| hepatitis b genotypes correlate with clinical outcomes in patients with chronic hepatitis b. | six genotypes (a-f) of hepatitis b virus (hbv) have been identified; however, the genotype-related differences in the pathogenicity of hbv remain unknown. therefore, we investigated the prevalence of hbv genotypes in taiwan and the association between distinct genotypes and severity of liver disease in a cross-sectional study. | 2000 | 10702206 |
| hepatitis b genotypes and the response to interferon therapy. | possible pathogenic differences among hepatitis b virus (hbv) genotypes have been observed; however, the response to interferon therapy among hbv genotypes remains unknown. we therefore analyzed the efficacy of interferon alfa in the treatment of chronic hepatitis b patients with different hbv genotypes. | 2000 | 11131465 |
| clinical and virological aspects of blood donors infected with hepatitis b virus genotypes b and c. | pathogenic and therapeutic differences among hepatitis b virus (hbv) genotypes have been documented. however, the association of virological characteristics with clinical differences among hbv genotypes remains unclear. we therefore studied the clinical and virological characteristics of taiwanese volunteer blood donors infected with hbv genotypes b and c. hbv genotypes were determined in 300 candidate blood donors positive for hbv surface antigen (hbsag), and sequences of the precore gene of th ... | 2002 | 11773087 |
| long-term clinical remission induced by corticosteroid withdrawal therapy (cswt) in patients with chronic hepatitis b infection: a prospective randomized controlled trial--cswt with and without follow-up interferon-alpha therapy. | the effectiveness of corticosteroid withdrawal therapy (cswt), with or without follow-up interferon-alpha (ifn-alpha), has not been reported for hbe antigen (hbeag) -positive patients with chronic hepatitis b. we conducted a prospective randomized controlled trial in 42 patients with hbeag- and hbv-dna-positive chronic hepatitis b (hbv genotype c: 38 patients) to assess the possible additive effect of follow-up ifn-alpha after cswt compared with cswt alone. hbeag seroconversion rates in the cswt ... | 2002 | 11855559 |
| hepatitis b virus genotype b is associated with earlier hbeag seroconversion compared with hepatitis b virus genotype c. | recent studies suggest that hepatitis b virus (hbv) genotype b is associated with less active liver disease than hbv genotype c. the aim of our study was to determine if hbv genotype b is associated with higher rates of spontaneous hepatitis b e antigen (hbeag) seroconversion compared with genotype c. | 2002 | 12055581 |
| efficacy of long-term interferon therapy in chronic hepatitis b patients with hbv genotype c. | infection with hepatitis b virus (hbv) genotype c predominates in japan. we analyzed the efficacy of interferon (ifn) alpha or beta in the treatment of chronic hepatitis b patients with hbv genotype c and the clinical predictors for therapeutic response. forty-three genotype c-infected, chronic hepatitis b e antigen (hbeag)-positive patients (32 men and 11 women with a mean age of 35.6+/-10.1 years) who had been treated with ifn therapy were retrospectively studied. the patients were classified ... | 2002 | 12119559 |
| hbv subtype as a marker of the clinical course of chronic hbv infection in japanese patients. | hepatitis b virus (hbv) genotype c is predominant in japan. however, many hbv subtypes are involved in each genotype, and the clinical manifestations in the patients associated with each subtype remain unknown. therefore, we investigated the relationship between hbv subtype and clinical aspects of chronic hbv infection. the subtype of 237 patients with chronic hbv infection, including 74 asymptomatic carriers, was determined. the subtypes of 110 hbv carriers undergoing long-term follow-up manage ... | 2002 | 12210405 |
| clinical outcomes of hepatitis b virus (hbv) genotypes b and c in japanese patients with chronic hbv infection. | the aims of this retrospective survey were to determine the epidemiologic distribution of hepatitis b virus (hbv) genotypes and analyze the genotype-related clinical differences among japanese patients with chronic hbv infection. the 158 surveyed patients with chronic hbv infection lived in fukuoka and okinawa were serially tested for serum alanine aminotransferase (alt) and hepatitis b e antigen (hbeag). follow-up was for a period of 10.8 +/- 6.4 years (mean +/- sd). the hbv genotypes were dete ... | 2002 | 12389939 |
| precore and core promoter mutations of hepatitis b virus and hepatitis b e antigen-negative chronic hepatitis b in korea. | the aims of this study were to determine the frequency of precore/core promoter mutations and hepatitis b e antigen (hbeag)-negative chronic hepatitis b (e-chb) in korea. | 2003 | 12480566 |
| basal core promoter mutations of hepatitis b virus increase the risk of hepatocellular carcinoma in hepatitis b carriers. | hepatitis b viral (hbv) genotype c is associated with the development of hepatocellular carcinoma (hcc) compared with genotype b; however, the virologic factors contributing to the pathogenic differences remain unknown. we investigated the prevalence of t1762/a1764 basal core promoter mutant in a cohort of 250 genotype b- or c-infected hbv carriers with different stages of liver disease to clarify a possible role for this mutant in hepatocarcinogenesis. | 2003 | 12557138 |
| hepatitis b virus genotype c takes a more aggressive disease course than hepatitis b virus genotype b in hepatitis b e antigen-positive patients. | one hundred forty-six hepatitis b e antigen (hbeag)-positive chronic hepatitis b patients were followed up for 32 +/- 13 months. all six patients with hepatocellular carcinoma had hepatitis b virus (hbv) genotype c. disease activity was greater in patients infected by hbv genotype c than in those infected by hbv genotype b in the hbeag-positive phase but not after hbeag seroconversion. | 2003 | 12624067 |
| molecular and serological aspects of hbsag-negative hepatitis b virus infections in north america. | a few hepatitis b virus (hbv) infections are characterized by the presence of hbv dna in serum or liver tissue, or both, in the absence of detectable hepatitis b surface antigen (hbsag) in serum. however, such infections have rarely been described previously in north american patients. in the present study, 31 hepatocellular carcinoma (hcc) patients from the united states and canada who had no detectable hbsag in their serum were studied. in these 31 hbsag-negative hcc patients, hbv dna was dete ... | 2003 | 12629639 |
