| comparative pathogenicity and transmissibility of pandemic h1n1, avian h5n1, and human h7n9 influenza viruses in tree shrews. | influenza a viruses (iavs) continuously challenge the poultry industry and human health. studies of iavs are still hampered by the availability of suitable animal models. chinese tree shrews (tupaia belangeri chinensis) are closely related to primates physiologically and genetically, which make them a potential animal model for human diseases. in this study, we comprehensively evaluated infectivity and transmissibility in chinese tree shrews by using pandemic h1n1 (a/sichuan/1/2009, pdmh1n1), av ... | 2019 | 31921093 |
| avian h5n1 influenza virus infection causes severe pneumonia in the northern tree shrew (tupaia belangeri). | avian-origin influenza viruses like h5n1 and h7n9 often cause severe symptoms with high mortality in humans. animal models are useful for clarification of the mechanisms of pathogenicity of these infections. in this study, to expand the potential utility of the northern tree shrew (tupaia belangeri) for influenza virus infection, we assessed the pathogenicity of h5n1 and h7n9 avian influenza viruses in tupaia. infectious virus was detected continuously from nasal, oral, tracheal, and conjunctiva ... | 2019 | 30684692 |
| tree shrew as a new animal model to study the pathogenesis of avian influenza (h9n2) virus infection. | outbreaks of avian influenza virus continue to pose threats to human health. animal models such as the mouse, ferret, and macaque are used to understand the pathogenesis of avian influenza virus infection in humans. we previously reported that the tree shrew (tupaia belangeri, family tupaiidae), which is regarded as a "low-level primate", has α2,3- and α2,6-linked sialic acid receptor distributions similar to those of humans and is potentially a useful mammalian model for studying mild human inf ... | 2018 | 30301950 |