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helicobacter pylori virulence factors as tools to study human migrations.helicobacter pylori is one of the most common infections worldwide. in most individuals it consists in a lifelong host-pathogen relationship without consequences, but in some subjects it is associated with peptic ulcer disease and gastric cancer. polymorphism in genes that code bacterial virulence factors, caga and vaca, are independently associated with the infection severe outcomes and are geographically diverse. in the last decade, accumulated knowledge allowed to characterize typical h. pylo ...201020144640
[helicobacter pylori in children and association with caga strains in mother-child transmission in the brazilian amazon region].the prevalence of helicobacter pylori infection was investigated in blood samples from 100 children aged 1 to 12 years and from their mothers, by means of the indirect hemagglutination and anti-caga methods, using elisa assays. from these 100 children, 79 stool samples were obtained and bacterial antigens in the stools were investigated using capture elisa. the antigens were detected in 54.4% (43/79) of the children, and serum antibodies in 43% (34/79). these methods presented similar performanc ...200919684978
interleukin-1 and tnf-alpha polymorphisms and helicobacter pylori in a brazilian amazon population.to study the association between interleukin-1 (il-1) and tumor necrosis factor (tnf)-alpha polymorphisms, infection by helicobacter pylori (h pylori) and the development of gastrointestinal diseases.200919322919
role of helicobacter pylori infection and lifestyle habits in the development of gastroduodenal diseases in a population from the brazilian amazon.although more than half of the world's population is colonized with helicobacter pylori, it remains unknown why this organism is able to produce severe disease in some hosts and be innocuous in others. the clinical outcome of infection is determined by several factors, including differences in the host response to bacterial stimulation, specific virulence factors of the organism and environmental influences, or a combination of these factors.201624322186
prevalence and risk factors associated with helicobacter pylori infection in native populations from brazilian western amazon.we evaluated the prevalence of, and factors associated with, helicobacter pylori infection in 222 subjects from 3 distinct communities of native populations (uru-eu-wau-wau indians and 2 riverine communities living on the banks of the machado river and in portuchuelo) living in isolation in the rainforest of brazilian western amazon. the overall prevalence was 78.8% (95% ci 72.7-83.9). the prevalence was higher in the machado river community compared with portuchuelo (chi2 = 3.84, p = 0.05), but ...200315259462
characterization of 23s rrna domain v mutations in gastric biopsy patients from the eastern amazon.resistance of helicobacter pylori to clarithromycin is characterised by simple point mutations in the 23s ribosomal rna (rrna) gene and is responsible for the majority of cases of failure to eradicate this bacterium. in this paper, we characterised the variability of the 23s rrna gene in biopsies of patients with gastric pathologies in the eastern amazon (northern region of brazil) using pcr and sequencing. a total of 49 sequences of h. pylori strains were analysed and of those, 75.6% presented ...201020512246
evaluation of helicobacter pylory colonization by serologic test (igg) and dyspepsia in volunteers from the countryside of monte negro, in the brazilian western amazon region.the present study intended to analyze the seroprevalence of helicobacter pylori, igg, and its relation to dyspepsia in a population from the western amazon region. during the "projeto bandeira cient+¡fica", a university of s+úo paulo medical school program, in monte negro's rural areas, state of rond+¦nia, 266 blood samples were collected from volunteers. the material was tested for igg antibodies anti-helicobacter pylori by elisa method and the participants were also interviewed on dyspepsia, h ...201021748228
differences in virulence markers between helicobacter pylori strains from the brazilian amazon region.this study compares virulence markers of helicobacter pylori isolated from patients in 2 cities in the brazilian amazon.201523856857
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