| sars-cov-2 and three related coronaviruses utilize multiple ace2 orthologs and are potently blocked by an improved ace2-ig. | the ongoing coronavirus disease 2019 (covid-19) pandemic has caused >20 million infections and >750,000 deaths. severe acute respiratory syndrome coronavirus 2 (sars-cov-2), the etiological agent of covid-19, has been found closely related to the bat coronavirus strain ratg13 (bat-cov ratg13) and a recently identified pangolin coronavirus (pangolin-cov-2020). here, we first investigated the ability of sars-cov-2 and three related coronaviruses to utilize animal orthologs of angiotensin-convertin ... | 2020 | 32847856 |
| are pangolins the intermediate host of the 2019 novel coronavirus (sars-cov-2)? | the outbreak of a novel corona virus disease 2019 (covid-19) in the city of wuhan, china has resulted in more than 1.7 million laboratory confirmed cases all over the world. recent studies showed that sars-cov-2 was likely originated from bats, but its intermediate hosts are still largely unknown. in this study, we assembled the complete genome of a coronavirus identified in 3 sick malayan pangolins. the molecular and phylogenetic analyses showed that this pangolin coronavirus (pangolin-cov-2020 ... | 2020 | 32407364 |
| identifying sars-cov-2-related coronaviruses in malayan pangolins. | the ongoing outbreak of viral pneumonia in china and across the world is associated with a new coronavirus, sars-cov-21. this outbreak has been tentatively associated with a seafood market in wuhan, china, where the sale of wild animals may be the source of zoonotic infection2. although bats are probable reservoir hosts for sars-cov-2, the identity of any intermediate host that may have facilitated transfer to humans is unknown. here we report the identification of sars-cov-2-related coronavirus ... | 2020 | 32218527 |
| comparison of severe acute respiratory syndrome coronavirus 2 spike protein binding to ace2 receptors from human, pets, farm animals, and putative intermediate hosts. | the emergence of a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (sars-cov-2), resulted in a pandemic. here, we used x-ray structures of human ace2 bound to the receptor-binding domain (rbd) of the spike protein (s) from sars-cov-2 to predict its binding to ace2 proteins from different animals, including pets, farm animals, and putative intermediate hosts of sars-cov-2. comparing the interaction sites of ace2 proteins known to serve or not serve as receptors allows the defin ... | 2020 | 32404529 |
| a systematic review of etiology, epidemiology, clinical manifestations, image findings, and medication of 2019 corona virus disease-19 in wuhan, china. | unknown origin pneumonia has been furiously spreading since the late of december 2019, subsequently spread to approximately all provinces and areas in china and many countries, which was announced as a public health emergency of international concern by world health organization (who). the studies on 2019 corona virus disease-19 (covid-19) conducted from various fields around the world. herein, the objective of the present study is to summarize the etiology, epidemiology, clinical manifestations ... | 2020 | 33080715 |
| sars-cov-2: zoonotic origin of pandemic coronavirus. | a novel disease, of unknown origin, causing a deadly pneumonia of human patients was reported in december 2019 in wuhan, hubei province of china. later called coronavirus disease (covid-19), it rapidly spread across china and worldwide. intensive research revealed that the etiological agent of the global covid-19 pandemic was a novel coronavirus named severe acute respiratory syndrome coronavirus 2 (sars-cov-2). the sars-cov-2 genome contains typical coronavirus genes but the receptor binding do ... | 2020 | 32985202 |
| phylogenomic proximity and comparative proteomic analysis of sars-cov-2. | the coronavirus disease (covid-19) belongs to the family severe acute respiratory syndrome (sars-cov). it can be more severe for some persons and can lead to pneumonia or breathing difficulties resulting in the death of immune-compromised patients. we performed a phylogenomic and phylogeographic tree from the collected datasets. phylogenomic analysis or sequence-based phylogeny showed an evolutionary relationship between the geographical strains. the phylogenomic tree grouped into two major clad ... | 2020 | 32835133 |
| comparative genomic signature representations of the emerging covid-19 coronavirus and other coronaviruses: high identity and possible recombination between bat and pangolin coronaviruses. | coronaviruses are responsible on respiratory diseases in animal and human. the combination of numerical encoding techniques and digital signal processing methods are becoming increasingly important in handling large genomic data. in this paper, we propose to analyze the sars-cov-2 genomic signature using the combination of different nucleotide representations and signal processing tools in the aim to identify its genetic origin. the sequence of sars-cov-2 was compared with 21 relevant sequences ... | 2020 | 32645523 |
| repurposing of clinically approved drugs for treatment of coronavirus disease 2019 in a 2019-novel coronavirus-related coronavirus model. | medicines for the treatment of 2019-novel coronavirus (2019-ncov) infections are urgently needed. however, drug screening using live 2019-ncov requires high-level biosafety facilities, which imposes an obstacle for those institutions without such facilities or 2019-ncov. this study aims to repurpose the clinically approved drugs for the treatment of coronavirus disease 2019 (covid-19) in a 2019-ncov-related coronavirus model. | 2020 | 32149769 |