| stability of fluorescent antibody conjugates stored under various conditions. | two experiments were carried out to determine the stability of fluorescent antibody conjugates. in experiment 1, francisella tularemia conjugates in the lyophilized state retained their original staining titer for 1,294 days when stored at 25, 4 to 5, and -20 c; at 37 c the conjugates were stable for at least 65 days. in the liquid state at ph 7.4 and 8.0 these conjugates were stable for 1,294 days at 4 to 5 and -20 c, whereas those stored at 25 c remained stable through days 473 and 160 of stor ... | 1976 | 3516 |
| differential effect of parenteral zinc on the course of various bacterial infections. | | 1977 | 22081 |
| induced metabolic sequelae of tularemia in the rat: correlation with tissue damage. | serum and liver zinc concentration, amino acid uptake by liver, seromucoid content, and alpha2-macrofetoprotein production were measured in vaccinated as well as nonimmune rats exposed to either virulent (schu s4) or attenuated (lvs) strains of francisella tularensi. it appears that liver damage (pyogranulomatous lesions) must occur before there is any alteration in the above variables. the presence of bacteria in the liver is not of itself sufficient to lead to the onset of systemic, induced me ... | 1975 | 51592 |
| protein synthesis in zinc deficient rats during tularemia. | the effect of zinc deficiency on protein synthesis in rats during tularemia was studied. five weeks prior to infection with the live vaccine strain of francisella tularensis, rats had been assigned to one of three dietary groups: zinc deficient (-zn), pair-fed (pf) or ad libitum (al). within 4 weeks, zinc deficiency manifested itself by diminished growth rate, decreased serum and liver zinc concentrations and alopecia. by 18 hour post infection, rats of all groups were febrile and exhibited an i ... | 1976 | 58980 |
| [effectiveness of the tularemia-antibody erythrocyte diagnostic agent for the detection of specific antigen and antibodies to it]. | the authors demonstrated the efficacy of utilization of tularemia antibody erythrocytic diagnostic agent. data are presented indicating a strict specificity and a high sensitivity of this diagnostic agent for detection of the vi-antigen both in the tularemia microbe cultures and in the suspensions of the organs of rodents which perished of tularemia, irrespective of the state of cadaver. there was revealed relationship between the sensitivity of the diagnostic agent and the virulence of the tula ... | 1978 | 78604 |
| activated lymphocytes trigger lymphoblast extravasation. | | 1978 | 96942 |
| [survival capacity of certain pathogens under environmental conditions]. | | 1979 | 103703 |
| a serologic survey of mule deer and elk in utah. | sera from mule deer (odocoileus hemionus) and elk (cervus canadensis) in central and northern utah were tested for the prevalence of antibodies to 11 diseases communicable to man or domestic livestock. antibodies to francisella tularensis (at 1:20) were found in 47 of 88 (53.4%) elk and 1 of 89 (1.1%) deer. a screening slide agglutination test for titers to brucella (at 1:20) showed two reactors in elk but none in deer sera. no positive antibody titers were obtained in tests for anaplasmosis, co ... | 1978 | 105153 |
| [accelerated diagnostic cultivation of pathogenic environmental microbes. ii. accelerated diagnostic cultivation of the causative agents of anthropozoonotic plague, glamders, melioidosis, brucellosis and tularemia]. | | 1978 | 106632 |
| changes in whole blood and serum components of grivet monkeys with experimental respiratory francisella tularensis infection. | grivet monkeys infected with virulent francisella tularensis strain schu s4 showed significant early changes in serum levels of trace metals, triglycerides and activities of alkaline phosphatase, lactate dehydrogenase and alpha-hydroxybutyrate dehydrogenase. free amino acid levels decreased slightly and there was a marked increase in the phenylalanine: tyrosine ratio. serum lysozyme activity and seromucoid levels also increased. kanamycin therapy produced remission of overt signs but the changes ... | 1978 | 106870 |
| tularemia in a group of nonhuman primates. | in an episode of tularemia in a canadian zoologic garden, three black and red tamarins (sanguinus nigricollis) and one talapoin (cercopithecus talapoin) died. a second talapoin developed abscesses in the tongue and submandibular area; this animal recovered with treatment. francisella tularensis was isolated from lung, liver, and spleen from each dead monkey and from pus collected from the tongue abscess of the sick talapoin. the attending veterinarian contracted the disease from a tamarin bite. ... | 1979 | 118145 |
| human tularemia at an urban zoo. | | 1979 | 120758 |
| enzyme-linked immunosorbent assay for immunological diagnosis of human tularemia. | the enzyme-linked immunosorbent assay (elisa) was applied for immunological diagnosis of human tularemia, using lipopolysaccharide from francisella tularensis as antigen. sera collected from patients, healthy individuals, and vaccinated volunteers were investigated for antibodies against f. tularensis by elisa and tube agglutination. in elisa all sera were titrated with a polyspecific anti-immunoglobulin enzyme conjugate. a limited number of consecutive sera from individual patients were also in ... | 1979 | 120873 |