| hepatitis b virus of genotype c persistence after recovery from acute hepatitis b virus infection in japan. | background/aims: this study aimed to determine the viremia status after clinical, biochemical and serological recovery from acute hepatitis b viral (hbv) infection. methods: we detected serum hbv-dna in 19 patients with acute hepatitis b during followed-up 6-43 months after onset, and analyzed hbv genotypes. results: 13 (72%) of 19 patients had detectable hbv dna at the point of 6 months after onset, and four (33%) of 12 patients had persisted viremia for more than 1 year although they were reco ... | 2003 | 12697245 |
| characterization of hepatitis b virus surface antigen and polymerase mutations in liver transplant recipients pre- and post-transplant. | we evaluated serum samples from 18 chronic hepatitis b virus (hbv) patients who underwent liver transplantation for the presence of hbv polymerase and s gene mutations and hbv genotype using a new commercially available sequencing assay. all three patients with hepatitis b immune globulin (hbig) treatment failure followed by nucleoside analogue treatment failure were infected with hbv genotype c; a pre-existing hbv s antigen (hbsag) mutation (sd144a) was identified in one patient pretransplant, ... | 2003 | 12780567 |
| influence of hepatitis b virus genotypes on the development of pres deletions and advanced liver disease. | hepatitis b virus (hbv) mutants with deletions in the pres region have not been evaluated for association with viral genotypes. in a case-control study, hbv dna samples collected from 80 each of carriers infected with hbv genotype b or c were examined for pres deletions. pres deletion mutants were found in a total of 37 of 160 (23%) hbv carriers. carriers with pres deletion mutants were older (56.0 +/- 12.7 vs 49.3 +/- 16.9 years, p < 0.05), were infected more frequently with hbv genotype c (84% ... | 2003 | 12794715 |
| a case-control study for early prediction of hepatitis b e antigen seroconversion by hepatitis b virus dna levels and mutations in the precore region and core promoter. | factors influencing and predictive of seroconversion from hepatitis b e antigen (hbeag) to antibody (anti-hbe) were sought in a case-control study of 61 patients with chronic hepatitis b who had been observed from 5 years before to 1 year after seroconversion, and 32 patients who did not seroconvert during the entire 6-year period. almost all of the patients (96%) were infected with hbv genotype c. hbv dna levels began to decrease 3 years before seroconversion in the seroconverters, while they r ... | 2003 | 12794716 |
| precore wild-type hepatitis b virus with g1896 in the resolution of persistent hepatitis b virus infection. | factors influencing the resolution of persistent hepatitis b virus (hbv) infection were sought for. | 2003 | 12867753 |
| [distribution of hepatitis b virus genotypes and its clinical significance in guangxi]. | to understand the distribution of hepatitis b virus genotype in guangxi and its clinical significance. | 2003 | 12870004 |
| role of hepatitis b virus genotypes in chronic hepatitis b exacerbation. | hepatitis b virus (hbv) genotypes and precore and core promoter mutations were determined in 318 patients with hbv. patients infected with hbv genotype b had a higher median alanine aminotransferase level and bilirubin level and a lower median albumin level during exacerbations of disease, compared with patients infected with hbv genotype c (all p<.001). by logistic regression analysis, hbv genotype b infection (p=.014) and low albumin levels (p=.006) were independently associated with a higher ... | 2003 | 12905145 |
| early response to interferon alpha treatment and long-term clinical outcome in japanese patients with chronic hbv genotype c infection. | genotype c of hepatitis b virus (hbv) has been shown to be associated with a poor clinical outcome and less favorable response to interferon (ifn) alpha therapy compared to genotype b. we evaluated the response to ifn alpha therapy and long-term clinical outcome in japanese patients with chronic active hbv genotype c infection. thirty japanese patients with chronic active hepatitis who received natural ifn alpha therapy were followed for 2-12 years (mean 5.9 years). twenty-four patients were tre ... | 2004 | 14654974 |
| short-term lamivudine for the treatment of chronic hepatitis b. | short-term lamivudine and its withdrawal were evaluated as regards an immunomodulatory therapy of chronic hepatitis b. lamivudine was given for 3 or 6 months to 23 patients with chronic hepatitis b who were infected with hepatitis b virus (hbv) genotype c, including 15 with hepatitis b e antigen (hbeag) and 8 without it. it decreased serum levels of alanine aminotransferase (alt) and hbv dna in hbeag-positive patients. flare-ups of alt and hbv dna after treatment were observed in most patients, ... | 2003 | 14688454 |
| hepatitis b genotypes in chronic hepatitis b and lamivudine therapy. | the influence of hepatitis b virus (hbv) genotypes on the natural history and the response to treatment of patients with chronic hepatitis b are of potential interest. compared to the patients with hbv genotype c, those with genotype b were of a younger age and had a higher cumulative rate of hepatitis b e antigen (hbeag) seroconversion during the initial 6 years of follow-up. the earlier hbeag seroconversion in the patients with genotype b, however, did not provide them with a benefit in terms ... | 2003 | 14688455 |
| genotype c of hepatitis b virus can be classified into at least two subgroups. | a genomic characterization of hepatitis b virus (hbv) was done for 56 pre-s1/pre-s2 genes and 10 full-length hbv genotype c isolates from five asian countries. phylogenetic analysis of the pre-s1/pre-s2 genes revealed two major groups within genotype c: one for isolates from southeast asia including vietnam, myanmar and thailand (named hbv/c1) and the other for isolates from far east asia including japan, korea and china (named hbv/c2). this finding was confirmed by phylogenetic analysis based o ... | 2004 | 14769886 |
