| histopathological observations of spontaneous regression of rous sarcomas in japanese quails. | turmors induced in japanese quails by the schmidt-ruppin strain of rous sarcoma virus were examined histopathologically. the following three phases were recognized in the quails whose tumors regressed finally (regressor). phase i was between days 4 and 7 of virus inoculation, when growth of tumor cells was seen with predominant infiltration of heterophils. phase ii, from days 10 to 14, was characterized by necrosis of tumor cells and focal accumulation of lymphoid cells which frequently formed f ... | 1975 | 172678 |
| viral glycoprotein synthesis studies in an established line of japanese quail embryo cells infected with the bryan high-titer strain of rous sarcoma virus. | although a glycoprotein with an approximate molecular weight of 43,000 is associated with purified virions of the bryan high-titer strain of rous sarcoma virus propagated on r(-)q cells, these virions lack gp85, the major glycoprotein of the avian tumor virus envelope. as measured by immune precipitation with a specific antiserum, gp85 does not accumulate to detectable levels in r(-)q cells. | 1976 | 178892 |
| characterization of an early cytotoxicity-inducing factor in sera of japanese quails after inoculation with rous sarcoma virus. | by pre-treatment with serum of normal spleen cells used in the microcytotoxicity assay, a humoral factor which induces cytotoxic activity in normal spleen cells was demonstrated in about 40% of sera of japanese quails as early as 3 days after inoculation with rous sarcoma virus (rsv). this cytotoxicity-inducing activity was not present either in the igm or the igg fraction obtained by sephadex gel filtration. in sera of quails with experimentally induced agammaglobulinemia, the cytotoxicity-indu ... | 1976 | 179959 |
| changes in phosphatidylinositol metabolism correlated to growth state of normal and rous sarcoma virus-transformed japanese quail cells. | second-passage japanese quail embryo cell cultures, normal or quantitatively transformed by rous sarcoma virus, were investigated for phospholipid composition and metabolism. cells cultivated at low and high population density as well as in the presence or absence of serum, have been compared by chemical analysis and in pulse-chase experiments. no differences in the lipid compositions between the normal and the tumor cells or between cells under different culture conditions were detected. in no ... | 1977 | 195714 |
| effects of dexamethasone on the morphogenesis of two mutants of rous sarcoma virus. | japanese quail cells transformed by the replication-defective, bryan high-titer strain of rous sarcoma virus, bh rsv(-)q, clone 3, revealed intracytoplasmic a-type particles after dexamethasone treatment. in the absence of dexamethasone, or when superinfected with a helper virus in the presence or absence of dexamethasone, no such particles were observed. chick embryo cells (cec) infected with a temperature-sensitive sarcoma virus mutant, la 334, coordinately defective for transformation and vir ... | 1978 | 204599 |
| rous sarcoma virus-transformed avian cells express four different cell surface antigens that are distinguishable by a cell-mediated cytotoxicity-blocking test. | japanese quails bearing avian sarcoma virus-induced tumors develop immune spleen cells that are cytotoxic in vitro against virally and chemically transformed cells, as well as against embryonic cells. the cell-mediated cytotoxicity can be blocked by soluble antigens extracted from in vitro cultured cells. the existence of partial as well as total blocking effects in tests with extracts from various transformed and untransformed virus-producing cells makes it possible to distinguish up to four di ... | 1978 | 207774 |
| assays for endogenous and exogenous lymphoid leukosis viruses and chick helper factor with rsv(--) cell lines. | japanese quail cells transformed by the envelope-defective bryan high-titer strain of rous sarcoma virus [r(-)q] were used as a source of the rous sarcoma virus genome in three kinds of assays. (i) the simplest and most sensitive assay for infectious, endogenous viruses of the chicken belonging to subgroup e involved infection of a mixture of r(-)q cells and turkey cells with the sample and assay of supernatants of these cells for focus formation on subgroup e susceptible cells. (ii) inactivated ... | 1979 | 222685 |
| host range of rous sarcoma virus pseudotype rsv(hprs-103) in 12 avian species: support for a new avian retrovirus envelope subgroup, designated j. | the host ranges of the rous sarcoma virus (rsv) pseudotype rsv(hprs-103) of a novel avian leukosis virus (alv), strain hprs-103, and representative rsv pseudotypes of subgroups a to f, have been determined in embryo fibroblasts from 12 avian species. domestic fowl, red jungle fowl, sonnerat's jungle fowl and turkey were susceptible to infection by rsv(hprs-103); ring-necked pheasant, japanese green pheasant, golden pheasant, japanese quail, guinea-fowl, peking duck, muscovy duck and goose were r ... | 1992 | 1331300 |