| [discovery of tularemia epizootics by way of detecting the tularemia microbe antigen in the droppings of predatory birds]. | | 1975 | 128957 |
| [effects of intradermally administered tularin sevac on the titre of slow agglutination reaction with the francisella tularensis antigen (author's transl)]. | | 1975 | 130981 |
| [exploration of natural foci of tularemia and plague in armenia using the serological examination of bird droppings and excrements of predatory mammals]. | forty strains of tularemia and 619 of plague microbes were isolated in 1974 in bacteriological examination of natural plague and tularemia foci from a great number of small mammals and their ectoparasites. at the same time in serological examination (in the antibody neutralization test) of bird pellets, 52 mummified cadavers, and 34 excretion samples of mammalian beasts of prey collected in armenia (its central and north-western part) in 1973 the antigen of tularemia microbe was revealed in 73, ... | 1978 | 149478 |
| [sensitivity to the differential dose of erythromycin and oleandomycin of various holarctic strains of tularemia microbe isolated in the kazakh ssr]. | the presence of strains of holarctic race of tuleremia microbe, both sensitive and resistant to the differential doses of erythromycine and oleandomycine was revealed at the territoryn of kazakh ssr. the existence of such strains does not permit to differentiate them into geographical races by the sensitivity to erythromycine and oleandomycine. | 1978 | 150182 |
| [geographical race typing of the causative agent of tularemia using antibiotics]. | reaction of the strains of the tularemia causative agent to erythromycin (100 gamma/ml) or oleandomycin (400 gamma/ml) is one of the taxonomic tests. the study of 82 strains of the holarctic race and 63 strains of the central asiatic race according to this test showed that the strains of the holarctic race were divided with respect to these macrolides into sensitive (biotype i) and resistant (biotype ii). the strains of the both races were isolated at the territory of the kazakh ssr. such a reac ... | 1978 | 151527 |
| [study of f. tularensis susceptibility to erythromycin in vitro (author's transl)]. | | 1978 | 151594 |
| [bactericidal effect of peracetic acid on francisella tularensis (author's transl)]. | | 1979 | 156076 |
| the human placental villitides: a review of chronic intrauterine infection. | | 1975 | 172296 |
| [an experimental study of mixed tularemia and omsk hemorrhagic fever infection in muskrats]. | musk-rats were infected simultaneously and at three-day interval with tularemia and omsk hemorrhagic fever (ohf); the course of this mixed infection under the mentioned conditions were studied. virological, microbiological and morphological data indicated that infection of musk-rats with ohf and tularemia caused development of mixed infection in them. a more severe course of mixed infection was associated with enhanced vascular affections caused by the action of the ohf virus. an inhibition of t ... | 1975 | 175620 |
| [sensitivity of various races of the tularemia microbe to erythromycin, oleandomycin and polymyxin]. | sensitivity of 66 strains of the tularemia microbe to erythromycin, oleandomycin and polymyxin was studied. it was shown that all the strains were resistant to polymyxin. the strains of the non-artic and central asiatic races and 64 per cent of the strains of the holarctic race were resistant to erythromycin and oleandomycin. | 1976 | 179462 |
| the effect of bacterial infections on ketone concentrations in rat liver and blood and on free fatty acid concentrations in rat blood. | the concentrations of cytoplasmic lactate and pyruvate and the nad+/nadh ratio and the concentrations of mitochondrial acetoacetate, beta-hydroxybutyrate, and the nad+/nadh ratio were determined in normal, fed, and fasted rats, and in rats infected with streptococcus pneumoniae, francisella tularensis, and salmonella typhimurium. the various infections were found to have little or no effect on the cytoplasmic parameters. in normal rats, fasting caused a marked increase in blood and hepatic keton ... | 1976 | 181658 |
| changes in whole blood and serum components during francisella tularensis and rabbit pox infections of rabbits. | rabbits infected with virulent francisella tularensis strain schu s4 or rabbit pox virus (utrecht strain) showed significant early changes in serum levels of trace metals, neutral fat and alkaline phosphatase activity. with f. tularensis infections a marked early leukopenia and a decrease in serum amino acids were also observed; the effect on amino acid levels was less pronounced in rabbit pox infections. in both diseases these changes preceded the appearance of acute phase globulins in the seru ... | 1977 | 204323 |
| [changes in the antibacterial effects of organs and tissues of ornithodoros papillipes birula ticks]. | | 1975 | 234572 |
