| bat lung epithelial cells show greater host species-specific innate resistance than mdck cells to human and avian influenza viruses. | with the recent discovery of novel h17n10 and h18n11 influenza viral rna in bats and report on high frequency of avian h9 seroconversion in a species of free ranging bats, an important issue to address is the extent bats are susceptible to conventional avian and human influenza a viruses. | 2018 | 29636078 |
| characterization of experimental oro-nasal inoculation of seba's short-tailed bats (carollia perspicillata) with bat influenza a virus h18n11. | in 2012 and 2013, the genomic sequences of two novel influenza a virus (iav) subtypes, designated h17n10 and h18n11, were identified via next-generation sequencing in the feces of the little yellow-shouldered fruit bat (sturnira lilium) and the flat-faced fruit-eating bat (artibeus planirostris), respectively. the pathogenesis caused by these viruses in their respective host species is currently insufficiently understood, which is primarily due to the inability to obtain and keep these bat speci ... | 2020 | 32093076 |
| human mxa is a potent interspecies barrier for the novel bat-derived influenza a-like virus h18n11. | the human innate immune factor mxa represents an effective interspecies barrier for zoonotic influenza a viruses (iavs) of animal origin. accordingly, human but not avian iavs efficiently escape the antiviral activity of mxa due to adaptive mutations in their viral nucleoprotein. partial mxa resistance can be acquired in intermediate hosts such as swine, which possess an antivirally active mx1 protein. intriguingly, mx1 of the bat carollia perspicillata, a host of the recently discovered bat inf ... | 2019 | 30945621 |