| genome-wide selection on codon usage at the population level in the fungal model organism neurospora crassa. | many organisms exhibit biased codon usage in their genome, including the fungal model organism neurospora crassa. the preferential use of subset of synonymous codons (optimal codons) at the macroevolutionary level is believed to result from a history of selection to promote translational efficiency. at present, few data are available about selection on optimal codons at the microevolutionary scale, that is, at the population level. herein, we conducted a large-scale assessment of codon mutations ... | 2012 | 22334579 |
| population genomics and local adaptation in wild isolates of a model microbial eukaryote. | elucidating the connection between genotype, phenotype, and adaptation in wild populations is fundamental to the study of evolutionary biology, yet it remains an elusive goal, particularly for microscopic taxa, which comprise the majority of life. even for microbes that can be reliably found in the wild, defining the boundaries of their populations and discovering ecologically relevant phenotypes has proved extremely difficult. here, we have circumvented these issues in the microbial eukaryote n ... | 2011 | 21282627 |