| phagocytosis of francisella tularensis by rhesus monkey peripheral leukocytes. | phagocytosis of francisella tularensis by rhesus monkey peripheral neutrophils (pmn, was assessed by autoradiography, electron microscopy, and biochemical techniques. pmn, in contrast to mononuclear phagocytes, were unable to phagocytize f. tularensis in vitro in the absence of immune serum. it is postulated that in the nonimmune host the innate inability of pmn to phagocytize f. tularensis deletes one of the possible mechanisms of host defense to bacterial infection and thus permits the early d ... | 1975 | 234911 |
| temporal appearance of opsonizing antibody to francisella tularensis: detection by a radiometabolic assay. | the burst in oxidative metabolism that is mediated through activation of the hexose monophosphate shunt and accompanies particle ingestion by polymorphonuclear leukocytes was used as the indicator in an in vitro radiometabolic assay for detection of specific opsonizing antibody to francisella tularensis. release of 14co2 from radiolabeled glucose was increased significantly when specific immune serum added to suspensions of monkey polymorphonuclear leukocytes and f. tularensis. with this method, ... | 1975 | 234915 |
| [sialic acid in f. tularensis and f. novicida antigens]. | sialic acid was revealed in the antigens of virulent (503/830 and schu) and vaccine (schu-attenuated and 15-reduced) strains of f. tularensis and also in the antigens of f. novicida isolated by the treatment with trichloracetic acid, by the thiobarbiturate method of warren. its content depended on the culture virulence. sialic acid was absent in the antigens of avirulent strains of the causative agent of tularemia (503-attenuated, 15-attenuated and 21/400), but, in difference from the virulent s ... | 1975 | 235820 |
| [the possibility of predicting the degree of plasmacyte reaction in response to administration of soluble antigen to mice]. | the work is devoted to the mathematical description of the accumulation of plasma cells in the spleen of cba mice immunized intraperitoneally. a dependence between the dynamics of the soluble antigen concentration in the blood and the plasmocytic reaction in the spleen was confirmed under experimental conditions. index a was suggested for detection of a change from the antigenic function to the accumulation of plasma cells. the mean values of index a were used to compare the calculated values of ... | 1975 | 235822 |
| tularaemia in the rat. i. the cellular basis on host resistance to infection. | rats infected with the live vaccine strain (lvs) of francisella tularensis develop in vivo and in vitro evidence of cellular hypersensitivity and a concomitant state of cellular resistance to infection. they key role of sensitized lymphocytes in cellular resistance was domonstrated in transfer experiments. using this technique, it was shown that thoracic duct lymphocytes from francisella immune donors conferred specific antimicrobial resistance on normal recipients, whereas antiserum afforded no ... | 1975 | 236983 |
| the mediator of cellular immunity. x. interaction of macrophages and specifically sensitized lymphocytes. | | 1975 | 237635 |
| biochemical and immunological properties of ribonucleic acid-rich extracts from francisella tularensis. | ribonucleic acid (rna)-rich extracts derived from the attenuated strain of francisella tularensis (strain lvs) protected swiss mice against lethal challenge with f. tularensis strain 425 but not against strain schu s4. no killed preparation, including an rna-rich extract from schu s4 itself, offered protection against strain schu s4 in contrast to the high level of protection offered against this strain by vaccination with live strain lvs. the protective activity observed against strain 425 was ... | 1975 | 237834 |
| relationship of serum beta-glucuronidase and lysozyme to pathogenesis of tularemia in immune and nonimmune rats. | a temporal study is reported of the febrile responses, tissue bacterial contents, and serum concentration of the lysosomal enzymes, beta-glucuronidase and lysozyme, in nonimmune rats inoculated with virulent or attenuated strains of francisella tularensis, and in immune rats challenged with either a high or low dose of virulent organisms. the level of serum beta-glucuronidase appears to be an indicator of hepatocyte damage, whereas serum lysozyme correlates with the appearance, frequency, and se ... | 1975 | 237835 |
| chronic shedding tularemia nephritis in rodents: possible relation to occurrence of francisella tularensis in lotic waters. | contamination of streams by francisella tularensis, a fastidious pathogen, was discovered by miller in russia. subsequently that contamination was found to be the source of extensive human outbreaks, and to occur as well in north america. circumstantial evidence supports a hypothesis that infected voles are responsible for the contamination, but when freshly isolated f. tularensis palaearctica is inoculated parenterally, only acute illness and death result whereas long-term contamination of stre ... | 1975 | 239255 |
