| laguna negra virus associated with hps in western paraguay and bolivia. | a large outbreak of hantavirus pulmonary syndrome (hps) recently occurred in the chaco region of paraguay. using pcr approaches, partial virus genome sequences were obtained from 5 human sera, and spleens from 5 calomys laucha rodents from the outbreak area. genetic analysis revealed a newly discovered hantavirus, laguna negra (ln) virus, to be associated with the hps outbreak and established a direct genetic link between the virus detected in the hps cases and in the c. laucha rodents, implicat ... | 1997 | 9375015 |
| laguna negra virus associated with hps in western paraguay and bolivia. | a large outbreak of hantavirus pulmonary syndrome (hps) recently occurred in the chaco region of paraguay. using pcr approaches, partial virus genome sequences were obtained from 5 human sera, and spleens from 5 calomys laucha rodents from the outbreak area. genetic analysis revealed a newly discovered hantavirus, laguna negra (ln) virus, to be associated with the hps outbreak and established a direct genetic link between the virus detected in the hps cases and in the c. laucha rodents, implicat ... | 1997 | 9375015 |
| patterns of infection with laguna negra virus in wild populations of calomys laucha in the central paraguayan chaco. | in 1995, an outbreak of hantavirus pulmonary syndrome occurred in the central paraguayan chaco. the primary reservoir of the virus, laguna negra virus, was identified as the vesper mouse, calomys laucha. over a 15-month period, we collected 1,090 small mammals at 12 locations representing 4 habitats common in the central paraguayan chaco. calomys laucha was common in agricultural habitats and uncommon in the native forest habitat. populations of c. laucha were greater during the dry season month ... | 2001 | 11791973 |
| patterns of infection with laguna negra virus in wild populations of calomys laucha in the central paraguayan chaco. | in 1995, an outbreak of hantavirus pulmonary syndrome occurred in the central paraguayan chaco. the primary reservoir of the virus, laguna negra virus, was identified as the vesper mouse, calomys laucha. over a 15-month period, we collected 1,090 small mammals at 12 locations representing 4 habitats common in the central paraguayan chaco. calomys laucha was common in agricultural habitats and uncommon in the native forest habitat. populations of c. laucha were greater during the dry season month ... | 2001 | 11791973 |
| analysis of hantavirus genetic diversity in argentina: s segment-derived phylogeny. | nucleotide sequences were determined for the complete s genome segments of the six distinct hantavirus genotypes from argentina and for two cell culture-isolated andes virus strains from chile. phylogenetic analysis indicates that, although divergent from each other, all argentinian hantavirus genotypes group together and form a novel phylogenetic clade with the andes virus. the previously characterized south american hantaviruses laguna negra virus and rio mamore virus make up another clade tha ... | 2002 | 11907216 |
| hantavirus pulmonary syndrome in northwestern argentina: circulation of laguna negra virus associated with calomys callosus. | the purpose of this study was to characterize the hantaviruses circulating in northwestern argentina. human and rodent studies were conducted in yuto, where most cases of hantavirus pulmonary syndrome (hps) occur. partial virus genome sequences were obtained from the blood of 12 cases of hps, and from the lungs of 4 calomys callosus and 1 akodon simulator. phylogenetic analysis showed that three genotypes associated with hps circulate in yuto. laguna negra (ln) virus, associated with c. laucha i ... | 2004 | 15569801 |
| hantavirus pulmonary syndrome in northwestern argentina: circulation of laguna negra virus associated with calomys callosus. | the purpose of this study was to characterize the hantaviruses circulating in northwestern argentina. human and rodent studies were conducted in yuto, where most cases of hantavirus pulmonary syndrome (hps) occur. partial virus genome sequences were obtained from the blood of 12 cases of hps, and from the lungs of 4 calomys callosus and 1 akodon simulator. phylogenetic analysis showed that three genotypes associated with hps circulate in yuto. laguna negra (ln) virus, associated with c. laucha i ... | 2004 | 15569801 |
| identifying rodent hantavirus reservoirs, brazil. | we describe the genetic analysis of samples from hantavirus pulmonary syndrome (hps) patients from southern and southeastern states of brazil and rodents captured at the presumed site of infection of these patients. a total of 65 samples that were antibody-positive for sin nombre or laguna negra virus by enzyme-linked immunosorbent assay were processed by nested reverse transcription-polymerase chain reaction (rt-pcr) by using several primer combinations in the m and s genome segments. pcr produ ... | 2004 | 15663849 |
