Publications
| efficient infection of primary tupaia hepatocytes with purified human and woolly monkey hepatitis b virus. | the asian tree shrew, tupaia belangeri, has been proposed as a novel animal model for studying hepatitis b virus (hbv) infection. here, we describe a protocol for efficient and reproducible infection of primary tupaia hepatocytes with hbv. we report that human serum interferes with hbv binding to the hepatocytes, thus limiting the maximum multiplicity of infection. purification of hbv virions by gradient sedimentation greatly enhances virus binding and infectivity. covalently closed circular dna ... | 2001 | 11333889 |
| prevention of hepatitis b virus infection in vivo by entry inhibitors derived from the large envelope protein. | 360 million people are chronically infected with the human hepatitis b virus (hbv) and are consequently prone to develop liver cirrhosis and hepatocellular carcinoma. as approved therapeutic regimens-which modulate patients' antiviral defenses or inhibit the viral reverse transcriptase-are generally noncurative, strategies interfering with other hbv replication steps are required. expanding on our demonstration that acylated peptides derived from the large hbv envelope protein block virus entry ... | 2008 | 18297057 |