Publications

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serologic survey for selected arboviruses and other potential pathogens in wildlife from mexico.during 1988 and 1989, a serologic survey of wildlife was conducted in northeastern mexico to determine the presence, prevalence, and distribution of arboviruses and other selected disease agents. eighty mammal specimens were tested. antibodies to vesicular stomatitis-indiana, venezuelan equine encephalitis-mena ii, rio grande virus, and vesicular stomatitis-new jersey were detected predominantly in small mammals. deer and mouflon (ovis musimon) had antibodies to bluetongue and epizootic hemorrha ...19921512876
serological evidence of california group and cache valley virus infection in minnesota white-tailed deer.blood samples were obtained from 138 white-tailed deer (odocoileus virginianus) harvested at three sites surrounding the greater minneapolis-st. paul, minnesota, metropolitan area (usa) and tested for neutralizing antibody to cache valley virus and three california serogroup (jamestown canyon, la crosse, trivittatus) viruses (bunyaviridae). deer at each site had neutralizing antibody to one or more california serogroup viruses and/or cache valley virus. the majority of adult deer (85%) had antib ...19911906113
investigations of the vertebrate hosts of eastern equine encephalitis during an epizootic in michigan, 1980.a study was undertaken to investigate an increase in reported cases of clinical encephalitis due to eastern equine encephalitis (eee) virus in horses and to determine the natural vertebrate hosts of that virus. horses, birds, and small mammals were sampled at sites in a contiguous area in st. joseph and kalamazoo counties, michigan, from 25 august to 5 september 1980. serum samples from four horses acutely ill with encephalitis and 16 of 39 pasture mates of ill horses had neutralizing (n) antibo ...19853010751
isolation of cache valley virus and detection of antibody for selected arboviruses in michigan horses in 1980.blood samples collected in september and november 1980 from 87 horses in southwestern michigan were examined for virus isolation and for plaque-reduction neutralizing antibody against selected arboviruses. cache valley virus was isolated from the blood of a clinically normal horse in st joseph county in september. the age-specific antibody prevalence for cache valley virus indicated enzootic transmission in the study area. the high antibody prevalence and the lack of age-specific antibody preval ...19873631684
cache valley virus in the del mar va peninsula. 3. serologic evidence for natural infection of dairy cattle. 19704192339
virus isolations from mosquitoes in southern ontario, 1976 and 1977.following the 1975 epidemic of st. louis encephalitis (sle) in ontario, programs were instituted to monitor virus activity in mosquito populations during 1976 and 1977. mosquitoes were trapped with cdc light traps and co2 cone traps, pooled by species, and tested for virus by intracerebral inoculation of suckling mice. in 1976, 51 175 mosquitoes were tested. sle virus was isolated from two mixed pools of culex pipiens--c. restuans mosquitoes. five isolations of california serogroup viruses were ...19806103747
epidemiological investigation for arboviruses in jamaica, west indies.arbovirus investigation in jamaica was undertaken between 1960 and 1975. serological studies showed that antibodies to dengue type virus and st. louis encephalitis virus (sle) were prevalent throughout the island for several years. in urban communities, the incidence of dengue antibody was higher than for sle; however, in children under 10 years of age antibody to both viruses was rarely present. in rural areas, sle was prevalent in adults and children. this virus was isolated fom culex nigripal ...19807406115
cache valley and potosi viruses (bunyaviridae) in white-tailed deer (odocoileus virginianus): experimental infections and antibody prevalence in natural populations.cache valley virus (cvv) and potosi virus (potv) are two closely related mosquito-borne viruses (bunyaviridae: bunyamwera group) that appear to circulate in several regions of the united states, especially the midwest. we determined the prevalence of specific neutralizing antibodies to both viruses in indiana white-tailed deer and conducted infection experiments to assess whether deer could serve as an vertebrate-amplifying host. cross-infection experiments also were carried out to investigate t ...19989840585
