| genetic identification of a new hantavirus causing severe pulmonary syndrome in argentina. | a fatal case of serologically confirmed hantavirus pulmonary syndrome (hps) was recently reported in southwestern argentina. nucleotide sequence analysis of pcr fragments from conserved regions of the s and m genomic segments of the virus, amplified from rna extracted from autopsy lung and liver tissues, showed the virus (referred as andes virus) to be novel. comparisons between andes virus genome sequences with the corresponding sequences of the more closely related hantaviruses revealed differ ... | 1996 | 8659118 |
| genetic diversity and epidemiology of hantaviruses in argentina. | phylogenetic analysis of a 292-nucleotide (nt) fragment of the hantavirus m genome segment from 36 rodent and 13 human samples from three known foci of hantavirus infection in argentina was conducted. a 1654-nt fragment of the m genome segment was analyzed for 1 representative of 7 genetically distinct hantavirus lineages identified. additionally, the nt sequence of the complete m genome segments of lechiguanas, oran, and hu39694 hantavirus genotypes was determined. nt sequence comparisons revea ... | 1998 | 9498428 |
| hantavirus pulmonary syndrome outbreak in argentina: molecular evidence for person-to-person transmission of andes virus. | an increase of hantavirus pulmonary syndrome (hps) cases around a southwestern argentina town and in persons living 1400 km away but in contact with those cases was detected during the spring of 1996. in order to evaluate person-to-person transmission we compared the homology of pcr-amplified viral sequences of 26 argentine and chilean cases. sixteen of them were epidemiologically linked cases and had the same sequence (epilink/96) in the s segment 3' noncoding region and in the m segment partia ... | 1998 | 9499807 |
| [epidemic outbreak of hantavirus pulmonary syndrome in argentina. molecular evidence of person to person transmission of andes virus]. | | 1998 | 9674243 |
| an outbreak of hantavirus pulmonary syndrome, chile, 1997. | an outbreak of 25 cases of andes virus-associated hantavirus pulmonary syndrome (hps) was recognized in southern chile from july 1997 through january 1998. in addition to the hps patients, three persons with mild hantaviral disease and one person with asymptomatic acute infection were identified. epidemiologic studies suggested person-to-person transmission in two of three family clusters. ecologic studies showed very high densities of several species of sigmodontine rodents in the area. | 1998 | 9866751 |
| [prevalence of anti-hantavirus antibodies in health care personnel in direct contact with patients with hantavirus pulmonary syndrome in temuco, chile 1997 to 1999]. | an outbreak of hantavirus cardiopulmonary syndrome (hvcs) caused by the andes virus, affected chile since 1995. antibodies to hantavirus in health care workers who had cared patients with hvcs in coybaique, argentinean reports and familial clustering of bantaviral illness, raised the possibility of person to person transmission. familial clustering could occur secondary to a similar exposure to a common infected environment of more than one member of the family. moreover, the prevalence of antib ... | 2000 | 11050834 |
| risks and prevention of nosocomial transmission of rare zoonotic diseases. | americans are increasingly exposed to exotic zoonotic diseases through travel, contact with exotic pets, occupational exposure, and leisure pursuits. appropriate isolation precautions are required to prevent nosocomial transmission of rare zoonotic diseases for which person-to-person transmission has been documented. this minireview provides guidelines for the isolation of patients and management of staff exposed to the following infectious diseases with documented person-to-person transmission: ... | 2001 | 11170953 |
| hantavirus pulmonary syndrome due to andes virus in temuco, chile: clinical experience with 16 adults. | to describe the clinical features and laboratory abnormalities of 16 adults with confirmed hantavirus pulmonary syndrome (hps) due to andes virus in temuco, chile. | 2001 | 11502657 |
| a lethal disease model for hantavirus pulmonary syndrome. | hantaviruses are associated with two human diseases, hemorrhagic fever with renal syndrome (hfrs) and hantavirus pulmonary syndrome (hps). development of vaccines and therapies to prevent and treat hfrs and hps have been hampered by the absence of a practical animal model. here we report that andes virus (andv), a south american hantavirus, is highly lethal in adult syrian hamsters. the characteristics of the disease in hamsters, including the incubation period, symptoms of rapidly progressing r ... | 2001 | 11601912 |
| [hantavirus in human and rodent population in an endemic area for hantavirus pulmonary syndrome in argentina]. | this paper analyzed the prevalence and distribution of serological reactivity to hantavirus (antibody against andes virus) of human population exposed to hantavirus and rodents trapped in the studied area. this study was developed in salta (orán and san martín departments), area with the highest incidence for hantavirus pulmonary syndrome (hps) in argentina. in december 1997, 453 healthy people were studied by serology and 39 rodents by serology and pcr. the studied individuals were distributed ... | 2002 | 11965841 |
| andes virus and first case report of bermejo virus causing fatal pulmonary syndrome. | two suspected hantavirus pulmonary syndrome (hps) cases from bolivia occurred in may and july 2000 and were confirmed by enzyme-linked immunosorbent assay (elisa)-andes using n-andes recombinant antigen serology. clot rnas from the two patients were subjected to reverse transcription-polymerase chain reaction (pcr) amplification and sequencing. we describe two characterized cases of hps. one was caused by infection with bermejo virus and the other with andes nort viral lineage, both previously o ... | 2002 | 11971782 |
| first human isolate of hantavirus (andes virus) in the americas. | we isolated andes virus (formal name: andes virus [andv], a species in the genus hantavirus), from serum of an asymptomatic 10-year-old chilean boy who died 6 days later of hantavirus pulmonary syndrome (hps). the serum was obtained 12 days after his grandmother died from hps and 2 days before he became febrile. no hantavirus immunoglobulin (ig) g or igm antibodies were detected in the serum sample. after three blind passages, andv antigens were detected in vero e6 cells by immunofluorescence as ... | 2002 | 12095430 |
| elevated generation of reactive oxygen/nitrogen species in hantavirus cardiopulmonary syndrome. | hantavirus cardiopulmonary syndrome (hcps) is a life-threatening respiratory disease characterized by profound pulmonary edema and myocardial depression. most cases of hcps in north america are caused by sin nombre virus (snv), which is carried asymptomatically by deer mice (peromyscus maniculatus). the underlying pathophysiology of hcps is poorly understood. we hypothesized that pathogenic snv infection results in increased generation of reactive oxygen/nitrogen species (rons), which contribute ... | 2002 | 12134039 |
