| identification of rodent homologs of hepatitis c virus and pegiviruses. | hepatitis c virus (hcv) and human pegivirus (hpgv or gb virus c) are globally distributed and infect 2 to 5% of the human population. the lack of tractable-animal models for these viruses, in particular for hcv, has hampered the study of infection, transmission, virulence, immunity, and pathogenesis. to address this challenge, we searched for homologous viruses in small mammals, including wild rodents. here we report the discovery of several new hepaciviruses (hcv-like viruses) and pegiviruses ( ... | 2013 | 23572554 |
| peromyscus as a model system for human hepatitis c: an opportunity to advance our understanding of a complex host parasite system. | worldwide, there are 185 million people infected with hepatitis c virus and approximately 350,000 people die each year from hepatitis c associated liver diseases. human hepatitis c research has been hampered by the lack of an appropriate in vivo model system. most of the in vivo research has been conducted on chimpanzees, which is complicated by ethical concerns, small sample sizes, high costs, and genetic heterogeneity. the house mouse system has led to greater understanding of a wide variety o ... | 2017 | 27498234 |