serologic survey for selected infectious disease agents in swift and kit foxes from the western united states.a serologic survey of swift fox (vulpes velox) and kit fox (v. macrotis) from the western usa was conducted for 12 infectious diseases. samples from swift fox were collected between 1987 and 1992 from colorado (n = 44), kansas (n = 10), and wyoming (n = 9). samples from kit fox were collected in california (n = 86), new mexico (n = 18), utah (n = 9), and arizona (n = 6). overall antibody prevalence rates were 33 of 110 (30%) for canine parvovirus (cpv), 9 of 72 (13%) for canine distemper virus ( ...200011085448
detection of adventitious viruses in biologicals--a rare occurrence.adventitious virus assays are performed as part of raw materials testing, cell-line characterization, and lot-release testing of biologicals such as monoclonal antibodies, gene therapy vectors, recombinant proteins, and vaccines. the testing methods follow guidance provided in the 9 cfr (bovine and porcine raw materials testing, and certain vaccine products) or points to consider documents (cell line characterization and evaluation of the majority of biologicals). the methodologies used and the ...200616566443
evaluation of the eastern cottontail sylvilagus floridanus as an amplifying vertebrate host for cache valley virus (bunyaviridae) in indiana.to evaluate the importance of eastern cottontails (sylvilagus floridanus) as amplifying hosts for cache valley virus (cvv), we tested hunter-provided blood samples from northern indiana for specific neutralizing (n) antibodies against this mosquito-borne bunya-virus. samples were collected during the winter of 1994-95. two seronegative eastern cottontails, captured in july 1995, were also infected with cvv by subcutaneous inoculation, and two others were infected by allowing cvv-infected mosquit ...200818263839
adventitious viruses detected in biopharmaceutical bulk harvest samples over a 10 year period.while viral safety is a major concern for biologics manufactured using mammalian cells, the numbers of viral contamination events reported in the literature are quite low. during a 10-year period during which biologics derived from a variety of mammalian cell culture processes were evaluated using the in vitro virus screening assay, only reovirus type 2 and cache valley virus were detected, and these only in biologics manufactured in chinese hamster ovary (cho) cells. from the literature, we kno ...201021502056
major emerging vector-borne zoonotic diseases of public health importance in canada.in canada, the emergence of vector-borne diseases may occur via international movement and subsequent establishment of vectors and pathogens, or via northward spread from endemic areas in the usa. re-emergence of endemic vector-borne diseases may occur due to climate-driven changes to their geographic range and ecology. lyme disease, west nile virus (wnv), and other vector-borne diseases were identified as priority emerging non-enteric zoonoses in canada in a prioritization exercise conducted by ...201526954882
arboviruses in north dakota, 2003-2006.to investigate arbovirus transmission in north dakota, we collected and screened mosquitoes for viral infection by vero cell culture assay. seven viruses were isolated from 13 mosquito species. spatial and temporal distributions of the important vectors of west nile virus (wnv), cache valley virus, jamestown canyon virus (jcv), and trivittatus virus are reported. snowshoe hare virus, potosi virus, and western equine encephalomyelitis virus were also isolated. the risks of culex tarsalis and aede ...201425487728
spatial-temporal analysis of cache valley virus (bunyaviridae: orthobunyavirus) infection in anopheline and culicine mosquitoes (diptera: culicidae) in the northeastern united states, 1997-2012.cache valley virus (cvv) is a mosquito-borne bunyavirus (family bunyaviridae, genus orthobunyavirus) that is enzootic throughout much of north and central america. white-tailed deer (odocoileus virginianus) have been incriminated as important reservoir and amplification hosts. cvv has been found in a diverse array of mosquito species, but the principal vectors are unknown. a 16-year study was undertaken to identify the primary mosquito vectors in connecticut, quantify seasonal prevalence rates o ...025325321
monitoring sheep and culicoides midges in montana for evidence of bunyamwera serogroup virus infection.a serological and entomological investigation was performed to monitor for potential bunyamwera (bun) serogroup virus activity in montana.201426392881