| complete nucleotide sequence of a chilean hantavirus. | we have determined the genomic sequence of an andes virus (andv) strain isolated from an infected oligoryzomys longicaudatus rodent trapped in chile in 1997. this strain, for which we propose the designation chile r123, reproduces essential attributes of hantavirus pulmonary syndrome (hps) when injected intramuscularly into laboratory hamsters (hooper et al., virology 289 (2001) 6-14). the l, m, and s segment sequences of chile r123 are 6562, 3671, and 1871 nt long, respectively, with an overall ... | 2002 | 12367756 |
| andes virus infection of cynomolgus macaques. | andes virus (andv), a member of the genus hantavirus, is a causative agent of hantavirus pulmonary syndrome (hps) and is the only hantavirus known to be transmissible from person to person. hps is found in north and south america and is often fatal. to test the virulence of andv in nonhuman primates, we exposed cynomolgus macaques to andes virus, either intravenously or by aerosol. the monkeys did not manifest clinical disease but showed significant lymphocyte decreases between days 8 and 11 pos ... | 2002 | 12447754 |
| active and passive vaccination against hantavirus pulmonary syndrome with andes virus m genome segment-based dna vaccine. | hantavirus pulmonary syndrome (hps) is a rapidly progressing human disease with one of the highest case fatality rates (30 to 50%) of any acute viral disease known. there are no vaccines, effective antiviral drugs, or immunologics to prevent or treat hps. in an attempt to develop hps medical countermeasures, we constructed an expression plasmid, pwrg/and-m, that contains the full-length m genome segment of andes virus (andv), a south american hantavirus. transfection experiments in cell culture ... | 2003 | 12941899 |
| hantavirus infection in children. | this article focuses on recent developments in knowledge about hantavirus infections and hantavirus cardiopulmonary syndrome in children. we highlight clinical characterization, epidemiology, pathogenesis, diagnostic techniques, and current alternatives for treatment and prevention. | 2004 | 14758117 |
| development of reassortant viruses between pathogenic hantavirus strains. | segment reassortment of negative strand viruses is an important mechanism for the development of new virus strains with altered pathogenicity. this study reports on in vitro generation of reassortants between andes (andv) and sin nombre (snv) viruses. although they both cause hantavirus pulmonary syndrome (hps), andv is the only hantavirus that has been transmitted from person to person (). following dual infection of cells with andv and snv, 8.9% of 337 progeny plaques contained reassortants, o ... | 2004 | 15351210 |
| hantavirus pulmonary syndrome in latin america. | since the identification of hantavirus pulmonary syndrome in the united states in 1993, latin america has been the region of the world where more hantaviruses have been identified, associated with human disease or not. this update shows the advances in the study of hantaviruses in several countries of the region and the problems that are still unresolved. | 2004 | 15353962 |
| andes virus stimulates interferon-inducible mxa protein expression in endothelial cells. | mxa is a cellular protein activated in cells treated with type i interferons. mxa protein is a member of the dynamin superfamily of large guanosine triphosphatases. a unique property of mx1 gtpases is their antiviral activity against a wide range of rna viruses. replication of several hantavirus strains is inhibited in cells constitutively expressing mxa protein. we have found that andes virus (andv) infection up regulates transcription of mxa rna and expression of mxa protein in human endotheli ... | 2005 | 15602733 |
| interactions and trafficking of andes and sin nombre hantavirus glycoproteins g1 and g2. | this study was designed to investigate the trafficking of andes virus (andv) and sin nombre virus (snv) glycoproteins and to determine if andv or snv glycoproteins g1 and g2 could be substituted for each other while still retaining normal trafficking. trafficking of hantaan virus (hntv) and snv glycoproteins has been studied and conflicting results were published regarding the golgi targeting of g1 and g2 when expressed individually. the results reported in this manuscript suggest that both snv ... | 2005 | 15629773 |
| andes virus m genome segment is not sufficient to confer the virulence associated with andes virus in syrian hamsters. | sin nombre virus (snv) and andes virus (andv), members of the genus hantavirus, in the family bunyaviridae, are causative agents of hantavirus pulmonary syndrome (hps) in north and south america, respectively. although andv causes a lethal hps-like disease in hamsters, snv, and all other hps-associated hantaviruses that have been tested, cause asymptomatic infections of laboratory animals, including hamsters. in an effort to understand the pathogenicity of andv in the hamster model, we generated ... | 2004 | 15262501 |
| hantavirus gc glycoprotein: evidence for a class ii fusion protein. | hantavirus cell entry is promoted by its envelope glycoproteins, gn and gc, through cell attachment and by fusion between viral and endosomal membranes at low ph. however, the role of gn and gc in receptor binding and cell fusion has not yet been defined. in this work, a sequence presenting characteristics similar to those of class ii fusion peptides (fps) of alphavirus e1 and flavivirus e proteins is identified within the hantavirus gc glycoprotein. a three-dimensional comparative molecular mod ... | 2005 | 16227214 |
| hantaan/andes virus dna vaccine elicits a broadly cross-reactive neutralizing antibody response in nonhuman primates. | at least four hantavirus species cause disease with prominent renal involvement-hemorrhagic fever with renal syndrome (hfrs); and several hantavirus strains cause disease with significant pulmonary involvement-hantavirus pulmonary syndrome (hps). the most prevalent and lethal hantaviruses associated with hfrs and hps are hantaan virus (htnv) and andes virus (andv), respectively. here, we constructed a dna vaccine plasmid (pwrg/ha-m) that contains both the htnv and andv m gene segments. rhesus ma ... | 2006 | 16378630 |
| [new epidemiologic and molecular evidence of person to person transmission of hantavirus andes sout]. | after the hantavirus pulmonary syndrome (hps) outbreak occurred in southern argentina (patagonia) in 1996, a new mechanism of hantavirus spread was described for andes virus (and): person-to-person transmission. since then, this mode of transmission has been limited to the endemic area of and sout lineage. we report here an hps case, patient a, with residence in buenos aires province, whose unique epidemiological risk factor was to have shared a trip to southern argentina with an already ill per ... | 2004 | 15034956 |
| peridomestic small mammals associated with confirmed cases of human hantavirus disease in southcentral chile. | cases of human hantavirus disease have been reported in chile since 1995, most of them in people living in rural and periurban areas. we conducted a peridomestic study of small mammals to evaluate the relationships between the presence of rodents with antibodies to andes virus confirmed human cases of hantavirus pulmonary syndrome in southcentral chile. the results of 20 sampled sites, which involved the capture of 272 mice over an 18-month period, showed the occurrence of 10 small mammal specie ... | 2004 | 15031522 |