| [isolation of the causative agent of tularemia from siberian lemmings in eastern taymyr]. | the authors present the results of bacteriological and serological study for tularemia of 498 lemmings caught in taimyr. positive results were revealed in 4 out of 98 sera examined in the indirect hemagglutination test. in carrying out 67 biological tests on albino mice there were isolated for the first time in the soviet union 6 cultures of the causative agent of tularemia from the spleen of lemmings. by morphological, cultural and virulent properties the cultures obtained failed to differ from ... | 1975 | 239505 |
| virulence factors of francisella tularensis. | the mechanism causing viable francisella tularensis to lose virulence in aerosols has been investigated. fully virulent organisms were found to be encapsulated and avirulent organisms from aged aerosols, decapsulated. capsules were also removed by suspension of f. tularensis in hypertonic sodium chloride. the resulting naked, but viable, organisms were predominantly avirulent for guinea-pigs challenged intraperitoneally. capsular material and cell walls were found to contain large amounts of lip ... | 1977 | 267668 |
| tularemia in metropolitan new york. | | 1978 | 280774 |
| the active e-rosette test: a sensitive in vitro correlate for human delayed-type hypersensitivity. | the "active" rosette test was adapted as an in vitro assay and correlated with human delayed cutaneous hypersensitivity (dch) to two microbial antigens. peripheral lymphocytes were purified from donors known to be responders or nonresponders to ppd-tuberculin or tularemia on the basis of prior dch reactions. skin test antigen, incubated with lymphocytes from antigen-sensitive donors, produced a significant increase (+2 s.d.) in the ability of the lymphocytes to form active rosette-forming cells ... | 1977 | 299750 |
| stimulation of subpopulations of human lymphocytes by a vaccine strain of francisella tularensis. | when purified t lymphocytes from individuals vaccinated with a viable, attenuated strain of francisella tularensis were incubated in vitro in the presence of heat-killed bacteria or a membrane preparation of the vaccine strain, they were stimulated to form blast cells and to synthesize deoxyribonucleic acid. the blast cells had the characteristics of t cells, being devoid of surface immunoglobulin and able to form rosettes with sheep erythrocytes. the stimulation occurred only when monocytes wer ... | 1978 | 307538 |
| endotoxin effects on the liver. | | 1977 | 320416 |
| cultivation and isolation of francisella tularensis on selective chocolate agar, as used routinely for the isolation of gonoccocci. | | 1977 | 320819 |
| determination of antibacterial antibodies in serum by immunoradiometric assays. | when used to determine immunopurified antibacterial globulins in saline-phosphate buffer, the detection sensitivities of direct competitive and indirect immunoradiometric assays were respectively 25 and 2 ng. normal human and rabbit sera interfered in both types of assay, markedly decreasing sensitivity and precision. various pre-treatments of sera and modifications of reaction conditions substantially decreased interference in the competitive assay without affecting the activity of added antibo ... | 1977 | 323486 |
| [change in phagocytic activity toward the agent of tularemia in highly sensitive animals with mixed infections]. | an increase of the ingestive and digestive capacity of neutrophils to the homologous causative agent and tularemia microbe was revealed by the opsonophagocytic test in microtus arvalis, albino mice and guinea pigs infected with sublethal yersinia pseudotuberculosis and salmonella typhimurium doses. in subsequent tularemia infection some of the animals displayed a reduction of the septicemia intensity, prolongation of the disease and elevation of the susceptibility threshold. period of manifestat ... | 1977 | 325967 |
| isolation of francisella tularensis from infected frozen human blood. | francisella tularensis was isolated from human blood that was frozen for 3 months before it was examined. before he became ill, the patient operated a "bush-hog" in an area thickly populated with rabbits. his illness was undiagnosed and untreated before his death. portions of blood and tissue homogenates from necropsy were injected intraperitoneally into mice and inoculated onto glucose-cysteine-blood agar plates. f. tularensis did not grow from the culture plates, but mice inoculated with the b ... | 1977 | 328528 |
| persistence of enterobacteriaceae in female adults of the biting gnat culicoides variipennis (diptera: ceratopogonidae). | | 1978 | 344884 |
| [protective reaction in ornithodoros papillipes to the causative agents of salmonellosis and tularemia and to staphylococcus]. | | 1978 | 356412 |
| isolation of francisella tularensis from mites haemogamasus nidi and laelaps hilaris in western slovakia. | isolating of f. tularensis from gamasid mites h. nidi parasitizing on the bank vole (cl. glareolus) and l. hilaris on the common vole (m. arvalis) are reported. the epidemiological significance of this finding is discussed. | 1979 | 388944 |
| isolation of pathogens other than yersinia pestis during plague investigations. | from 1975 to 1978, 37 isolates of pasteurella multocida, 1 of salmonella enteriditis, and 5 of francisella tularensis were recovered from 42 mammalian specimens and 1 flea pool submitted for examination for evidence of infection with yersinia pestis. most of the specimens were collected during investigations of either a human plague infection or a reported epizootic among rodent populations. all specimens were of species regularly or occasionally involved in plague or tularemia cycles in nature ... | 1979 | 392123 |
