| sabin attenuated lsc/2ab strain of poliovirus spreads to the spinal cord from a peripheral nerve in bonnet monkeys (macaca radiata). | vaccine-associated paralytic poliomyelitis is a serious concern while using the live attenuated oral polio vaccine for the eradication of poliomyelitis. the bonnet monkey model of poliovirus central nervous system (cns) infection following experimental inoculation into the ulnar nerve allows the comparative study of wild-type and attenuated poliovirus invasiveness. dosages >/=10(4) tcid(50) of mahoney strain of poliovirus type 1 [pv1(m)] result in paralysis. in contrast, even with 10(7) tcid(50) ... | 2001 | 11369876 |
| experimental poliomyelitis in bonnet monkey. clinical features, virology and pathology. | we have investigated the distribution of virus and the pathology in the spinal cords of bonnet monkeys (macaca radiata) with experimental paralytic poliomyelitis induced by inoculating poliovirus type 1 (mahoney) into the right ulnar nerve. viraemia and alimentary tract infection due to the inoculated virus were found in all monkeys. between two and seven days after the onset of limb paralysis, the animals were killed and the spinal cord examined. virus was isolated from the cervical enlargement ... | 1993 | 8388833 |
| intestinal immunity induced by inactivated poliovirus vaccine. | in order to detect any intestinal immunity against poliovirus infection induced by parenteral vaccination with inactivated poliovirus vaccine (ipv), experiments were conducted in monkeys (macaca radiata). all animals were seronegative (antibody not detected at 1:2 dilution of serum) before investigation. sixteen monkeys were vaccinated with three doses of ipv at monthly intervals. groups of four vaccinated and two seronegative control animals were fed 100 median monkey infectious doses (100 mid5 ... | 1987 | 3037815 |
| ulnar nerve inoculation of poliovirus in bonnet monkey: a new primate model to investigate neurovirulence. | a new monkey model of poliovirus neurovirulence has been developed avoiding the currently used intraspinal injection route which traumatizes the spinal cord. poliovirus type 1 (0.1 ml) was inoculated into the ulnar nerve of bonnet monkeys (macaca radiata) at the right elbow. five monkeys were inoculated with 10(7) tcid of lsc/2ab (sabin vaccine strain); none developed any illness. limb paralysis, clinically resembling spinal poliomyelitis in children, developed in all four monkeys given greater ... | 1992 | 1320307 |