| evidence of a cross-protective immune response to influenza a in the cotton rat model. | epidemiologic evidence suggests that cross-protective immune responses to influenza a viruses that have different hemagglutinin and neuraminidase subtypes occur in humans. this study characterized this heterosubtypic immunity in cotton rats (sigmodon hispidus). animals were infected with influenza a/pr/8/34 (h1n1) or a/wuhan/359/95 (h3n2), and then challenged with a/wuhan/359/95(h3n2) virus 4 weeks later. viral titers, respiratory rates, and pathology of the respiratory tract following primary a ... | 2006 | 16860444 |
| antibody contributes to heterosubtypic protection against influenza a-induced tachypnea in cotton rats. | influenza virus infection or vaccination evokes an antibody response to viral hemagglutinin (ha) and neuraminidase (na) surface glycoproteins, which results in immunity against influenza a viruses of the same ha and na subtype. a heterosubtypic immune response that offers some protection against different influenza a subtypes has been suggested from epidemiologic studies in human influenza outbreaks, and has been induced in experimental animal models. original studies of such cross-protection sh ... | 2008 | 18355405 |
| Efficacy of trivalent inactivated influenza vaccines in the cotton rat Sigmodon hispidus model. | Annually adjusted inactivated influenza vaccines can prevent infection and limit the spread of seasonal influenza when vaccine strain closely matches circulating strain. For the years when the match is difficult to achieve, a rapid screening of a larger repertoire of vaccines may be required but is difficult to accomplish due to the lack of a convenient small animal model of seasonal influenza vaccines. The goal of this work was to determine whether the cotton rat Sigmodon hispidus, a small labo ... | 2011 | 22210139 |
| receptor characterization and susceptibility of cotton rats to avian and 2009 pandemic influenza virus strains. | animal influenza viruses (aivs) are a major threat to human health and the source of pandemic influenza. a reliable small-mammal model to study the pathogenesis of infection and for testing vaccines and therapeutics against multiple strains of influenza virus is highly desirable. we show that cotton rats (sigmodon hispidus) are susceptible to avian and swine influenza viruses. cotton rats express α2,3-linked sialic acid (sa) and α2,6-linked sa residues in the trachea and α2,6-linked sa residues ... | 2013 | 23192875 |