| experimental transfection of macaca sylvanus with cloned human hepatitis b virus. | due to the absence of easily accessible animal models for the study of hepatitis b virus (hbv), the possibility of using macaca sylvanus, a monkey originating from morocco, north africa, was investigated. three monkeys were intrahepatically inoculated with a replication-competent head-to-tail hbv dna plasmid dimer construct. the hbv surface antigen and hbv dna were detected prior to alanine aminotransferase elevation in the serum of two of three hbv-inoculated monkeys at day 2 post-transfection ... | 2002 | 12075082 |
| discovery of naturally occurring transmissible chronic hepatitis b virus infection among macaca fascicularis from mauritius island. | despite a high prevalence of hepatitis b virus (hbv) infection in endangered apes, no hbv infection has been reported in small, old-world monkeys. in search for a small, nonhuman primate model, we investigated the prevalence of hbv infection in 260 macaque (cercopithecidae) sera of various geographical origins (i.e., morocco, mauritius island, and asia). hbv-positive markers were detected in cynomolgus macaques (macaca fascicularis) from mauritius island only, and, remarkably, hbv dna was positi ... | 2013 | 23536484 |