| identifying rodent hantavirus reservoirs, brazil. | we describe the genetic analysis of samples from hantavirus pulmonary syndrome (hps) patients from southern and southeastern states of brazil and rodents captured at the presumed site of infection of these patients. a total of 65 samples that were antibody-positive for sin nombre or laguna negra virus by enzyme-linked immunosorbent assay were processed by nested reverse transcription-polymerase chain reaction (rt-pcr) by using several primer combinations in the m and s genome segments. pcr produ ... | 2004 | 15663849 |
| hantavirus pulmonary syndrome in central bolivia: relationships between reservoir hosts, habitats, and viral genotypes. | in august 2002, two cases of hantavirus pulmonary syndrome (hps) were confirmed in mineros and concepcion, within the santa cruz department of bolivia. extensive alteration of the native ecosystem, from dense forest to pasture or sugarcane, had occurred in both regions. an ecologic assessment of reservoir species associated with the human disease identified a single hantavirus antibody-positive oligoryzomys microtis from mineros and three hantavirus antibody-positive calomys callosus from concep ... | 2005 | 15728866 |
| hantavirus pulmonary syndrome in central bolivia: relationships between reservoir hosts, habitats, and viral genotypes. | in august 2002, two cases of hantavirus pulmonary syndrome (hps) were confirmed in mineros and concepcion, within the santa cruz department of bolivia. extensive alteration of the native ecosystem, from dense forest to pasture or sugarcane, had occurred in both regions. an ecologic assessment of reservoir species associated with the human disease identified a single hantavirus antibody-positive oligoryzomys microtis from mineros and three hantavirus antibody-positive calomys callosus from concep ... | 2005 | 15728866 |
| truncated hantavirus nucleocapsid proteins for serotyping sin nombre, andes, and laguna negra hantavirus infections in humans and rodents. | sin nombre virus (snv), andes virus (andv), and laguna negra virus (lanv) have been known as the dominant causative agents of hantavirus pulmonary syndrome (hps). andv and lanv, with different patterns of pathogenicity, exist in a sympatric relationship. moreover, there is documented evidence of person-to-person transmission of andv. therefore, it is important in clinical medicine and epidemiology to know the serotype of a hantavirus causing infection. truncated snv, andv, and lanv recombinant n ... | 2010 | 20335425 |
| rickettsia bellii, rickettsia amblyommii, and laguna negra hantavirus in an indian reserve in the brazilian amazon. | the purpose of this study was to identify the presence of rickettsia and hantavirus in wild rodents and arthropods in response to an outbreak of acute unidentified febrile illness among indians in the halataikwa indian reserve, northwest of the mato grosso state, in the brazilian amazon. where previously surveillance data showed serologic evidence of rickettsia and hantavirus human infection. | 2014 | 24742108 |
| rickettsia bellii, rickettsia amblyommii, and laguna negra hantavirus in an indian reserve in the brazilian amazon. | the purpose of this study was to identify the presence of rickettsia and hantavirus in wild rodents and arthropods in response to an outbreak of acute unidentified febrile illness among indians in the halataikwa indian reserve, northwest of the mato grosso state, in the brazilian amazon. where previously surveillance data showed serologic evidence of rickettsia and hantavirus human infection. | 2014 | 24742108 |
| viral load of patients with hantavirus pulmonary syndrome in argentina. | hantavirus causes severe illness including pneumonia, which leads to hospitalization and often death. at present, there is no specific treatment available. the hantavirus pathogenesis is not well understood, but most likely both virus-mediated and host-mediated mechanisms, are involved. the aim of this study was to correlate viral load in samples of hantavirus pulmonary syndrome cases and hantavirus infected individuals, with clinical epidemiological parameters and disease outcome. the variables ... | 2015 | 26087934 |
| detection of different south american hantaviruses. | hantaviruses are the etiologic agents of hemorrhagic fever with renal syndrome (hfrs) in old world, and hantavirus pulmonary syndrome (hps)/hantavirus cardiopulmonary syndrome (hcps), in the new world. serological methods are the most common approach used for laboratory diagnosis of hcps, however theses methods do not allow the characterization of viral genotypes. the polymerase chain reaction (pcr) has been extensively used for diagnosis of viral infections, including those caused by hantavirus ... | 2015 | 26220480 |
