| [occurrence and distribution of fruiting body-forming myxobacteria in siebengebirge. comparative studies with special reference to characteristic biotypes]. | in the region of the "siebengebirge" near bonn, six characteristic biotopes were studied with respect to the occurrence of fruiting body forming myxobacteria. 23 different species, belonging to the 8 known genera, were found. the number of species in the respective biotopes varied between 6 and 17, the average numbers of species per sampling area were between 2.1 and 10.0. 15 species were found on dung pellets of wild living herbivorous mammals. deciduous forest soils contained 13 species in spr ... | 1979 | 121178 |
| [clone cultures of archangium violaceum]. | | 1967 | 4878541 |
| [studies on nutrition physiology in archangium violaceum]. | | 1967 | 4878544 |
| [a bacteriolytic enzyme of archangium violaceum (myxobacteriales). i. enzyme activities in vivo under different conditions]. | | 1969 | 4915431 |
| studies on a bacteriolytic enzyme of archangium violaceum (myxobacteriales). ii. partial purification and properties of the enzyme. | | 1969 | 4985530 |
| studies on the genus archangium (myxobacterales). ii. the effect of temperature and carbohydrates on some physiological processes. | | 1967 | 5586970 |
| [studies on archangium violaceum. contribution to the study of myxobacteria]. | | 1965 | 5875032 |
| [effect of various storage methods on the viability of myxobacteria]. | viability of myxobacteria strains myxococcus xanthus uncm 10041, polyangium cellulosum uncm 10043, archangium gephyra uncm 10001 stored by the methods of lyophilization, cryoconservation, drying on paper discs, suspending in distilled water or physiological solution under a layer of mineral oil. the best results on viability preservation of all three studied strains were obtained when using the method of cryoconservation. it has been shown that the strains m. xanthus and a. gephyra preserve the ... | 2001 | 11944333 |
| archazolid and apicularen: novel specific v-atpase inhibitors. | v-atpases constitute a ubiquitous family of heteromultimeric, proton translocating proteins. according to their localization in a multitude of eukaryotic membranes, they energize many different transport processes. since their malfunction is correlated with various diseases in humans, the elucidation of the properties of this enzyme for the development of selective inhibitors and drugs is one of the challenges in v-atpase research. | 2005 | 16080788 |
| myxobacters from arid mexican soil. | myxobacters were found to be common inhabitants of the arid soils from the monterrey, nuevo leon, mexico, area. thirteen species of the genera myxococcus, archangium, cystobacter, stigmatella, polyangium, and chondromyces were isolated on a mineral salts agar supplemented with bakers' yeast and filter paper. greater species diversity per soil sample was found in the region receiving 400 to 800 mm of annual rainfall as compared with soils from an area having only 200 to 400 mm of rainfall. | 1976 | 16345178 |
| aurafuron a and b, new bioactive polyketides from stigmatella aurantiaca and archangium gephyra (myxobacteria). fermentation, isolation, physico-chemical properties, structure and biological activity. | new antibiotic polyketides, named aurafuron a (1) and b (2) were isolated from culture extracts of myxobacteria of the species stigmatella aurantiaca and archangium gephyra, strain ar 10844. by multi-step chromatography 1 and 2 were separated from a variety of other non-related co-metabolites, and their structures elucidated by spectroscopic methods as new 5-alkenyl-3 3(2h)-furanones. aurafurons inhibited the growth of some filamentous fungi and additionally, aurafuron b was weakly active agains ... | 2005 | 15981410 |
| cyrmenins, new beta-methoxyacrylate inhibitors of the electron transport. production, isolation, physico-chemical and biological properties. | new antibiotic compounds, named cyrmenins, were isolated from the culture broth of strains of the myxobacteria cystobacter armeniaca and archangium gephyra. the compounds belong to the group of beta-methoxyacrylate (moa) inhibitors and are the first naturally occuring nitrogen-linked moas. the cyrmenins show nearly the same antifungal activity as strobilurin a, but are less toxic in a growth inhibition assay with l929 mouse cells. cyrmenins inhibit nadh oxidation by submitochondrial particles fr ... | 2003 | 14700275 |