| prevalence of antibodies to hantavirus among family and health care worker contacts of persons with hantavirus cardiopulmonary syndrome: lack of evidence for nosocomial transmission of andes virus to health care workers in chile. | nosocomial transmission of andes virus has been documented in argentina, but has not yet been proven in chile. we studied 215 contacts (106 family member contacts and 109 health care worker contacts) of 20 index cases of hantavirus cardiopulmonary syndrome (hcps) in chile. the seroprevalence of igg antibodies against andes virus was 1.9% (95% confidence interval [ci] = 0.34-6.3%) among the family members and 0.0% (95% ci = 0-3.2%) among the health care workers. our data suggest that there is no ... | 2004 | 15031521 |
| the complex ecology of hantavirus in paraguay. | following an outbreak of hantavirus pulmonary syndrome (hps) in the paraguayan chaco in 1995, calomys laucha was identified as the rodent host for the hantavirus associated with these cases. to explore the possibility of additional hantaviruses in paraguay, we collected 636 mammals from 10 of the 17 departments. plasma from 27 animals in alto paraguay and boquer6n in the chaco and neembucú and itapúa in the eastern region had antibody to andes virus antigens. of these 27, five individuals (among ... | 2003 | 14628942 |
| complete sequence of the genome of the human isolate of andes virus chi-7913: comparative sequence and protein structure analysis. | we report here the complete genomic sequence of the chilean human isolate of andes virus chi-7913. the s, m, and l genome segment sequences of this isolate are 1,802, 3,641 and 6,466 bases in length, with an overall gc content of 38.7%. these genome segments code for a nucleocapsid protein of 428 amino acids, a glycoprotein precursor protein of 1,138 amino acids and a rna-dependent rna polymerase of 2,152 amino acids. in addition, the genome also has other orfs coding for putative proteins of 34 ... | 2003 | 14513715 |
| characterization of shock in a hamster model of hantavirus infection. | human hantavirus cardiopulmonary syndrome (hcps) due to andes, sin nombre and other hantaviruses is characterized by severe pulmonary capillary leak and cardiogenic shock. hamsters, the only animal manifesting hcps-like disease, were instrumented with radiotelemeters that enabled ambulatory intracarotid blood pressure recording within an animal biosafety level-4 facility. following infection with andes virus, blood pressure and heart rate decreased slowly in a biphasic manner during the first 7 ... | 2006 | 16950493 |
| serological survey of hantavirus in jardinopolis county, brazil. | hantaviruses are the causative agents of severe human diseases such as cardiopulmonary syndrome (cps), described for the first time in 1993. approximately 200 cases of this emergent disease were reported in brazil until august 2002, with a 40% fatality rate. in may 2001, a hantavirus serologic survey was carried out among 15-70-year-old inhabitants of jardinopolis county, state of são paulo, brazil. blood samples of 818 inhabitants from urban and rural areas were collected by digitopuncture and ... | 2003 | 12966548 |
| hantavirus prevalence in the ix region of chile. | an epidemiologic and seroprevalence survey was conducted (n=830) to assess the proportion of persons exposed to hantavirus in ix region chile, which accounts for 25% of reported cases of hantavirus cardiopulmonary syndrome. this region has three geographic areas with different disease incidences and a high proportion of aboriginals. serum samples were tested for immunoglobulin (ig) g antibodies by enzyme-linked immunosorbent assay against sin nombre virus n antigen by strip immunoblot assay agai ... | 2003 | 12890323 |
| andes hantavirus as possible cause of disease in travellers to south america. | hantaviruses in europe and asia cause haemorrhagic fever with renal syndrome and epidemic nephritis (mortality rate <1-15%). new strains of hantaviruses cause hantavirus pulmonary syndrome (hps) from canada to south america. andes virus mortality rate is about 30% in chile. | 2007 | 17161316 |
| andes virus associated with hantavirus pulmonary syndrome in northern argentina and determination of the precise site of infection. | hantavirus pulmonary syndrome (hps) has been documented in the salta and jujuy provinces of northern argentina since 1991 and 1997, respectively, accounting for almost 50% of the cases of hps reported in this country. andes (and) virus, specifically the and virus nort lineage, was previously associated with human disease in this region. genetic analysis of viral medium rna segments obtained from 18 hps cases showed the existence of three and virus nort sublineages co-circulating in these two pro ... | 2002 | 12224579 |
| complete nucleotide sequence of the m rna segment of andes virus and analysis of the variability of the termini of the virus s, m and l rna segments. | hantavirus pulmonary syndrome (hps) has been recognized increasingly as a significant public health problem in south america since andes virus was first discovered in argentina. here, the isolation of andes virus is reported from an infected rodent captured in argentina in close vicinity to the place of the first hps case, ah1. the complete nucleotide sequences of the virus m segment, partial l segment and the termini of the s, m and l segment genome rnas were determined. the andes virus m rna s ... | 2002 | 12185264 |
| prospective evaluation of household contacts of persons with hantavirus cardiopulmonary syndrome in chile. | andes virus (andv) infection, which has a case fatality rate of 37% in chile, often occurs in household clusters and may be transmitted from person to person. | 2007 | 17471425 |
| temporal analysis of andes virus and sin nombre virus infections of syrian hamsters. | andes virus (andv) and sin nombre virus (snv) are rodent-borne hantaviruses that cause a highly lethal hemorrhagic fever in humans known as hantavirus pulmonary syndrome (hps). there are no vaccines or specific drugs to prevent or treat hps, and the pathogenesis is not understood. syrian hamsters infected with andv, but not snv, develop a highly lethal disease that closely resembles hps in humans. here, we performed a temporal pathogenesis study comparing andv and snv infections in hamsters. snv ... | 2007 | 17475651 |
| detection and typing of human pathogenic hantaviruses by real-time reverse transcription-pcr and pyrosequencing. | because the clinical course of human infections with hantaviruses can vary from subclinical to fatal, rapid and reliable detection of hantaviruses is essential. to date, the diagnosis of hantavirus infection is based mainly on serologic assays, and the detection of hantaviral rna by the commonly used reverse transcription (rt)-pcr is difficult because of high sequence diversity of hantaviruses and low viral loads in clinical specimens. | 2007 | 17717126 |