| hepatitis b genotypes correlate with tumor recurrence after curative resection of hepatocellular carcinoma. | hepatitis b virus (hbv) genotype c is associated with the development of hepatocellular carcinoma (hcc), compared with genotype b. this study aims to investigate whether hbv genotypes influence the clinicopathologic features and long-term prognosis of patients after curative resection of hcc. | 2004 | 15017634 |
| genotypic dominance and novel recombinations in hbv genotype b and c co-infected intravenous drug users. | pathogenic differences among hepatitis b virus (hbv) genotypes have been documented. however, the interaction between different hbv genotypes remains unclear. herein, we chose hbv genotypes b (hbv/b) and c (hbv/c) co-infected intravenous drug users to study this issue. hbv genotype was determined in 40 hbsag, anti-hcv, and anti-hdv co-positive intravenous drug users by using genotype-specific primers. the distribution of hbv genotype was as follows: hbv genotype b alone in 29 (72.5%); hbv genoty ... | 2004 | 15042642 |
| double point mutation in the core promoter region of hepatitis b virus (hbv) genotype c may be related to liver deterioration in patients with chronic hbv infection. | hepatitis b virus (hbv) genotype c has a more severe pathogenesis than genotype b in japan. we retrospectively investigated the relationship between hbv genotype and the core promoter (cp) (nt 1762 and 1764) and precore (prec) (nt 1896) mutations of the hbv genome. | 2004 | 15086598 |
| role of hepatitis b virus genotypes ba and c, core promoter and precore mutations on hepatocellular carcinoma: a case control study. | the role of hepatitis b virus (hbv) genotypes, core promoter (cp) and precore mutants on hepatocellular carcinoma (hcc) is still controversial. we aimed to determine their role on the development and clinical features of hcc. hbv genotypes and cp/precore mutations were determined in 90 hcc patients and 180 matched control patients. in the 90 hcc patients, 22 (24.4%) and 68 (75.6%) had subtype ba and genotype c, respectively. the prevalence of genotype c and cp mutations was significantly higher ... | 2004 | 15090469 |
| structure of pre-s2 n- and o-linked glycans in surface proteins from different genotypes of hepatitis b virus. | the middle-sized (m) surface proteins of hepatitis b virus (hbv) and other orthohepadnaviruses contain a conserved n-glycan in their pre-s2 domain, which is essential for the secretion of viral particles. recently, we also found o-glycans in the pre-s2 domain of m protein from woodchuck hepatitis virus (whv) and hbv genotype d. since the o-glycosylation motif is not conserved in all genotypes of hbv, the glycosylation patterns of hbv genotypes a and c were analysed. pre-s2 (glyco)peptides were r ... | 2004 | 15218190 |
| common genotypes of hepatitis b virus. | to find out the frequency of common genotypes of hepatitis-b virus (hbv). | 2004 | 15233887 |
| genotype c hepatitis b virus infection is associated with an increased risk of hepatocellular carcinoma. | identification of risk factors for the development of hepatocellular carcinoma (hcc) is important for hcc surveillance in chronic hepatitis b virus (hbv) infection. our aim was to study the independent risk factors and effect of hbv genotypes on hcc development in a prospective longitudinal cohort of chronic hepatitis b patients. | 2004 | 15361502 |
| hepatitis b virus genotypes, phylogeny and occult infection in a region with a high incidence of hepatocellular carcinoma in china. | to determine the genotypes and phylogeny of hepatitis b viruses (hbvs) in asymptomatic hbv carriers, and the prevalence of occult hbv infection in long an county, guangxi zhuang autonomous region, an area with a high incidence of hepatocellular carcinoma. | 2004 | 15484297 |
| [reappraisal of hbv genotypes and clinical significance in koreans using maldi-tof mass spectrometry]. | recent studies have shown that the genotype of hepatitis b virus (hbv) may correlate with the disease natural history and treatment outcome. however, several of these studies used low sensitivity assays in a small number of patients, and this has precluded an accurate evaluation of korean hbv genotypes. we analyzed korean hbv genotypes in a large population by employing a new technology, restriction fragment mass polymorphism (rfmp) using maldi-tof mass spectrometry, in a sensitive and specific ... | 2004 | 15613801 |
| [genotyping of hepatitis b virus and its clinical significance in patients with chronic hepatitis b]. | to investigate the distribution of hepatitis b virus (hbv) genotypes in guangdong and explore its clinical significance. | 2005 | 15699014 |
| favorable efficacy of long-term lamivudine therapy in patients with chronic hepatitis b: an 8-year follow-up study. | the long-term efficacy of lamivudine therapy in patients with hepatitis b virus (hbv) infection is still not clear. in this study, 20 non-cirrhotic japanese patients infected with hbv received lamivudine therapy for more than 1 year and were followed for a median period of 8.5 years (range, 6.7-8.7 years). the rates of hbe antigen (hbeag) negative, hbv-dna undetectable, and alanine aminotransferase (alt) normal level at the start of lamivudine were 55%, 25%, and 20% and 85%, 80%, and were 80%, r ... | 2005 | 15714490 |
| re-analysis of a human hepatitis b virus (hbv) isolate from an east african wild born pan troglodytes schweinfurthii: evidence for interspecies recombination between hbv infecting chimpanzee and human. | according to current estimates, hepatitis b virus (hbv) has infected 2 billion people worldwide and among them, 360 million suffer from chronic hbv infection. except humans, hbv or hbv-like viruses have also been isolated from different species of apes and mammals. although recombination has been described to occur extensively between different genotypes within the human hbv lineage, no recombination event has ever been reported between human and non-human primate hbv sequences. it was our objec ... | 2005 | 15777724 |
| infectious source factors affecting the severity of sexually transmitted acute hepatitis due to hepatitis b virus genotype c. | the aim of this study was to identify clinical features and virological aspects of infectious sources that are related to the severity of sexually transmitted acute hepatitis b virus (hbv) infection in patients, especially in cases of genotype c. | 2005 | 15812183 |