| [agents of zoonoses and the environment of their habitats. iii. adaptive variability and ecotypes]. | | 1977 | 405989 |
| host resistance to the lvs strain of francisella tularensis in bcg vaccinated mice. | | 1977 | 411926 |
| [mechanism of the changes in the animal reactivity to tularemia in mixed infection]. | experiments were conducted on albino rats infected with listeria or salmonelloses, and then with tularemia; differences were revealed in the duration of manifestation of nonspecific resistance associated with peculiarities of pathogenesis and immunogenesis of the background infections. one of the significant factors causing an increase of albino rats resistance to tularemia in mixed infection was activation of the immunomorphological reaction promoting accelerated development of specific immunit ... | 1978 | 415458 |
| clinical, epidemiological and therapeutical experience with human tularaemia: the role of hamster hunters. | fifty patients suffering from tularaemia were treated in our department. the most frequent occupation of the tularaemia patients was hamster hunter. the most important source of the tularaemic infection (90%) was the hamster (cricetus cricetus). we observed the cutano-glandular form in 90% of the patients and internal tularaemia in 10%. the antibiotics used (streptomycin i. m., oxytetracycline and doxycycline per os) were effective. | 1979 | 437894 |
| pneumonic tularemia on martha's vineyard. | | 1979 | 481515 |
| resistance to tick-borne francisella tularensis by tick-sensitized rabbits: allergic klendusity. | mammals become hypersensitive to ticks that feed upon them. that hypersensitivity was thought responsible for an observation that a large number of francisella tularensis-infected dermacentor variabilis failed to infect a rabbit previously exposed to ticks of that species. in a series of tests of that hypothesis, rabbits sensitized to ticks were often significantly more resistant than control animals to tick-borne tularemia. the conditions that determine the klendusity are thought to be variable ... | 1979 | 484770 |
| tuleremia in the raven (corvus corax). | | 1979 | 492969 |
| role of the liver in regulation of ketone body production during sepsis. | during caloric deprivation, the septic host may fail to develop ketonemia as an adaptation to starvation. because the plasma ketone body concentration is a function of the ratio of hepatic production and peripheral usage, a pneumococcal sepsis model was used in rats to measure the complex metabolic events that could account for this failure, including the effects of infection on lipolysis and esterification in adipose tissue, fatty acid transport in plasma and the rates of hepatic ketogenesis an ... | 1979 | 500825 |
| [present-day problems of natural foci and the prevention of tularemia]. | | 1979 | 506600 |
| [further study of a natural focus of tularemia on biriuchiĭ island]. | | 1979 | 516954 |
| time of lymphocyte response after onset of tularemia and after tularemia vaccination. | blood lymphocytes were prepared from 6 patients at various time intervals after the onset of tularemia and from 10 subjects after vaccination against this disease. lymphocytes were also prepared from subjects who had been vaccinated 1 and 2 years previously. the lymphocytes were incubated in the presence of membranes of the vaccine strain. lymphocytes obtained 2 weeks or later after onset of the disease responded to the membranes with increased deoxyribonucleic acid synthesis, whereas lymphocyte ... | 1979 | 521485 |
| cellular fatty acid composition of francisella tularensis. | several unusual fatty acids characterized strains of francisella tularensis. long-chain (c20-c26) acids and the hydroxy acids 2-hydroxy-decanoate, 3-hydroxy-hexadecanoate, and 3-hydroxy-octadecanoate appeared to be of special diagnostic value. | 1979 | 521490 |
| [cytopathic effect of the tularemia microbe on a culture of peritoneal macrophages]. | morphological analysis of the process of interaction of tularemia microbe strains differing by virulence with macrophages demonstrated that all these strains produced a lethal effect on macrophages obtained from the animales sensitive to the infection. the macrophages obtained from the animals were but little sensitive to tularemia and were resistant to the action of the causative agent of this infection. the data obtained led to a supposition on the presence in the tularemia causative agent of ... | 1977 | 562567 |
| tularemia pneumonia in washington, dc. a report of three cases with possible common-source exposures. | in june 1978, three cases of tularemia pneumonia occurred in persons residing in the washington, dc, area. the patients, all men, became ill three to four days after a brief session training their hunting dogs in an undeveloped wooded area adjacent to a housing complex. one of the dogs, which later died, had captured a wild rabbit during the training session. all three men had handled the rabbit while familiarizing their dogs with the rabbit's scent. the men had no other common exposure that was ... | 1979 | 573806 |
