1975 | 46557 |
| letter: whooping-cough vaccination. | | 1975 | 47031 |
| rapid and high production of precipitating antibodies in rats. | | 1975 | 47372 |
| a new method for the measurement of the opsonin titres of antisera to bordetella pertussis. | | 1975 | 47859 |
| rat tumour allografts evoke anaphylactic antibody responses. | in vitro assays of release of histamine from peritoneal mast cells showed that wistar rats produced anaphylactic antibody in response to a single immunization with an allogeneic sarcoma. the response occurs early after immunization, and no adjuvant is needed. the thermolability of the anaphylactic antibody suggests that it is ige. | 1975 | 48504 |
| inuction of immunological tolerance in immunoglobulin e b lymphocytes in rats. | immunological tolerance has been induced in 2,4-dinitrophenyl (dnp)-specific bone marrow-derived or b lymphocytes of the ige and igg antibody classes by treatment of rats with the dnp derivative of d-amino acid copolymer, d-glutamic acid, d-lysine (d-gl). the tolerant state is manifested as an inability of treated rats to produce serum anti-dnp antibodies and the failure of peritoneal cells from tolerant animals to release histamine following in vitro antigen challenge. the implications of these ... | 1975 | 48523 |
| taxonomic distribution of the antigen eliciting bactericidal antibody for bordetella pertussis. | strains of bordetella pertussis varied in their ability to elicit (in mice) an antibody bactericidal for an antiserum-sensitive strain of b. pertussis, although antibody was usually detectable after only one injection. high titres were produced by a course of seven injections with all strains of b. pertussis tested (six of phase i and three of phase iv) but not with three strains of other bordetella species nor with two unrelated organisms, a finding of possible taxonomic value. preliminary inve ... | 1975 | 49392 |
| induction of hypersensitivity to carboxymethylcellulose in cattle. | cattle were more readily sensitised than guinea pigs to carboxymethylcellulose. freund's complete adjuvant enhanced, but was not essential for, sensitisation. schultz-dale responses were obtained from pulmonary tissues of sensitised cattle but their sera failed to induce passive cutaneous anaphylaxis. cattle could possibly be sensitised by carboxymethylcellulose contained in drug formulations. | 1975 | 50616 |
| [immunochemical study of the antigenic structure of bacteria of genus bordetella. iv. fractionation of b. pertussis extracts and study of the immunochemical and biological properties of the isolated fractions]. | fractionation of an extract of pertussis microbes was carried out with the aid of gel-filtration on sephadex g-100, ion-exchange chromatography on deae-cellulose, and preparative electrophoresis. fractions differing in serological, immunogenic activity and the content of antigenic components were isolated. in using the method of gel-filtration of sefadex g-100 the greatest serological, immunogenic and histamine-sensitizing activity was possessed by the high-molecular fraction containing 8 of 11 ... | 1975 | 50683 |
| use of pertussis vaccine in an epidemic involving hospital staff. | an epidemic of pertussis occurred among hospital staff caring for paediatric patients. eight physicians and five nurses were affected. pertussis developed in six newborn infants exposed to infected hospital staff in the nursery. erythromycin prophylaxis was used to control the epidemic. clinical pertussis developed in five adults infected with bordetella pertussis before erythromycin was used, whereas symptoms developed in only one of the eight adults who became infected after erythromycin proph ... | 1975 | 51354 |
| the antibody responses to myelin basic protein (bp) in lewis rats: the effects of bordetella pertussis. | a time-course study was made of the systemic humoral immune response of lewis rats to myelin basic protein (bp) as influenced by the dosage of ancillary pertussis adjuvant. peak activities were observed 5 to 7 weeks after injection. when injected proximal to bp and mycobacterium butyricum in complete freund's adjuvant (cfa), bordetella pertussis at the level of 4 billion organisms doubled the antibody-binding activity of rat sera for 125i-labeled bp as compared to activities obtained with 0, 2, ... | 1975 | 51876 |
