| genetic and biochemical characterization of a novel metallo-β-lactamase, tmb-1, from an achromobacter xylosoxidans strain isolated in tripoli, libya. | an achromobacter xylosoxidans strain from the tripoli central hospital produced a unique metallo-β-lactamase, designated tmb-1, which is related to dim-1 (62%) and gim-1 (51%). bla(tmb-1) was embedded in a class 1 integron and located on the chromosome. the tmb-1 β-lactamase has lower k(cat) values than both dim-1 and gim-1 with cephalosporins and carbapenems. the k(m) values were more similar to those of gim-1 than those of dim-1, with the overall k(cat)/k(m) values being lower than those for g ... | 2012 | 22290947 |