| cat-bite tularemia. | | 1977 | 578542 |
| an outbreak of tularemia in mink. | an outbreak of tularemia in farm raised mink is reported. twenty-six of approximately 5000 mink succumbed within a 10 day period. prodromal signs were minimal. necropsy revealed necrotic nodules scattered in the parenchyma of the lungs, liver, spleen, and mesenteric lymph nodes. francisella tularensis was isolated from spleens, livers and lungs. | 1978 | 618716 |
| tularemia in canada: francisella tularensis agglutinins in alberta ground squirrel sera. | | 1978 | 638920 |
| investigations of mammals in the surroundings of akhtopol (bulgaria) on the incidence of tularemia. | | 1978 | 640529 |
| involvement of hepatic metallothioneins in hypozincemia associated with bacterial infection. | hypozincemia was induced in rats by salmonella typhimurium and live vaccine strain francisella tularensis (lvs) infections. hepatic synthesis of zinc-binding proteins (zbp) was studied in order to elucidate the mechanisms involved in the redistribution of zinc from plasma to liver occurring during infectious illness. zbp, labeled in vivo with 65zn, were isolated and identified as metallothioneins based, in part, on their heat stability, dimorphism, and amino acid composition. cysteine was the ma ... | 1978 | 645856 |
| [the role of lemmings in natural tularemia foci of arctic regions]. | the presence of taimyr of independent natural tularemia foci of tundra type was revealed on the basis of isolation of tularemia causative agent from lemmings and the objects of external environment and detection of a specific antigen in the pellets of birds-myophages and mummified cadavers of animals. possible ways of circulation of the microbe in the lemming population are discussed. | 1978 | 665024 |
| [geographical difference in susceptibility to macrolide antibiotics among naturally occurring strains of francisella tularensis (author's transl)]. | | 1978 | 671743 |
| [selected chapters from clinical bacteriology. v. tularemia]. | | 1978 | 674083 |
| [sensitivity of the causative agent of tularemia to antibiotics]. | sensitivity of the tularemia causative agent of different geographical races to antibiotics such as streptomycin, tetracycline, gentamicin, rifampicin (20 strains), ampicillin, polymyxin m, erythromycin, oleandomycin (361 strains) and lincomycin (294 strains) was studied. high sensitivity of the tularemi a microbe to streptomycin, tetracycline, rifampicin (mic of 10 gamma/ml), gentamicin (mic of 1 gamma/ml) and resistance to 50 gamma of ampicillin and 1000 gamma/ml of polymyxin m were found. com ... | 1978 | 686695 |
| enigmatic resistance of sheep (ovis aries) to infection by virulent francisella tularensis. | tularemia in range sheep is an occasional cause of severe economic loss from mortality and unthriftiness as well as a hazard to persons in contact with the animals. epizootics are unpredictable and explosive, therefore, prophylaxis is more practical than therapy. live vaccine of proven value in man and in beavers was inoculated into mature ewes and elicited antibodies without harm to the sheep. however, challenge of immunity was not possible because virulent francisella tularensis in large doses ... | 1978 | 688073 |
| [present-day status of tularemia prevention in the ussr and further tasks]. | despite the presence of natural foci of infection at the territory of all the union republics (excluding the kirghiz ssr) and intensive epizootics among rodents, tularemia in the ussr is under full control from 1965. further differentiation of antitularemia measures, depending on local conditions of economy management and the presence of natural foci of infection is necessary. | 1978 | 746999 |
| [experimental substantiation of the possibility of aerosol immunization with a live tularemia vaccine]. | | 1978 | 747027 |
| [cultivation of f. tularensis in developing chick embryos]. | in cultivation of the causative agent of tularemia in the organism of chick embryos (8-10 days of incubation) it was found that the virulent strains multiplied intensively in the yolk sacs causing the death of the embryos on the 3rd-4th day after the infection; as to the virulent strains-they were only preserved in the embryos. the period of death of the embryos and the accumulation of bacteria depended on the strain virulence. no differences in the anatomical structure of the cells belonging to ... | 1975 | 766523 |
| [stabilization of the immunogenic properties of vaccinal strains of bacteria]. | | 1976 | 790870 |
| [nitrofurantoin-test for the differentiation of bordetella bronchiseptica (author's transl)]. | bordetella bronchiseptica is primarily resistant against nitrofurantoin (mic greater than 200 mug/ml), and this feature can be used for the differentiation of the organism from other gram-negative coccobacteria. nitrofurantoin paper disks (300 mug) failed to affect the growth of 150 strains of b. bronchiseptica isolated from different animal hosts, but they produced marked inhibition zones in the cultures of the followingspecies: pasteurella multocida, pasteurella pneumotropica, pasteurella haem ... | 1975 | 809944 |