| archazolids, new cytotoxic macrolactones from archangium gephyra (myxobacteria). production, isolation, physico-chemical and biological properties. | novel cytotoxic compounds, archazolid a and b, were isolated from the culture broth of strains of the myxobacteria archangium gephyra and cystobacter sp. archazolids consist of a macrocyclic lactone ring with a thiazole side chain and showed high activity against mammalian cells. the ic50 values with different cell lines ranged from 0.1 to 1 ng/ml. an incubation of ptk2 potoroo cells with archazolid a (5 ng/ml) led to the formation of vacuoles in the er, a phenomenon that is typical for inhibito ... | 2003 | 12931860 |
| argyrins, immunosuppressive cyclic peptides from myxobacteria. i. production, isolation, physico-chemical and biological properties. | a group of cyclic peptides consisting of 8 amino acid residues, named argyrins a to h, were isolated from the culture broth of strains of the myxobacterium archangium gephyra. argyrin b was found to be a potent inhibitor of t cell independent antibody formation by murine b cells and strongly inhibited the two way murine mixed lymphocyte reaction. all argyrins had slight antibiotic activity, especially against pseudomonas sp., and inhibited growth of mammalian cell cultures. the growth inhibition ... | 2002 | 12195959 |
| [clusterization of halophilic and halotolerant eubacteria using whole-cell protein electrophoresis data]. | total cell proteins of the nineteen halophilic and halotolerant eubacteria isolated from marine sediments and highly mineralized formation waters of oil fields were investigated by sds gel electrophoresis. the microorganisms studied, phenotypically identified as belonging to the genera dietzia, rhodococcus, staphylococcus, cytophaga, brevibacterium, and archangium, were found to form clearly distinguishable clusters (20-30% similarity at the generic level) on the dendrogram derived from electrop ... | 2000 | 11315673 |
| tubulysins, new cytostatic peptides from myxobacteria acting on microtubuli. production, isolation, physico-chemical and biological properties. | new cytostatic compounds, tubulysins, were isolated from the culture broth of strains of the myxobacteria archangium gephyra and angiococcus disciformis. the compounds are peptides partly consisting of unusual amino acids and are distantly related to the dolastatins. the tubulysins were not active against bacteria and only little against fungi, but showed high cytostatic activity against mammalian cell lines with ic50 values in the picomolar range. an incubation with 50 ng/ml tubulysin a led to ... | 2000 | 11099220 |
| melithiazols, new beta-methoxyacrylate inhibitors of the respiratory chain isolated from myxobacteria. production, isolation, physico-chemical and biological properties. | new antibiotic compounds, melithiazols, were isolated from the culture broth of strains of the myxobacteria melittangium lichenicola, archangium gephyra, and myxococcus stipitatus. the compounds belong to the group of beta-methoxyacrylate (moa) inhibitors and are related to the myxothiazols. the melithiazols show high antifungal activity, but are less toxic than myxothiazol a and its methyl ester in a growth inhibition assay with mouse cell cultures. the melithiazols inhibit nadh oxidation by su ... | 1999 | 10580385 |
| the correlation between morphological and phylogenetic classification of myxobacteria. | in order to determine whether morphological criteria are suitable to affiliate myxobacterial strains to species, a phylogenetic analysis of 16s rdnas was performed on 54 myxobacterial strains that represented morphologically 21 species of the genera angiococcus, archangium, chondromyces, cystobacter, melittangium, myxococcus, polyangium and stigmatella, five invalid species and three unclassified isolates. the analysis included 12 previously published sequences. the branching pattern confirmed t ... | 1999 | 10425789 |
| gephyronic acid, a novel inhibitor of eukaryotic protein synthesis from archangium gephyra (myxobacteria). production, isolation, physico-chemical and biological properties, and mechanism of action. | a new antibiotic compound, gephyronic acid was isolated from the culture broth of the myxobacterium, archangium gephyra strain ar 3895. up to 3 mg/liter was produced during the logarithmic and stationary growth phase. the compound is an aliphatic acid, which tends to form a hemiacetal. both forms inhibited growth of yeasts and molds (mic 1-25 micrograms/ml) and had a cytostatic effect on mammalian cell cultures (ic50 10-60 ng/ml). gephyronic acid is a specific inhibitor of eukaryotic protein syn ... | 1995 | 7868385 |
