| molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998. | enterovirus 71 (ev71) (genus enterovirus, family picornaviridae), a common cause of hand, foot, and mouth disease (hfmd), may also cause severe neurological diseases, such as encephalitis and poliomyelitis-like paralysis. to examine the genetic diversity and rate of evolution of ev71, we have determined and analyzed complete vp1 sequences (891 nucleotides) for 113 ev71 strains isolated in the united states and five other countries from 1970 to 1998. nucleotide sequence comparisons demonstrated t ... | 1999 | 10559310 |
| virology, epidemiology, pathogenesis, and control of enterovirus 71. | first isolated in california, usa, in 1969, enterovirus 71 (ev71) is a major public health issue across the asia-pacific region and beyond. the virus, which is closely related to polioviruses, mostly affects children and causes hand, foot, and mouth disease with neurological and systemic complications. specific receptors for this virus are found on white blood cells, cells in the respiratory and gastrointestinal tract, and dendritic cells. being an rna virus, ev71 lacks a proofreading mechanism ... | 2010 | 20961813 |