| glycyl-l-glutamine stimulates the accumulation of a12 acetylcholinesterase but not of nicotinic acetylcholine receptors in quail embryonic myotubes by a cyclic amp-independent mechanism. | myotubes prepared from the japanese quail embryo at 9 days gestation were cultivated in the presence of glycyl-l-glutamine (gly-gln, beta-endorphin c-terminal dipeptide) or glycyl-glutamic acid (gly-glu), and changes in the activity of acetylcholinesterase (ache) molecular forms and binding of 125i-alpha-bungarotoxin (alpha bgt) to cell surface nicotinic acetylcholine receptors were measured. the a12 oligomer was the major form of ache in the cultures. the activity of all molecular forms of the ... | 1990 | 2156012 |
| tumor production in the japanese quail by the schmidt-ruppin strain of rous sarcoma virus. | | 1965 | 4285380 |
| selective response of the japanese quail to various strains of rous sarcoma virus. | shipman, charles jr. (indiana university school of medicine, indianapolis), and alvin s. levine. selective response of the japanese quail to various strains of rous sarcoma virus. j. bacteriol. 92:161-163. 1966.-the bryan "high-titer," carr-zilber, harris, prague, schmidt-ruppin, and "29" strains of rous sarcoma virus were used to initiate tumors in the japanese quail (coturnix coturnix japonica). although all strains produced tumors upon primary inoculation, only the bryan "high-titer" and harr ... | 1966 | 4287403 |
| propagation of b77 virus and three strains of rous sarcoma virus in japanese quail. | | 1968 | 4300930 |
| tumor development and induction of resistance by rous sarcoma virus in japanese quail. | | 1968 | 4306753 |
| growth curve and distribution of rous sarcoma virus (bryan) in japanese quail. | on primary infection with the bryan strain of rous sarcoma virus (rsv), the growth curve of the virus in the brain of japanese quail was similar to that observed in chicks and turkey poults. infectious virus disappeared from the brain after inoculation. after an eclipse period during which no virus was detectable, infectious virus began to appear at 2 days and reached maximal titers in the brain samples at 7 days after inoculation. when japanese quail were infected intracerebrally with rsv, rela ... | 1967 | 4316245 |
| characterization of rous sarcoma virus-related sequences in the japanese quail. | we detected sequences related to the avian retrovirus rous sarcoma virus within the genome of the japanese quail, a species previously considered to be free of endogenous avian leukosis virus elements. using low-stringency conditions of hybridization, we screened a quail genomic library for clones containing retrovirus-related information. of five clones so selected, one, lambda q48, contained sequence information related to the gag, pol, and env genes of rous sarcoma virus arranged in a contigu ... | 1986 | 3016302 |
| lysis of rsv-transformed japanese quail cells by a factor from normal quail serum. | normal sera of japanese quails caused lysis of tumor cells from a rous sarcoma virus (rsv)-induced quail tumor (qt cells). other tumor cell lines, including rsv-transformed quail embryo cells and methylcholanthrene-induced quail tumors, were not lysed. this naturally occurring cytolytic factor (nclf) was sensitive to heating at 56 degrees c, zymosan, and inulin, and it required magnesium but not calcium for the expression of its activity. these results suggested that nclf activity was mediated b ... | 1978 | 207650 |
| syncytium formation of japanese quail embryo fibroblasts on double infection with rous sarcoma virus and measles virus. | | 1973 | 4367561 |
| cellular immunity induced by rous sarcoma virus in japanese quail. ii. effect of thymectomy and bursectomy on oncogenesis of rous sarcoma virus. | | 1971 | 4397201 |
| continuous tissue culture cell lines derived from chemically induced tumors of japanese quail. | several continuous tissue culture cell lines were established from methylcholanthrene-induced fibrosarcomas of japanese quail. the lines consist either of fibroblastic elements, round refractile cells or polygonal cells. they show transformed characteristics in agar colony formation and hexose uptake, and most are tumorigenic. their cloning efficiency in plastic dishes is not increased over that of normal quail embryo fibroblasts. the quail tumor cell lines do not produce endogenous avian oncovi ... | 1977 | 194709 |
| ["pharaoh" line culture of japanese quail cells as a leukosis-free system for virus reproduction]. | contamination of japanese quail, strain pharaoh, cell culture with oncogenous and infectious avian viruses was studied. the susceptibility of the embryonal cell cultures of the japanese quail, strain pharaoh, to measles, parotitis and fixed rabies viruses was also determined. it was found that the sera of pubertal quails had no antibody to rous sarcoma virus (rsv), strains brian, rsv (rav-1), schmidt-ruppin, carr-zilber, as well as to marek's disease and newcastle disease viruses. no reverse tra ... | 1980 | 6251636 |
| [study of viral contamination of japanese quail and cell cultures from their embryos]. | agents identified as adenovirus celo were isolated from organ suspensions of 1500 japanese quails (jq) in 4 experiments. no contaminating viruses were found in examinations of cell cultures prepared from the kidneys of 80 jq. negative results were obtained in examinations of 163 antigens from jq organs in the cofal test. agents identified as mycoplasma were isolated in 16 cases from 736 specimens of the virus-containing fluid used for manufacture of measles virus. according to the results of the ... | 1981 | 6266156 |
