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differential tropism of sars-cov and sars-cov-2 in bat cells.severe acute respiratory syndrome coronavirus 2 did not replicate efficiently in 13 bat cell lines, whereas severe acute respiratory syndrome coronavirus replicated efficiently in kidney cells of its ancestral host, the rhinolophus sinicus bat, suggesting different evolutionary origins. structural modeling showed that rbd/rsace2 binding may contribute to the differential cellular tropism.202032730733
comparative tropism, replication kinetics, and cell damage profiling of sars-cov-2 and sars-cov with implications for clinical manifestations, transmissibility, and laboratory studies of covid-19: an observational study.severe acute respiratory syndrome coronavirus 2 (sars-cov-2) was reported from china in january, 2020. sars-cov-2 is efficiently transmitted from person to person and, in 2 months, has caused more than 82 000 laboratory-confirmed cases of coronavirus disease 2019 (covid-19) and 2800 deaths in 46 countries. the total number of cases and deaths has surpassed that of the 2003 severe acute respiratory syndrome coronavirus (sars-cov). although both covid-19 and severe acute respiratory syndrome (sars ...202032835326
genetic evolution analysis of 2019 novel coronavirus and coronavirus from other species.the corona virus disease 2019 (covid-19) caused by severe acute respiratory syndrome coronavirus 2 (sars-cov-2) is a public health emergency of international concern. however, so far, there are still controversies about the source of the virus and its intermediate host. here, we found the novel coronavirus was closely related to coronaviruses derived from five wild animals, including paguma larvata, paradoxurus hermaphroditus, civet, aselliscus stoliczkanus and rhinolophus sinicus, and was in th ...202032169673
infection of bat and human intestinal organoids by sars-cov-2.a novel coronavirus-severe acute respiratory syndrome coronavirus 2 (sars-cov-2)-emerged in humans in wuhan, china, in december 2019 and has since disseminated globally1,2. as of april 16, 2020, the confirmed case count of coronavirus disease 2019 (covid-19) had surpassed 2 million. based on full-genome sequence analysis, sars-cov-2 shows high homology to sars-related coronaviruses identified in horseshoe bats1,2. here we show the establishment and characterization of expandable intestinal organ ...202032405028
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