haemagglutination profiles of helicobacter species that cause gastritis in man and animals.thirty-five helicobacter pylori isolates, 21 h. mustelae isolates and four strains of h. felis were compared for their ability to agglutinate red blood cells (rbcs). isolates were examined in a slide haemagglutination assay with rbcs from 11 animal species, including rodents, carnivores and primates, as well as man. rbcs were agglutinated by 65-90% of h. mustelae isolates and 16-57% of h. pylori isolates. treatment of h. mustelae with pronase and heat inhibited haemagglutination (ha) whereas hea ...19921279175
influence of colloidal bismuth subcitrate on enzyme secretion from isolated rat pancreatic acinar cells.bismuth salts are currently used as monotherapy or in combination with antibiotics for the treatment of helicobacter pylori-associated peptic ulcer disease. besides encouraging clinical results with colloidal bismuth subcitrate (cbs), there is an ongoing fear of organ toxicity with the use of bismuth salts. to study potential toxic effects of cbs under short-term exposure, we tested the influence of cbs on amylase secretion from isolated rat pancreatic acinar cells under basal conditions and fol ...19921282729
role of helicobacter pylori in duodenal ulcer. 19921282863
follicular gastritis and its association with helicobacter pylori infection.fifty endoscopic biopsies with follicular gastritis (fg) were reviewed to define the frequency of association of fg and helicobacter pylori (h pylori) infection. all biopsies were studied in sections stained with hematoxylin and eosin and no special techniques were employed. in forty-two out of the fifty cases (84%) h pylori was documented and most of the gastritis showed activity. there was no correlation between the quantity of follicles and the number of bacilli; some biopsies with few follic ...19921283226
extranodal lymphomas: the malt concept.extranodal lymphomas account for as many as 40% of non-hodgkin's lymphomas and most arise in the gastro-intestinal tract which is a major lymphoid organ in its own right. gastrointestinal (gut) associated lymphoid tissue (galt) and that of other mucosae (malt), differs both structurally and functionally from nodal lymphoid tissue and low grade b cell lymphomas arising in the gastrointestinal tract and other mucosae have been found to recapitulate the structure and cytological features of malt. m ...19921283245
bile acid therapy for helicobacter pylori. 19921294096
low prevalence of gastric metaplasia in the duodenal mucosa in peru.we compared the prevalence of gastric metaplasia of the duodenal mucosa (gm) and its characteristics in 204 peruvian patients from a low socioeconomic level with the corresponding prevalence reported in dyspeptic patients from a developed country, the united kingdom. gastric metaplasia was significantly less prevalent in the peruvian than in the united kingdom series. however, when present, gm was not significantly different in extent or frequency of colonization by helicobacter pylori or associ ...19921294634
[clinical significance of anti-helicobacter pylori antibody in the diagnosis of helicobacter pylori infection in chronic gastritis]. 19921294662
helicobacter pylori and dyspepsia in an arab determine the incidence and significance of the detection of helicobacter pylori in an arab population, 116 patients with dyspepsia were studied. 89 percent of these patients had h. pylori detected by culture or/and histological definition of campylobacter-like organisms. by the modified rapid urease test (rut) 80% of the patients had h. pylori (sensitivity of 91%, specificity of 75%). irrespective of the endoscopic diagnosis, the presence of h. pylori was associated with histologic evidence ...19921295138
[helicobacter pylori, gastritis, and peptic ulcer]. 19921295291
[association of stomach ulcer and helicobacter pylori. prognostic implications].helicobacter pylori is known to be responsible for most cases of chronic gastritis, but its role in the outcome of gastric ulcer is unknown. the purpose of this study was to determine the prevalence of h. pylori infection before and after treatment of gastric ulcer, the micro-organism being untreated. the trial involved 26 patients with an acute episode of gastric ulcer, who had undergone endoscopy with biopsy of the antrum, the fundus and the ulcer rim at the initial examination and then 6 week ...19921297129
hypertrophic protein-losing gastropathy. a retrospective analysis of 40 cases in the netherlands. the dutch ménétrier study group.hypertrophic protein-losing gastropathy is a rare clinical entity of unknown etiology. seventeen of 50 gi units in the netherlands, surveying their patient material, documented at least 1 positive case. altogether, 40 patients (25 male and 15 female; mean age, 44.3 years) fulfilled the usually accepted criteria. main complaints were epigastric pain (65%), asthenia (60%), anorexia (45%), weight loss 45%, edema (37.5%), and vomiting (37.5%). hypoalbuminemia of < 35 g/l was found in 81%, and an abn ...19921298040
helicobacter pylori: past, present, and future.helicobacter pylori has now been recognized as one of the most common chronic human infections. it has been accepted as an important aetiologic agent in non-immune chronic gastritis and plays a key role in the aetiology of duodenal ulcer. it may also be involved in the pathogenesis of gastric cancer.19921298043
use of clo test in the detection of helicobacter pylori infection and its correlation with histologic gastritis. 19921299736