| loss of protective antigen, histamine-sensitising factor and envelope polypeptides in cultural variants of bordetella pertussis. | five bordetella pertussis strains of phase i were grown in conventional casamino-acid medium and in media modified by adding high concentrations of mgso4 or nicotinic acid. cells grown in high-magnesium media (in the c-mode) had only about 4% of the protective antigen (pa) and 6% of the histamine-sensitising factor (hsf) of cells from the normal medium. envelopes from c-mode organisms when examined by sds-page showed a loss of 28k and 30k polypeptide bands. similar parallel losses of pa, hsf and ... | 1976 | 57240 |
| protection by pertussis vaccine. little cause for concern. | it was estimated from a survey of 418 children aged three weeks to twelve years with bacteriologically confirmed whooping-cough that about 95% of vaccinated children are protected by current vaccine. protection could be increased even further by the greater use of adsorbed rather than plain vaccine and by closer adherence to a vaccination schedule. the lower incidence of infection, resulting from widespread acceptance of this highly effective vaccine, would also greatly reduce the exposure of in ... | 1976 | 57464 |
| isolation and properties of the leukocytosis- and lymphocytosis-promoting factor of bordetella pertussis. | the leukocytosis- and lymphocytosis-promoting factor (lpf) of bordetella pertussis has been isolated to near homogeneity by physical, chemical, and electron microscopical criteria. lpf contains 14.5% nitrogen and is lipid and carbohydrate free. it is apparently composed of four polypeptide subunits. lpf caused leukocytosis and lymphocytosis in "nude" as well as in normal mice. in addition, purified lpf also induced histamine sensitization and hypoglycemia and refractoriness to the hyperglycemic ... | 1976 | 58054 |
| letter: protective activity of whooping-cough convalescent serum and serum-iga level in mice infected with bordetella pertussis. | | 1976 | 59233 |
| [additive activity of ige and igga anaphylactic antibodies in rats (author's transl)]. | anaphylactic antibodies of two different classes are produced in rats: ige and igga. when injected into the skin of normal animals, ige remains at the site of injection for two weeks or more, while igga diffuses out within hours. in order to determine whether the anaphylactic reaction produced by one class of antibody is modified by the simultaneous presence of the other class of antibody, sites were prepared in normal rats with ige antibody and 24 hours later igga antibody was injected into the ... | 1976 | 60078 |
| antigen, host and adjuvant requirements for induction of hyperacute experimental autoimmune encephalomyelitis. | a hyperacute form of experimental autoimmune encephalomyelitis (heae) was induced in lewis rats using small doses (3.2 mug) of guinea pig myelin basic protein as immunogen and b. pertussis vaccine as adjuvant. myelin basic proteins from species other than guinea pig (rat, man, monkey, pig, ox, rabbit and sheep) induced only ordinary eae with this adjuvant. heae was more readily distinguished from ordinary eae by clinical criteria (early onset, with a rapid and severe course, and high incidence o ... | 1976 | 63374 |
| induction of an igm anti-(bovine)-igg response in mice by bacterial lipopolysaccharide. | | 1976 | 63917 |
| [vaccine from the cell fragments of bordetella pertussis. i. protective, sensitizing properties and morphological characteristics of the vaccine]. | the authors present the results of studying the protective and sensitizing properties of a new preparation made of a ultrasonic disintegrate of pertussis microbes treated by ethyl ether. as shown by electron microscopy, the preparation consisted of the cell wall elements (the membrane), remnants of the cytoplasm and protectosome, i.e. it represented a vaccine consisting of cell fragments. in crude and sorbed condition it possessed marked protective properties (a test on mice). the content of pro ... | 1976 | 64095 |
| [antimicrobial immunity as a factor in stimulating antitumor mechanisms]. | | 1976 | 66658 |
| [role of disorders of cyclic adenosine-3',5'--monophosphate (camp) in the pathogenesis of bronchial asthma]. | | 1977 | 67651 |
| hyperacute allergic encephalomyelitis: a single determinant. | heae cannot be induced in either guinea pigs using 10(10) or 20x10(10) organisms of b. pertussis or in rabbits using 4x10(10) organisms of b. pertussis and basic protein from the following species: guinea pig, lewis rat, human, bovine, porcine, monkey and rabbit. the only encephalitogenic region for lewis rats which also produces heae in lewis rats is not encephalitogenic in either rabbits or guinea pigs. therefore it seems highly probably that there is only one heae determinant for all species ... | 1977 | 69608 |
