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predictors of delayed-type hypersensitivity to candida albicans and anti-epstein-barr virus antibody among children in kilimanjaro, tanzania.we evaluated sex, age, nutritional status, and infectious disease (id) as predictors of two biomarkers of cell-mediated immunity (cmi), delayed-type hypersensitivity to candida albicans (dth-candida), and anti-epstein-barr virus antibody (ebv ab), among 200 children in kilimanjaro, tanzania. dth-candida, which decreases with compromised cmi, was positively associated with age (or: 1.27; 95% ci: 1.02, 1.57) and triceps skinfold (tsf; or: 1.16; 95% ci: 1.02, 1.26), and inversely associated with he ...201323460387
expanding the hygiene hypothesis: early exposure to infectious agents predicts delayed-type hypersensitivity to candida among children in kilimanjaro.multiple lines of evidence suggest that infections in early life prevent the development of pathological immune responses to allergens and autoantigens (the hygiene hypothesis). early infections may also affect later immune responses to pathogen antigen.201222616000
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