| cross-protection against challenge with puumala virus after immunization with nucleocapsid proteins from different hantaviruses. | hantaviruses are rodent-borne agents that cause hemorrhagic fever with renal syndrome or hantavirus pulmonary syndrome in humans. the nucleocapsid protein (n) is relatively conserved among hantaviruses and highly immunogenic in both laboratory animals and humans, and it has been shown to induce efficient protective immunity in animal models. to investigate the ability of recombinant n (rn) from different hantaviruses to elicit cross-protection, we immunized bank voles with rn from puumala (puuv) ... | 2002 | 12050380 |
| hantavirus pulmonary syndrome: at the crossroads. | the initial identification in 1993 of hantavirus pulmonary syndrome as a novel, highly fatal respiratory illness among american indians in the southwestern usa in 1993 opened the window to the recognition of a well-established pan-american zoonosis with a myriad of causative viruses and rodent vectors, although all are new world hantaviruses among new world sigmodontine rodents. the clinical spectrum of symptoms has also been expanded to include asymptomatic infection through to fulminant hemorr ... | 2001 | 11979134 |
| analysis of hantavirus genetic diversity in argentina: s segment-derived phylogeny. | nucleotide sequences were determined for the complete s genome segments of the six distinct hantavirus genotypes from argentina and for two cell culture-isolated andes virus strains from chile. phylogenetic analysis indicates that, although divergent from each other, all argentinian hantavirus genotypes group together and form a novel phylogenetic clade with the andes virus. the previously characterized south american hantaviruses laguna negra virus and rio mamore virus make up another clade tha ... | 2002 | 11907216 |
| seasonal variation in prevalence of antibody to hantaviruses in rodents from southern argentina. | we conducted a small mammal trapping study to investigate temporal variation in prevalence of infection in hantavirus reservoir populations in the patagonian andes mountain range, rio negro province, argentina. rodent blood samples collected in natural and periurban habitats and at the home of an hantavirus pulmonary syndrome (hps) case patient were analysed by enzyme-linked immunosorbent assay. organ tissue samples were tested by polymerase chain reaction (pcr) and nucleotide sequence analysis. ... | 2001 | 11679129 |
| [hantavirus pulmonary syndrome in buenos aires province]. | in argentina the first hantavirus pulmonary syndrome (hps) cases were characterized in 1995. since then, argentina is the country with the highest number of notified cases in south america. the disease is distributed in northern, southern and central regions of the country, being buenos aires the most affected province from the central region. in this study, we present seasonal and geographical distribution of hps cases in buenos aires province, the association with diverse viral lineages and th ... | 2001 | 11374136 |
| [hantavirus pulmonary syndrome in southern argentina]. | andes virus was identified in 1995 as the etiologic agent of hantavirus pulmonary syndrome (hps) in southern argentina. we describe herein the main clinical characteristics of 25 hps confirmed cases acquired in this area between 1993 and september 1999. the mean age was 34 years (range 11-70), with 72% males. clinical characteristics were similar to those previously reported for sin nombre virus (snv) cases. however, in this group of patients we also observed conjuntival injection in 10/25 (42%) ... | 2000 | 11050803 |
| choclo virus infection in the syrian golden hamster. | andes virus and choclo virus are agents of hantavirus pulmonary syndrome. andes virus in hamsters almost always causes a disease that is pathologically indistinguishable from fatal hantavirus pulmonary syndrome. the purpose of this study was to assess the pathogenicity of choclo virus in hamsters. none of 18 hamsters infected with choclo virus exhibited any symptom of disease. no evidence of inflammation or edema was found in the lungs of the 10 animals killed on days 7, 9, 11, 13, and 16 post-i ... | 2008 | 18385367 |
| synthesis of 1-beta-d-ribofuranosyl-3-ethynyl-[1,2,4]triazole and its in vitro and in vivo efficacy against hantavirus. | there are no fda approved drugs for the treatment of hemorrhagic fever with renal syndrome (hfrs), a serious human illnesses caused by hantaviruses. clinical studies using ribavirin (rbv) to treat hfrs patients suggest that it provides an improved prognosis when given early in the course of disease. given the unique antiviral activity of rbv and the lack of other lead scaffolds, we prepared a diverse series of 3-substituted 1,2,4-triazole-beta-ribosides and identified one with antiviral activity ... | 2008 | 18394724 |
| [hantavirus in chile: review and cases analysis since 1975]. | since the identification of the first case of hantavirus infection in chile in 1995, a great advance in the knowledge of the disease natural history has occurred. there is evidence to suppose that the infection by andes virus in suburban areas of argentina and chile, whose natural reservoir is oligoryzomys longicaudatus, has been present but unidentified for a long time. we describe a serologically proven case occurred in 1975. the clinical presentation of the disease slightly differs from that ... | 1999 | 10835761 |
| development and evaluation of a solid-phase enzyme immunoassay based on andes hantavirus recombinant nucleoprotein. | hantavirus pulmonary syndrome (hps) with high mortality rate has been reported in five countries in south america. rapid accurate methods are important both for monitoring acute infections and for epidemiological studies. the andes virus nucleoprotein amino acid sequence has a high identity percentage compared with other sequences of this region and has been chosen for the development of diagnostic reagents. andes nucleoprotein expressed in escherichia coli was applied as antigen in igg, iga and ... | 2000 | 10670565 |
| assessment of person-to-person transmission of hantavirus pulmonary syndrome in a chilean hospital setting. | person-to-person transmission of andes hantavirus among healthcare workers was reported in argentina for the first time in 1996. to determine whether such transmission of the virus occurred during a 1997 outbreak of hantavirus pulmonary syndrome (hps) in southern chile due to andes virus, we conducted a serological and epidemiological study in the coyhaique regional hospital, where the majority of hps patients were admitted. workers in every department of the hospital were evaluated for immunogl ... | 1998 | 9868619 |
| rio mamore virus: genetic characterization of a newly recognized hantavirus of the pygmy rice rat, oligoryzomys microtis, from bolivia. | human hantavirus disease occurs throughout much of south america. the rodent hosts and the specific etiologic agent(s) are largely unknown, but many reported cases occurred within the habitation ranges of oryzomine rodents (rice rats). we have identified a genetically novel hantavirus (rio mamore virus [rm]) of the pygmy rice rat oligoryzomys microtis in bolivia. the complete sequence of the small (s) genome and the partial sequence of the medium (m) genome are described. this virus is closely r ... | 1997 | 9311652 |
