| pegivirus avoids immune recognition but does not attenuate acute-phase disease in a macaque model of hiv infection. | human pegivirus (hpgv) protects hiv+ people from hiv-associated disease, but the mechanism of this protective effect remains poorly understood. we sequentially infected cynomolgus macaques with simian pegivirus (spgv) and simian immunodeficiency virus (siv) to model hiv+hpgv co-infection. spgv had no effect on acute-phase siv pathogenesis-as measured by siv viral load, cd4+ t cell destruction, immune activation, or adaptive immune responses-suggesting that hpgv's protective effect is exerted pri ... | 2017 | 29073258 |