| epidemiological and virological characteristics of 2 subgroups of hepatitis b virus genotype c. | we aimed to investigate the characteristics of hepatitis b virus (hbv) genotype c subgroups in hong kong and their relationship with hbv genotype c in other parts of asia. | 2005 | 15897987 |
| co-infection with hepatitis b virus genotype d and other genotypes in western japan. | genotypes b and c are the prevalent hepatitis b virus (hbv) genotypes in eastern asia. although very rare in this region of the world, genotype d was found to be prevalent in a small area of western japan. in this study, we confirm the frequency and clinical significance of co-infection with different genotypes among patients from that area infected with genotype d. | 2005 | 15920351 |
| overlapping gene mutations of hepatitis b virus in a chronic hepatitis b patient with hepatitis b surface antigen loss during lamivudine therapy. | disappearance of hepatitis b surface antigens (hbsag) in chronic hepatitis b usually indicates clearance of hepatitis b virus (hbv) infection. however, false hbsag negativity with mutations in pre-s2 and 'a' determinant has been reported. it is also known that ymdd mutations decrease the production of hbv and escape detection of serum hbsag. here, we report overlapping gene mutations in a patient with hbsag loss during the lamivudine therapy. after 36 months of lamivudine therapy in a 44-yrold k ... | 2005 | 15953865 |
| [hepatitis b virus genotypes and alanine aminotransferase levels in hbeag negative patients with chronic hepatitis b and liver cirrhosis]. | to investigate genotypes of the hepatitis b virus (hbv) and alanine aminotransferase (alt) levels of hbeag negative patients with chronic hepatitis b and liver cirrhosis. | 2005 | 16042881 |
| clinical and virological differences between hepatitis b virus genotypes b and c: a case-control study. | the pathogenic significance of hepatitis b virus (hbv) genotypes is undefined. the aim of this study was to elucidate the differences in clinical and virologicalfeatures between hbv genotypes b and c by conducting a case-control study in thai patients who were chronically infected with the virus. | 2004 | 16083192 |
| influence of hla-drb1 alleles and hbv genotypes on interferon-alpha therapy for chronic hepatitis b. | to investigate the influence of hla-drb(1) alleles and hbv genotypes on interferon-alpha therapy for chronic hepatitis b. | 2005 | 16094724 |
| hepatitis b virus genotype c prevails among chronic carriers of the virus in korea. | hepatitis b virus (hbv) is one of the major causative agents of chronic liver diseases in korea. hbv has been classified into 8 genotypes by a divergence of >8% in the entire genomic sequence, and have distinct geographic distributions. there are limited data on the relevance between hbv genotypes and clinical outcomes in korea. to investigate the clinical feature relating to hbv genotype in korea, a total 120 serum samples with hbsag (65 from seoul and 55 from the other city in korea) were obta ... | 2005 | 16224156 |
| clinical significance of hepatitis b virus (hbv) genotypes and precore and core promoter mutations affecting hbv e antigen expression in taiwan. | to assess the prevalence and clinical significance of hepatitis b virus (hbv) genotypes and precore and core promoter mutations in taiwan, a cohort of 200 taiwanese chronic hepatitis b patients was analyzed. the hbv genotypes and sequences of the precore and the core promoter regions were determined in 66 asymptomatic carriers and 134 patients who had liver biopsy-verified chronic hepatitis and liver cirrhosis. the hbv e-antigen (hbeag)-negative patients had a higher frequency of mutations at co ... | 2005 | 16333089 |
| hepatitis b virus genotypes among the jarawas: a primitive negrito tribe of andaman and nicobar islands, india. | the jarawas, a classical hunter-gatherer tribe of andaman and nicobar islands, india, were living in isolation for several centuries. they came into contact with the civilized world recently. serological studies carried out among them revealed that hepatitis b virus (hbv) infection is hyper-endemic. the present study was carried out to investigate the possible origin of hbv infection in jarawas. genotyping, rflp analysis, sequencing, and sequence analysis revealed the prevalence of hbv genotype ... | 2006 | 16514497 |
| role of hepatitis b viral load and basal core promoter mutation in hepatocellular carcinoma in hepatitis b carriers. | several hepatitis b viral factors correlate with the progression of chronic liver disease. however, the independent and interactive effects of each known viral factor on the development of hepatocellular carcinoma (hcc) remain largely unknown. | 2006 | 16586363 |
| genotypes of hepatitis b virus among voluntary blood donors in northern thailand. | there are distinct ethnogeographic variations for the distribution of various hepatitis b virus (hbv) genotypes, and pathogenic and therapeutic differences are also observed. in general, genotype b infection has a relatively better prognosis than genotype c. in thailand, genotypes c and b were reported as the major genotypes; however, there were no previous reports of hbv genotyping in the north of the country. from 1998 to 2000, 216 hbsag-positive serum samples (164 males and 52 females, aged 1 ... | 2006 | 16731031 |
| nucleotide change of codon 38 in the x gene of hepatitis b virus genotype c is associated with an increased risk of hepatocellular carcinoma. | the hepatitis b virus (hbv) genotype c is associated with the development of hepatocellular carcinoma (hcc). in addition, the hbv x gene, which encodes the pleiotropic transactivator hbx, has also been associated with the development of hcc. in this study, we investigated whether nucleotide changes in the x gene of genotype c are associated with the development of hcc. | 2006 | 17050029 |
