| the uptake in vitro of dyes, monosaccharides and amino acids by the filarial worm brugia pahangi. | the uptake in vitro of various substances by brugia pahangi was investigated using infective larvae obtained from aedes aegypti and worms removed from meriones unguiculatus at 2, 3, 10, 20 and 90 days post-infection. worms incubated in growth medium 199 containing 1% trypan blue possessed demonstrable dye in the oral orifice, the anterior oesophageal lumen and the external openings of the vulva and the cloaca or anus but the dye was not found in the gut lumen even after incubation for 24 h. no u ... | 1979 | 481911 |
| quantitative aspects of the development of mosquito transmitted brugia malayi and brugia pahangi and their distribution in jirds, meriones unguiculatus. | twenty-two jirds, meriones unguiculatus, were exposed to the bites of 2250 females of aedes aegypti carrying an estimated total of 2464 larvae of brugia malayi, and 13 jirds were offered for blood feeding to 1450 mosquitoes infected with about 4460 larvae of brugia pahangi. on necropsy of the jirds, four months after feeding of the mosquitoes, a total of 88 adult filariae of b. malayi and 143 of b. pahangi were recovered in 20 and 13 jirds respectively. the majority of the adult filariae was obt ... | 1979 | 483379 |
| studies with brugia pahangi. 20. an investigation of 23 anthelmintics using different screening techniques. | 23 anthelmintics were tested against brugia pahangi microfilariae and infective larvae in vitro and in aedes aegypti infected with b. pahagi and jirds (meriones unguiculatus) infected with a b. pahangi/patei hybrid. there was little correlation between the results obtained in vitro and in infected insects and the results obtained in these tests gave no indication of the activity in jirds. three of the compounds were macrofilaricidal in jirds and these were tested in cats infected with b. pahangi ... | 1978 | 734717 |
| brugia malayi: ivermectin inhibits the exsheathment of microfilariae. | brugia malayi-infected microfilaremic jirds (meriones unguiculatus) were treated with ivermectin at a single dose of 200 micrograms/kg of body weight injected subcutaneously. susceptible aedes aegypti mosquitoes were fed on treated jirds 24 hours later. mosquitoes fed on untreated jirds served as controls. infected mosquitoes were dissected at 1, 3, 24, 48, 72, and 96 hr after the blood meal, and differential counts of sheathed microfilariae, exsheathed microfilariae, and cast sheaths were perfo ... | 1992 | 1539753 |
| on the infectivity of early third-stage brugia larvae isolated from the abdomen of aedes aegypti. | third-stage larvae (l3) of wuchereria bancrofti, brugia malayi and b. pahangi are known to be recovered not only from the head and thorax but also from the abdomen of dissected vector mosquitoes. for epidemiological reasons, was of interest to determine whether l3 larvae from the abdomen of the vector would be infectious for the final host. early abdominal l3 larvae of b. pahangi isolated as early as on day 7 post-infection (p.i.) from aedes aegypti were injected s.c. into five male meriones ung ... | 1992 | 1584752 |
| brugia malayi and brugia pahangi: transmission blocking activity of ivermectin and brugian filarial infections in aedes aegypti. | brugia malayi- or brugia pahangi-infected, microfilaremic jirds (meriones unguiculatus) were treated with ivermectin at a single dose of 200 micrograms/kg body weight, administered subcutaneously. after different time intervals, aedes aegypti mosquitoes were fed on treated or untreated jirds. sausage stage, l2, and l3 larvae failed to develop in mosquitoes that fed on jirds from 15 to 30 days post-treatment. after 1 month, the numbers of l3 larvae recovered from mosquitoes fed on treated b. paha ... | 1990 | 2209785 |
| variable infectivity of third-stage larvae of brugia malayi. | infectivity of third-stage larvae of brugia malayi was assessed following intraperitoneal inoculation into jirds, meriones unguiculatus. larvae were of two ages and were derived from two sites in aedes aegypti mosquitoes, i.e., specimens collected from the thorax 11 days after infection and from the head on day 14. larvae from the thorax had just completed the second moult and measured 990 to 1100 micron in length. only 6% of these specimens developed to adult worms in jirds. larvae that migrate ... | 1985 | 2866213 |