| hantaan virus nucleocapsid protein binds to importin alpha proteins and inhibits tumor necrosis factor alpha-induced activation of nuclear factor kappa b. | hantaviruses such as hantaan virus (htnv) and andes virus cause two human diseases, hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome, respectively. for both, disease pathogenesis is thought to be immunologically mediated and there have been numerous reports of patients with elevated levels of proinflammatory and inflammatory cytokines, including tumor necrosis factor alpha (tnf-alpha), in their sera. multiple viruses have developed evasion strategies to circumvent the host ... | 2009 | 19019947 |
| genetic characterization and phylogeny of andes virus and variants from argentina and chile. | andes virus, one of five hantaviruses known to cause hantavirus pulmonary syndrome (hps), emerged in 1995 in southwestern argentina (lópez et al. (1996) virology 220, 223-226). the complete nucleotide sequence of andes virus s genome segment was determined and compared with sequences of viral rnas in autopsy tissues of more recently reported hps cases from southwestern argentina and south of chile (cases esq h-1/96 and ch h-1/96). andes virus s segment was found to be 1876 nucleotides in length ... | 1997 | 9255937 |
| distribution and abundance of sigmodontine rodents in relation to hantavirus in neuquén, argentina. | in order to estimate spatial distribution, temporal variation, and prevalence of andes hantavirus antibody in the rodent community, and especially in oligoryzomys longicaudatus populations, four different ecosystems were trapped seasonally between spring 2001 and winter 2002 in neuquen, northwestern argentinean patagonia. five peridomestic settings were sampled within the same period. the rodent o. longicaudatus had the widest distribution in neuquen, as it was the only species captured at every ... | 2005 | 16007965 |
| human and rodent humoral immune responses to andes virus structural proteins. | in the present work we identified b-cell epitopes recognized by sera of humans and rodents naturally infected with andes virus, a hantavirus present in chile and argentina. analysis of patient and rodent sera with overlapping peptides revealed 21 human and rodent epitopes on the three structural proteins. whereas in the nucleoprotein the region comprising aa 248-260 was shown to be the key determinant of human sera, the major antigenic site of rodent antibody reactivity is located at aa 326-338. ... | 2005 | 15780882 |
| adenovirus vectors expressing hantavirus proteins protect hamsters against lethal challenge with andes virus. | hantaviruses infect humans following aerosolization from rodent feces and urine, producing hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. due to the high rates of mortality and lack of therapies, vaccines are urgently needed. nonreplicating adenovirus (ad) vectors that express andes hantavirus (andv) nucleocapsid protein (adn) or glycoproteins (adg(n) and adg(c)) were constructed. ad vectors were tested for their ability to protect syrian hamsters from a lethal andv inf ... | 2009 | 19403663 |
| phage display selection of cyclic peptides that inhibit andes virus infection. | specific therapy is not available for hantavirus cardiopulmonary syndrome caused by andes virus (andv). peptides capable of blocking andv infection in vitro were identified using antibodies against andv surface glycoproteins gn and gc to competitively elute a cyclic nonapeptide-bearing phage display library from purified andv particles. phage was examined for andv infection inhibition in vitro, and nonapeptides were synthesized based on the most-potent phage sequences. three peptides showed leve ... | 2009 | 19515773 |
| sensitivity of andes hantavirus to antiviral effect of human saliva. | | 2009 | 19624946 |
| community-acquired pneumonia: new facets of an old disease--hantavirus pulmonary syndrome. | it seems that with climatic and geoecologic changes, hantaviruses have re-emerged as human pathogens related to increases in interaction between humans and rodent reservoirs. infection with snv in north america and the andes virus in south america can produce infection manifest initially as a flu-like illness. in the setting of a history of possible exposure to rodents or their excreta, clinical symptoms and laboratory clues such as thrombocytopenia should raise the suspicion of hps. clinical de ... | 2005 | 15763221 |
| evaluation of an enzyme-linked immunosorbent assay based on araraquara virus recombinant nucleocapsid protein. | laboratory diagnosis of hantavirus cardiopulmonary syndrome (hcps) in brazil has been performed mostly by detection of igm antibodies to recombinant antigen purified from sin nombre virus and andes virus (andv). recently, a recombinant nucleocapsid (rn) protein of araraquara virus (arav), a brazilian hantavirus, was obtained in escherichia coli. to evaluate arav rn as antigen for antibody detection, serum samples from 30 patients from argentina seropositive for hantavirus were tested. all sample ... | 2009 | 19635882 |
| transmission study of andes hantavirus infection in wild sigmodontine rodents. | our study was designed to contribute to an understanding of the timing and conditions under which transmission of andes hantavirus in oligoryzomys longicaudatus reservoir populations takes place. mice were caged in test habitats consisting of steel drums containing holding cages, where seronegative rodents were exposed to wild seropositive individuals by freely sharing the same cage or being separated by a wire mesh. tests were also performed for potential viral transmission to mice from excreme ... | 2004 | 15479837 |
| study of andes virus entry and neutralization using a pseudovirion system. | andes virus (andv), a member of the hantavirus genus in the family bunyaviridae, causes an acute disease characteristic of new-world hantaviruses called hantavirus pulmonary syndrome (hps). hps is a highly pathogenic disease with a case-fatality rate of 40%. andv is the only hantavirus reported to spread directly from human-to-human. the aim of the present study was to develop a quantitative and high-throughput pseudovirion assay to study andv infection and neutralization in biosafety level 2 fa ... | 2010 | 19903496 |
| bidirectional virus secretion and nonciliated cell tropism following andes virus infection of primary airway epithelial cell cultures. | hantavirus pulmonary syndrome (hps) is an acute disease resulting from infection with any one of a number of new world hantaviruses. hps has a mortality rate of 40% and, unlike many other severe respiratory diseases, often occurs in young, healthy adults. infection is usually initiated after inhalation of rodent excreta containing virus particles, but human-to-human transmission has been documented. postmortem tissue samples show high levels of viral antigen within the respiratory endothelium, b ... | 2006 | 16414986 |