| predominance of hepatitis b virus genotype c among karens, the 'old settlers' of andaman and nicobar islands, india. | the karens, or 'old settlers', migrated from myanmar to andaman and nicobar islands 80 years ago. a high hbv exposure rate among them has been reported. a study of 34 hbsag carriers was done to investigate the origin of hbv infection among the karens. rflp-based genotyping was confirmed by sequencing and phylogenetic analysis. the predominance of hbv/c1/cs suggests that they carried hbv during their migration, retained it, and in addition, acquired hbv/d2 from the people of mainland india. the r ... | 2007 | 17216140 |
| lamivudine and ifn-beta sequential therapy in hbe antigen-positive patients with chronic hepatitis b virus genotype c infection. | sequential treatment with lamivudine and interferon (ifn) has induced sustained biochemical and virologic responses in the majority of patients with chronic hepatitis b in france. however, the efficacy of sequential treatment in patients with chronic hepatitis b virus (hbv) genotype c infection has not been evaluated. twenty-four hbe antigen-positive patients were treated with 100 mg lamivudine alone for 16-32 weeks, then with both 6 mu ifn-beta and lamivudine for 4 weeks, and lastly with ifn-be ... | 2007 | 17348818 |
| clinical and virological characteristics of hepatitis b virus subgenotypes ba, c1, and c2 in china. | hepatitis b virus (hbv) subgenotypes ba, c1 (cs), and c2 (ce) are the most prevalent hbv variants in china. to investigate the virological characteristics of these subgenotypes and their clinical implications, we enrolled a cohort of 211 patients in the guangdong province of china, including 132 with chronic hepatitis b virus infection (ch), 32 with liver cirrhosis (lc), and 47 with hepatocellular carcinoma (hcc) according to clinical examination, liver function test, and ultrasonograph results. ... | 2007 | 17376881 |
| detection of hepatitis b virus genotypes using oligonucleotide chip among hepatitis b virus carriers in eastern china. | to determine the genotype distribution of hepatitis b virus (hbv) with a newly oligonucleotide chip assay among the hbv carriers in eastern china. | 2007 | 17461500 |
| distribution and characteristics of hepatitis b virus genotype c subgenotypes in china. | genetic diversity within the same hepatitis b virus (hbv) genotype indicates the presence of several subgenotypes. we have found that genotype c is the most common in china, and this study aimed to determine the geographical distribution and characteristics of hbv-c subgenotypes in the country. a cohort of 534 patients with chronic hbv genotype c infection, collected across china, was analysed by nucleotide sequencing or polymerase chain reaction-restriction fragment length polymorphism. hbv-c1/ ... | 2007 | 17501764 |
| variations in the core promoter/pre-core region in hbv genotype c in japanese and northern vietnamese patients. | hepatitis b virus (hbv) subgenotypes cs (c1) and ce (c2) are common in east asia. to investigate the genomic difference of hbv genotype c between two separated regions, 50 subgenotype cs-infected vietnamese and 70 subgenotype ce-infected japanese patients were enrolled for analysis. the patients were categorized to either a hepatocellular carcinoma group (hcc) or a non-hcc group including liver cirrhosis, chronic hepatitis, and asymptomatic carriers. hbv serology, hbv-dna level, and variations i ... | 2007 | 17607788 |
| clinical significance and evolution of core promoter and precore mutations in hbeag-positive patients with hbv genotype b and c: a longitudinal study. | the aims of this longitudinal study were to investigate whether the clinical outcome and evolution of core promoter and precore mutations were different during hepatitis b e antigen (hbeag) seroconversion between hepatitis b virus (hbv) genotypes b and c in hbeag-positive patients with chronic hepatitis b. | 2007 | 17617124 |
| [relationship between hepatitis b virus genotypes and liver fibrosis]. | to study the relationship between hepatitis b virus (hbv) genotypes and liver fibrosis. | 2007 | 17666340 |
| subgenotypes of hepatitis b virus genotype c do not correlate with disease progression of chronic hepatitis b in taiwan. | hepatitis b virus (hbv) genotype c (hbv/c) has two subgenotypes: hbv/cs and ce. the prevalence and clinical implications of subgenotype cs and ce in taiwanese hbv carriers remain unknown. | 2007 | 17696938 |
| association between lamivudine sensitivity and the number of substitutions in the reverse transcriptase region of the hepatitis b virus polymerase. | this study aimed to identify the viral factors responsible for poor sensitivity to lamivudine (lam). we analyzed 49 lam-treated chronic hepatitis b patients infected with hepatitis b virus (hbv) genotype c. serum hbv dna reached a level below the detection limit of the sensitive pcr assay in 31 (63.3%) within the first 24 weeks of lam therapy (good responder group). of the patients who did not achieve undetectable levels of hbv dna within 24 weeks (poor responder group), 15 (83.3%) experienced v ... | 2007 | 17697019 |
| [interruption failure of heptitis b virus vaccination in mother-to-infant transmission and heptitis b virus genotypes and prec/bcp mutations]. | to investigate the association of heptitis b virus (hbv) genotypes and precore(prec)/basal core promoter(bcp) mutation with interruption failure of hbv vaccination in mother-to-infant transmission. | 2007 | 17850697 |
| analysis of the complete hepatitis b virus genome in patients with genotype c chronic hepatitis and hepatocellular carcinoma. | hepatitis b virus (hbv) genotype c and the basic core promoter (bcp) mutations were reported to be associated with the development of hepatocellular carcinoma (hcc). in this study the full sequences of hbv genomes were analyzed in order to find the other predictors of hcc development. we determined the full sequences of hbv genomes in 24 genotype c carriers who developed hcc (hcc group) at the beginning of follow-up and at the time of hcc diagnosis, and 20 patients who did not develop hcc (non-h ... | 2007 | 17888035 |
| the high incidence of the emergence of entecavir-resistant mutants among patients infected with lamivudine-resistant hepatitis b virus. | hepatitis b virus (hbv) infection remains to be one of the most prevailing infection in the world, causing chronic liver diseases. although lamivudine has been effective to suppress hbv replication, longer durations of administration can lead to the emergence of drug-resistant mutant viruses, followed by reactivation of hepatic inflammation (breakthrough hepatitis). moreover, the optimal period of administration as well as the effects of anti-viral nucleot(s)ide such as lamivudine, adefovir, and ... | 2007 | 17917412 |