| evolution and taxonomy in the genus brucella: concepts on the origins of the contemporary species. | the flow of thought on evolution of the organisms in the genus brucella was traced through the literature. the finding of brucella suis type 2 in hares provided impetus for much speculation on the changeability of species characteristics. recent reports, largely by soviet investigators, focus on the subjects of the sweep of evolution in this genus through eons of the geologic time scale and also on the possible parentages of the recently discovered species. these papers were translated and perti ... | 1976 | 816230 |
| an indirect immunoradiometric assay of microbes. | | 1976 | 819619 |
| an indirect radiolabelled antibody staining technique for the rapid detection and identification of bacteria. | | 1976 | 821910 |
| immunization against tularemia: analysis of the effectiveness of live francisella tularensis vaccine in prevention of laboratory-acquired tularemia. | a retrospective analysis was made of cases of laboratory-acquired infections with francisella tularensis among civilian employees at fort detrick, maryland. the incidence and clinical presentation of tularemia during the decade 1950-1959, when the phenol-killed foshay vaccine was used routinely for immunization of employees, were compared with similar data from the first decade (1960-1969) after the live tularemia vaccine had come into use. the incidence of typhoidal tularemia fell (from 5.70 to ... | 1977 | 833449 |
| [detection of the agent of tularemia in the mongolian people's republic]. | | 1977 | 855520 |
| modulation of delayed-type hypersensitivity and cellular immunity to microbial vaccines: effects of cyclophosphamide on the immune response to tularemia vaccine. | treatment of guinea pigs with cyclophosphamide before immunization with killed tularemia vaccine in freund incomplete adjuvant produced a prolongation and intensification of delayed-type hypersensitivity and in vitro lymphocyte transformation reactions to tularemia antigen. such reactions resemble those ordinarily associated with the administration of live tularemia vaccine, killed vaccine in freund complete adjuvant, or recovery from natural infection. the immunopotentiation lasted longer than ... | 1977 | 924675 |
| [isolation of bordetella bronchiseptica strains from wild animals captured in ankara, konya, urfa and viransehir'de]. | | 1976 | 933893 |
| [catalase activity in the agent of tularemia]. | the catalase activity was studied in the extracts of 27 strains of francisella tularensis belonging to three geographical races. the most active enzyme was possessed by nonarctic strains, and the least--by holarctic. japanese variant of the holarctic race was separated in an individual group since it possessed a higher catalase activity in comparison with the typical strains. the central asian race occupied an intermediate position by this sign and was placed between the japanese variant and the ... | 1976 | 941605 |
| pathogenesis and pathology of respiratory tularaemia in the rabbit. | the development of pathological lesions in the organs of rabbits was examined at intervals from 1 h to 4 days after aerosol infection with francisella tularensis. the earliest change, accumulation of polymorphonuclear leucocytes (pmn) in ulmonary alveolar ducts, occurred at 19 h. from the 2nd day multiple foci of necrosis and pmn infiltration were present in large airways and alveoli throughout the lungs and progressively increased in size. pulmonary arteritis was a prominent feature of the infe ... | 1976 | 952731 |
| [brucellosis, tularemia and borreliosis isolated from wild animals captured in ankara, konya, urfa and nevsehir provinces in turkey]. | 621 citellus, 41 mus musculus, 35 microtus, 442 meriones, 70 rattus rattus, 56 turtle, 89 hare, 1 hamster, 1 hedgehog and 1 sea snake, altogether 1379 wild animals were captured in ankara, konya, urfa and nevşehir. neither brucella or francisella tularansis could be isolated nor borrelia could be seen. 1/40-1/80 agglutination titers obtained in 3 out of 134 sera taken from citellus, in 3 out of 264 sera taken from guinea pigs which were inoculated with spleen, liver and kidney suspensions of wil ... | 1976 | 979704 |
| [mixed infection with tularemia and omsk hemorrhagic fever in experiments on aquatic field mice]. | the authors carried out an experimental study of some aspects of the pathogenesis of mixed tularemia and omsk hemorrhagic fever infection in arvicola terrestris l. the results obtained reflected the dynamics of development of the pathological process of the mixed infection, peculiarities of distribution of francisella tularensis and of the viral antigen in different organs, the character of pathomorphological changes in the organism at different periods after the administration of the causative ... | 1976 | 983583 |
| [role of gamasids in the epizootiology of tularemia]. | 10 strains of francisella tularensis were isolated from 4 species of gamasid mites, laelaps muris, l. multispinosus, hyperlaelaps amphibius and haemolaelaps glasgowi, in natural nidi of tularemia in the tumen district. under experimental conditions l. muris is often infected with tularemia agent on sick animals but preserves it at an indoor temperature not more than a week and does not transmit it transovarially. haemogamasus ambulans preserve the agent within the same period. l. muris and hirst ... | 1976 | 1023146 |