| laguna negra virus infection causes hantavirus pulmonary syndrome in turkish hamsters (mesocricetus brandti). | laguna negra virus (lnv) is a new world hantavirus associated with severe and often fatal cardiopulmonary disease in humans, known as hantavirus pulmonary syndrome (hps). five hamster species were evaluated for clinical and serologic responses following inoculation with 4 hantaviruses. of the 5 hamster species, only turkish hamsters infected with lnv demonstrated signs consistent with hps and a fatality rate of 43%. clinical manifestations in infected animals that succumbed to disease included s ... | 2016 | 25722219 |
| laguna negra virus infection causes hantavirus pulmonary syndrome in turkish hamsters (mesocricetus brandti). | laguna negra virus (lnv) is a new world hantavirus associated with severe and often fatal cardiopulmonary disease in humans, known as hantavirus pulmonary syndrome (hps). five hamster species were evaluated for clinical and serologic responses following inoculation with 4 hantaviruses. of the 5 hamster species, only turkish hamsters infected with lnv demonstrated signs consistent with hps and a fatality rate of 43%. clinical manifestations in infected animals that succumbed to disease included s ... | 2016 | 25722219 |
| hantavirus pulmonary syndrome in santa cruz, bolivia: outbreak investigation and antibody prevalence study. | we report the results of an investigation of a small outbreak of hantavirus pulmonary syndrome in 2002 in the department of santa cruz, bolivia, where the disease had not previously been reported. two cases were initially reported. the first case was a physician infected with laguna negra virus during a weekend visit to his ranch. four other persons living on the ranch were igm antibody-positive, two of whom were symptomatic for mild hantavirus pulmonary syndrome. the second case was a migrant s ... | 2012 | 23094116 |
| hantavirus pulmonary syndrome in santa cruz, bolivia: outbreak investigation and antibody prevalence study. | we report the results of an investigation of a small outbreak of hantavirus pulmonary syndrome in 2002 in the department of santa cruz, bolivia, where the disease had not previously been reported. two cases were initially reported. the first case was a physician infected with laguna negra virus during a weekend visit to his ranch. four other persons living on the ranch were igm antibody-positive, two of whom were symptomatic for mild hantavirus pulmonary syndrome. the second case was a migrant s ... | 2012 | 23094116 |
| molecular epidemiology of laguna negra virus, mato grosso state, brazil. | we associated laguna negra virus with hantavirus pulmonary syndrome in mato grosso state, brazil, and a previously unidentified potential host, the calomys callidus rodent. genetic testing revealed homologous sequencing in specimens from 20 humans and 8 mice. further epidemiologic studies may lead to control of hps in mato grosso state. | 2012 | 22607717 |
| molecular epidemiology of laguna negra virus, mato grosso state, brazil. | we associated laguna negra virus with hantavirus pulmonary syndrome in mato grosso state, brazil, and a previously unidentified potential host, the calomys callidus rodent. genetic testing revealed homologous sequencing in specimens from 20 humans and 8 mice. further epidemiologic studies may lead to control of hps in mato grosso state. | 2012 | 22607717 |
| a lethal disease model for new world hantaviruses using immunosuppressed syrian hamsters. | hantavirus, the hemorrhagic causative agent of two clinical diseases, is found worldwide with variation in severity, incidence and mortality. the most lethal hantaviruses are found on the american continent where the most prevalent viruses like andes virus and sin nombre virus are known to cause hantavirus pulmonary syndrome. new world hantavirus infection of immunocompetent hamsters results in an asymptomatic infection except for andes virus and maporal virus; the only hantaviruses causing a le ... | 2017 | 29077702 |
| a lethal disease model for new world hantaviruses using immunosuppressed syrian hamsters. | hantavirus, the hemorrhagic causative agent of two clinical diseases, is found worldwide with variation in severity, incidence and mortality. the most lethal hantaviruses are found on the american continent where the most prevalent viruses like andes virus and sin nombre virus are known to cause hantavirus pulmonary syndrome. new world hantavirus infection of immunocompetent hamsters results in an asymptomatic infection except for andes virus and maporal virus; the only hantaviruses causing a le ... | 2017 | 29077702 |