morphologic study of the gastric mucosa during helicobacter pylori infections.the purpose of the present, study was to underline the importance of the use of sem in the evaluation of helicobacter pylori (hp) - induced gastritis. gastric biopsies from eleven patients affected by hp infections were examined using light microscope (lm), transmission electron microscope (tem) and scanning electron microscope (sem). sem allowed for the localization of even small groups of bacteria and to demonstrate the many morphologic changes due to the infective phlogosis. the signs of cell ...19921303067
colloidal bismuth subcitrate in non-ulcer dyspepsia.the effect of colloidal bismuth subcitrate (de-nol) on symptoms, helicobacter pylori status and histological features was studied in 35 patients with non-ulcer dyspepsia. pain (34 cases) and gas bloat (18) were the predominant symptoms. h pylori was present in 26 (74.3%) patients. gastritis and duodenitis were present in 29 of 32 and 22 of 31 cases respectively in whom biopsies were available. relief in symptoms after treatment was seen in 29 (82.8%) cases. improvement in gastritis and duodeniti ...19921303406
risk factors for stomach cancer in sixty-five chinese counties.stomach cancer mortality data were compared with dietary and biochemical data from 65 chinese counties to provide clues to reasons for the marked geographic variation of stomach cancer mortality rates in china. sex-specific correlation and multivariate regression analyses showed significant positive associations with consumption of salted vegetables and eggs, prevalence of antibodies to helicobacter pylori, and levels of plasma albumin; and significant negative associations with intake of green ...19921306092
gastric intestinal metaplasia in ethnic groups in the southwestern united states.the incidence of gastric cancer has declined dramatically in the united states during this century. however, the incidence of gastric cancer among hispanics, blacks, and native americans remains 2-3-fold higher than among whites in this country. populations with an increased risk of gastric cancer have predominantly the "intestinal" type of gastric cancer, and intestinal metaplasia is regarded as a histological precursor lesion of this type of gastric cancer. we sought to establish the prevalenc ...19921303129
antibodies to helicobacter pylori and pepsinogen levels in children from costa rica: comparison of two areas with different risks for stomach children and adolescents from two areas of costa rica with contrasting gastric cancer risks, two factors suspected to be linked to the natural history of the disease were tested: serum antibodies to helicobacter pylori and serum pepsinogen levels. one hundred fifty-five subjects from the high-risk area of turrubares were compared to 127 from the low-risk area of hojancha. no significant differences were found in the prevalence of igg or iga antibodies to helicobacter pylori between the two re ...19921302556
[treatment of chronic gastritis with traditional chinese medicine--yingwei tablet].a prospective controlled study on the treatment of 60 cases chronic gastritis with tcm yingwei tablet as well as sucrafati and doperidone tablets from oct. 1990 to sep. 1991 were done. 30 patients in each group. the cases in treated group took yingwei tablet while that in control group took sucrafati and doperidone tablets. before and after treatment, the patients were examined by gastroscope, pathology and helicobacter pylori. the results showed that total effective rate, the gastroscopically e ...19921302541
use of polymerase chain reaction-amplified helicobacter pylori urease structural genes for differentiation of isolates.helicobacter pylori has been demonstrated as an etiologic agent of human gastritis and peptic ulcer formation. however, there is no straightforward basis to distinguish different isolates. we used the polymerase chain reaction (pcr) to amplify the urease structural subunit genes, urea and ureb, which, when digested with appropriate restriction endonucleases, allow the differentiation of patterns on agarose gels. pcr amplification was possible with dna rapidly extracted from h. pylori by alkaline ...19921313051
expression of helicobacter pylori urease genes in escherichia coli grown under nitrogen-limiting conditions.helicobacter pylori produces a potent urease that is believed to play a role in the pathogenesis of gastroduodenal diseases. four genes (urea, ureb, urec, and ured) were previously shown to be able to achieve a urease-positive phenotype when introduced into campylobacter jejuni, whereas escherichia coli cells harboring these genes did not express urease activity (a. labigne, v. cussac, and p. courcoux, j. bacteriol. 173:1920-1931, 1991). results that demonstrate that h. pylori urease genes could ...19921313413
[combined traditional chinese and western medicine in the treatment of intractable ulcer].the curative effects of combined traditional chinese and western medicine in 508 patients of intractable peptic ulcer with gastroscopy confirmation were evaluated. the patients were divided into chuanjia weidan group (group i, 260 patients) and cimetidine group (group ii, 248 patients). debridement, injection and drug covering of ulcer surfaces were followed by oral chinese medicine chuanjia weidan (50 g daily) or cimetidine (800 mg every night) for 4 weeks. in group i, 95.6% of patients with ga ...19921298466
[relation between helicobacter pylori and pathogenesis of chronic atrophic gastritis and the research of its prevention and treatment].the total detectable rate of helicobacter pylori (hp) of 485 patients suffering from gastric diseases was 59.6%. the hp in gastric mucosa of chronic atrophic gastritis (cag) patients was separated from the cell culture in vitro and transferred successively. the mice were perfused with exciccate alum, and the rabbits with aspirin to injure their gastric mucosa, then hp was perfused. result showed that the change of experimental animals was identical with that of cag patients by means of bacteriol ...19921298465