| highly differentiated, resting gn-specific memory cd8+ t cells persist years after infection by andes hantavirus. | in man, infection with south american andes virus (andv) causes hantavirus cardiopulmonary syndrome (hcps). hcps due to andv is endemic in southern chile and much of argentina and increasing numbers of cases are reported all over south america. a case-fatality rate of about 36% together with the absence of successful antiviral therapies urge the development of a vaccine. although t-cell responses were shown to be critically involved in immunity to hantaviruses in mouse models, no data are availa ... | 2010 | 20174562 |
| serological assays for the detection of human andes hantavirus infections based on its yeast-expressed nucleocapsid protein. | the objective of the study was to develop and evaluate igm and igg elisas and an igg western blot test for the serological detection of human infections with andes virus (andv), the major cause of hantavirus cardiopulmonary syndrome (hcps) in south america. | 2006 | 16428893 |
| person-to-person transmission of andes virus. | despite the fact that rodents are considered to be the infectious source of hantavirus for humans, another route of transmission was demonstrated. andes virus (andv) has been responsible for most of the cases recorded in argentina. person-to-person transmission of andv sout lineage was described during an outbreak of hantavirus pulmonary syndrome in southwest argentina. in this study, we analyzed 4 clusters that occurred in 2 disease-endemic areas for different andv lineages. we found new eviden ... | 2005 | 16485469 |
| neutralizing antibodies in survivors of sin nombre and andes hantavirus infection. | we evaluated titers of homotypic and heterotypic neutralizing antibodies (nabs) to andes and sin nombre hantaviruses in plasma samples from 20 patients from chile and the united states. all but 1 patient had high titers of nab. none of the plasma samples showed high titers against the heterologous virus. | 2006 | 16494739 |
| pathogenic hantaviruses andes virus and hantaan virus induce adherens junction disassembly by directing vascular endothelial cadherin internalization in human endothelial cells. | hantaviruses infect endothelial cells and cause 2 vascular permeability-based diseases. pathogenic hantaviruses enhance the permeability of endothelial cells in response to vascular endothelial growth factor (vegf). however, the mechanism by which hantaviruses hyperpermeabilize endothelial cells has not been defined. the paracellular permeability of endothelial cells is uniquely determined by the homophilic assembly of vascular endothelial cadherin (ve-cadherin) within adherens junctions, which ... | 2010 | 20463083 |
| development of a lentiviral vector system to study the role of the andes virus glycoproteins. | to infect target cells, enveloped viruses use their virion surface proteins to direct cell attachment and subsequent entry via virus-cell membrane fusion. how hantaviruses enter cells has been largely unexplored. to study early steps of andes virus (andv) cell infection, a lentiviral vector system was developed based on a simian immunodeficiency virus (siv) vector pseudotyped with the andv-gn/gc envelope glycoproteins. the incorporation of gn and gc onto siv-derived vector particles was assessed ... | 2010 | 20619306 |
| diagnosis and treatment of new world hantavirus infections. | the purpose of this review is to summarize the current knowledge regarding the diagnosis and treatment of indigenous new world hantavirus infections. | 2006 | 16940866 |
| the 3' untranslated region of the andes hantavirus small mrna functionally replaces the poly(a) tail and stimulates cap-dependent translation initiation from the viral mrna. | in the process of translation of eukaryotic mrnas, the 5' cap and the 3' poly(a) tail interact synergistically to stimulate protein synthesis. unlike its cellular counterparts, the small mrna (smrna) of andes hantavirus (andv), a member of the bunyaviridae, lacks a 3' poly(a) tail. here we report that the 3' untranslated region (3'utr) of the andv smrna functionally replaces a poly(a) tail and synergistically stimulates cap-dependent translation initiation from the viral mrna. stimulation of tra ... | 2010 | 20660206 |
| incubation period of hantavirus cardiopulmonary syndrome. | the potential incubation period from exposure to onset of symptoms was 7-39 days (median 18 days) in 20 patients with a defined period of exposure to andes virus in a high-risk area. this period was 14-32 days (median 18 days) in 11 patients with exposure for <48 hours. | 2006 | 16965713 |
| rapid immunochromatographic test for hantavirus andes contrasted with capture-igm elisa for detection of andes-specific igm antibodies. | hantavirus is associated with hemorrhagic fever with renal syndrome (hfrs) and hantavirus pulmonary syndrome (hps). the clinical diagnosis of hantavirus infections has been confirmed routinely by the immunofluorescence antibody assay (ifa) or enzyme-linked immunosorbent assay (elisa). a rapid and easy diagnostic test for hantavirus infection is required. a new immunochromatographic assay for hantavirus, poc-puu, useful for the diagnosis of epidemic nephrophaty associated with hantavirus puumala ... | 2007 | 17133547 |
| andes and prospect hill hantaviruses differ in early induction of interferon although both can downregulate interferon signaling. | hantavirus pulmonary syndrome (hps) is a severe respiratory disease which is thought to result from a dysregulated immune response to infection with pathogenic hantaviruses, such as sin nombre virus or andes virus (andv). other new world hantaviruses, such as prospect hill virus (phv), have not been associated with human disease. activation of an antiviral state and cell signaling in response to hantavirus infection were examined using human primary lung endothelial cells, the main target cell i ... | 2007 | 17202220 |
| detection of crimean-congo hemorrhagic fever, hanta, and sandfly fever viruses by real-time rt-pcr. | the development of sensitive and specific nucleic acid diagnostic assays for viral pathogens is essential for proper medical intervention. this chapter describes four fluorescence-based pcr assays to detect the crimean-congo hemorrhagic fever (cchfv), andes (andv), hantaan (hanv), and sandfly fever sicilian (sfsv) viruses. these assays are based on species-specific hydrolysis probes targeting the nucleocapsid protein gene for cchfv and sfsv and the glycoprotein gene for andv and hanv. all four a ... | 2011 | 21116810 |
| aromatic and polar residues spanning the candidate fusion peptide of the andes virus gc protein are essential for membrane fusion and infection. | hantaviruses infect human cells through cell attachment and subsequent fusion of viral and cellular membranes at low ph. this largely unknown entry process is mediated by the gn and gc glycoproteins, anchored at the viral envelope membrane. performing bioinformatic analysis and peptide-liposome-binding assays we suggested in a former report that gc of andes virus (andv) and other hantaviruses corresponds to the viral fusion protein sharing characteristics with class ii fusion proteins. to gain i ... | 2010 | 21123541 |
| clusters of hantavirus infection, southern argentina. | person-to-person transmission of a hantavirus was first confirmed during a 1996 outbreak of hantavirus pulmonary syndrome in southern argentina, where andes virus is endemic. to identify other episodes of secondary transmission, we reviewed reports of 51 cases of hantavirus infection from this region (november 1993-june 2005). nine clusters involving 20 cases (39.2%) were found. two patients, who had symptoms 3 weeks after they shared risks for rodent exposure, were considered a cluster. the oth ... | 2007 | 17370522 |
