| directions for future research on the pathogenesis of arenaviral infections. | the pathogenesis of arenavirus infection is considered separately for the haemorrhagic fever (hf) syndrome and for lymphocytic choriomeningitis (lcm) virus infection of rodents. experimental models of hf have received only limited study, mainly because of the virulence of the causal agents. two useful models (junin virus in guinea-pigs and machupo virus in rhesus monkeys) are now available and an attempt is made to delineate crucial questions for future studies, including the physiology of shock ... | 1975 | 1085229 |
| candid no. 1 argentine hemorrhagic fever vaccine protects against lethal junin virus challenge in rhesus macaques. | the protective efficacy of candid no. 1, a live-attenuated vaccine against argentine hemorrhagic fever (ahf), was evaluated in non-human primates. twenty rhesus macaques immunized 3 months previously with graded doses of candid no. 1 (16-127, 000 pfu), as well as 4 placebo-inoculated controls, were challenged with 4.41 log10 pfu of virulent p3790 strain junin virus. all controls developed severe clinical disease; 3 of 4 died. in contrast, all vaccinated animals were fully protected; none develop ... | 1992 | 1338783 |
| aerosol infection of rhesus macaques with junin virus. | the purpose of our work was to determine if aerosols of junin virus can infect rhesus macaques and if the disease is the same as that produced by virus inoculated parenterally. the 6 macaques exposed to the virus by aerosol became acutely ill during the 3rd week after exposure, and all died. three died by day 21, while the remainder died after 1 month. junin virus was found primarily in visceral organs of those animals dying before 21 days after infection and in the central nervous system tissue ... | 1992 | 1371270 |
| actions of complement on junin virus. | fresh sera from normal rhesus monkeys, guinea pigs, and rabbits inactivated 90%-99% of the infectivity of vero cell-passaged, attenuated strains of junin virus (jv) within 60 minutes. selective depletion studies showed that inactivation occurred by the classical complement pathway. complement had little effect on virulent jv strains. adsorption of the fresh sera with jv-infected vero cells showed that inactivation was not mediated by low levels of antibodies in normal sera. the cells used for pr ... | 1989 | 2546249 |
| ribavirin prophylaxis and therapy for experimental argentine hemorrhagic fever. | junin virus-infected rhesus macaques received prophylactic and therapeutic ribavirin to assess the potential of this drug for treating humans with argentine hemorrhagic fever. when ribavirin was administered intramuscularly at the time of experimental infection with the lethal p3790 strain of junin virus, all animals were protected from clinical disease. a delay in the initiation of therapy until after the onset of illness resulted in improvement and resolution of systemic signs of disease; howe ... | 1988 | 2848441 |
| experimental argentine hemorrhagic fever in rhesus macaques: virus-specific variations in pathology. | two isolates of junin virus (espindola and ledesma) inoculated into rhesus macaques produced distinct lesions which were strain-constant and similar to reported human cases of argentine hemorrhagic fever. the espindola isolate was associated with hemorrhagia, necrosis of bone marrow, and mild hepatocellular necrosis. ledesma isolate was associated with pronounced polioencephalomyelitis and autonomic ganglioneuritis, but very mild or absent hepatocellular necrosis, bone marrow necrosis, and hemor ... | 1987 | 3039051 |
| safety and immunogenicity of a live-attenuated junin (argentine hemorrhagic fever) vaccine in rhesus macaques. | the safety and immunogenicity of candid #1, a live-attenuated junin virus vaccine, were evaluated in rhesus macaques. candid #1 was inoculated subcutaneously in graded doses ranging from 16 to 127,200 plaque-forming units (pfu) into four groups of five animals each; four controls received saline. there was no significant effect of the immunization on any physical, hematologic, or biochemical parameter measured. junin virus was recovered by cocultivation from peripheral blood mononuclear cells (p ... | 1993 | 8385886 |