construction of isogenic urease-negative mutants of helicobacter pylori by allelic exchange.isogenic urease-negative mutants of helicobacter pylori were constructed by allelic replacement. a region of cloned h. pylori dna containing the structural urease genes (urea and ureb) was disrupted by insertion of a mini-tn3-km transposon. electrotransformation of h. pylori cells with kanamycin-ureb-disrupted derivative plasmids resulted in isolation of kanamycin-resistant h. pylori transformants. competence for electrotransformation appeared to be restricted to certain wild-type h. pylori isol ...19921320607
helicobacter pylori and gastroduodenal disorders. 19921334317
gastric secretory abnormalities in duodenal ulcer: primary or secondary to helicobacter pylori infection?hypersecretion of gastric acid, gastrin, and pepsinogen are considered to be causally related to duodenal ulcer diathesis. until recently, these abnormalities have been considered to be primary and largely genetically determined. however, helicobacter pylori infection has been shown to be responsible for several of the abnormalities of gastric secretion in duodenal ulcer. h. pylori infection is not only associated with chronic active inflammation but also with a reduction of somatostatin produci ...19921298057
a low cost method to produce a gaseous environment for the isolation of helicobacter pylori.a low cost method (lcm) to produce a gaseous environment for the isolation of helicobacter pylori, was compared with the standard gas park system. the lcm uses a carbonated antacid tablet, a plastic bag with tap water, a candle, and a wide-mouthed glass jar provided with a tight-fitting metallic screw cap and a rubber gasket. antral gastric biopsies from 153 cases were incubated by duplicate on blood agar plates and treated with the two methods. in 95 cases the agent was isolated from both, and ...19921340031
[helicobacter pylori in barrett esophagus].the authors evaluated the prevalence of colonize by helicobacter pylori in 21 adults patients with barrett's esophagus; 12 males and 9 females; with ranges of age from 21 to 81 years and a medium of 56.4 years old. it was detected in 23.8% that helicobacter pylori was positive in barrett's esophagus, being quite higher, 26.6% in patients over 50 years old. in the five cases with positive helicobacter pylori, the barrett esophagus presented a fundic gastric mucosa and no one intestinal metaplasia ...19921340675
[helicobacter pylori in patients with ulcerative dyspepsia].a group of consecutive patients with ulcer dyspepsia were studied by endoscopy, antral and duodenal biopsy; by histologic determination of helicobacter pylori (hp) and by silver staining (warthin starry technique). 68.31% were found to be infected. in those patients who showed chronic antritis (69.30% of the patients), hp was present in 92.85% of cases. in gastric and duodenal ulcer patients, similar rates were shown (76.47% and 76.92% respectively. in cases with normal histology findings hp was ...19921340676
[duodenal ulcer: the current etiopathogenic concepts, acid hypersecretion? helicobacter pylori? nonsteroidal anti-inflammatory drugs?]. 19921340682
gastric abnormalities in humoral immune deficiency syndromes.patients with late-onset hypogammaglobulinaemia have a very high risk of developing gastric cancer. in such patients there is a high frequency of atrophy of the gastric mucosa. this is reflected in low gastrin content of the antral mucosa, low serum pepsinogen a level and pepsinogen a/c ratio, and reduced serum gastrin secretion in response to bombesin stimulation. there is no evidence to support a role of helicobacter pylori infection in the aetiopathology of these gastric abnormalities, althou ...19921298045
some ultrastructural aspects of helicobacter pylori gastritis.ultrastructural examinations of biopsy specimens of the gastric mucosa were performed in 20 patients with chronic gastritis proven by endoscopy and microscopy. the presence of the helicobacter pylori bacteria was found in close contact with epithelial cells of the antrum and corpus of the stomach. the bacteria were not present in the areas of frequently observed intestinal metaplasia. there were ultrastructural changes on the surface and within the cytoplasm of the epithelial mucous cells, which ...19921296168
[the recurrence of duodenal ulcer after treatment for helicobacter pylori. a randomized, double-blind, placebo-controlled study].we studied 63 duodenal ulcer (du) patients (p) diagnosed by upper gastrointestinal endoscopy (uge) and helicobacter pylori positive (hp). patients were randomized, double-blinded to receive placebo (pg) 30p or amoxicillin plus metronidazole 33p (tg). all of them took famotidine for six weeks and at this point uge was performed. du healing was similar in both groups. hp eradication was possible in 14/24p of tg and 4/23 of pg (58.33% vs 17.39%) difference was statistically significant. du recurren ...19921340835
[the diagnostic potentials of an immunological method for detecting helicobacter (campylobacter) pylori]. 19921294826
[a new approach to the antibacterial therapy of chronic antral gastritis associated with helicobacter pylori].the authors proposed an original method of treatment for antral gastritis associated with helicobacter pylori and combined with duodenal ulcer. the principle of the method consists in a successive gastric lavage with alkaline and antibacterial (metronidazole) solutions twice a week for a fortnight. three groups of patients were under observation (37 examinees with chronic antral gastritis associated with helicobacter pylori and combined with duodenal ulcer). ten persons who were enlisted into th ...19921294825
