| novel ambler class a carbapenem-hydrolyzing beta-lactamase from a pseudomonas fluorescens isolate from the seine river, paris, france. | a pseudomonas fluorescens isolate (pf-1) resistant to carbapenems was recovered during an environmental survey performed with water from the seine river (paris). it expressed a novel ambler class a carbapenemase, bic-1, sharing 68 and 59% amino acid identities with beta-lactamases sfc-1 from serratia fonticola and the plasmid-encoded kpc-2, respectively. beta-lactamase bic-1 hydrolyzed penicillins, carbapenems, and cephalosporins except ceftazidime and monobactams. the bla(bic-1) gene was chromo ... | 2010 | 19901091 |