| marburg virus angola infection of rhesus macaques: pathogenesis and treatment with recombinant nematode anticoagulant protein c2. | the procoagulant tissue factor (tf) is thought to play a role in the coagulation disorders that characterize filoviral infections. in this study, we evaluated the pathogenesis of lethal infection with the angola strain of marburg virus (marv-ang) in rhesus macaques and tested the efficacy of recombinant nematode anticoagulant protein c2 (rnapc2), an inhibitor of tf/factor viia, as a potential treatment. | 2007 | 17940973 |
| temporal characterization of marburg virus angola infection following aerosol challenge in rhesus macaques. | marburg virus (marv) infection is a lethal hemorrhagic fever for which no licensed vaccines or therapeutics are available. development of appropriate medical countermeasures requires a thorough understanding of the interaction between the host and the pathogen and the resulting disease course. in this study, 15 rhesus macaques were sequentially sacrificed following aerosol exposure to the marv variant angola, with longitudinal changes in physiology, immunology, and histopathology used to assess ... | 2015 | 26202230 |
| filoviruses infect rhesus macaque synoviocytes in vivo and primary human synoviocytes in vitro. | the most commonly reported symptom of post-ebola virus disease syndrome in survivors is arthralgia, yet involvement of the joints in acute or convalescent ebola virus infection is not well characterized in human patients or animal models. through immunohistochemistry, we found that the lining synovial intima of the stifle (knee) is a target for acute infection by ebola virus/kikwit, ebola virus/makona-c05, and marburg virus/angola in the rhesus macaque model. furthermore, histologic analysis, im ... | 2020 | 32479821 |