helicobacter pylori and peptic ulcer diseases: prevalence and association with antral gastritis in 210 patients.evidence is accumulating that helicobacter pylori infection plays a major contributory role in peptic ulcer disease [duodenal ulcer (du) and gastric ulcer (gu)] and non-ulcer dyspepsia (nud). we, therefore, studied prospectively 210 consecutive patients with upper gastrointestinal symptoms (62 du, 38 gu and 110 nud) to determine the prevalence of h. pylori infection and to investigate their association with histological gastritis. using endoscopic biopsy of the gastric antrum for diagnosing h. p ...19921293255
helicobacter pylori infection and gastroduodenal disease: a comparison of endoscopic findings, histology, and urease test determine the prevalence and significance of helicobacter pylori (h. pylori) infection, biopsies of the antral mucosa were obtained from 139 patients and 43 asymptomatic volunteers. the specimens were examined by hematoxylin-eosin staining and the ureas test. the detection rate of h. pylori by histologic examination was 91.3% in patients with duodenal ulcer, 75.0% in those with combined duodenal and gastric ulcer, 63.6% in those with gastric ulcer, 22.9% in those with gastric carcinoma, 36.4% ...19921293070
[pathogenesis of peptic ulcer: role of helicobacter pylori gastritis and its course during antibiotic and/or antisecretory treatment].a systematic investigation of the histologic pattern of antral and corpus gastritis has been carried out in 1177 patients with various clinical conditions. an increased rate and severity of antral mucosa gastritis activity as well as surface epithelium cytotoxic lesions and helicobacter pylori colonization, coupled with low rates and severity of the same parameters in corpus mucosa gastritis (usually of superficial nature so as to spare the integrity of acidopeptic glands) were the main features ...19921343564
helicobacter pylori and gastroduodenal disease: pathogenesis and host-parasite interaction.helicobacter pylori has been shown to be the cause of chronic active gastritis and the evidence that it is involved in the development of peptic ulcer disease and gastric cancer is compelling. narrow host range, tissue specificity, and chronic inflammation are hallmarks of infection. the study of virulence determinants has just begun but it seems likely that urease, adhesins, cytotoxins, and mediators of inflammation will prove to be important.19921344668
use of an ammonia electrode for rapid quantification of helicobacter pylori urease: its use in the endoscopy room and in the assessment of urease inhibition by bismuth subsalicylate.the use of an ammonia electrode to quantify ammonia liberated by urease from helicobacter pylori was assessed in an in vitro study. it was found to be highly sensitive (down to 0.7 ppm nh3) and highly reproducible (coefficient of variation 6.0%). inhibition of urease by bismuth subsalicylate was evaluated as urease testing is often used to assess clearance of h. pylori in patients treated with bismuth. concentrations of bismuth subsalicylate up to 5 mg/ml had no inhibitory effect but bismuth sub ...19921291402
acid secretion, 1932-92: advances, adaptations, and paradoxes.this paper reviews the evolution of our understanding of various aspects of gastric acid secretion over the past 60 years. embryologic aspects and neonatal acid secretion are considered, and the relationship between parietal cell mass and acid secretion and the changing concepts of parietal cell activation are discussed. the effect of aging on acid secretion and the relevance of acid secretion in health and disease are reviewed, and current views on adaptation to therapeutic inhibition of acid s ...19921290062
gastric carcinoma: failed adaptation to helicobacter pylori.helicobacter pylori is the major cause of chronic gastritis. unlike bacterial infections in general, h. pylori acquisition causes a chronic, usually life-long infection. after acquisition, chronic inflammation (gastritis) appears and develops slowly into atrophic gastritis (with intestinal metaplasia) in a proportion of affected subjects. inflammation and atrophy result from a failure of the immune system to eliminate the h. pylori infection. in infected stomach, several cascades of reactions ar ...19921290056
eradicating helicobacter pylori. 19921345967
eradicating helicobacter pylori. 19921345968
does the stomach adapt to helicobacter pylori?to shed some light on the question of gastric adaptation to helicobacter pylori infection, an overview is given of the various histopathological and clinical consequences of h. pylori infection in man. h. pylori infection can be considered as a chronic bacterial infection. for many individuals there is a balance between a low degree of infection and a low degree of inflammation. the microbial or host factors in adaptation of this balance are largely unknown. if and how 'downregulation' of the in ...19921290055
helicobacter pylori infection induces a decrease in immunoreactive-somatostatin concentrations of human stomach.immunoreactive-somatostatin (ir-somatostatin) concentrations of the gastric mucosa and gastric juice with helicobacter pylori infection were measured in the human stomach. one hundred seventy-one patients (106 males, 65 females; mean age, 52.0; range, 19-84 years) were registered. gastric juice and mucosa were obtained with the usual endoscopy procedure. somatostatin concentration was measured by radioimmunoassay. the ir-somatostatin concentrations in the h. pylori-negative group were significan ...19921346517
