| sequestration of plasmodium falciparum-infected erythrocytes to chondroitin sulfate a, a receptor for maternal malaria: monoclonal antibodies against the native parasite ligand reveal pan-reactive epitopes in placental isolates. | plasmodium falciparum parasites express variant adhesion molecules on the surface of infected erythrocytes (ies), which act as targets for natural protection. recently it was shown that ie sequestration in the placenta is mediated by binding to chondroitin sulfate a via the duffy binding-like (dbl)-gamma 3 domain of p falciparum erythrocyte membrane protein 1 (pfemp1(csa)). conventional immunization procedures rarely result in the successful production of monoclonal antibodies (mabs) against suc ... | 2002 | 12149234 |