| the effect of different types of skin surfaces on the transmission of brugia pahangi infective larvae by the mosquito aedes aegypti. | the transmission of brugia pahangi from aedes aegypti into meriones unguiculatus was compared for four different skin surfaces (hairy, cloth, clean, greasy). unshaven jirds reduced the feeding avidity of infective mosquitoes. the loss of larvae from infective mosquitoes was greatest when these insects fed on "exposed" skin surfaces. significantly fewer infective larvae penetrated the host when infective mosquitoes fed on a jird through a thin layer of cloth. | 1985 | 3992643 |
| scanning electron microscope study on larvae of wuchereria bancrofti from the vector and from experimental rodent hosts. | the surface structures of larvae of wuchereria bancrofti from liberia were examined by scanning electron microscopy. for this study microfilariae from man, first-stage, second-stage, and third-stage larvae from the vector aedes aegypti, and fourth-stage larvae from the experimental rodent hosts mastomys natalensis and meriones unguiculatus were available. from these larvae the structure of the anterior ends, the cuticle in the midbody regions, and the posterior ends are presented. as an obvious ... | 1980 | 7003854 |
| the infectivity of microfilariae of brugia pahangi of different ages to aedes aegypti. | by transferring microfilariae of brugia pahangi which had been born over a 24-hour period in the peritoneal cavities of jirds (meriones unguiculatus) to the blood circulation of other jirds, infections of known age were tested for their ability to develop into third-stage larvae (l3) in mosquitoes aedes aegypti. microfilariae less than three days old were not able to develop to l3. microfilariae which had been in circulation for three days to six months were capable of developing if ingested. | 1982 | 7096971 |
| effect of ivermectin on two filaria-vector pairs. brugia malayi-aedes aegypti; litomosoides sigmodontis-bdellonyssus bacoti. | the effect of ivermectin was studied on two filaria-vector pairs, brugia malayi-aedes aegypti and litomosoides sigmodontis-bdellonyssus bacoti. the rodent hosts, respectively mastomys coucha and meriones unguiculatus, were treated with ivermectin doses of 0.05 mg/kg, or 0.2 mg/kg or 2 mg/kg. batches of vectors were fed on rodents, infected or not, treated or not, from h7 to d43 post-ivermectin. vector survival was observed and dissections were performed to study the filarial development. it appe ... | 1993 | 8215116 |
| susceptibility of various mosquitoes of california to subperiodic brugia malayi. | laboratory experiments were conducted to determine the susceptibility of six species of mosquitoes, representing three genera, to subperiodic brugia malayi. the black-eye, liverpool strain of aedes aegypti was the susceptible control. mosquitoes were fed on microfilaremic jirds (meriones unguiculatus). all mosquitoes, except wild caught culex erythrothorax, were laboratory-reared and allowed to feed when 8 to 10 days old. anopheles freeborni, anopheles hermsi, and culiseta inornata proved refrac ... | 1995 | 8533667 |
| comparative development of brugia pahangi and variation in acid hydrolase enzyme titers in. | the development of the filarial nematode brugia pahangi was monitored and compared in susceptible (black eye) and refractory (rock) strains of aedes aegypti. simultaneously, the activities of acid phosphatase, beta-glucuronidase, alpha-glucosidase, and n-acetyl-beta-glucosaminidase were measured. three- to five-day-old females of both strains were fed on infected and uninfected clawed jirds (meriones unguiculatus) then dissected or homogenized at 2 h, at 24-h intervals for 5 days, and at 8 and 1 ... | 2000 | 11198915 |
| suppression of brugia malayi (sub-periodic) larval development in aedes aegypti (liverpool strain) fed on blood of animals immunized with microfilariae. | preliminary studies were carried out to investigate the role of filarial specific antibodies, raised in an animal model against the filarial parasite, brugia malayi (sub-periodic), in blocking their early development in an experimental mosquito host, aedes aegypti (liverpool strain). in order to generate filarial specific antibodies, mongolian gerbils, meriones unguiculatus, were immunized either with live microfilariae (mf) of b. malayi or their homogenate. mf were harvested from the peritoneal ... | 2005 | 16113889 |