| [immunologic shifts in the body of albino rats under the effect of chloroprene]. | | 1976 | 1025975 |
| common enterobacterial antigen in yersinia enterocolitica. | production of the common enterobacterial antigen (ca) by strains of yersinia enterocolitica (y.e.) serotypes 3 and 9 (winblad), by strains of 5 different y.e. serogroups (wauters) and various other bacteria was examined. antibody against ca was raised by immunization of rabbits with e. coli o 14. extract prepared from s. typhimurium was used for the sensitization of sheep erythrocytes with ca. absorption and haemagglutination inhibition experiments showed that ca could be detected in heat extrac ... | 1975 | 1098394 |
| one-half century of tularemia in florida. | | 1975 | 1099166 |
| [detection of the causative agent of tularemia in the organs of animals in the early stages of development of the infection]. | a study was made of a possibility of detection of the causative agent of tularemia in the organism of albino mice at early stages of development of the infection after subcutaneous infection with 1, 10 and 100 microbial cells of strains no. 503/834 (holarctic race) and schu (nearctic race). the following examinations were made: cultivation on nutrient media, immunofluorescent study, the antibody neutralization test and the passive hemagglutination test with erythrocytic diagnostic agents. the mi ... | 1975 | 1108514 |
| [use of the immunofluorescence method to detect the causative agent of tularemia in developing chick embryos]. | there was shown a possibility of using the immunofluorescent method for detection of the causative agent of tularemia in the developing chick embryos, infected with the virulent strains 503 (holoarctic race) and schu (nonarctic race). the greatest accumulation of bacteria was revealed in the yolk sacs, and the least--in the chorionallantoic fliud; the greatest accumulation of bacteria was observed on the 3rd--4th days after the infection. in infection with various doses of the causative agent--f ... | 1975 | 1108521 |
| [phagocytic activity of the neutrophils in tularemia in animals with varying infective sensitivity]. | a study was made of the ingestive capacity of blood neutrophils; there were revealed no significant differences in the intact animals with a different infectious sensitivity to tularemia. with the development of infection the ingestive activity of leukocytes increased in the infected highly sensitive animals, but the digestive function was not manifest. in albino rats (with a low sensitivity to tularemia) the disease induced an intensification of the ingestive and the manifestation of the digest ... | 1975 | 1108522 |
| cyclic kinetics and mathematical expression of the primary immune response to soluble antigen. vi. the possibility of prediction of plasma cell reaction in the spleen of mice immunized with soluble antigen. | a mathematical expression of the accumulation of the plasma cells in the spleen of cba mice immunized intraperitoneally is presented. the dependence of the plasma cell reaction in the spleen on the kinetics of antigen concentration in the blood was confirmed. for the transition from antigen to plasma cells, index a was proposed. the mean values of index a were used for comparison of the calculated and experimental values of the plasma cell reaction and the recorded differences were not great. in ... | 1975 | 1176044 |
| a microbiologic study of the urban gray squirrel. | bacteriologic, virologic, and serologic examinations were conducted on 180 urban gray squirrels (sciurus carolinensis) during a 1-year period in a metropolitan area. evidence was not found of infections with leptospires, enteric or other bacteria, rickettsial agents, francisella tularensis, or arthropod-borne viruses. the squirrels were remarkably free of evidence of bacterial or viral infections of importance to man and lower animals. | 1975 | 1176356 |
| pathogenesis of tularemia in immune and nonimmune rats. | pathogenesis of tularemia in nonimmune rats given (intraperitoneal inoculation) virulent strain (schu s4) or vaccinal strain (lvs) of francisella tularensis and in immune rats given schu s4 is described. both lvs and schu s4 caused pyogranulomas in liver and spleen of nonimmune rats. nonimmune rats given 10(4) schu s4 organisms did not survive beyond 72 hours, but immune rats given challenge inoculum of 10(8) schu s4 organisms developed lesions and survived. larger doses of lvs resulted in earli ... | 1975 | 1190592 |
| stimulation of human lymphocytes by a vaccine strain of francisella tularensis. | an immune response to francisella tularensis was demonstrated in man by the lymphocyte stimulation test. peripheral blood lymphocytes were obtained from 26 individuals vaccinated with a viable tularemia vaccine, from 29 unvaccinated individuals, and from two patients who had recently undergone tularemia. the lymphocytes were incubated in the presence of various dilutions of heat-killed bacteria of the vaccine strain. the bacteria induced a deoxyribonucleic acid synthesis in the lymphocytes from ... | 1975 | 1193733 |