| whooping-cough vaccine. | | 1977 | 70722 |
| simplified silver-plating stain for flagella. | rhodes' silver-plating technique for staining flagella was tested for its reliability and convenience as a routine procedure in the clinical laboratory. modifications were made in the stain preparation and the procedure of staining and were tested with smears of known motile gram-negative nonfermentative bacilli. the stain has proved to be accurate and reliable and can be easily utilized with a minimum of training. | 1977 | 72075 |
| rosette-forming mast cells in rat anaphylaxis. immunological characteristics of mast cell rosettes. | peritoneal mast cells from immunized rats can form rosettes with antigen-coated sheep red blood cells. the receptor responsible for this active rosette formation is shown to be ige cytophilic antibody: rosettes are inhibited by previous contact of mast cells with antigen, or with anti-ige antiserum; the kinetics of mast cell rosettes following a primary immunization with ovalbumin and bordetella pertussis vaccine is similar to the kinetics of reaginic antibody response. furthermore, a reaginic s ... | 1977 | 73505 |
| [protection against infection with bordetella pertussis by an oligopeptide from bordetella pertussis (author's transl)]. | we have isolated from bordetella pertussis an oligopeptide with characteristic amino acid composition. this peptide was applied to mice in standardized tests for pertussis immunization. in three tests with three independent isolates of peptide, a significant and dose dependent protection was observed. one microgram of peptide per mouse produces the same protective effect as 0.1 iu of pertussis vaccine. it is important to note that similar peptides can be isolated from other bacteria and other dn ... | 1978 | 77606 |
| partial purification and some properties of inhibitors to the hemagglutinating activity of leukocytosis-promoting factor (lpf) from bordetella pertussis [proceedings]. | | 1978 | 79665 |
| [sensitivity of microorganisms isolated from swine to aqueous and proteinic solutions of gentamycin]. | employing a microbiologic method (in vitro) the activity was investigated of gentamicin dso pharmachim, dissolved in water, in normal swine gamma-globulin, and in normal swine polyglobulin with regard to swine strains of escherichia coli, salmonella choleraesis bordetella bronchiseptica, and pseudomonas aeruginosa as well as mycoplasms. a strong sensitivity was found to exsist in all tested strains (except for the mycoplasms) to gentamycin both in a water and in a protein solution. the in vivo t ... | 1978 | 80055 |
| the effect of alpha-fetoprotein on the immune response. iv. effect of treatment with alpha-fetoprotein on mice infected with bacteria in various experimental conditions. | | 1978 | 87184 |
| antigens in penicillin allergy. iv. induction of ige antibody response in mice after daily treatment with contaminated but not with pure penicillin. | | 1979 | 90657 |
| ige production in two types of genetically different rats. | | 1979 | 91951 |
| [isolation of fractions from bordetella parapertussis extracts and their use for preparing an erythrocyte diagnostic preparation]. | soluble parapertusis antigen, serologically active, having hemosensitive properties and containing only 2 antigenic components was obtained by the method of ethanol fractionation of microbial extracts. this method is simple and convenient for production purposes. the antigen thus obtained was used for the production of a highly specific erythrocytic diagnostic preparation (formalinized, liquid). when tested in reaction with animal and human sera, the new diagnostic preparation proved to be suffi ... | 1979 | 92121 |
| characteristics of the t-dependent alpha(1 leads to 6) glucosyl (dextran) antibody response induced in mice with isomaltohexaose coupled to chicken gamma-globulin. | isomaltohexaose flavazole coupled to chicken gamma-globulin (im6-cgg) induced t cell-dependent anti-alpha(1 leads to 6) dextran-specific igm and igg responses in cba, balb/c and a strain mice. the igg responses were of restricted heterogeneity as judged by isoelectric focusing, and belonged mostly to the igg1 subclass with a minor igg3 component in the case of balb/c and cba mice. all four subclasses of igg were produced in a strain mice. in contrast, native dextran b 512 induces exclusively t c ... | 1979 | 93549 |