orthobunyaviruses, a common cause of infection of livestock in the yucatan peninsula of mexico.to determine the seroprevalence of selected orthobunyaviruses in livestock in the yucatan peninsula of mexico, a serologic investigation was performed using serum samples from 256 domestic animals (182 horses, 31 sheep, 1 dog, 37 chickens, and 5 turkeys). all serum samples were examined by plaque reduction neutralization test using cache valley virus (cvv), cholul virus (chlv), south river virus (sourv), kairi virus, maguari virus, and wyeomyia virus. of the 182 horses, 60 (33.0%) were seroposit ...201223045250
what can akabane disease teach us about other arboviral diseases.viruses of the simbu serogroup cause lesions to foetuses that are seen at birth and that correlate with the stage of pregnancy at which the dam first contracts the virus. the simbu serogroup comprises arboviruses known to cause outbreaks of abnormal parturitions in domestic ruminants; these abnormalities include abortion, stillbirth, and congenitally deformed neonates. simbu serogroup members include: akabane virus (akav), aino virus, cache valley virus, and schmallenberg virus. lately, dairy he ...201627723047
serological survey for antibodies to mosquito-borne bunyaviruses among us national park service and us forest service employees.serum samples from 295 employees of great smoky mountains national park (grsm), rocky mountain national park (romo), and grand teton national park with adjacent bridger-teton national forest (grte-btnf) were subjected to serological analysis for mosquito-borne bunyaviruses. the sera were analyzed for neutralizing antibodies against six orthobunyaviruses: la crosse virus (lacv), jamestown canyon virus (jcv), snowshoe hare virus (sshv), california encephalitis virus, and trivittatus virus (tvtv) b ...201626855300
isolations of cache valley virus from aedes albopictus (diptera: culicidae) in new jersey and evaluation of its role as a regional arbovirus vector.the asian tiger mosquito, aedes albopictus (skuse), is an invasive species and a major pest problem in urban and suburban locales in new jersey. to assess its potential role as an arbovirus vector, we sampled ae. albopictus from two new jersey counties over a 3-yr period and estimated the prevalence of virus infection by vero cell culture and reverse transcription-polymerase chain reaction assays. three virus isolates were obtained from 34,567 field-collected ae. albopictus, and all were identif ...201324843937
northern range expansion of the asian tiger mosquito (aedes albopictus): analysis of mosquito data from connecticut, usa.the asian tiger mosquito (aedes albopictus) is an invasive species and important arbovirus vector that was introduced into the u.s. in the 1980's where it continues to expand its range. winter temperature is an important constraint to its northward expansion, with potential range limits located between the 0° and -5°c mean cold month isotherm. connecticut is located within this climatic zone and therefore, ae. albopictus was monitored statewide to assess its northern range expansion and to delin ...201728545111
seroprevalence of cache valley virus and related viruses in sheep and other livestock from saskatchewan, canada.cache valley virus, an orthobunyavirus, is an important cause of ovine neonatal malformations. information on the seroprevalence of this virus in saskatchewan livestock populations is lacking. the objectives of this study were to determine the seroprevalence of cache valley virus and closely related viruses in sheep, cattle, goats, horses, and mule deer in saskatchewan by performing a plaque-reduction neutralization test using cache valley virus. in total, sera from 130 sheep from 50 flocks were ...201829606729
cache valley virus in aedes japonicus japonicus mosquitoes, appalachian region, united states.we detected cache valley virus in aedes japonicus, a widely distributed invasive mosquito species, in an appalachian forest in the united states. the forest contained abundant white-tailed deer, a major host of the mosquito and virus. vector competence trials indicated that ae. j. japonicus mosquitoes can transmit this virus in this region.201829460762
seasonal distribution, blood-feeding habits, and viruses of mosquitoes in an open-faced quarry in connecticut, 2010 and 2011.seasonal abundance of mosquitoes, their viruses, and blood-feeding habits were determined at an open-faced quarry in north branford, ct, in 2010 and 2011. this unique habitat had not previously been sampled for mosquitoes and mosquito-borne viruses. thirty species of mosquitoes were identified from 41,719 specimens collected. coquillettidia perturbans, aedes trivittatus, and ae. vexans were the most abundant species and represented 34.5%, 17.7%, and 14.8% of the totals, respectively. jamestown c ...201831442119
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