dna patterns of helicobacter pylori isolated from gastric antrum, body, and duodenum.biopsy specimens for culture of helicobacter pylori were obtained from two different sites in the antrum, gastric body, and duodenal cap in 20 patients during endoscopic investigation of dyspepsia. h. pylori was identified in 64 isolates obtained from 15 of the 20 patients. analysis of chromosomal dna from these isolates of h. pylori showed that 13 of 15 patients harbored a single strain of h. pylori throughout their stomach and duodenum. two differing h. pylori types were found in two patients. ...19921347029
helicobacter pylori infection and overcrowding in childhood. 19921347120
bismuth subsalicylate in the treatment of h2 blocker resistant duodenal ulcers: role of helicobacter pylori.fifty nine patients with helicobacter pylori positive duodenal ulcers that failed to heal after a six week course of treatment with h2 blockers were randomly assigned to one of the following three regimens: (i) bismuth subsalicylate, 600 mg three times daily (n = 19), (ii) ranitidine, 300 mg at night (n = 20), (iii) bismuth subsalicylate plus ranitidine (n = 20). cumulative ulcer healing rates after four and eight weeks respectively were as follows: bismuth subsalicylate 74% (14/19) and 95% (18/ ...19921347278
[h2-receptor antagonist-refractory ulcer--its pathophysiology and role of proton-pump inhibitors].among h2-receptor antagonist (h2ra)-refractory ulcers, non-responders that did not heal after 5 months therapy had high intraluminal ph in the basal condition and high sensitivity to inhibition of acid secretion by h2ra but possessed gastric mucosa to generate less prostaglandins. combination therapy of pge1-analogue with h2ra healed these ulcers by 60%. proton-pump inhibitor (ppi) exerted a complete inhibition of acid secretion in these patients and the rate of healing was 88%. helicobacter pyl ...19921347325
[proton pump inhibitors: their merits and demerits, and perspectives for future investigation].proton pump inhibitors have a potent antisecretory activity and are under development in many pharmaceutical companies. in this paper, the merits and demerits of the drugs, which have been revealed by experimental studies in humans and animals, are reviewed. issues of the drugs which remain to be examined in the future are also discussed in reletion to their application in peptic ulcer patients. the issues include 1) genotoxicity of the drugs with long-term treatment; 2) their possible contribut ...19921347330
[clinical importance of helicobacter pylori infections in childhood].within the last ten years an increasing number of helicobacter pylori-related inflammatory gastroduodenal diseases in children has been reported. the aim of this paper is to describe the range of helicobacter pylori infections in children including diagnosis and treatment by application of colloidal bismuth salts.19921289643
dna fingerprints of helicobacter pylori before and after treatment with test whether a hypoacidic environment may potentially "stress" helicobacter pylori dna, encouraging the emergence of strain variation.19921282520
antigenicity of helicobacter pylori investigation of the sodium dodecyl sulfate-polyacrylamide gel electrophoresis (sds-page) profiles of lipopolysaccharides (lpss) extracted from seven strains of helicobacter pylori revealed that these molecules were silver stainable and exhibited a high degree of variability in their patterns. two strains synthesized a variety of sizes of lps molecules such that fractionation by sds-page resulted in a stepwise gradation of bands which extended from the top to the bottom of the silver-stained ...19921280651
histamine h2-receptor antagonists in peptic ulcer disease. efficacy in healing peptic ulcers.duodenal ulcer healing depends on the degree and length of inhibition of gastric secretion and upon the duration of therapy, while gastric ulcer healing is dependent mainly on the duration of therapy. currently marketed doses of the histamine h2-receptor antagonists heal between 77 and 92% of duodenal ulcers at 4 weeks, and adjuvant treatment to eradicate helicobacter pylori increases this rate. once-daily administration is as effective as more frequent dosing regimens and may even result in hig ...19921280563
childhood living conditions and helicobacter pylori seropositivity in adult life.infection with helicobacter pylori increases an individual's risk of peptic ulceration and gastric cancer. in the developed world, prevalence of infection rises with age and varies with social class. we used a cross-sectional study design to test the hypothesis that h pylori infection would be more closely associated with childhood living conditions than with current socioeconomic status. prevalence of igg antibodies against h pylori was determined with an enzyme-linked immunosorbent assay in 21 ...19921348299
urease-associated heat shock protein of helicobacter pylori.helicobacter pylori urease is an extracellular, cell-bound enzyme with a molecular weight of approximately 600,000 (600k enzyme) comprising six 66k and six 31k subunits. a 62k protein is closely associated with the h. pylori urease, both in crude preparations and after gel filtration; this protein can be removed from the urease by ion-exchange chromatography without inactivating the enzyme. we purified this urease-associated protein and determined its n-terminal amino acid sequence. the sequence ...19921348725