| [genetic susceptibility to andes hantavirus: association between severity of disease and hla alíeles in chilean patients]. | andes hantavirus (andv) infection in chile has a variable clinical expression, and infected individuals may present with different grades of disease severity. this study aimed to determine if clinical expression of andv infection in chilean patients is associated with the hla system. hla alíeles a, b, drb1 and dqb1, were studied in two groups of patients with confirmed andv infection: 41 patients with a mild disease course (without respiratory failure and cardiovascular shock) and 46 patients wi ... | 2007 | 17989838 |
| hantavirus pulmonary syndrome: encephalitis caused by virus andes. | hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome (hps) are rodent-borne emerging diseases caused by members of the genus hantavirus, family bunyaviridae. some species of hantavirus may cause encephalitis, but this is the first report in andes virus associated to hps. | 2011 | 21240581 |
| immune serum produced by dna vaccination protects hamsters against lethal respiratory challenge with andes virus. | hantavirus pulmonary syndrome (hps) is a highly pathogenic disease (40% case fatality rate) carried by rodents chronically infected with certain viruses within the genus hantavirus of the family bunyaviridae. the primary mode of transmission to humans is thought to be inhalation of excreta from infected rodents; however, ingestion of contaminated material and rodent bites are also possible modes of transmission. person-to-person transmission of hps caused by one species of hantavirus, andes viru ... | 2008 | 18032485 |
| maporal virus as a surrogate for pathogenic new world hantaviruses and its inhibition by favipiravir. | pathogenic hantaviruses geographically distributed in the old world cause haemorrhagic fever with renal syndrome (hfrs), whereas new world hantaviruses are the aetiological agents of hantavirus cardiopulmonary syndrome (hcps). ribavirin, a drug associated with toxicities, is presently indicated for treatment of hfrs, whereas treatment of the more frequently lethal hcps is limited to supportive care. because of the need for safe and effective antivirals to treat severe hantaviral infections, we e ... | 2011 | 21566265 |
| new and old world hantaviruses differentially utilize host cytoskeletal components during their life cycles. | recently we reported that the n protein of the old world hantavirus, hantaan (htnv), traffics on microtubules to the er-golgi intermediate compartment (ergic) prior to its movement to the golgi and requires an intact ergic for viral replication. we have extended these studies to the new world hantaviruses, andes virus (andv) and black creek canal virus (bccv), and an additional old world hantavirus, seoul virus (seov). these studies support microtubule-dependent trafficking of the n protein to e ... | 2008 | 18234268 |
| prevalence of hantavirus infection in wild rattus norvegicus and r. rattus populations of buenos aires city, argentina. | to determine the prevalence of infection with hantaviruses in wild rattus norvegicus and r. rattus populations in areas of buenos aires city. | 2008 | 18291001 |
| hantavirus rna in saliva from patients with hemorrhagic fever with renal syndrome. | hantaviruses cause 2 zoonotic diseases, hemorrhagic fever with renal syndrome (hfrs) and hantavirus cardiopulmonary syndrome. infection is usually initiated after inhalation of virus-contaminated rodent excreta. in addition to the zoonotic infection route, growing evidence suggests person-to-person transmission of andes virus. for this reason, we studied whether saliva from hfrs patients contained hantavirus. during an outbreak in northern sweden of nephropathia epidemica (ne), a milder form of ... | 2008 | 18325254 |
| characterization of cross-reactive and serotype-specific epitopes on the nucleocapsid proteins of hantaviruses. | the hantavirus nucleocapsid (n) protein fulfills several key roles in virus replication and assembly and is the major antigen in humoral immune responses in humans and mice. here we report on epitopes involved in serotype-specific and cross-reactive recognition of the n proteins of hantaviruses using monoclonal antibodies (mabs) against the n proteins of andes virus (andv) and sin nombre virus (snv). the mabs define at least twelve different epitopic patterns which span eight sequences, includin ... | 2008 | 18342973 |
| nmr structure of the n-terminal coiled coil domain of the andes hantavirus nucleocapsid protein. | the hantaviruses are emerging infectious viruses that in humans can cause a cardiopulmonary syndrome or a hemorrhagic fever with renal syndrome. the nucleocapsid (n) is the most abundant viral protein, and during viral assembly, the n protein forms trimers and packages the viral rna genome. here, we report the nmr structure of the n-terminal domain (residues 1-74, called n1-74) of the andes hantavirus n protein. n1-74 forms two long helices (alpha1 and alpha2) that intertwine into a coiled coil ... | 2008 | 18687679 |
| case report: t-cell responses during clearance of andes virus from blood cells 2 months after severe hantavirus cardiopulmonary syndrome. | hantavirus cardiopulmonary syndrome (hcps) due to andes virus (andv) is endemic in chile and argentina and currently demonstrates a case-fatality rate of 37% in humans. by contrast to the chronically infected rodents, it is believed that andv in humans is cleared during the acute phase. moreover, to date, both magnitude and quality of human t-cell responses during andv infection and clearance are unknown. using ifn-gamma and granzyme b elispot assays as well as flow cytometry, we prospectively s ... | 2008 | 18814258 |
| roles for the recycling endosome, rab8, and rab11 in hantavirus release from epithelial cells. | hantavirus structural proteins are believed to localize to intracellular membranes often identified as golgi membranes, in virus-infected cells. after virus budding into the golgi luminal space, virus-containing vesicles are transported to the plasma membrane via trafficking pathways that are not well defined. using the new world hantavirus, andes virus, we have investigated the role of various rab proteins in the release of hantavirus particles from infected cells. rabs 8 and 11 were found to c ... | 2008 | 18951604 |
| hantavirus antibodies in rodents and human cases with pulmonary syndrome, rio negro, argentina. | in río negro province, argentina, human cases of hantavirus pulmonary syndrome (hps) appeared in the region of subantarctic forests. the andes virus (andv) has been identified in the region both in oligoryzomys longicaudatus rodents and in humans, with the main transmission being from rodents to humans but also showing the possibility of human to human transmission. between 1996 and 2004, in 40 campaigns, 29.960 night-traps for capturing live rodents were set up. blood samples were obtained from ... | 2008 | 18977707 |
