| the interferon-alpha gene family of marmota himalayana, a chinese marmot species with susceptibility to woodchuck hepatitis virus infection. | the interferon-alpha (ifn-alpha) gene family is an important part of the immune system. recombinant interferon-alpha is widely used to treat viral hepatitis and malignant diseases. marmota himalayana has been found to be susceptible to woodchuck hepatitis virus, a virus genetically related to hepatitis b virus (hbv), and is suitable as an animal model for studies on hbv infection. here, the ifn-alpha gene family of m. himalayana (cwifn-alpha) was characterized. sequence data indicate that the cw ... | 2008 | 17936902 |
| evaluation of mitochondrial toxicity in marmota himalayana treated with metacavir, a novel 2',3'-dideoxyguanosine prodrug for treatment of hepatitis b virus. | metacavir (pna) is a novel synthetic nucleoside analogue for the treatment of hepatitis b virus (hbv). our recent studies showed that pna, a prodrug of 2',3'-dideoxyguanosine (ddg), exhibited lower mitochondrial toxicity in long-term cultures of hepg2 cells. in the current study, we examined the long-term effects of pna on mitochondrial toxicity in marmota himalayana (himalayan marmot). himalayan marmots were treated daily with oral pna (50 or 100 mg/kg), ziduvidine (azt) (100 mg/kg), or water ( ... | 2011 | 21282436 |
| transcriptome analysis and comparison of marmota monax and marmota himalayana. | the eastern woodchuck (marmota monax) is a classical animal model for studying hepatitis b virus (hbv) infection and hepatocellular carcinoma (hcc) in humans. recently, we found that marmota himalayana, an asian animal species closely related to marmota monax, is susceptible to woodchuck hepatitis virus (whv) infection and can be used as a new mammalian model for hbv infection. however, the lack of genomic sequence information of both marmota models strongly limited their application breadth and ... | 2016 | 27806133 |
| nucleoside analogues alone or combined with vaccination prevent hepadnavirus viremia and induce protective immunity: alternative strategy for hepatitis b virus post-exposure prophylaxis. | the current strategies for hepatitis b virus (hbv) post-exposure prophylaxis (pep) are not generally available in remote and rural areas of developing countries and/or carry potential risks for infection with blood-borne transmitted pathogens. nucleotide analogues (nas) are successfully used for human immunodeficiency virus pep, and maybe effective for hbv pep. in this study, we tested the na-based strategies for hbv pep using the chinese woodchuck model. | 2014 | 24583157 |
| molecular characterization of the type i ifn receptor in two woodchuck species and detection of its expression in liver samples from woodchucks infected with woodchuck hepatitis virus (whv). | type i interferons (ifn-α/β) serve as the first line of defense against viral infection and share the same type i ifn receptor (ifnar) complex, which is composed of ifnar1 and -2. the eastern woodchuck (marmota monax) and chinese woodchuck (marmota himalayana) are suitable for studying hepatitis b virus (hbv) infection. here, the complete or partial sequences of the ifnars of both species were obtained and analyzed. small interference rnas targeting wifnar1 and -2 specifically down-regulated the ... | 2012 | 22705153 |
| genetic and molecular features for hepadnavirus and plague infections in the himalayan marmot. | the himalayan marmot (marmota himalayana), a natural host and transmitter of plague, is also susceptible to the hepadnavirus infection. to reveal the genetic basis of the hepadnavirus susceptibility and the immune response to plague, we systematically characterized the features of immune genes in himalayan marmot with those of human and mouse. we found that the entire major histocompatibility complex region and the hepatitis b virus pathway genes of the himalayan marmot were conserved with those ... | 2020 | 32308030 |