helicobacter pylori infection with age. 19921349144
helicobacter pylori in experimental acute and chronic gastric and duodenal ulcer in buffalo [correction of bufallo] rats.the experiment was performed using inbred buffalo rats to confirm the coincidence between peptic, gastric and duodenal ulcer and helicobacter pylori infection. the results suggest an unquestionable meaning of helicobacter pylori appeared to be as strong ulcerogenic factor in rats as ligation of pylorus and diffusely administrated histamine.19921308048
short- and long-term management of peptic ulcer disease: current role of h2-antagonists.with numerous active agents available to treat peptic ulcer disease both acutely and long-term, this paper reviews various aspects of these agents and their effect on the disease process, reviewing efficacy, compliance, incidence of relapse, side-effect profile, drug interactions and the effect on the natural history of peptic ulcer disease. helicobacter pylori is obviously a factor in the occurrence of peptic ulcer disease, but with the high prevalence of asymptomatic infection and evidence sug ...19921349553
helicobacter pylori, chronic gastritis and peptic ulcer.h. pylori infection is strongly associated with chronic gastritis and is probably the main course of chronic inflammation in the gastric mucosa. acquisition of the infection will lead to gastritis and the eradication of the bacterium results in healing and final cure of the gastritis. chronic gastritis and h. pylori infection may occur in antrum and/or corpus, and will gradually result in atrophy of the underlying mucosa in a great number of affected persons. correspondingly, impairments in seve ...19921307646
h2 receptor antagonist or h. pylori eradication?to assess the healing and relapse rate of duodenal ulcer (du) treated with h2 receptor antagonists in helicobacter pylori (hp) positive vs negative cases, we analysed 95 cases of endoscopically proven duodenal ulcer. h. pylori colonization was found in 73 (77%) patients before treatment. no difference was observed in the pre-treatment characteristics between patients with hp positive and hp negative duodenal ulcers. healing rates with h2 receptor antagonist at 8 weeks were 90% and 91% respective ...19921350800
helicobacter pylori seropositivity in symptom-free children. 19921351204
serological tests to monitor treatment of helicobacter pylori. 19921351623
serological tests to monitor treatment of helicobacter pylori. 19921351624
comparison of three different methods for evaluation of helicobacter pylori (h.p.) in human dental plaque.helicobacter pylori (h.p.) is a microorganism involved in peptic ulcer disease. to clarify the role of human dental plaque as a reservoir of h.p. and to compare different methods of investigation the authors studied 20 patients, 17 males main age 56 +/- 12 and 3 females 52 +/- 7, gastro-duodenal h.p. positive. the trial was carried out by cultural, biochemical and microscopical plaque analysis. cultural and microscopical method were h.p. positive in 80% patients, urease in 100%, alkaline phospha ...19921307023
helicobacter pylori, gastritis and duodenitis in the healing process of duodenal ulcer.the occurrence of antral gastritis, duodenitis, gastric metaplasia and helicobacter pylori (h. pylori) were compared between 63 endoscopically proven duodenal ulcer (du) patients and 34 non-ulcer dyspepsia (nud) patients with no ulcer history and no ulcer present as documented by endoscopy. the du group showed a significantly higher rate of active antral gastritis (89% vs 41% p less than 0.05), a higher antral h. pylori carrying rate (76% vs 27% p less than 0.01), a higher rate of active chronic ...19921352340
clarithromycin and omeprazole for helicobacter pylori. 19921353155
helicobacter pylori infection in early infancy. 19921354827
age-related increase of helicobacter pylori frequency in symptom-free and in dyspeptic children. 19921355229
molecular typing of helicobacter pylori by chromosomal and plasmid dna organization.diverse strains of helicobacter pylori were examined in order to initiate a molecular epidemiological typing scheme for this agent of human gastritis. twelve differently-sized plasmids from 1.8 to 63 kbp were identified in those strains harbouring extrachromosomal dna. recombinant dna probes were cloned randomly from the chromosome of the (plasmid-free) type strain (nctc 11637), and used to probe genomic southern blots for restriction site variation in and around homologous loci. genus-specific ...19921356227
helicobacter pylori infection in children. 19921305650
[non ulcer dyspepsia, endoscopic gastritis and helicobacter pylori].we studied 33 patients with non ulcer dyspepsia and endoscopic gastritis. 21 were female (63.4%) and 12 male (36.4%). helicobacter pylori (hp) was investigated by gastric mucosal biopsy. urease test, gram, culture, and histology were performed in all and two or more of these test hat to be positive to consider hp infection. 16/33 resulted hp positive (48.8%). erosive gastritis was most commonly associated with h.p. infection (62.5%). this was statistically significant. in all the cases hp positi ...19921305113
[acid-peptic disease associated with helicobacter pylori in children. report of a case]. 19921308293
structural comparison of urease and a groel analog from helicobacter pylori.electron microscopy of purified protein preparations indicated that helicobacter pylori urease consisted of circular particles that are 13 nm in diameter, some of which showed indications of threefold rotational symmetry. a groel analog of h. pylori (hp60k) appeared as a disc-shaped molecule with a diameter similar to that of urease but possessed sevenfold rotational symmetry. in a side-view projection, hp60k appeared as two or four discs stacked side by side.19921358875