| comparison of complete sequences of hepatitis b virus genotype c between inactive carriers and hepatocellular carcinoma patients before and after seroconversion. | most patients who acquire chronic hepatitis b virus (hbv) infection by perinatal transmission become inactive carriers (ic) after hepatitis b e (hbe) antigen seroconversion, whereas some patients have persistent abnormal serum transaminase levels and develop hepatocellular carcinoma (hcc) in the anti-hbe-positive phase. the aim of this study was to investigate the hcc-related mutations of hbv. | 2007 | 17940837 |
| [a study of hepatitis b virus subtypes in patients chronically infected with genotype b or c of hepatitis b virus in guizhou]. | to investigate hepatitis b virus (hbv) subtypes in patients chronically infected with genotype b or c of hepatitis b virus in guizhou and to study the relationship between the subtypes and the progression of their liver diseases. | 2007 | 17963595 |
| [efficacy of adefovir dipivoxil was not related to genotypes b and c of hepatitis b virus: a randomized, double-blind, multicenter clinical study]. | to determine the relationship between the response to adefovir dipivoxil (adv) treatment in patients with hbv genotypes b and c of hbeag positive chronic hepatitis b. | 2007 | 17971947 |
| long-term tracking of hepatitis b viral load and the relationship with risk for hepatocellular carcinoma in men. | little is known about the longitudinal course of hepatitis b virus (hbv) load and its relationship with the development of hepatocellular carcinoma (hcc). we conducted a case-cohort study nested within a cohort of 2874 hbv surface antigen-positive male taiwanese government employees aged 30 years or older. hbv genotype and dna levels (i.e. viral load) were tested using polymerase chain reaction-based assays on plasma samples from 112 cases and 1031 non-cases. prediagnostic plasma levels of hbv d ... | 2008 | 17999990 |
| hepatitis b viral factors and clinical outcomes of chronic hepatitis b. | hepatitis b virus (hbv) infection is an important health problem and the major cause of chronic hepatitis, cirrhosis as well as hepatocellular carcinoma (hcc) worldwide. the natural history of chronic hbv infection can be divided into 4 dynamic phases in hbv carriers who acquire the virus early in life. in general, the frequency and severity of hepatitis flares in the immune clearance or reactivation phase predict disease progression in hbv carriers, and early hbeag seroconversion typically conf ... | 2008 | 18058038 |
| high viral load and hepatitis b virus subgenotype ce are associated with increased risk of hepatocellular carcinoma. | we aimed to investigate the impact of hepatitis b virus (hbv) dna and hbv genotypes/subgenotypes on the risk of hepatocellular carcinoma (hcc). | 2008 | 18182659 |
| effects of antiviral agents and hbv genotypes on intrahepatic covalently closed circular dna in hbeag-positive chronic hepatitis b patients. | to evaluate the effects of antiviral agents and hbv genotypes on intrahepatic covalently closed circular dna (ccc dna) in hbeag-positive chronic hepatitis b patients. | 2008 | 18300356 |
| [distribution of hepatitis b virus genotypes and its clinical significance]. | to study the distribution of hepatitis b virus genotypes in handan area and clarify the genotype-related difference in clinic. | 2007 | 18322607 |
| [effects of antiviral agents on intrahepatic ccc dna in hbeag-positive chronic hepatitis b patients]. | to evaluate the effects of antiviral agents on intrahepatic hbv covalently closed circular dna (cccdna) in hbeag-positive chronic hepatitis b patients. | 2008 | 18364079 |
| profile, spectrum and significance of hepatitis b virus genotypes in chronic hbv-infected patients in yunnan, china. | there are significant variations in the geographical distribution of hepatitis b virus (hbv) genotypes throughout the world, and some genotypes are associated with different clinical outcomes. eight genotypes of human hbv (designated a-h) have been reported. the present study was designed to examine the distribution of hbv genotypes among patients at various stages of chronic type b liver disease in yunnan province, china, and to explore its significance and the relationship of hbv genotype with ... | 2008 | 18522881 |
| genotypes of hepatitis b virus among children in chiang mai, thailand. | in sub-saharan africa, the pacific, and particularly asia, hepatitis b virus (hbv) infection is highly endemic, the most common route of transmission is perinatal. to minimize the number of horizontal transmissions, we determined the prevalence of hbv genotypes among children in northern thailand. from a survey of 1,231 schoolchildren in chiang mai during 1998 to 2000, 55 (4.5%) were found positive for hbsag. fifty-three hbsag-positive samples were available for this study. these came from 28 gi ... | 2008 | 18564677 |
| expression profiles and function of toll-like receptors 2 and 4 in peripheral blood mononuclear cells of chronic hepatitis b patients. | toll-like receptors (tlrs) play a central role in sensing and initiating innate antiviral response. in this study, we first investigated the expression of tlr1-10 mrna transcripts in peripheral blood mononuclear cells (pbmcs) from chronic hbv-infected (chb) patients and healthy donors by quantitative real-time pcr. the expression of tlr1, tlr2, tlr4 and tlr6 transcripts was significantly lower in pbmcs from chb patients, and the down-regulation of tlr2 was related to hbv genotype c. flow cytomet ... | 2008 | 18565796 |
| construction and expression of eukaryotic plasmids containing lamivudine-resistant or wild-type strains of hepatitis b virus genotype c. | to construct eukaryotic expression plasmids of full-length hepatitis b virus (hbv) genotype c genome, which contain lamivudine-resistant mutants (yidd, yvdd) or wild-type strain (ymdd), and to observe the expression of hbv dna and antigens [hepatitis b surface antigen (hbsag) and hepatitis b e antigen (hbeag)] of the recombinant plasmids in hepg2 cells. | 2008 | 18595141 |
