delayed disease progression in cynomolgus macaques infected with ebola virus makona late 2013, the largest documented outbreak of ebola hemorrhagic fever started in guinea and has since spread to neighboring countries, resulting in almost 27,000 cases and >11,000 deaths in humans. in march 2014, ebola virus (ebov) was identified as the causative agent. this study compares the pathogenesis of a new ebov strain, makona, which was isolated in guinea in 2014 with the prototype strain from the 1976 ebov outbreak in the former zaire. both strains cause lethal disease in cynomolgus ...201526402165
transcriptome analysis of circulating immune cell subsets highlight the role of monocytes in zaire ebola virus makona pathogenesis.existing models of ebola virus disease (evd) suggest antigen-presenting cells are initial targets ofzaire ebolavirus(zebov).in vitrostudies have shown that zebov infection of monocytes and macrophages results in the production of inflammatory mediators, which may cause lymphocyte apoptosis. however, these findings have not been corroborated byin vivostudies. in this study, we report the first longitudinal analysis of transcriptional changes in purified monocytes, t-cells, and b-cells isolated fr ...201729123522
comparison of transcriptomic platforms for analysis of whole blood from ebola-infected cynomolgus macaques.ebola virus disease (evd) is a serious illness with mortality rates of 20-90% in various outbreaks. evd is characterized by robust virus replication and strong host inflammatory response. analyzing host immune responses has increasingly involved multimodal approaches including transcriptomics to profile gene expression. we studied cynomolgus macaques exposed to ebola virus makona via different routes with the intent of comparing rna-seq to a nanostring ncounter codeset targeting 769 non-human pr ...201729116224
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