serological assessment of helicobacter pylori eradication. 19921359233
[usefulness of the 14c-urea marked test in the detection of helicobacter pylori in patients with dyspepsia].this study was undertaken to evaluate the usefulness of the urea test (ut) in the detection of helicobacter pylori (hp) in dyspeptic patients. the ut was done in 105 patients with dyspepsia who underwent endoscopy and biopsy. hematoxylin-eosin and warthin starry tissue stains were performed for hp detection, and the resulting microscopic findings were considered as the gold standard. the sensitivity, specificity, and positive and negative predictive values of the ut were of 95%, 63%, 85% and 83% ...19921308296
[drug therapy of peptic ulcer in the elderly].medical therapy of peptic ulcers in elderly patients should depend on drugs which have to be administered only once daily. in addition, the ideal compound should have minimal side effects as well as minimal, if any, interactions with concomitant forms of therapy. from this point of view, acid-inhibitory drugs are preferable to other anti-ulcer drugs, the latter having little importance in advanced age. for ulcer healing, the proton pump inhibitor omeprazole is recommended, whereas h2-blockers (p ...19921359717
studies on antiulcer drugs. vi. 4-furyl-2-guanidinothiazoles and related compounds as potent histamine h2-receptor antagonists.a series of 4-furyl-2-guanidinothiazole derivatives and related compounds were synthesized and evaluated for histamine h2-receptor antagonist and gastric acid antisecretory activities. among them, compounds i-17, i-48 and i-49 showed high activities in these tests. in addition, compound i-17 possessed potent inhibitory activities on each of the gastric ulcers induced by stress, ethanol and hcl-aspirin. on the other hand, compound i-48 demonstrated antimicrobial activity against helicobacter pylo ...19921359931
biotypes and dna fingerprints of cytotoxigenic helicobacter pylori from patients with gastritis and peptic ulceration in italy.variations in biotypic and dna characteristics of 21 strains of helicobacter pylori from patients in central italy with histologically defined gastritis and/or peptic ulcers were studied. the strains had the same preformed enzyme biotype but differed in motility and cytotoxigenic activity. the presence or absence of these two characteristics were closely associated in 73% of strains and were used to define three phenotypic subsets. strains of subset 1 (mot+ tox+) were most common (52%) particula ...19921315293
pcr-based rflp analysis of dna sequence diversity in the gastric pathogen helicobacter pylori.dna sequence diversity among 60 independent isolates of the gastric pathogen helicobacter pylori was assessed by testing for restriction fragment length polymorphisms (rflps) in several pcr-amplified gene segments. 18 mbol and 27 haeiii rflps were found in the 2.4 kb urea-ureb (urease) segment from the 60 strains; this identified 44 separate groups, with each group containing one to four isolates. with one exception, each isolate not distinguished from the others by rflps in urea-ureb was distin ...19921361982
bacterial flagellar diversity and significance in pathogenesis.bacterial flagella are structurally diverse, ranging from the thoroughly investigated model examples found in escherichia coli and salmonella typhimurium to the more exotic sheathed flagella of, for example, helicobacter pylori, and the complex multi-flagellin endoflagella found in many spirochaetes. we summarize some of the emerging structural and genetic findings relating to these more novel flagellar types, and outline their possible significance in the pathogenicity of some medically importa ...19921362173
new look at chronic gastritis.chronic gastritis (cg) is classified as type a (autoimmune) and type b [bacterial-helicobacter pylori (hp)]. even type a gastritis is initiated by hp (despite its low incidence in the gastric mucosa), as the incidence of antibodies against hp (anti-hp) in sera of patients with pernicious anemia (pa) is high. anti-hp cross react with gastric mucosal antigens, including alpha and beta subunits of the proton pump (parietal cell antigen) and determine the damage in fundus-body and/or antral mucosa. ...19921318891
endogenously formed n-nitroso compounds and nitrosating agents in human cancer etiology.humans are exposed to preformed n-nitroso compounds (noc), but also to a wide range of precursors and nitrosating agents which can react in vivo to form potentially carcinogenic noc and diazo compounds. nitrite, nitrate and nitrosating agents can also be synthesized endogenously in enzymic reactions mediated by bacteria, activated macrophages and neutrophils. the latter two cell types generate, via the enzyme nitric oxide synthase, the nitric oxide radical that is involved in cytotoxicity, and i ...19921339085
[does helicobacter pylori cause stomach cancer?]. 19911365939
[nonulcerative dyspepsia associated with helicobacter pylori].30 patients with non ulcer dyspepsia (nud) were evaluated to find out if there was a relationship with helicobacter pylori (hp) infection. gastric biopsies from the antrum were taken and two of them sent to pathology to be stained with h&e and warthin-starry. the other three were sent to microbiology, for urease-test, culture and frotis with gram stain. to diagnose hp was necessary to get it at least in two of the performed test. this was possible in 20 (66.66%). chronic active gastritis was obs ...19921340809