| bordetella pertussis in a partially immunized host: case report. | | 1978 | 96376 |
| [sensitivity of bordetella bronchiseptica, pasteurella multocida and mycoplasma hyorhinis strains isolated from pigs towards antibiotics and chemotherapeutic agents]. | | 1978 | 100928 |
| bacterial and mycoplasma flora of a laboratory colony of the common marmoset (callithrix jacchus). | a survey was carried out to characterise the bacterial and mycoplasma flora of a closed colony of marmosets, callithrix jacchus. bordetella bronchiseptica and staphylococcus aureus were the only potential bacterial pathogens isolated from the colony; candida albicans was also identified. s aureus and c albicans were the only organisms which were associated with macroscopic lesions or overt disease. post mortem examination of the animals proved only reliable method of establishing the presence of ... | 1978 | 102075 |
| a comparison of bacterial flora isolated by transtracheal aspiration and pharyngeal swabs in macaca fascicularis. | the pulmonary flora of 30 monkeys (macaca fascicularis) was sampled by the transtracheal aspiration technique and the pharyngeal swab method, and the results were compared. the transtracheal aspiration technique yielded lower numbers of bacteria in both aerobic and anaerobic cultures. the bacteria isolated by transtracheal aspiration were predominately pure culture, thereby lowering the possibility of contamination from commensal flora. bordetella bronchiseptica was isolated from 23.3% of the mo ... | 1979 | 110978 |
| [devitalization of bordetella bronchiseptica in vitro using vapors of persterile and triethyl glycol]. | using the method of bacterial carriers, the devitalizing effect was studied of persteril and triethylene glycol vapours, acting in vitro, on a 24-hour culture of a mixture of 39 strains of bordetella bronchiseptica, isolated from the nasal cavity of pigs which came from five stocks suffering from the clinical form atrophic rhinitis. after exposure of the carriers of bordetella bronchiseptica to the action of spontaneously developing vapours o the mentioned chemicals, the devitalizing effect was ... | 1979 | 111400 |
| [immune response to tetanus toxoid in mice receiving protein deficient diet immediately after weaning]. | the humoral immune response to tetanus toxoid is evaluated by passive haemagglutination test in mice receiving low diet immediately after weaning during 15 and 30 days. the results show that the more deficient mice give the best antitoxin titers but after the challenge the antibody immune response become proportional to the protein restriction. in other respects and antitoxin titers are higher in 30 days restricted mice than in 15 days deficient ones. the effect of bordetella pertussis adjuvant ... | 1978 | 122306 |
| [rearing of germfree rabbits and establishment of an spf rabbit colony]. | baby rabbits hysterectomy-derived from conventional japanese white rabbits were reared under aseptic condition by feeding with 4 types of artificial diets. rabbit milk for the artificial diet was obtained from conventional dams at 7--25 days after delivery. the artificial diets was given by stomach tube twice a day. the total volumes of diet given (ml per day) were y = 2.3x + a (1 to approximately 14 days of age), y = 32.2 + a (l5 to approximately 25 days of age), or y = (32.2 + a) - 37.5 (x - 2 ... | 1979 | 155008 |
| [rearing of germfree guinea pigs and establishment of an spf guinea pig colony]. | new born guinea pigs of hartley strain derived by hysterectomy were fed commercial pellets, cow's milk, egg yolk and vitamin mixture since 0 days of age, when they were kept at 31 +/- 1 degrees c. out of 33 animals, 30 were reared for 40 days under aseptic state and they were transfered to a barrierred facility to establish an spf colony free from bordetella bronchiseptica, streptococcus zooepidemicus (animal c), salmonella spp., tyzzer's organisms, mycoplasma spp., reo 3 virus, sendai virus, ei ... | 1979 | 155009 |
| [establishment of a colony of japanese white rabbits free from coccidia and their breeding performance (author's transl)]. | a colony of rabbits free from coccidia was established in 1974 by weaning young at 25 days of age from dams infected with coccidia. until now bordetella, pasteurella and psoroptes cuniculi have not been detected either, and neither diarrhea nor death has occurred in weanlings of the colony. however, the mortality of sucklings was significantly high owing to cannibalism and tread by their dams. the weaning rate was effectively improved by use of a large nursing cage (3,100 cm2) and sterilized hay ... | 1979 | 160872 |