| the role of nk cells in tumor growth assessed by induction of their suppressor cells in japanese quails. | in japanese quails treated with chicken amniotic fluid (chamf) which had been previously shown to induce suppressor cells to natural killer (nk) cells, tumors appeared with shortened incubation periods after inoculation with schmidt-ruppin strain of rous sarcoma virus (sr-rsv) compared with untreated quails. the tumors in chamf-treated quails subsequently grew in a similar pattern to those in untreated quails, whereas by challenging with a lower dose of the virus, enhanced tumor growth was obser ... | 1981 | 6273620 |
| effector mechanisms against rous sarcomas in quail. | the inhibitory effect on tumor growth of thymus-derived cells in the avian virus system has been demonstrated by several investigators. here we report two kinds of experiments performed to test the role of various potential effector cells in the immune response against rous sarcomas. in vivo experiments in japanese quail using the antimacrophage agent silica implicate the macrophage as a further mechanism in the defense against rous sarcoma virus-induced tumors. induction of a nonspecific inflam ... | 1983 | 6308587 |
| cellular immunity induced by rous sarcoma virus in japanese quail. i. effect of anti-lymphocyte serum on oncogenesis of rous sarcoma virus. | | 1970 | 4323495 |
| the leukocyte response of japanese quail to rous sarcoma virus-induced tumors. | in male japanese quail, different circulating leukocyte responses were observed for progressors (birds developing a massive tumor that persisted throughout the experiment) and regressors (birds developing a tumor that gradually disappeared) after initial challenge with rous sarcoma virus (rsv). blood was sampled before and at weekly intervals postinoculation. blood smears were prepared and stained with diff quik, and a light microscope (1000 x) was used in a direct count of 50 fields. leukocytes ... | 1994 | 7832716 |
| dna in uninfected and virus-infected cells complementary to avian tumor virus rna. | the 70s rna component of several avian tumor viruses was hybridized with dna extracted from avian tumor virus-infected and uninfected chicken and japanese quail cells. tritium-labeled 70s rnas from rous sarcoma virus (rsv), rous associated virus-1 (rav-1), rav-60, and schmidt-ruppin-rsv (sr-rsv) hybridize from 3 to 10 times more with dna from uninfected chicken cells than with dna from escherichia coli, calfthymus, or baby hamster kidney cells. after infection of chicken cells with rsv(rav-1), s ... | 1971 | 4332808 |
| suppression of natural killer cell activity by chicken alpha-fetoprotein in japanese quails. | spleen cells taken from quails treated with chicken alpha-fetoprotein (ch-afp) showed reduced natural killer (nk) activity as did spleen cells taken from quails treated with chicken amniotic fluid (chamf) in which the presence of ch-afp was demonstrated by a gel precipitation test. the ch-afp-induced reduction of nk activity was shown to be mediated by suppressor cells. in addition, ch-afp-treated quails developed tumors with shorter latent periods than those of the tumors that developed in untr ... | 1983 | 6187964 |
| japanese quail egg embryo as a host for viruses. | rauscher, frank j. (national cancer institute, bethesda, md.), james a. reyniers, and miriam r. sacksteder. japanese quail egg embryo as a host for viruses. j. bacteriol. 84:1134-1139. 1962.-the egg embryo of japanese quail (coturnix coturnix japonica, temminck and schlegel) was found to support readily the growth of a wide range of viruses known to infect chicken eggs. methods commonly used in studying viruses in chicken eggs were modified and adapted to the quail egg. the procedures are descri ... | 1962 | 16561976 |
| induction and characterization of splenic suppressor cells directed to natural killer cells in japanese quails. | intravenous inoculation of chicken amniotic fluid (chamf) markedly reduced natural killer (nk) cell activity of spleen cells from japanese quails. the reduction of nk activity was mediated by non-adherent thymus-dependent lymphoid cells which were resistant to treatment with anti-immunoglobulin serum and sensitive to treatment with anti-thymocyte serum in the presence of complement. the suppressing activity was selectively directed to nk cells, since rous sarcoma virus-specific cytotoxicity or h ... | 1981 | 6458715 |
| tissue-specific expression of mouse tyrosinase gene in cultured chicken cells. | a mouse tyrosinase cdna has been combined with different promoters and inserted into several replication-competent avian leukosis proviruses and the viruses were transferred into cultured albino chick cells by viral infection. expression of the tyrosinase gene depended on one of four promoter sequences: the resident constitutive promoter (rous sarcoma virus long-terminal repeat; rsv-ltr), 471 bp from the mouse tyrosinase gene-associated promoter, 519 bp from the japanese quail tyrosinase gene as ... | 1994 | 8082718 |
| focus formation by japanese quail cells infected with rous sarcoma virus. | | 1963 | 14069826 |