[gastroduodenitis and helicobacter pylori in uremic patients].we studied 26 patients (p) with end stage renal failure (rf) and 26 healthy volunteers (hv) to investigate the prevalence of helicobacter pylori (hp) and its relation with chronic gastritis (cg) and chronic duodenitis (cd). we analyzed 312 gastric and duodenal mucosal biopsies stained with h & e and giemsa. categorical data were assessed by the x2 and fisher's exact test. probability values of p < 0.05 were considered significant. endoscopic lesions correlated with histological gastritis and duo ...19921340811
pathophysiology and clinical relevance of helicobacter pylori.considerable knowledge has recently accumulated on the mechanism by which helicobacter pylori (h. pylori) induces chronic gastritis. although h. pylori is not an invasive bacterium, soluble surface constituents can provoke pepsinogen release from gastric chief cells or trigger local inflammation in the underlying tissue. urease appears to be one of the prime chemoattractants for recruitment and activation of inflammatory cells. release of cytokines, such as tumor necrosis factor alpha, interleuk ...19921341068
progress with proton pump inhibition.the proton pump, a h+/k(+)-atpase located on the secretory canalicular membrane of the parietal cell, forms the final pathway for gastric acid secretion. omeprazole is concentrated in the secretory canaliculus, where it is converted to its active form, which binds covalently with the h+/k(+)-atpase, thus inhibiting acid secretion arising from any stimulus. meta-analysis has defined the primary determinants for peptic ulcer healing as the degree of acid suppression, the duration of suppression ov ...19921341069
distinct patterns of chronic gastritis associated with carcinoid and cancer and their role in tumorigenesis.a series of 60 gastric endocrine tumors comprised 44 body-fundus argyrophil carcinoids, of which 23 arose in a background of hypergastrinemia and type a chronic atrophic gastritis (a-cag), mainly with histologic patterns suggestive of an autoimmune process. only 22 percent (compared with 19 percent of 58 tumor-free a-cag cases) of 36 carcinoids and 21 percent of 19 a-cag carcinoids investigated had helicobacter pylori (hp) colonization, against 50 percent of 14 cag-associated neuroendocrine carc ...19921341079
indirect immunofluorescence determination of the frequency of anti-h. pylori antibodies in brazilian blood donors.1. the accuracy of an indirect immunofluorescence (iif) test for the serodiagnosis of helicobacter pylori infection was evaluated in adult patients and compared with culture, preformed urease test and smears stained with carbolfuchsin. 2. we studied 80 consecutive patients submitted to gastroduodenoscopy (17 of whom were found to have duodenal ulcer) plus 57 patients with duodenal ulcer. 3. h. pylori was identified by microbiological methods in 65 of the 80 consecutive patients and in all 57 pat ...19921342599
[acute erosive gastritis and helicobacter pylori infection]. 19921345353
eradicating helicobacter pylori. 19921345965
mechanism of helicobacter pylori pathogenesis: focus on mucus.although the clinical data provide increasingly convincing indications that helicobacter pylori (h. pylori) is a causative factor in gastritis and peptic ulcer, the advances toward the clear understanding of this bacterium's pathogenic action are slow in coming. having a niche bordering two major perimeters of gastric mucosal defense, h. pylori is capable of exerting detrimental effects on the mucus layer, as well as surface cells of the gastric epithelium. to cause such an effect, the bacteria ...19921378466
eradicating helicobacter pylori. 19921345966
ribosomal rna gene restriction patterns of helicobacter pylori: analysis and appraisal of hae iii digests as a molecular typing system.ribosomal rna gene restriction patterns (ribopatterns) of 162 strains of helicobacter pylori from 93 patients were studied to assess their suitability for use as the basis of a molecular typing system. computer-assisted numerical analysis of hae iii ribopatterns of 122 strains from 9 countries in 4 continents showed that almost every strain had a distinct and unique ribopattern and only strains from the same individual were genomically matched in all bands or with minor (1-2 band) differences. h ...19921379934
impaired helicobacter pylori urease enzyme activity by histamine 2 receptor antagonist. 19921346480
review article: maintenance treatment with h2-receptor antagonists for peptic ulcer recent years a number of different strategies for managing patients with peptic ulcer disease have become available. the present review discusses the relative merits of each form of treatment. intermittent treatment (whether given in response to symptoms or as a prophylactic regimen prescribed seasonally or at weekends) fails to prevent ulcer recurrence and leaves patients at risk of haemorrhage and perforation. anti-helicobacter pylori therapy, although useful in certain circumstances, canno ...19921347467
monoclonal antibodies against the native urease of helicobacter pylori: synergistic inhibition of urease activity by monoclonal antibody combinations.monoclonal antibodies (mabs) against the native urease of helicobacter pylori nctc 11637 were found to clearly inhibit the urease activity. interestingly, synergistic inhibition by two mabs recognizing different subunits was also observed. ten mabs were produced and classified as two isotypes of the immunoglobulin g (igg) subclass, igg1, and igg2a. western blot (immunoblot) analysis using sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed that five mabs recognized the large subunit ...19921383158
Displaying items 1 - 100 of 40408