| identification of nonfermentative gram-negative bacteria in the clinical laboratory. | a simplified, concise scheme was developed for the identification of nonfermentative, gram-negative bacteria which have most frequently been reported in the literature as definite or possible agents of human disease. these organisms included apyocyanogenic pseudomonas aeruginosa, p. fluorescens, p. putida, p. stutzeri, p. maltophilia, p. putrefaciens, p. cepacia, p. alcaligenes, flavobacterium species, bordetella bronchiseptica, acinetobacter anitratum (herellea vaginicola), a. iwoffi (mima poly ... | 1975 | 163060 |
| the effects of humoral, cellular and non-specific immunity on intracerebral bordetella pertussis infections in mice. | when mice were injected intracerebrally with doses of bordetella pertussis vaccine greater than 5 imd 50 and challenged intracerebrally 14 days later with virulent b. pertussis there was an immediate reduction in the numbers of organisms. an analysis of this in vivo bactericidal effect has shown that large doses of an unrelated vaccine, salmonella typhosa, equivalent in cell mass to about 50 imd 50 of b. pertussis vaccine can achieve this effect, so for such doses the effect must be partly non-s ... | 1975 | 163275 |
| the role of adenoviruses in the pertussis syndrome. | to define the role of adenoviruses in the pertussis syndrome, a study was done of a group of 134 children with clinical pertussis and a healthy control population of similar age, race, sex, and socioeconomic status. adenovirus infections occurred in 30 (22.4%) of 134 patients with the pertussis syndrome and 5 (4.9%) of 101 control subjects (p smaller than 0.001). b. pertussis was recovered from 46 (34.3%) patients, and from 18 (39.1%) of these patients adenoviruses were also isolated. although a ... | 1975 | 163305 |
| affinity and specificity of antisera against human fsh and tsh obtained by immunizing rabbits with highly purified hormone preparations. | two groups of 4 rabbits were immunized according to the method described by vaitukaitis et al. (1971). one group was given 55 mu g (900 iu) fsh/animal and the other 100 mu g (o.5 iu) tsh/animal. two highly specific antisera against fsh and one specific antiserum against tsh were obtained. the fsh antisera showed affinities towards lh and tsh of 0.13 and 0.25% respectively as compared to that of fsh. the tsh antisera showed affinities towards lh and fsh of 2.2 and 1.7% respectively as compared to ... | 1975 | 163562 |
| lack of requirement for cell cooperation in the antibody response to dnp conjugated to levan. | | 1975 | 163703 |
| recovery of b lymphocyte responsiveness after complete radioactive antigen suicide, and the affinity of antibody made after incomplete suicide. | | 1975 | 163705 |
| further studies on the inheritance of responsiveness to pertussis hsf in mice. | inheritance of responsiveness to histamine-sensitizing factor of pertussis bacilli (hsf) was investigated in (c3h/hej times c57bl/6j)f1 hybrids, backcross progeny of this hybrid to c57bj/6j parent (c3h/hej times dba/2j)f1 hybrids, and in backcross progeny of this hybrid to dba/2j parent. it was found that transmission is not by virtue of a single autosomal dominant gene, as has been postulated. rather, inheritance of responsiveness to hsf is far more complex, probably involving polygenic transmi ... | 1975 | 163803 |
| respiratory and humoral immune response to aerosol and intramuscular pertussis vaccine. | animal experiments have shown that respiratory administration of pertussis antigen induces a protective immune response. in this study pertussis antibody in human respiratory secretions was measured and the response to aerosol and intramuscular pertussis immunization investigated. substanial increases in this antibody occurred after aerosol immunization but no changes were found in serum antibody. the reverse was observed after intramuscular pertussis vaccine in adults but not with aerosol immun ... | 1975 | 164502 |
| lymphocyte depletion induced by cholera toxin; relationship to adrenal cortical function. | intravenous injection of cholera toxin (choleragen) into mice caused a profound lymphocytopenia associated with marked cellular depletion of the lymph nodes, spleen, and thymus. after administration of 1 mu g of choleragen, lymphocytopenia was mot marked at 24 hr; recovery occurred 6 to 10 days later. similarly depletion of lymph nodes and spleen was maximal at 24 hr with recovery by 14 days. choleragen also caused a marked elevation of serum corticosterone and lymphocyte depletion was not obser ... | 1975 | 164505 |