| protective efficacy of a bivalent recombinant vesicular stomatitis virus vaccine in the syrian hamster model of lethal ebola virus infection. | outbreaks of filoviral hemorrhagic fever occur sporadically and unpredictably across wide regions in central africa and overlap with the occurrence of other infectious diseases of public health importance. | 2011 | 21987746 |
| andes virus antigens are shed in urine of patients with acute hantavirus cardiopulmonary syndrome. | hantavirus cardiopulmonary syndrome (hcps) is a highly pathogenic emerging disease (40% case fatality rate) caused by new world hantaviruses. hantavirus infections are transmitted to humans mainly by inhalation of virus-contaminated aerosol particles of rodent excreta and secretions. at present, there are no antiviral drugs or immunotherapeutic agents available for the treatment of hantaviral infection, and the survival rates for infected patients hinge largely on early virus recognition and hos ... | 2009 | 19279096 |
| andes virus infections in the rodent reservoir and in humans vary across contrasting landscapes in chile. | hantavirus cardiopulmonary syndrome (hcps) is an emerging infectious disease first reported in chile in 1995. andes hantavirus (andv) is responsible for the more than 500 cases of hcps reported in chile. previous work showed that andv is genetically differentiated in chile across contrasting landscapes. to determine whether the reservoir rodent (oligoryzomys longicaudatus) populations are also geographically segregated, we conducted range-wide spatial genetic analyses of o. longicaudatus in chil ... | 2010 | 19632357 |
| Spatial but not temporal co-divergence of a virus and its mammalian host. | Co-divergence between host and parasites suggests that evolutionary processes act across similar spatial and temporal scales. Although there has been considerable work on the extent and correlates of co-divergence of RNA viruses and their mammalian hosts, relatively little is known about the extent to which virus evolution is determined by the phylogeographic history of host species. To test hypotheses related to co-divergence across a variety of spatial and temporal scales, we explored phylogen ... | 2011 | 21880089 |
| andes virus recognition of human and syrian hamster beta3 integrins is determined by an l33p substitution in the psi domain. | andes virus (andv) causes a fatal hantavirus pulmonary syndrome (hps) in humans and syrian hamsters. human alpha(v)beta(3) integrins are receptors for several pathogenic hantaviruses, and the function of alpha(v)beta(3) integrins on endothelial cells suggests a role for alpha(v)beta(3) in hantavirus directed vascular permeability. we determined here that andv infection of human endothelial cells or syrian hamster-derived bhk-21 cells was selectively inhibited by the high-affinity alpha(v)beta(3) ... | 2010 | 19846530 |
| expression profiling of lymph node cells from deer mice infected with andes virus. | deer mice (peromyscus maniculatus) are the principal reservoir hosts of sin nombre virus (snv), the cause of the great majority of hantavirus cardiopulmonary syndrome (hcps) cases in north america. snv, like all hantaviruses with their reservoirs, causes persistent infection without pathology in deer mice and appear to elicit a regulatory t cell response. deer mice are also susceptible to andes virus (andv), which causes the great majority of hcps cases in south america, but they clear infection ... | 2013 | 23570545 |
| [geographic expansion of hantavirus pulmonary syndrome in argentina. the southernest case report]. | since 1995 more than 1000 cases of hantavirus pulmonary syndrome (hps) were reported in argentina, a severe disease and often fatal to humans. most cases were associated with andes virus (and) that caused few events of person-to-person transmission. several lineages of pathogenic and viruses have been described, including and south, hosted by the rodent oligoryzomys longicaudatus which affects the patagonian region of argentina and chile. we studied the clinical and epidemiological characteristi ... | 2009 | 20053606 |
| the major cellular sterol regulatory pathway is required for andes virus infection. | the bunyaviridae comprise a large family of rna viruses with worldwide distribution and includes the pathogenic new world hantavirus, andes virus (andv). host factors needed for hantavirus entry remain largely enigmatic and therapeutics are unavailable. to identify cellular requirements for andv infection, we performed two parallel genetic screens. analysis of a large library of insertionally mutagenized human haploid cells and a sirna genomic screen converged on components (srebp-2, scap, s1p a ... | 2014 | 24516383 |
| pathogenic hantaviruses direct the adherence of quiescent platelets to infected endothelial cells. | hantavirus infections are noted for their ability to infect endothelial cells, cause acute thrombocytopenia, and trigger 2 vascular-permeability-based diseases. however, hantavirus infections are not lytic, and the mechanisms by which hantaviruses cause capillary permeability and thrombocytopenia are only partially understood. the role of beta(3) integrins in hemostasis and the inactivation of beta(3) integrin receptors by pathogenic hantaviruses suggest the involvement of hantaviruses in altere ... | 2010 | 20181715 |
| modulation of apoptosis and immune signaling pathways by the hantaan virus nucleocapsid protein. | herein, we show a direct relationship between the hantaan virus (htnv) nucleocapsid (n) protein and the modulation of apoptosis. we observed an increase in caspase-7 and -8, but not -9 in cells expressing htnv n protein mutants lacking amino acids 270-330. similar results were observed for the new world hantavirus, andes virus. nuclear factor kappa b (nf-kappab) was sequestered in the cytoplasm after tumor necrosis factor receptor (tnfr) stimulation in cells expressing htnv n protein. further, t ... | 2010 | 20227103 |
| truncated hantavirus nucleocapsid proteins for serotyping sin nombre, andes, and laguna negra hantavirus infections in humans and rodents. | sin nombre virus (snv), andes virus (andv), and laguna negra virus (lanv) have been known as the dominant causative agents of hantavirus pulmonary syndrome (hps). andv and lanv, with different patterns of pathogenicity, exist in a sympatric relationship. moreover, there is documented evidence of person-to-person transmission of andv. therefore, it is important in clinical medicine and epidemiology to know the serotype of a hantavirus causing infection. truncated snv, andv, and lanv recombinant n ... | 2010 | 20335425 |
| temporal and spatial host abundance and prevalence of andes hantavirus in southern argentina. | andes virus (and) is a hantavirus hosted by the sigmodontine rodent oligoryzomys longicaudatus in southern argentina, where it is responsible for most cases of hantavirus pulmonary syndrome (hps). our study provides data about the spatial variation in abundance of the rodent host of and hantavirus. we report results of a longitudinal study performed in a locality of the andean region of chubut province. from november 2003 (spring) to july 2006 (winter), o. longicaudatus was the most common speci ... | 2010 | 20645121 |