| [myxobacteria (myxobacteriales) on leaf surfaces]. | 140 leaf samples were examined, 73 of which (= 52.1%) contained myxobacteria. three species of the genus myxococcus, m. virescens, m. fulvus and m. coralloides, could be found more or less frequently in the phyllosphere of woody plants and annuals. archangium gephyra was observed only once. there was no significant difference in the occurrence of myxobacteria between evergreen leaves and leaves from deciduous trees and shrubs. fruit-trees yielded the best results. | 1981 | 6801873 |
| [fine structure of myxobacterium archangium sp]. | | 1968 | 5735984 |
| [knowledge of cellulolytic activity of archangium violaceum]. | | 1969 | 5395138 |
| on the distribution of myxobacteria in the temperate south america (author's transl). | 60 soil samples from southern chile, mainly from forests and grassland, yielded six species of myxobacteria. in forest soils myxococcus coralloides and myxococcus fulvus occur frequently, in grassland soils myxococcus coralloides and archangium gephyra are predominating. myxococcus virescens, melittangium lichenicola, and cytobacter fuscus have been observed rarely. it is pointed out that due to climate factors a high soil acidity causes the low nuber of myxobacter species. a comparison with the ... | 1978 | 27046 |
| archazolid a-15-o-β-d-glucopyranoside and iso-archazolid b: potent v-atpase inhibitory polyketides from the myxobacteria cystobacter violaceus and archangium gephyra. | two structurally novel analogues of the macrolides archazolids a and b, archazolid a-15-o-β-d-glucopyranoside (archazolid e, 5) and iso-archazolid b (archazolid f, 6), were isolated from the myxobacterium cystobacter violaceus and archangium gephyra, respectively. macrolactone 5 represents the first 15-o-glycoside of the archazolids. iso-archazolid b (6) incorporates a c-3 alkene and presents the first constitutional isomer reported for this natural product class. the structures of these polyket ... | 2011 | 21513292 |
| discovery of 23 natural tubulysins from angiococcus disciformis an d48 and cystobacter sbcb004. | the tubulysins are a family of complex peptides with promising cytotoxic activity against multi-drug-resistant tumors. to date, ten tubulysins have been described from the myxobacterial strains angiococcus disciformis an d48 and archangium gephyra ar 315. we report here a third producing strain, cystobacter sp. sbcb004. comparison of the tubulysin biosynthetic gene clusters in sbcb004 and an d48 reveals a conserved architecture, allowing the assignment of cluster boundaries. a sbcb004 strain con ... | 2010 | 20338521 |
| first total synthesis of cyrmenin b1. | a short and efficient synthesis of cyrmenin b(1), an antifungal metabolite of myxobacteria cystobacter armeniaca and archangium gephyra, is described. the crucial steps of the synthesis included the formation of the dehydroalanine moiety from the corresponding serine acetate and the formation of the beta-methoxyacrylate system via trimethylsilyldiazomethane methylation of the corresponding beta-hydroxy enamide. | 2009 | 19035819 |
| argyrin a reveals a critical role for the tumor suppressor protein p27(kip1) in mediating antitumor activities in response to proteasome inhibition. | a reduction in the cellular levels of the cyclin kinase inhibitor p27(kip1) is frequently found in many human cancers and correlates directly with patient prognosis. in this work, we identify argyrin a, a cyclical peptide derived from the myxobacterium archangium gephyra, as a potent antitumoral drug. all antitumoral activities of argyrin a depend on the prevention of p27(kip1) destruction, as loss of p27(kip1) expression confers resistance to this compound. we find that argyrin a exerts its eff ... | 2008 | 18598941 |
| stereochemical determination of archazolid a and b, highly potent vacuolar-type atpase inhibitors from the myxobacterium archangium gephyra. | [structure: see text] the relative and absolute stereochemistry of the structurally unique 24-membered myxobacterial macrolides archazolid a and b, highly potent vacuolar-type atpase (v-atpase) inhibitors in vitro and in vivo, was determined on the basis of a combination of extensive high-field nmr studies, including j-based configuration analysis, molecular modeling, and chemical methods. | 2006 | 17020294 |