| [characteristics of the low molecular antigens of pertussis bacteria]. | the authors elaborated a method of obtaining pertussis soluble antigenic complex by dialysis through the cellophane membrane against the physiological saline at a temperature of 4 degrees c. an antigen which was active in the passive hemagglutination and neutralization of antibodies tests was revealed in the dialyzate. the amount of this antigen in the dialyzate increased gradually up to the 7th day and then became stabilized. the serological activity of the antigen after evaportation increased ... | 1975 | 164747 |
| [comparative study of nutrient media for isolation of the agents of pertussis and parapertussis]. | taking into consideration literature data pointing to a possibility of a marked improvement of the quality of the medium for the isolation of the causative agents of pertussis and parapertussis, an experimental study was made of the sensitivity of the nutrient media produced by the dagestan institute of nutrient media, a medium made from dry and also of a number of media modified by the authors prepared on its basis. pure freshly-isolated and museum b. pertussis cultures were used in the observa ... | 1975 | 164750 |
| [the response of blood neutrophils (the ppn test) to pertussis allergen in children with pertussis and children immunized with adpt vaccine]. | the authors present materials on the study of the reaction of blood neutrophils (ppn test) to pertussis allergen in children suffering from pertussis and immunized with adpt vaccine. results obtained in examining 111 children showed that the ppn test was specific and could be used for assessment of allergic manifestations in children suffering from pertussis or immunized with adpt vaccine. taking into consideration the harmlessness and expressiveness of the ppn test it can be recommended for stu ... | 1975 | 164751 |
| factors influencing the stability of acid-precipitated polyvalent bordetella pertussis bulk suspensions. | according to the statistical analysis of the potency values of acid precipitated polyvalent bulk suspensions of bordetella pertussis, the potency of suspensions decreased below 8 iu/30 iou during storage for 5 to 9.8 years. the average annual decrease over a 13-year period was 2.03 iu/30 iou. the periodicity in the decrease of potency values was assumed to be connected with changes in the quality of the casein hydrolysate ingredient of the medium. periodic functions employed to approach potency ... | 1975 | 164759 |
| the use of bordetella pertussis preserved in liquid nitrogen as a challenge suspension in the kendrick mouse protection test. | | 1975 | 165201 |
| the use of spheroplast-derived strains to differentiate between bordetella pertussis heat-labile agglutinogens and protective antigen for mice. | | 1975 | 165202 |
| cell-envelope proteins of bordetella pertussis. | cell-envelope polypeptides of eight phase-i and five phase-iv strains of bordetella pertussis were compared by sds-polyacrylamide gel electrophoresis. all phase-i strains gave a strikingly similar but complex pattern of protein bands, which did not appear to vary with known differences in heat-labile agglutinogens. phase-iv strains gave the same pattern as phase-i strains, except that one band was missing and another was either much reduced or absent. envelopes from phase-i strains grown in horn ... | 1975 | 165297 |
| immunodeficiency in the chicken. i. disparity in suppression of antibody responses to various antigens following surgical bursectomy. | the extent of suppression of antibody response by bursectomy (bx) was examined as a measure of the seeding sequence of different clones from the bursa to peripheral lymphoid tissues. chickens were bursectomized surgically 1, 4 or 7 days after hatching and immunized later with four antigens: sheep red blood cells (srbc); bordetella pertussis (bp); human serum albumin (hsa); influenza virus (iv). the kinetics of the antibody responses were delayed in bursectomized birds when compared with the cont ... | 1975 | 166036 |