| adding interferon to lamivudine enhances the early virologic response and reversion of the precore mutation in difficult-to-treat hbv infection. | the virologic impact of adding interferon to antiviral nucleoside therapy was studied in japanese patients having perinatally transmitted hepatitis b virus (hbv) genotype c. | 2008 | 18600390 |
| recurrence of hepatitis b-related hepatocellular carcinoma is associated with high viral load at the time of resection. | to identify the risk factors for recurrence of hepatitis b virus (hbv)-related hepatocellular carcinoma (hcc) after resection. | 2008 | 18616655 |
| associations between hepatitis b virus genotype and mutants and the risk of hepatocellular carcinoma. | the risk of hepatocellular carcinoma (hcc) increases with increasing level of hepatitis b virus (hbv) in serum (viral load). however, it is unclear whether genetic characteristics of hbv, including hbv genotype and specific genetic mutations, contribute to the risk of hcc. we examined the hcc risk associated with hbv genotypes and common variants in the precore and basal core promoter (bcp) regions. | 2008 | 18695135 |
| prospective comparison of abbott realtime hbv dna and versant hbv dna 3.0 assays for hepatitis b dna quantitation: impact on hbv genotype monitoring. | the quantitation of human hepatitis b virus (hbv) in the serum of infected patients is recommended to characterize the course of chronic hbv infection. the aim of this prospective study was to evaluate the performance of the abbott realtime pcr assay for hbv dna quantitation by comparison with the standard versant hbv dna 3.0 assay. the better sensitivity and broader dynamic range of hbv dna quantitation using the abbott realtime pcr assay was confirmed by the study of 362 serum samples from 311 ... | 2008 | 18929599 |
| nih consensus development statement on management of hepatitis b. | to provide health care providers, patients, and the general public with a responsible assessment of currently available data on the management of hepatitis b. | 2008 | 18949020 |
| [adenovirus-mediated transduction of hbv/c genome into hepg2 cell line]. | to establish a method for efficient transfer of 1.3-fold hbv/c genome into hepg2 cell line using adenoviral vector system for studying the replication and antigen expression of hbv. | 2008 | 18971166 |
| the distribution of hbv genotypes and clinical significance in familial clustering in an infected population with unfavorable prognosis. | using a nested-pcr genotyping system, we analyzed the viral genotypes in hbv-infected patients from hbv clustering infection families (cifs), as compared with hbv infected patients without familial infection history. the patients in the cif group showed significantly increased prevalence of genotype c infection, while genotype b was absent. additionally, in the genotype c carriers younger than 50 years old, the prevalence of hcc and lc were significantly increased in cif compared to the control. ... | 2008 | 18982245 |
| diagnosis of hepatitis b virus infection through serological and virological markers. | hepatitis b virus (hbv) infection is an important health problem and the major cause of chronic hepatitis, cirrhosis and hepatocellular carcinoma (hcc) worldwide. the natural history of chronic hbv infection can be divided into four dynamic phases in hbv carriers who acquire the virus early in life. diagnosis of hbv infection is usually through serological and virological markers. hepatitis b surface antigen (hbsag) is the hallmark of hbv infection and is the first serological marker to appear i ... | 2008 | 19072403 |
| an overview of molecular epidemiology of hepatitis b virus (hbv) in india. | hepatitis b virus (hbv) is one of the major global public health problems. in india, hbsag prevalence among general population ranges from 2% to 8%, placing india in intermediate hbv endemicity zone and the number of hbv carriers is estimated to be 50 million, forming the second largest global pool of chronic hbv infections. india is a vast country, comprised of multiracial communities with wide variations in ethnicity and cultural patterns, which is attributable to its geographical location, ge ... | 2008 | 19099581 |
| [analysis of the relevance of the mutations of the precore and basic core promoter in hbv genome with the dna amount of hbv viremia]. | in the course of hepatitis b, serum concentrations of the virus usually fall following sero-conversion, characterized by the loss of hbe antigen and appearance of detectable anti-hbe. however, hepatitis b viremia may persist even after sero-conversion. we assessed the association of continuous viremia with the precore (pc) (g1896a) mutation, basic core promoter (bcp) (a1762t, g1764a) mutations, the viral genotype and the quantity of viral dna. neither pc nor bcp mutations were detected in the vi ... | 2009 | 19489434 |
| associations between hepatitis b virus mutations and the risk of hepatocellular carcinoma: a meta-analysis. | the association between hepatitis b virus (hbv) mutations and hepatocarcinogenesis remains controversial because of conflicting data in the literature. we conducted a meta-analysis of case-control and cohort studies to examine hbv pres, enhancer ii (enhii), basal core promoter (bcp), and precore mutations in relation to the risk of hepatocellular carcinoma (hcc). | 2009 | 19574418 |
| [surveillance for occult hbv infection and hbsag variants in blood donors]. | occult hepatitis b virus (hbv) infection status of blood donors in a southern city in china was investigated by immunological assays and nucleic acid testing. overall, 17 (0.19%, 95% ci: 0.11%-0.30%) of the 9023 hbsag negative samples were found to be positive for the presence of hbv dna. "a" epitope sequences were obtained from 14 among them. mutation(s) in aa124-aa147 existed in 6 (42.9%, 6/14) samples and 4 (66.7%, 4/6)were g145r mutation. ratio of genotype c in occult donors (10/17) was stat ... | 2009 | 19634759 |
| characteristics of general distribution of hepatitis b virus genotypes in china. | based on differences in the virus nucleotide sequence, hepatitis b virus (hbv) genotypes are presently divided into genotypes a-h. the geographic distributions of hbv genotypes differ in countries and regions. to determine the general characteristics of their distributions in the mainland of china, we reviewed articles on hbv genotypes published in china. | 2009 | 19666409 |
