| genome-wide analysis of ivermectin response by onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity. | treatment of onchocerciasis using mass ivermectin administration has reduced morbidity and transmission throughout africa and central/south america. mass drug administration is likely to exert selection pressure on parasites, and phenotypic and genetic changes in several onchocerca volvulus populations from cameroon and ghana-exposed to more than a decade of regular ivermectin treatment-have raised concern that sub-optimal responses to ivermectin's anti-fecundity effect are becoming more frequen ... | 2017 | 28746337 |