| effect of bordetella pertussis extract and vasoactive amines on vascular permeability. | vasxular permeability to evans blue dye and 131-i-labeled human serum albumin was studied in normal mice and in mice treated with alkaline saline extracts (se) from bordetella pertussis cells. skin sites inoculated intracutaneously with small doses of histamine, serotonin, or a combination of these 2 substances were more permeable in se-treated mice than in normal animals. intravenously administered catecholamines were able to reduce in varying degrees the vascular permeability induced by seroto ... | 1975 | 166102 |
| [letter: whooping cough: isolation of a severe form]. | | 1975 | 166543 |
| a procedure for removing red cells and dead cells from lymphoid cell suspensions. | a procedure is described for simultaneously removing red cells and dead cells from lymphoid cell suspensions, based on the observation that when populations of lymphoid cells are centrifuged on a mixture of isopaque/ficoll, dead cells and red cells sediment whereas viable cells float. the technique very efficiently removed red cells from a wide range of lymphoid cell suspensions and eliminated lymphocytes killed by mechanical stress, by antibody and complement and by prolonged tissue culture. th ... | 1975 | 167077 |
| studies on the immunizing capacity of orally administered particulate antigens. i. the efficiency of killed bordetella pertussis cells. | the single i.p. injection of 2.5 times 10-8 killed b. pertussis cells protected 23 out of a group of 24 nmri mice (95.8%) against the subsequent intracerebral infection, whilst 13 out of 24 mice (54.2%) survived the intracerebral challenge with virulent b. pertussis cells after prior oral administration of 2.5 times 10-11 killed b. pertussis cells, as demonstrated by the mouse protection test. similar treatment with non-specific substances, such as egg white and saline, did not result in any inc ... | 1975 | 167535 |
| alterations in adenyl cyclase activity and glucose utilization of bordetella pertussis-sensitized mouse spleen. | | 1975 | 167788 |
| letter: techniques for recovery of b. pertussis on culture. | | 1975 | 169342 |
| evaluation of antitumor activity of bordetella pertussis in two murine tumor models. | the antitumor activity of three preparations of killed bordetella pertussis (bp) (eli lilly crude and fluid pertussis vaccines and parke-davis pertussis vaccine) was studied in the b16 melanoma and cad2 mammary adenocarcinoma models. in these tumor systems; bp had weak and variable tumor inhibitory activity and did not augment tumor rejection immunity. the intratumor injection of bp did not affect the growth of the b16 tumor but significantly inhibited the growth of the cad2 tumor. however, the ... | 1975 | 169359 |
| leukocytosis-promoting factor of bordetella pertussis. | | 1975 | 169413 |
| proceedings: hemagglutinating substance of bordetella pertussis. | | 1975 | 169414 |
| [activity of pertussia antibodies in various immunoglobulins isolated from sera of rabbits immunized with pertussia vaccine]. | | 1975 | 169442 |
| influence of bordetella pertussis and bacterial endotoxins on the immunological reactivity of germfree mice. | as compared to specifically pathogen-free nmri mice, in principle, the immunological reactivity of germfree mice of the same strain and age was not found to be reduced. this is documented by the cellular kinetics of the primary immune responses, evoked by the intraperitoneal (i.p.) injection of either a "saturated" dose of 4 times 10(8) sheep erythrocytes (se) or the simultaneous injection of 4 times 10(8) se and 3 times 10(9) killed bordetella pertussis organisms (po). thereby, adjuvancy of po ... | 1975 | 169652 |
| studies on the adjuvant effect of bordetella pertussis vaccine to sheep erythrocytes in the mouse. i. in vitro enhancement of antibody formation with normal spleen cells. | the adjuvant effect of bordetella pertussis vaccine (pv) on the antibody response to sheep erythrocytes (srbc) has been studied in vitro with the mishell-dutton immunization technique. the addition of pv to cultures of spleen cells obtained from normal non-immunized mice markedly enhanced the plaque-forming cell response to srbc. the greatest enhancement was evident at 24 hr of culture. pv was also shown to enhance the antibody response of spleen cells that had been depleted of either t lymphocy ... | 1975 | 170337 |
| [properties of recently isolated bordetella pertussis]. | | 1975 | 170434 |
| [drug sensitivity of recently isolated bordetella pertussis and bordetella parapertussis]. | | 1975 | 170435 |
| [serotyping of recently isolated bordetella pertussis]. | | 1975 | 170436 |
| [effect of infectious diseases on levels of pertussis antibodies in children vaccinated against pertussis]. | | 1975 | 170650 |