Publications
| structural analysis of covid-19 spike protein in recognizing the ace2 receptor of different mammalian species and its susceptibility to viral infection. | the pandemic covid-19 was caused by a novel coronavirus-2 (sars-cov-2) that infects humans through the binding of glycosylated sars-cov-2 spike 2 protein to the glycosylated ace2 receptor. the spike 2 protein recognizes the n-terminal helices of the glycosylated metalloprotease domain in the human ace2 receptor. to understand the susceptibility of animals for infection and transmission, we did sequence and structure-based molecular interaction analysis of 16 ace2 receptors from different mammali ... | 2021 | 33552834 |
| susceptibility of livestock to sars-cov-2 infection. | we report pilot studies to evaluate the susceptibility of common domestic livestock (cattle, sheep, goat, alpaca, rabbit, and horse) to intranasal infection with sars-cov-2. none of the infected animals shed infectious virus via nasal, oral, or faecal routes, although viral rna was detected in several animals. further, neutralizing antibody titres were low or non-existent one month following infection. these results suggest that domestic livestock are unlikely to contribute to sars-cov-2 epidemi ... | 2021 | 34749583 |