| high serum adiponectin correlates with advanced liver disease in patients with chronic hepatitis b virus infection. | adiponectin possesses anti-inflammatory and insulin-sensitizing properties. little is known about the role of adiponectin in hepatitis b-related liver disease. | 2009 | 19669362 |
| comparison and significance of specific and non-specific cellular immunity in patients with chronic hepatitis b caused by infection with genotypes b or c of hepatitis b virus. | the present study was designed to investigate possible relationships between the genotypes of hepatitis b virus (hbv) and the hbv-specific cytotoxic t lymphocyte (ctl) responses. hbv genotypes, hbv specific ctl hbv dna and other markers of hbv infection were determined in 138 patients with chronic hepatitis b. the results showed that the patients infected with genotype c (n=62) had a significantly lower hbv-specific ctl response than those who were infected with hbv genotype b (p<0.01). hbv dna ... | 2009 | 19727589 |
| ikappabalpha gene promoter polymorphisms are associated with hepatocarcinogenesis in patients infected with hepatitis b virus genotype c. | genetic predisposition of nuclear factor-kappa b (nf-kappab)-signaling pathways linking inflammation to hepatitis b virus (hbv)-induced hepatocellular carcinoma (hcc) remains unresolved. we conducted a case-control study to determine the associations of the polymorphisms within the promoter regions of nfkb1 encoding nf-kappab1 and nfkbia encoding ikappabalpha with the development of hcc. a total of 404 healthy controls, 482 non-hcc subjects with hbv infection and 202 patients with hcc were inclu ... | 2009 | 19797428 |
| hepatitis b virus genotype b has an earlier emergence of lamivudine resistance than genotype c. | hepatitis b virus (hbv) genotype b and c seem not to affect the therapeutic response to lamivudine (3tc). whether a given genotype has an earlier emergence of 3tc resistance remains unclear. we thus conducted this study to elucidate the association of hbv genotype with the emergence of 3tc-resistant strains in taiwanese patients. | 2009 | 20032545 |
| hbv genotype c is independently associated with cirrhosis in community-based population. | to determine the association of hepatitis b virus (hbv) genotypes with probable cirrhosis and fatty liver in community-based populations. | 2010 | 20082486 |
| molecular epidemiology of health care-associated transmission of hepatitis b and c viruses. | the term "molecular epidemiology" has been ascribed to a host of different activities that involve gene-sequence analysis. some examples of molecular epidemiology include modeling exercises of phylogenetic trees to reconstruct epidemics; studies of the evolution of hepatitis c virus (hcv); rates of nucleotide substitution in the hepatitis b virus (hbv) surface (s) gene; variations in the core promoter/pre-core/core region of hbv genotype c from different sources; analysis of hbv surface antigen ... | 2010 | 20123438 |
| distribution and hepatocellular carcinoma-related viral properties of hepatitis b virus genotypes in mainland china: a community-based study. | hepatitis b virus (hbv) genotypes, replication status, and mutations have been associated with the risk of hepatocellular carcinoma (hcc). our aim was to study the distribution and hcc-related viral properties of hbv genotypes/subgenotypes in mainland china. | 2010 | 20160279 |
| [drug resistance, genotype, and serotype of hepatitis b virus in nucleos(t)ide analogue naive patients with chronic hepatitis b]. | to investigate drug resistance, genotype and serotype of hepatitis b virus (hbv) in nucleos(t)ide analogue (na) naive patients with chronic hepatitis b (chb). | 2010 | 20196945 |
| prevalence of hepatitis b virus genotypes and their relationship to clinical laboratory outcomes in tibetan and han chinese. | this study was designed to investigate the prevalence of hepatitis b virus (hbv) genotypes in tibetan and han nationalities in sichuan province, china, and their clinical significance. sera from 376 patients (286 han nationals, 90 tibetan nationals) were genotyped by polymerase chain reaction. of the 286 han nationals, 127 were hbv asymptomatic carriers, 90 were symptomatic patients and 69 had hepatocellular carcinoma. the distribution of hbv genotypes was related to geography as well as ethnici ... | 2010 | 20233529 |
| t3098c and t53c mutations of hbv genotype c is associated with hbv infection progress. | to analyze the association between mutation(s) in pres region of hbv and hepatitis b disease progress in chinese patients with genotype c chronic hbv infection. | 2009 | 20337225 |
| occult hbv infection in anti-hbs-positive young adults after neonatal hb vaccination. | previous follow-up on our neonatal hb vaccination cohorts with 80,000 individuals in qidong, china, showed significant protective efficacy of immunization against hbv infection in childhood. however, some vaccinees were found to be hbsag negative, but anti-hbs positive and anti-hbc positive at age 10-11 years. to study this phenomenon, 2919 vaccinees at age 19-21 years were sampled from the cohort. hbsag(-), anti-hbs(+) and anti-hbc(+) were found in 124/2919 (4.2%) of the vaccinees. hbv dna was ... | 2010 | 20637763 |
| genetic variations of hepatitis b virus and serum aflatoxin-lysine adduct on high risk of hepatocellular carcinoma in southern guangxi, china. | southern guangxi area is one of the endemic areas for hepatocellular carcinoma (hcc) in china. this study evaluates the roles of genetic variations of hepatitis b virus (hbv) and aflatoxin b(1) (afb(1)) exposure in the formation of hcc in this high-risk area. | 2010 | 20650537 |
| hbv mutations in untreated hiv-hbv co-infection using genomic length sequencing. | hiv infection has a significant impact on the natural progression of hepatitis b virus (hbv) related liver disease. in hiv-hbv co-infected patients, little is known about mutations in the hbv genome, which can influence severity of liver disease. the aim of this study was to characterize and to determine the frequency of known clinically significant mutations in the hbv genomes from hiv-hbv co-infected patients and from hbv mono-infected patients. to accomplish this, genomic length hbv sequencin ... | 2010 | 20655563 |